scholarly journals Synthesis of composite materials based on calcium phosphates and blood components

2019 ◽  
Vol 55 (2) ◽  
pp. 135-141 ◽  
Author(s):  
I. E. Glazov ◽  
R. A. Vlasov ◽  
V. K. Krut’ko ◽  
O. N. Musskaya
Keyword(s):  
Composite Materials ◽  
Thermal Treatment ◽  
Simulated Body Fluid ◽  
Alkaline Medium ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Calcium Phosphates ◽  
Maximum Growth ◽  
Blood Components ◽  
The Matrix

Composites based on calcium phosphates in the matrix of biopolymer (citrated plasma and fibrin) were synthesized in neutral and alkaline medium. At pH 7 brushite composites were obtained, whereas at pH 11 amorphized hydroxyapatite was precipitated. Disruption of precipitation conditions led to the formation of tricalcium phosphate impurity, which was detected by XRD after thermal treatment of composites at 800 °C. Composition and morphology of calcium phosphates did not depend on biopolymer nature. To determine bioactivity degree, composites were incubated in model Simulated Body Fluid (SBF) for 75 days. It was found that composites based on amorphized hydroxyapatite incorporated in biopolymer matrix have maximum growth of biomimetic layer of apatite.

Hydroxyapatite formation on porous ceramics of alpha-tricalcium phosphate in a simulated body fluid

2010 ◽  
Vol 21 (6) ◽  
pp. 1921-1926 ◽  
Author(s):  
Tomohiro Uchino ◽  
Kohei Yamaguchi ◽  
Ichiro Suzuki ◽  
Masanobu Kamitakahara ◽  
Makoto Otsuka ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Porous Ceramics ◽  
Hydroxyapatite Formation

Formation of hydroxyapatite on ceramics consisting of tricalcium phosphate in a simulated body fluid

2008 ◽  
Vol 116 (1349) ◽  
pp. 96-99 ◽  
Author(s):  
Tomohiro UCHINO ◽  
Kohei YAMAGUCHI ◽  
Giichiro KAWACHI ◽  
Koichi KIKUTA ◽  
Masanobu KAMITAKAHARA ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Tricalcium Phosphate ◽  
Body Fluid

Effects of Surface Modification of Titania on In Vitro Apatite-Forming Ability

2014 ◽  
Vol 604 ◽  
pp. 196-199 ◽  
Author(s):  
Inga Narkevica ◽  
Jurijs Ozolins ◽  
Liga Berzina-Cimdina
Keyword(s):  
Surface Modification ◽  
Thermal Treatment ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Uv Light ◽  
Biological Response ◽  
Surface Activation ◽  
Living Body ◽  
Artificial Materials

Surface properties of a material play a significant role in manipulating biological response of living body to artificial materials. The aim of this work was put on bioactivity assessment of TiO2 ceramic after thermal treatment and further surface activation with UV-light. The in vitro apatite-forming ability was examined by soaking the samples into the simulated body fluid for several days. The research shows that nanostructural surface and UV irradiation accelerates formation of apatite on TiO2 pellets.

scholarly journals Biomimetic Coating of Modified Titanium Surfaces with Hydroxyapatite Using Simulated Body Fluid

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Mohsin Nazir ◽  
Ong Pei Ting ◽  
Tan See Yee ◽  
Saravanan Pushparajan ◽  
Dasan Swaminathan ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Energy Dispersive Spectrometer ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Phosphate Coatings ◽  
Infrared Spectrometer ◽  
Sbf Solution ◽  
The Fourier Transform

This study investigated the viability of coating commercially pure titanium (CPTi) surfaces, modified via sandblasting and acid etching, with hydroxyapatite (HA)/tricalcium phosphate coatings using a simulated body fluid (SBF) solution. The samples were immersed in SBF from 3 to 7 days. The morphology and the chemistry of the HA/tricalcium phosphate coating were then analysed. Prior to immersion in SBF, the samples were sandblasted and acid etched to mimic the morphology and roughness of commercially available dental implants. The SBF aided in the formation of crystalline HA/tricalcium phosphate coatings on all the samples. The coatings were uniform and had roughness values higher than the underlying substrate. The highest roughness values for the coatings on the surfaces were obtained at 7 days of immersion in SBF with averageSavalues of 2.9 ± 0.2 µm. The presence of HA/tricalcium phosphate on the surfaces was confirmed by the Scanning Electron Microscope (SEM), Energy Dispersive Spectrometer (EDS), the X-Ray Diffraction (XRD), and the Fourier Transform Infrared Spectrometer (FTIR) analysis. This study shows that it is possible to obtain an adequate and uniform hydroxyapatite coating on pure titanium substrates in a shorter period of time with characteristics that favour the ultimate goal of implants therapy, that is, osseointegration.

Crystallization of a Bone-like Apatite from a Milk-Containing Revised Simulated Body Fluid (SBF)

2007 ◽  
Vol 330-332 ◽  
pp. 641-644
Author(s):  
Sergey V. Dorozhkin ◽  
Elena I. Dorozhkina ◽  
S. Salman ◽  
Faik N. Oktar
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Calcium Phosphates ◽  
Double Diffusion ◽  
Negative Influence ◽  
Cow Milk ◽  
Constant Composition ◽  
Ionic Concentrations ◽  
Water As Solvent ◽  
Crystallization Conditions

Revised simulated body fluid (rSBF) was prepared using a conventional route but all the chemicals were dissolved in commercial cow milk instead of de-ionized water. To accelerate crystallization and increase the amount of precipitates, the influence of milk on the crystallization of calcium phosphates was studied in supersaturated solutions equal to 4 times the ionic concentrations of rSBF. The experiments were carried out in physiological conditions, i.e. pH of 7.35–7.40, temperature of 37.0 (± 0.2) °C, and duration of 7 days, using a constant-composition double-diffusion (CCDD) device, which enables slow precipitation in strictly controlled crystallization conditions. Similar experiments with 4 times the ionic concentrations of rSBF using de-ionized water as solvent were carried out as control. For comparison purposes, another set of experiments with 4 times the ionic concentrations of rSBF in de-ionized water also containing 40 g of bovine serum albumin (BSA) per liter was also conducted. The experimental results showed that the behavior of milk was similar to the presence of dissolved BSA. Some components of milk, presumably proteins, co-precipitated with calcium phosphates. This phenomenon had a strong negative influence on the crystallinity of the precipitates.

Apatite Formation on Porous TCP In Vitro: A Comparative Study between Static and Dynamic RSBF Systems

2007 ◽  
Vol 280-283 ◽  
pp. 1581-1584
Author(s):  
Chun Lin Deng ◽  
Ji Yong Chen ◽  
Yang Leng ◽  
Xin Long Wang ◽  
Yao Wu ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Comparative Study ◽  
Dynamic System ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Apatite Formation ◽  
Static System ◽  
Inner Pore

Porous tricalcium phosphate ceramics were immersed in static and dynamic revised simulated body fluid (RSBF) at 37°C. Morphology, composition and phase of precipitates on TCP were identified by SEM, FTIR and TEM methods. FTIR and TEM results indicated the deposits on the inner pore walls of TCP were OCP, and SEM results implied that the deposited way of precipitates in static system was different from that in dynamic system.

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