scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

Salivary polypeptide/hyaluronic acid multilayer coatings act as “fungal repellents” and prevent biofilm formation on biomaterials

2018 ◽  
Vol 6 (10) ◽  
pp. 1452-1457 ◽  
Author(s):  
Jianchuan Wen ◽  
Chih-Ko Yeh ◽  
Yuyu Sun
Keyword(s):  
Hyaluronic Acid ◽  
Self Assembly ◽  
Biofilm Formation ◽  
Design Principle ◽  
Multilayer Coatings ◽  
Layer By Layer ◽  
Denture Stomatitis ◽  
Polyelectrolyte Layer ◽  
Assembly Technology ◽  
Systemic Health

Candida-associated denture stomatitis (CADS) is a common, recurring clinical complication in denture wearers that can lead to serious oral and systemic health problems. Polyelectrolyte layer-by-layer (LBL) self-assembly technology on denture materials offers a new design principle for controlling fungal biofilm formation.

Preparation and Characterization of Nano-Films Materials

2011 ◽  
Vol 492 ◽  
pp. 160-163
Author(s):  
Cai Xia Li ◽  
Qing Lv ◽  
Jie Song ◽  
Dan Yu Jiang ◽  
Qiang Li
Keyword(s):  
Self Assembly ◽  
Chemical Properties ◽  
Layered Compounds ◽  
Insertion Reaction ◽  
Layer By Layer ◽  
Vis Spectroscopy ◽  
Assembly Technique ◽  
Assembly Technology ◽  
Physical And Chemical

Nano-sheets are two-dimensional sheet materials exfoliated from the inorganic layered compounds by various physical and chemical methods. Their unique characteristics insertion reaction and excellent physical and chemical properties have attracted more and more researchers' widespread interests. Selecting quartz glass as the substrate, using layer by layer self-assembly technology, different nano-films materials are prepared. UV/Vis spectroscopy confirmed nano-films materials have been successfully assembled using LBL self-assembly technique. Raman spectrum are mainly used to analyze and characterize the structure of nano-films materials.

UV-Enhanced Bioactivity of PS/TiO2 Coating Prepared by Layer-by-Layer Self-Assembly Method

2010 ◽  
Vol 434-435 ◽  
pp. 579-581
Author(s):  
Zhi Xian Zhang ◽  
Fan Xiao ◽  
Fei Gao
Keyword(s):  
Uv Irradiation ◽  
Ultraviolet Irradiation ◽  
Self Assembly ◽  
Raw Material ◽  
Layer By Layer ◽  
Titanium Coating ◽  
Water Contact ◽  
Oh Groups ◽  
Assembly Method ◽  
Assembly Technology

The TiO2 nanopowder was prepared with TiOSO4 as raw material at low temperature by hydrolysis method, and microspheres coated polyethylene and TiO2 were then fabricated on titanium by layer-by-layer self-assembly technology. Using ultraviolet irradiation of titanium coating in distilled water for some time, titanium with enhanced bioactivity was achieved when immersed in simulated body fluid (SBF). The morphology, size and crystal shape before and after ultraviolet irradiation were characterized by scanning electron microcopy (SEM) and X-ray diffraction (XRD). UV irradiation of titanium results in the conversion of Ti4+ to Ti3+ and the generation of oxygen vacancies, which could react with the absorbed water to form basic Ti–OH groups. Compared with the coating non-UV irradiation, the UV-irradiated coatings do not present any obvious differences in morphology, surface roughness, grain size and phase component; however, they have more abundant basic Ti–OH groups thus the water contact angle decreases greatly so the surface become much more hydrophilic.

Bioactivity of L-b-L Self-Assembly TiO2 Hollow Spheres by UV Irradiation Enhanced

2011 ◽  
Vol 328-330 ◽  
pp. 1495-1498
Author(s):  
Fan Xiao ◽  
Wei Li ◽  
Fei Gao ◽  
Zhi Xian Zhang
Keyword(s):  
Simulated Body Fluid ◽  
Uv Irradiation ◽  
Self Assembly ◽  
Body Fluid ◽  
Irradiation Time ◽  
Hollow Spheres ◽  
Layer By Layer ◽  
Assembly Technology ◽  
Hydrolysis Of ◽  
Better Than

