Determination of Ascorbic Acid Based on Gold Nanoparticles-L-Alanine/GCE

2011 ◽  
Vol 214 ◽  
pp. 498-502 ◽  
Author(s):  
Hai Yan Kuang ◽  
Jia Hong He ◽  
Qiang Xu ◽  
Zhong Rong Song
Keyword(s):  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Self Assembly ◽  
High Sensitivity ◽  
Glass Electrode ◽  
Layer By Layer ◽  
Current Time ◽  
Electrochemical Behaviors ◽  
Assembly Technology

A Gold nanoparticles-L-alanine modified glass electrode has been successfully fabricated by using layer-by-layer self-assembly technology and used for determination of ascorbic acid. First, the clean electrode was immersed into L-Alanine solution to acquire a L-Alanine film on the surface of GCE and dried at room temperature, then the gold colloid was dipped onto the L-Alanine film. The electrochemical behaviors of ascorbic acid at the modified electrode were investigated by cyclic voltammetry and current-time techniques. The results showed that the sensor produced high sensitivity and good stability to ascorbic acid and the current was linear with the concentration of ascorbic acid in the range of 1.20×10-5 to 1.60×10-4 mol/L with a detection limit of 1.00×10-5 mol/L.

scholarly journals Rapid Determination of Ochratoxin A in Grape and Its Commodities Based on a Label-Free Impedimetric Aptasensor Constructed by Layer-by-Layer Self-Assembly

Toxins ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 71 ◽  
Author(s):  
Mina Nan ◽  
Yang Bi ◽  
Huali Xue ◽  
Sulin Xue ◽  
Haitao Long ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Self Assembly ◽  
Electrochemical Impedance ◽  
Rapid Determination ◽  
Grape Juice ◽  
High Sensitivity ◽  
Layer By Layer ◽  
Label Free ◽  
Transfer Resistance

A simple and sensitive label-free impedimetric aptasensor for rapid determination of ochratoxin A (OTA) has been developed, which was based on the combination between thiolated aptamer and gold nanoparticles by layer-by-layer self-assembly. Because of the interaction between aptamer and OTA, the relative normalized electron-transfer resistance (ΔRct) values obtained by electrochemical impedance spectroscopy (EIS) was proportional to the concentration of OTA and showed a good linear relationship from 0.1 to 10.0 ng/mL, with a lower detection limit (0.030 ng/mL) than one-step thiolated DNA aptasensor. The established method was successfully applied to detect and analyze OTA in table wine and grape juice, and the recovery was 90.56%–104.21% when PVP effective removed of phenolic substances. The label-free impedimetric aptasensor was used for rapid detection and quantitation of OTA in the inoculated grapes with the Aspergillus Nigri (H1), and the production of OTA (62.4 μg/kg, 20 μg/kg) far exceeded the maximum levels of 2 μg/kg after inoculation for three days. The developed method exhibited a good specificity, high sensitivity, time-efficient, and it could be applied to detect the OTA concentration in grape and its commodities.

scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

Gold Nanoparticles Modified Titania Nanotube Arrays for Amperometric Determination of Ascorbic Acid

2010 ◽  
Vol 43 (18) ◽  
pp. 2809-2822 ◽  
Author(s):  
T. G. Satheesh Babu ◽  
P. V. Suneesh ◽  
T. Ramachandran ◽  
Bipin Nair
Keyword(s):  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Nanotube Arrays ◽  
Amperometric Determination ◽  
Titania Nanotube Arrays ◽  
Titania Nanotube

Fabrication of microelectrodes using flow layer-by-layer self assembly of gold nanoparticles

2012 ◽  
Vol 52 (5) ◽  
pp. 1043-1051 ◽  
Author(s):  
Panittamat Kumlangdudsana ◽  
Adisorn Tuantranont ◽  
Stephan Thierry Dubas ◽  
Luxsana Dubas
Keyword(s):  
Gold Nanoparticles ◽  
Self Assembly ◽  
Layer By Layer

Layer-by-layer self-assembly of 2D graphene nanosheets, 3D copper oxide nanoflowers and 0D gold nanoparticles for ultrasensitive electrochemical detection of alpha fetoprotein

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 56583-56589 ◽  
Author(s):  
Yulan Wang ◽  
Dan Wu ◽  
Yong Zhang ◽  
Xiang Ren ◽  
Yaoguang Wang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Copper Oxide ◽  
Electrochemical Detection ◽  
Self Assembly ◽  
Graphene Nanosheets ◽  
Electrochemical Immunosensor ◽  
Alpha Fetoprotein ◽  
Quantitative Detection ◽  
Layer By Layer ◽  
Label Free

In this work, a novel and ultrasensitive label-free electrochemical immunosensor was developed for the quantitative detection of alpha fetoprotein (AFP).

Salivary polypeptide/hyaluronic acid multilayer coatings act as “fungal repellents” and prevent biofilm formation on biomaterials

2018 ◽  
Vol 6 (10) ◽  
pp. 1452-1457 ◽  
Author(s):  
Jianchuan Wen ◽  
Chih-Ko Yeh ◽  
Yuyu Sun
Keyword(s):  
Hyaluronic Acid ◽  
Self Assembly ◽  
Biofilm Formation ◽  
Design Principle ◽  
Multilayer Coatings ◽  
Layer By Layer ◽  
Denture Stomatitis ◽  
Polyelectrolyte Layer ◽  
Assembly Technology ◽  
Systemic Health

Candida-associated denture stomatitis (CADS) is a common, recurring clinical complication in denture wearers that can lead to serious oral and systemic health problems. Polyelectrolyte layer-by-layer (LBL) self-assembly technology on denture materials offers a new design principle for controlling fungal biofilm formation.

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