Research on the Technology of Order Change for Machine Manufacturing Enterprises Information

2012 ◽  
Vol 246-247 ◽  
pp. 966-969
Author(s):  
Jian Qing Chen
Keyword(s):  
Adverse Effects ◽  
Audit Process ◽  
Application Form ◽  
Change Orders ◽  
Manufacturing Enterprises ◽  
Order Change

Order changes too frequently or even out of control, will have very adverse effects on their business; therefore the control of change orders is essential. This paper first analyzes the characteristics and forms of mechanical order changes, and then the application form finishing methods on the classification of the demand for change orders and change orders, and finally the general machinery enterprises in order to change the audit process and principles.

Classifications of Objections Based on the Legal Assessment of a Reservation by Objecting States

2014 ◽  
Vol 16 (3) ◽  
pp. 333-370
Author(s):  
Marina Girshovich
Keyword(s):  
Human Rights ◽  
Adverse Effects ◽  
Functional Approach ◽  
Theoretical Interpretation ◽  
Advisory Opinion ◽  
Legal Assessment ◽  
Human Rights Treaties ◽  
International Obligations

Current doctrine assumes that the “Vienna regime” delinked objections from the criterion of object and purpose (op) compatibility of reservations. Shifting the focus from reservations to objections, this article finds implicit continuity between the Genocide Advisory Opinion and the Vienna regime: in both cases the op criterion enables a distinction between objections on the grounds of incompatibility of reservations (op objections) and all others. Embracing this distinction, a new theoretical interpretation of the Vienna regime safeguards against the adverse effects of objections, namely a “reinforced two-tier test” is suggested, whereby any reservation may be subject to an assessment of opposability (non-op objections) and a double assessment of permissibility. Adopting a functional approach, the article suggests a classification of international obligations based on the applicability of the Vienna regime’s various safeguard mechanisms, locating the roles of objections to reservations to human rights treaties in context.

scholarly journals Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Charles McCartan ◽  
Robert Mason ◽  
S. R. Jayasinghe ◽  
Lyn R. Griffiths
Keyword(s):  
Adverse Effects ◽  
Genetic Information ◽  
Molecular Basis ◽  
Genetic Basis ◽  
Muscle Size ◽  
Systemic Diseases ◽  
Ongoing Debate ◽  
Traditional Classification ◽  
And Function

Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities.

Product Diversification and Profitability in German Manufacturing Firms

2011 ◽  
Vol 231 (3) ◽  
Author(s):  
Nils Braakmann ◽  
Joachim Wagner
Keyword(s):  
Negative Impact ◽  
Point Of View ◽  
Product Diversification ◽  
Firm Characteristics ◽  
Single Product ◽  
Economic Point ◽  
Manufacturing Enterprises ◽  
Detailed Classification ◽  
Rich Data

SummaryWe use unique rich data for German manufacturing enterprises to investigate the product diversification - firm performance relationship.We find that an increase in the degree of product diversification has a negative impact on profitability when observed and unobserved firm characteristics are controlled for. The effects are statistically significant and large from an economic point of view. This helps to understand the fact that nearly 40 percent of all enterprises with at least 20 employees are single-product firms according to a detailed classification of products, and that multi-product enterprises with a large number of goods are a rare species.

Assessment of Implementation Capability for Design-Manufacturing Integration Based on Support Vector Machine

2012 ◽  
Vol 522 ◽  
pp. 842-846
Author(s):  
Song Chen ◽  
Ye Zhuang Tian ◽  
Yang Yang ◽  
Liu Yan
Keyword(s):  
Support Vector Machine ◽  
New Product Development ◽  
Evaluation Method ◽  
Complex Adaptive System ◽  
New Product ◽  
Support Vector ◽  
Manufacturing Enterprises ◽  
Effective Evaluation ◽  
Complex Adaptive

Design-manufacturing integration is one of the most signicant contemporary trends in new product development (NPD) for manufacturing enterprises. Exploring the implementation capability of manufacturing enterprises through the assessment of design-manufacturing integration is an important and crucial step for determining what kind of design-manufacturing integration is appropriate for manufacturing enterprises. However, quantitative evaluation of design-manufacturing integration is rather limited so far. In this paper, we view design-manufacturing integration as a complex adaptive system (CAS), an effective evaluation method for design-manufacturing integration is proposed. To classify the manufacturing enterprises into which can quickly adapt to the environment or not, support vector machine is utilized. Selecting relevant features among the features available for classification of was also dealt with. The experiment results demonstrate the proposed method is useful for Design-manufacturing integration quantitatively.

scholarly journals ANALISIS KORELASI BIAYA CHANGE ORDER TERHADAP BOBOT PEKERJAAN PADA DUA PROYEK JALAN ASPAL PROVINSI BANTEN

2020 ◽  
Vol 3 (1) ◽  
pp. 175
Author(s):  
Dominicus Edwin ◽  
Mega Waty
Keyword(s):  
Correlation Analysis ◽  
Construction Projects ◽  
Pearson Correlation ◽  
Original Data ◽  
Parameter Change ◽  
Change Orders ◽  
Change Order ◽  
Degree Of Confidence ◽  
Order Change