Using nano-TiO2 particles obtained by hydrolysis of titanium oxysulfate (TiOSO4) as the precursor, and polystyrene (PS) spheres as the template, TiO2 hollow spheres were successfully deposited on CPTi substrates through layer-by-layer self-assembly technology. After ultraviolet light (UV) irradiation, the TiO2 coatings were soaked in simulated body fluid (SBF) to explore their bioactivities. The effects of UV irradiation time and UV irradiation media on the bioactivities of nano TiO2 coatings were investigated. The results show that bone-like apatite can be formed on the surface of nano TiO2 coating irradiated by UV, and this reveals that the irradiated coating has good bioactivity. The amount of apatite formed on the surface of the coating increases with the increase of UV irradiation time. UV-irradiated media also influence the bioactivity of the coating. The bioactivities of nano TiO2 coatings irradiated in air and SBF are better than that in water.

scholarly journals pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

2015 ◽  
Vol 6 ◽  
pp. 2504-2512 ◽  
Author(s):  
Manuel Häuser ◽  
Klaus Langer ◽  
Monika Schönhoff
Keyword(s):  
Self Assembly ◽  
Glycolic Acid ◽  
Ph Value ◽  
Particle System ◽  
Plga Nanoparticles ◽  
Ph Sensitive ◽  
Layer By Layer ◽  
Triggered Release ◽  
Layer System ◽  
H Nmr

Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA nanoparticles are coated by polyelectrolytes using the layer-by-layer self-assembly technique, employing poly(acrylic acid) (PAA) as a pH-sensitive component and poly(diallyldimethylammonium chloride) (PDADMAC) as the releasable polycation. The pH during multilayer deposition plays a major role and influences the titration curve of the layer system. The pH-tunability of PAA is intensively investigated with regard to the pH region, in which the particle system becomes uncharged. The isoelectric point can be shifted by employing suitable deposition pH values. The release is investigated by quantitative 1H NMR, yielding a pH-dependent release curve. A release of PDADMAC is initiated by a decrease of the pH value. The released amount of polymer, as quantified by 1H NMR analysis, clearly depends on the pH value and thus on the state of deprotonation of the pH-sensitive PAA layer. Subsequent incubation of the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative.

Preparation Mechanism of Electrostatic Self-Assembled Polyelectrolyte Film Using Quartz Crystal Microbalance

2012 ◽  
Vol 499 ◽  
pp. 63-66
Author(s):  
Ning Mei Hao ◽  
Dong Zhi Zhang ◽  
Bo Kai Xia ◽  
Kai Wang ◽  
Chun Yue Wan
Keyword(s):  
Quartz Crystal Microbalance ◽  
Self Assembly ◽  
Quartz Crystal ◽  
Nanocomposite Films ◽  
Layer By Layer ◽  
Level Control ◽  
Sequential Adsorption ◽  
Polyelectrolyte Film ◽  
Oppositely Charged ◽  
Multi Layer Film

Electrostatic layer-by-layer (LbL) self-assembly is widely used in sequential adsorption of nanometer-thick monolayers of oppositely charged polyelectrolytes to form a multi-layer film with molecular-level control over the architecture. To offer functional material for the potential application, this paper exploits PDDA and PSS as polycation and polyanion for LbL self-assembly to fabricate polyelectrolyte nanocomposite films. The preparation and film-growing mechanism is investigated under the influences of multi-factor such as polyelectrolyte concentration, ionic strength, and assembling duration using quartz crystal microbalance (QCM). The research results indicate the formation mechanism of multi-layer PDDA/PSS films and offer fundamental basis for the optimum preparation of polyelectrolyte films.

Preparation of the Layer-by-Layer Deposited Silver Nanoparticles Multilayer Films on Poly(ethylene Terephalate) Substrate

2011 ◽  
Vol 189-193 ◽  
pp. 1362-1365
Author(s):  
De Shan Cheng ◽  
Xiao Yan Liu ◽  
Ji Hong Wu ◽  
Wei Dong Yu
Keyword(s):  
Silver Nanoparticles ◽  
Self Assembly ◽  
Inductively Coupled Plasma ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Inductively Coupled ◽  
Assembly Technology ◽  
Poly Ethylene ◽  
Pet Film ◽  
Pet Substrate

This research presented the preparation of multilayer films on poly(ethylene terephalate) (PET) Substrate by electrostatic self-assembly technology. The silver nanoparticles were characterized by UV–vis spectrometry and scanning electron microscopy (SEM). The sequential dipping of hydrolyzed PET substrate in dilute solutions of poly(diallyldimethyl ammonium chloride)(PDDA) and silver nanoparticles to fabricate multilayer films. The multilayer films were monitored by UV–vis spectrometry, the surface plasmon resonance (SPR) obtained at 420 nm confirmed the existence of nanosilver on the PET film. The silver nanoparticles were also verified by the Inductively Coupled Plasma Spectrometry (ICP) and thermogravimetric analysis of the multilayer film. The transmission spectra indicated that the PET films contained silver nanoparticles have better UV protection property.

