Alginate–Chitosan Nanocapsules for Controlled Release of Low Molecular Drugs Tegafur and DHAD
2013 ◽
Vol 647
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pp. 264-268
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Keyword(s):
Alginate–chitosan nanocapsules (Alg-CS NCs) were prepared by a two-stage process. The NCs were loaded with two low molecular drugs-tegafur and Mitoxantrone Hydrochloride(DHAD). Results revealed that these two drugs exhibited different drug loading and release characteristics. The drug loading and encapsulation efficiency of tegafur (<1%) were both lower than those of DHAD with the drug loading at about 20%~60% and encapsulation efficiency over 90%. However, tegafur showed a visible burst release phenomenon and the cumulative release rate of tegafur was much higher than that of DHAD.
Keyword(s):
Keyword(s):
2021 ◽
Vol 21
(9)
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pp. 4565-4572