Synthesis, Characterization and Crystallization of Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone)

2010 ◽  
Vol 152-153 ◽  
pp. 1665-1668
Author(s):  
Lian Liu ◽  
Pei Wang ◽  
Chao Qu ◽  
Zhi Yong Wei ◽  
Min Qi
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Relative Length ◽  
Copolymer Composition ◽  
Poly Ethylene Glycol ◽  
Crystallization Behaviors ◽  
Poly Ethylene ◽  
Xrd Patterns ◽  
High Yields ◽  
Dsc Curves

A family of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-PCL) were synthesized in high yields by the ring-opening polymerization of monomethoxy-terminated poly(ethylene glycol) (mPEG) with ε-caprolactone in the presence of stannous octoate (Sn(Oct)2). Their crystallization behaviors were studied by DSC, XRD. The results illustrated that crystallization behaviors of the copolymers depended on the copolymer composition and the relative length of each block in copolymers. The melting peak of PCL block appeared gradually in the XRD patterns and DSC curves in copolymers, with increasing of the length of PCL blocks.

Synthesis and characterization of methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide-co-ε-caprolactone) di block copolymers: Effects of block lengths and compositions

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Yodthong Baimark ◽  
Mangkorn Srisa-ard ◽  
Jirasak Threeprom ◽  
Robert Molloy ◽  
Winita Punyodom
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Diblock Copolymers ◽  
Poly Ethylene Glycol ◽  
H Nmr ◽  
Random Character ◽  
Ft Ir ◽  
Poly Ethylene ◽  
Dsc Curves

AbstractMethoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide-co-ε- caprolactone) diblock copolymers, designated as MPEG-b-PDLLGCL, with different MPEG block lengths and DLL:G:CL ratios were synthesized via ring-opening polymerization in bulk using MPEG and stannous octoate as the initiating system. The diblock copolymers were characterized using a combination of FT-IR, 1HNMR, GPC and DSC. The percentage yields of the diblock copolymers were in excess of 90%. 1H-NMR analysis confirmed that the PDLLGCL blocks contained at least some random character. From their DSC curves, the diblock copolymers were amorphous in morphology. Their glass transition temperatures decreased as the MPEG block length increased and as G and CL units were incorporated.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Perfluoropolyether/poly(ethylene glycol) triblock copolymers with controllable self-assembly behaviour for highly efficient anti-bacterial materials

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64170-64179 ◽  
Author(s):  
Jing Song ◽  
Qun Ye ◽  
Wang Ting Lee ◽  
Xiaobai Wang ◽  
Tao He ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Click Reaction ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Highly Efficient ◽  
Poly Ethylene ◽  
High Yields

A series of perfluoropolyether/poly(ethylene glycol) (PFPE/PEG) triblock copolymers PEG/PFPE/PEG (P1–P3) and PFPE/PEG/PFPE (P4–P5) were prepared via thiol–ene click reaction in high yields.

An Efficient and Green Procedure for the Preparation of 2-{2-[N′-(2-Hydroxybenzylidene)hydrazino]thiazol-4-yl}phenols

2007 ◽  
Vol 60 (4) ◽  
pp. 302 ◽  
Author(s):  
Vinod T. Kamble ◽  
Bhaskar S. Davane ◽  
Sanjay A. Chavan ◽  
Raghunath B. Bhosale
Keyword(s):  
Ethylene Glycol ◽  
Environmentally Benign ◽  
Preparation Procedure ◽  
Poly Ethylene Glycol ◽  
Thiazole Derivatives ◽  
Peg 400 ◽  
Convenient Approach ◽  
Poly Ethylene ◽  
High Yields ◽  
Green Procedure

An efficient and convenient approach for the synthesis of thiazole derivatives from α-halo ketones, thiosemicarbazide, and o-hydroxybenzaldehydes in poly(ethylene glycol) (PEG-400) is described. The preparation procedure presented is operationally simple and environmentally benign. Some of the major advantages of this procedure are high yields and ease of operation.

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