Determination of Ascorbic Acid Based on Gold Nanoparticles-L-Alanine/GCE

2011 ◽  
Vol 214 ◽  
pp. 498-502 ◽  
Author(s):  
Hai Yan Kuang ◽  
Jia Hong He ◽  
Qiang Xu ◽  
Zhong Rong Song
Keyword(s):  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Self Assembly ◽  
High Sensitivity ◽  
Glass Electrode ◽  
Layer By Layer ◽  
Current Time ◽  
Electrochemical Behaviors ◽  
Assembly Technology

A Gold nanoparticles-L-alanine modified glass electrode has been successfully fabricated by using layer-by-layer self-assembly technology and used for determination of ascorbic acid. First, the clean electrode was immersed into L-Alanine solution to acquire a L-Alanine film on the surface of GCE and dried at room temperature, then the gold colloid was dipped onto the L-Alanine film. The electrochemical behaviors of ascorbic acid at the modified electrode were investigated by cyclic voltammetry and current-time techniques. The results showed that the sensor produced high sensitivity and good stability to ascorbic acid and the current was linear with the concentration of ascorbic acid in the range of 1.20×10-5 to 1.60×10-4 mol/L with a detection limit of 1.00×10-5 mol/L.

Combinatorial Research of Molecular Technologies and Surface Nanostructures Applied to the Development of Antifouling Coatings

2019 ◽  
Vol 19 (6) ◽  
pp. 3647-3653 ◽  
Author(s):  
Bing Yin ◽  
Chaohong Liu
Keyword(s):  
Self Assembly ◽  
Surface Hydrophobicity ◽  
Layer By Layer ◽  
Bacterial Cells ◽  
Multilayered Films ◽  
Antimicrobial Coatings ◽  
Surface Nanostructures ◽  
Assembly Technology ◽  
The Right ◽  
Organic Particles

Contact antimicrobial coatings have been a subject of increasing interest partly because of the contribution of biocide release coatings to antibiotic resistance. The surface hydrophobicity of these coatings can enhance their effectiveness and stability. In this work, polyethyleneimine (PEI) was quaternized with 1-bromoalkane and iodomethane, and a concept for antimicrobial coatings was developed on the basis of the polyelectrolyte multilayered films. The multilayered films were endowed with antibacterial property by grafting modified polycation (higher charge density) and with fouling-release property by constructing microstructures and nanostructures with low surface energy (long alkyl chains). The resultant polycation-coated substrates were able to kill the encountered bacterial cells on contact, and to release the dead bacteria and organic particles. The conclusion demonstrated that the microbicidal functionality could be imparted onto surfaces using layer-by-layer (LbL) self-assembly technology by using the right combination of molecular technologies and surface nanostructures, as well as the assembly and/or post-assembly experimental technical factors.

Fabrication of Oxide Compound Nano-Films Materials by LBL Self-Assembly Technology

2012 ◽  
Vol 512-515 ◽  
pp. 1696-1699
Author(s):  
Cai Xia Li ◽  
Peng Fei Zhu ◽  
Dan Yu Jiang ◽  
Qing Lv ◽  
Qiang Li
Keyword(s):  
Cobalt Oxide ◽  
Self Assembly ◽  
Tantalum Oxide ◽  
Chemical Properties ◽  
Electrostatic Attraction ◽  
External Object ◽  
Layer By Layer ◽  
Oxide Compound ◽  
Assembly Technology ◽  
Object Level

LBL (layer by layer) fabrication was based on the electrostatic attraction between the nanosheets host partial with electric charges and external object with opposite charges. By changing the property of the object, level defects can also be introduced, so that the nano-films with remarkable physica-chemical properties can be prepared. Tantalum oxide and cobalt oxide nano-films materials were made via LBL self-assembly technology in this work

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