In every project, one thing that often happens is a change order. Change order is a change of work after the contract is signed by the owner and contractor. These changes can occur at the beginning, middle, or in construction projects. To minimize change orders, a change order correlation analysis can be done using the original data, with the parameters change order ratio in addition (CORA) and change order ratio in substraction (CORS). The data used in this study uses two original change order contract data on projects in Banten Province. This study produced 4 correlation results obtained from Pearson correlation in the SPSS program. The results of the correlation of the weight of each work to CORA on project 1 did not show any correlation. The results of the correlation of weights for each work with CORA project 2 and the results of the correlation of weights with CORS project 2 showed a significant correlation at the 95% degree of confidence. The results of the correlation of the weight of each work with CORS project 1 showed a very significant correlation at the 99% degree of confidence.AbstrakDalam setiap proyek, salah satu hal yang sering terjadi ialah change order. Change order adalah perubahan pekerjaan setelah kontrak yang ditandatangani oleh pemilik dan kontraktor. Perubahan itu dapat terjadi pada awal, tengah, ataupun pada dalam proyek konstruksi. Untuk meminimalisir change order maka dapat dilakukan analisis korelasi change order menggunakan data asli, dengan parameter change order ratio in addition (CORA) dan change order ratio in substraction (CORS). Data yang digunakan pada studi ini menggunakan dua data asli kontrak change order pada proyek konstruksi jalan aspal di Provinsi Banten. Baik data proyek 1 maupun data proyek 2 memiliki data kontrak change order biaya awal dan data biaya setelah terjadinya change order. Studi ini menghasilkan 4 hasil korelasi yang di dapat dari korelasi pearson pada program SPSS. Hasil korelasi bobot tiap pekerjaan terhadap CORA pada proyek 1 tidak menunjukan adanya korelasi. Hasil korelasi bobot tiap pekerjaan dengan CORA proyek 2 dan hasil korelasi bobot dengan CORS proyek 2 menunjukan adanya korelasi yang signifikan pada tingkat derajat kepercayaan 95%. Hasil korelasi bobot tiap pekerjaan dengan CORS proyek 1 menunjukan adanya korelasi yang sangat signifikan pada tingkat derajat kepercayaan 99%.

scholarly journals Modelo de auditoría integral para pequeñas Cooperativas de Ahorro y Crédito ecuatorianas. // Model of integral audit for small Ecuadorian saving and credit cooperatives.

Ciencia Unemi ◽  
2017 ◽  
Vol 10 (23) ◽  
pp. 49
Author(s):  
Fernando Veloz Navarrete ◽  
Diana Vargas Ulloa ◽  
Cesar Villa Maura
Keyword(s):  
Decision Making ◽  
Management Tool ◽  
Audit Process ◽  
Transdisciplinary Approach ◽  
Credit Cooperatives ◽  
Control And Prevention ◽  
Toma De Decisiones ◽  
And Performance ◽  
Single Instrument

La presente investigación expone la implementación de la “Auditoría Integral” asumida como herramienta gerencial para pequeñas Cooperativas de Ahorro y Crédito Ecuatorianas, ubicadas en el segmento 4, de acuerdo a la clasificación del Sistema Popular y Solidario. La novedad reside en la adopción de las prácticas comunes de auditorías diversas, aplicadas a las pequeñas entidades, sean estas de control y prevención, gestión, cumplimiento y financieras. El enfoque transdisciplinario es revelado como una estrategia y método para lograr resultados más acertados según Edgar Morín; al adoptar e imbricar estás técnicas de manera complementaria en un instrumento único, proporcionan de forma simplificada, coherente y pertinente, los pasos del proceso de auditoría para la toma oportuna de las decisiones y reorientaciones estratégicas. Es propuesta la “Auditoría Integral” como instrumento de monitoreo a la gestión empresarial, que responda en la pertinencia de la toma de decisiones, dadas las características y particularidades propias de este tipo de empresas, donde la gestión resulta un proceso estratégico y decisorio, en el éxito y desempeño de las mismas. ABSTRACTThe present research presents the implementation of the "Integral Audit" which is assumed as a management tool for small Ecuadorian Saving and Credit Cooperatives located in segment 4 according to the classification of the Popular and Solidary System. The new thing lies in the adoption of common auditing practices, applied to small entities that can be either of control and prevention, management, compliance and financial. The transdisciplinary approach is presented as a strategy and method to achieve more successful results according to Edgar Morín; by adopting and interweaving these techniques in a complementary way into a single instrument, they provide with the steps of the audit process for timely decision-making and strategic reorientation in a simplified, coherent and relevant way. It is proposed the "integral audit" as a monitoring tool for business management that responds in the pertinence of decision making, given the characteristics and particularities of these types of companies, where management is a strategic and decisive process for the success and performance of them.

scholarly journals KNIME-based Analysis of Off-Target Effect of Drugs Related to The Molecular 2D Fingerprint

