Fabrication of Porous β-Tricalcium Phosphate with Collagen Composite Materials

Author(s):  
Yuki Igarashi ◽  
Junichi Matsushita
2018 ◽  
Vol 483 (1) ◽  
pp. 59-63
Author(s):  
V. Smirnov ◽  
◽  
M. Goldberg ◽  
A. Krylov ◽  
S. Smirnov ◽  
...  

2018 ◽  
Vol 483 (1) ◽  
pp. 275-278
Author(s):  
V. V. Smirnov ◽  
M. A. Goldberg ◽  
A. I. Krylov ◽  
S. V. Smirnov ◽  
O. S. Antonova ◽  
...  

2021 ◽  
Vol 1 (19) ◽  
pp. 20-21
Author(s):  
A.I. Zimina ◽  
P.A. Zhukova ◽  
F.S. Senatov

Composite materials based on polylactide, polyhydroxybutyrate and tricalcium phosphate have been developed for the reconstruction of unloaded bone defects.


2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Qing Li ◽  
Tong Wang ◽  
Gui-feng Zhang ◽  
Xin Yu ◽  
Jing Zhang ◽  
...  

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additionalβ-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.


Author(s):  
I. E. Glazov ◽  
R. A. Vlasov ◽  
V. K. Krut’ko ◽  
O. N. Musskaya

Composites based on calcium phosphates in the matrix of biopolymer (citrated plasma and fibrin) were synthesized in neutral and alkaline medium. At pH 7 brushite composites were obtained, whereas at pH 11 amorphized hydroxyapatite was precipitated. Disruption of precipitation conditions led to the formation of tricalcium phosphate impurity, which was detected by XRD after thermal treatment of composites at 800 °C. Composition and morphology of calcium phosphates did not depend on biopolymer nature. To determine bioactivity degree, composites were incubated in model Simulated Body Fluid (SBF) for 75 days. It was found that composites based on amorphized hydroxyapatite incorporated in biopolymer matrix have maximum growth of biomimetic layer of apatite.


2008 ◽  
Vol 569 ◽  
pp. 237-240
Author(s):  
Yuki Igarashi ◽  
Junichi Matsushita

Biomaterials have been developed and used for bone grafting. Here, we study a fabrication of composite for bone tissue engineering by combining tricalcium phosphate and collagen. This tricalcium phosphate and collagen composite material may be applicable for use as a bone substitute. The β-tricalcium phosphate (β-TCP) is the one of the most investigated biomaterials due to its biocompatibility and good bioactivity. The β-TCP is used in a filling purpose to the bone defect region such as bone fractures. It is known that β-TCP substitutes it for a self bone in the body. The ingredient of the real bone is made of hydroxyapatite and collagen. In this study, the purpose was at giving the mechanical property and biological property which were near to a bone with β-TCP and collagen this time. We evaluate what kind of action collagen addition.


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