Loading and Unloading Properties of Encapsulated Methylene Blue in Silica Nanoparticles for Photodynamic Applications

2014 ◽  
Vol 1024 ◽  
pp. 292-295 ◽  
Author(s):  
Ghaseb N. Makhadmeh ◽  
Azlan Abdul Aziz ◽  
Khairunisak Abdul Razak
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Diffusion Process ◽  
Physical Properties ◽  
Red Blood Cells ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Target Area ◽  
Loading And Unloading

In this report, we discussed the physical properties of encapsulated Methylene Blue (MB) by Silica Nanoparticles (SiNPs) intended for photodynamic therapy application. The aim of this discussion is to determine the suitable concentration of MB which can be delivered to the target area. Results shows that the size of SiNP is not affected by the change in MB concentration from out-diffusion process even when the concentration of loaded MB were reduce by more than 50 percent. The applicability of the encapsulated MB in SiNP was demonstrated on Red Blood Cells (RBCs) and the results were compared to those obtained from naked MB.

scholarly journals Photodynamic Inactivation of Candida albicans in Blood Plasma and Whole Blood

Antibiotics ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 221 ◽  
Author(s):  
Vera Sousa ◽  
Ana T. P. C. Gomes ◽  
Américo Freitas ◽  
Maria A. F. Faustino ◽  
Maria G. P. M. S. Neves ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Blood Plasma ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Antimicrobial Photodynamic Therapy ◽  
Photodynamic Inactivation ◽  
Blood Components

The few approved disinfection techniques for blood derivatives promote damage in the blood components, representing risks for the transfusion receptor. Antimicrobial photodynamic therapy (aPDT) seems to be a promising approach for the photoinactivation of pathogens in blood, but only three photosensitizers (PSs) have been approved, methylene blue (MB) for plasma and riboflavin and amotosalen for plasma and platelets. In this study, the efficiency of the porphyrinic photosensitizer Tri-Py(+)-Me and of the porphyrinic formulation FORM was studied in the photoinactivation of Candida albicans in plasma and in whole blood and the results were compared to the ones obtained with the already approved PS MB. The results show that FORM and Tri-Py(+)-Me are promising PSs to inactivate C. albicans in plasma. Although in whole blood the inactivation rates obtained were higher than the ones obtained with MB, further improvements are required. None of these PSs had promoted hemolysis at the isotonic conditions when hemolysis was evaluated in whole blood and after the addition of treated plasma with these PSs to concentrates of red blood cells.

scholarly journals Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells

Small ◽  
2009 ◽  
Vol 5 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Igor I. Slowing ◽  
Chia-Wen Wu ◽  
Juan L. Vivero-Escoto ◽  
Victor S.-Y. Lin
Keyword(s):  
Mesoporous Silica ◽  
Red Blood Cells ◽  
Silica Nanoparticles ◽  
Hemolytic Activity ◽  
Blood Cells ◽  
Mesoporous Silica Nanoparticles

scholarly journals Nanocomposites based on graphene oxide and mesoporous silica nanoparticles: Preparation, characterization and nanobiointeractions with red blood cells and human plasma proteins

2018 ◽  
Vol 437 ◽  
pp. 110-121 ◽  
Author(s):  
Leandro C. Fonseca ◽  
Maciel M. de Araújo ◽  
Ana Carolina M. de Moraes ◽  
Douglas S. da Silva ◽  
Ariane G. Ferreira ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Red Blood Cells ◽  
Silica Nanoparticles ◽  
Human Plasma ◽  
Blood Cells ◽  
Plasma Proteins ◽  
Mesoporous Silica Nanoparticles
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