2021 ◽  
Vol 24 ◽  
pp. 256-266
Author(s):  
Nihayatul Karimah ◽  
Gijs Schaftenaar
Keyword(s):  
Adverse Effects ◽  
Statistical Significance ◽  
Similarity Searching ◽  
Expectation Value ◽  
Open Source Data ◽  
Source Data ◽  
Similarity Ensemble Approach ◽  
Target Effect ◽  
Target Effects

Purpose: Structurally similar molecules are likely to have similar biological activity. In this study, similarity searching based on molecular 2D fingerprint was performed to analyze off-target effects of drugs. The purpose of this study is to determine the correlation between the adverse effects and drug off-targets. Methods: A workflow was built using KNIME to run dataset preparation of twenty-nine targets from ChEMBL, generate molecular 2D fingerprints of the ligands, calculate the similarity between ligand sets, and compute the statistical significance using similarity ensemble approach (SEA). Tanimoto coefficients (Tc) are used as a measure of chemical similarity in which the values between 0.2 and 0.4 are the most common for the majority of ligand pairs and considered to be insignificant similar. Result: The majority of ligand sets are unrelated, as is evidenced by the intrinsic chemical differences and the classification of statistical significance based on expectation value. The rank-ordered expectation value of inter-target similarity showed a correlation with off-target effects of the known drugs. Conclusion: Similarity-searching using molecular 2D fingerprint can be applied to predict off-targets and correlate them to the adverse effects of the drugs. KNIME as an open-source data analytic platform is applicable to build a workflow for data mining of ChEMBL database and generating SEA statistical model.

Automated classification technique for edge-on galaxies based on mathematical treatment of brightness data

2021 ◽  
Vol 21 (10) ◽  
pp. 264
Author(s):  
Mohamed Eassa ◽  
Ibrahim Mohamed Selim ◽  
Walid Dabour ◽  
Passent Elkafrawy
Keyword(s):  
Adverse Effects ◽  
Weighting Factor ◽  
Current Work ◽  
Special Treatment ◽  
Mathematical Treatment ◽  
Automated Classification ◽  
Milky Way Galaxy ◽  
High Brightness ◽  
Classification Technique

Abstract Classification of edge-on galaxies is important to astronomical studies due to our Milky Way galaxy being an edge-on galaxy. Edge-on galaxies pose a problem to classification due to their less overall brightness levels and smaller numbers of pixels. In the current work, a novel technique for the classification of edge-on galaxies has been developed. This technique is based on the mathematical treatment of galaxy brightness data from their images. A special treatment for galaxies’ brightness data is developed to enhance faint galaxies and eliminate adverse effects of high brightness backgrounds as well as adverse effects of background bright stars. A novel slimness weighting factor is developed to classify edge-on galaxies based on their slimness. The technique has the capacity to be optimized for different catalogs with different brightness levels. In the current work, the developed technique is optimized for the EFIGI catalog and is trained using a set of 1800 galaxies from this catalog. Upon classification of the full set of 4458 galaxies from the EFIGI catalog, an accuracy of 97.5% has been achieved, with an average processing time of about 0.26 seconds per galaxy on an average laptop.

IV steroids during long episodes of Kleine-Levin syndrome

Neurology ◽  
2018 ◽  
Vol 90 (17) ◽  
pp. e1488-e1492 ◽  
Author(s):  
Antoine Léotard ◽  
Elisabeth Groos ◽  
Charlotte Chaumereuil ◽  
Laure Peter-Derex ◽  
Andrea O. Rossetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Adverse Effects ◽  
Risk Ratio ◽  
Muscle Pain ◽  
Disease Duration ◽  
Naturalistic Study ◽  
Previous Episode ◽  
Episode Duration ◽  
Class Iv

ObjectiveTo retrospectively compare the benefits (episode cessation) and risks of IV methylprednisolone (IV-MP) vs abstention during prolonged Kleine-Levin syndrome (KLS) episodes.MethodsA total of 26 patients with KLS received 1 g/d IV-MP for 3 days during 1 to 6 episodes each (totaling 43 IV-MP sessions). The change of episode duration with IV-MP (vs previous episode duration) was compared with the change duration between 2 consecutive episodes in 48 untreated patients matched for age, sex, age at KLS onset, number of episodes, and disease duration (more treated than untreated patients had long episodes).ResultsEleven patients (42.3%) had an episode that was at least 1 week shorter than the preceding one when they received IV-MP therapy, whereas shorter episodes were significantly less frequent (10.4%) in the untreated group. This benefit was more marked (65.5% responders, 12 fewer days in an episode vs 0 days in the untreated patients) when IV-MP was infused before the 10th day of the episode. Mild, transient adverse effects (insomnia, muscle pain, nervousness/restlessness, but no manic switching) were reported by 61.3% of patients. No specific responder profile was identified.ConclusionIn this open-labeled, naturalistic study, early IV-MP (following the protocol for multiple sclerosis relapses) had a good benefit/risk ratio during KLS episodes in patients with long episodes (with half of the patients having an early cessation of episodes).Classification of evidenceThis study provides Class IV evidence that for patients with long episodes of KLS, IV steroids decrease the duration of KLS episodes.

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