The Role of Carotenoid Pigments in Cr(VI) Tolerance, Biosorption and Bioaccumulation by Rhodotorula mucilaginosa UCM Y-1776 and its Mutants

To compare Cr (VI) tolerance, biosorption and bioaccumulation for initial carotenoidsproducing yeast Rhodotorula mucilaginosa UCM Y-1776 and its mutants, twenty stable mutants with various intensity of colors were obtained using nitrosoguanidine (NSG). The ultraviolet was found to be inefficient as a mutagen in our study. Light- and non-pigmented mutants (4L and 2) demonstrated a significant growth inhibition by 30 mg/l Cr (VI) whereas wild strain was able to grow at much higher chromium concentrations (500 mg/l). Cr (VI) sorption ability of R. mucilaginosa UCM Y-1776 was higher than those of mutants. Cr (VI) sorption/uptake parameters (Qmax, b) were found to be close for initial pink-pigmented R. mucilaginosa UCM Y-1776 (Qmax = 950 5M/g), and its light-pigmented mutant 4L (Qmax = 678 5M/g) and non-pigmented mutant 2 (Qmax = 790 5M/g) by non-living biomass. Non-pigmented “white” mutant 2 showed the highest ability to sorb chromium ions by living biomass (Qmax = 1020 mmol/g). The least chromiumtolerant light-pigmented (mutant 4L) and non-pigmented yeasts showed the highest chromium uptake for living biomass. The results showed that the presence of carotenoids did not affect Cr (VI) ions sorption by yeast biomass which could highlight significance of chitin and glucan-mannoprotein complex in chromium biosorption. However pigment absence increased Cr (VI) bioaccumulation by living yeast demonstrating the protective role of carotenoids against hexavalent chromium toxicity.

Download Full-text

Protective role of peroxiredoxin-4 in heart failure

Clinical Science ◽

10.1042/cs20191072 ◽

2020 ◽

Vol 134 (1) ◽

pp. 71-72

Author(s):

Naseer Ahmed ◽

Masooma Naseem ◽

Javeria Farooq

Keyword(s):

Heart Failure ◽

Cardiac Fibroblasts ◽

Protective Role ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Total Antioxidant ◽

Galectin 3 ◽

Consequent Increase ◽

And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Download Full-text

Parenting Behaviors and Anxiety in Young Adults

Journal of Individual Differences ◽

10.1027/1614-0001/a000169 ◽

2015 ◽

Vol 36 (3) ◽

pp. 170-176 ◽

Cited By ~ 5

Author(s):

Erin N. Stevens ◽

Joseph R. Bardeen ◽

Kyle W. Murdock

Keyword(s):

Effortful Control ◽

Parenting Behaviors ◽

Protective Role ◽

Anxiety Symptoms ◽

Interactive Effects ◽

Parental Overprotection ◽

High Control ◽

Development Of Anxiety ◽

The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

Download Full-text