Porous Silicas for Enhanced Drug Release

2014 ◽  
Vol 91 ◽  
pp. 79-81
Author(s):  
Abina M. Crean ◽  
Robert J. Ahern ◽  
Rakesh Dontireddy ◽  
Walid Faisil ◽  
John P. Hanrahan ◽  
...  
Keyword(s):  
Surface Area ◽  
Water Solubility ◽  
Solid Dispersions ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica ◽  
High Energy ◽  
Drug Dissolution ◽  
Drug Candidates ◽  
Drug Molecules

Low drug water-solubility is a major challenge to overcome in the development of tablet or capsule dosage forms for a large number of promising drug candidates. Strategies to improve drug solubility and dissolution involve chemical, physical and formulation approaches. An emerging formulation approach to increase drug dissolution and solubility involves the creation of solid dispersions of drug molecules on to a high surface area inorganic carrier, such as porous silica. The combined benefits of a hydrophilic inorganic substrate, increased drug surface area and a high-energy drug form facilitate rapid drug dissolution into aqueous based media and can create supersaturated drug solutions. The work presented provides a brief overview of the silica grades investigated, processes employed to load drugs onto the silica substrates, provide some examples of the ability of silica to enhance drug dissolution and highlight some of the challenges in the development of these novel drug delivery systems.

scholarly journals Synthesis and characterization of porous silica and polyaniline-porous silica composite materials with high surface area

2014 ◽  
Vol 49 (1) ◽  
pp. 1-8
Author(s):  
US Akhtar ◽  
MK Hossain ◽  
MS Miran ◽  
MYA Mollah
Keyword(s):  
Electron Microscopy ◽  
Pore Size ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica ◽  
Nitrogen Adsorption ◽  
High Specific Surface Area ◽  
Molar Ratio ◽  
Cylindrical Pore

Porous silica materials were synthesized from tetraethyl orthosilicate (TEOS) using Pluronic P123 (non-ionic triblock copolymer, EO20PO70O20) as template under acidic conditions which was then used to prepare polyaniline (PAni) and porous silica composites (PAnisilica) at a fixed molar ratio. These materials were characterized by nitrogen adsorption-desorption isotherm measured by Barrett-Joyner- Halenda (BJH) method and pore size distribution from desorption branch and surface area measured by the Brunauer-Emmett-Teller (BET) method, scanning electron microscopy (SEM), transmission electron microscopy (TEM), TEM-energy dispersive X-ray (EDX) and Fourier transform infrared (FT-IR) spectroscopy. The composite maintains its structure even after the polymerization and the polymer is dispersed on the inorganic matrix. The rod-like porous silica was about 1?m to 1.5 ?m long and on an average the diameter was in the range of 300- 500 nm. The SEM and TEM images show well ordered 2d hexagonal pore, high specific surface area (850 m2g-1) and uniform pore size of ca. 6.5 nm in diameter. After incorporation of PAni inside the silica pore, framework of porous silica did not collapse and the surface area of the composite was as high as 434 m2g-1 which was 5.5 time higher than our previous report of 78.3 m2g-1. Due to shrinkage of the framework during the incorporation of aniline inside the silica, the pore diameter slightly increase to 7.5 nm but still showing Type IV isotherm and typical hysteresis loop H1 implying a uniform cylindrical pore geometry. DOI: http://dx.doi.org/10.3329/bjsir.v49i1.18847 Bangladesh J. Sci. Ind. Res. 49(1), 1-8, 2014

scholarly journals Bridging the performance gap between electric double-layer capacitors and batteries with high-energy/high-power carbon nanotube-based electrodes

2016 ◽  
Vol 4 (38) ◽  
pp. 14586-14594 ◽  
Author(s):  
Helena Matabosch Coromina ◽  
Beatrice Adeniran ◽  
Robert Mokaya ◽  
Darren A. Walsh
Keyword(s):  
Carbon Nanotube ◽  
Surface Area ◽  
Power Density ◽  
High Power ◽  
Electric Double Layer ◽  
High Surface ◽  
High Surface Area ◽  
High Energy ◽  
Performance Gap ◽  
Double Layer Capacitors

The energy/power density of EDLCs containing high surface area carbon nanotube-based electrodes bridges the performance gap between conventional EDLCs and batteries.

scholarly journals Nitrogen self-doped activated carbons via the direct activation of Samanea saman leaves for high energy density supercapacitors

RSC Advances ◽  
2019 ◽  
Vol 9 (38) ◽  
pp. 21724-21732 ◽  
Author(s):  
Vichuda Sattayarut ◽  
Thanthamrong Wanchaem ◽  
Pundita Ukkakimapan ◽  
Visittapong Yordsri ◽  
Paweena Dulyaseree ◽  
...  
Keyword(s):  
Energy Density ◽  
Surface Area ◽  
Activated Carbons ◽  
High Surface ◽  
High Surface Area ◽  
High Energy ◽  
High Energy Density ◽  
Direct Activation ◽  
Samanea Saman

Nitrogen self-doped activated carbons with high surface area obtained via the direct activation of Samanea saman leaves for high energy density supercapacitors.

Aloe vera Derived Activated High-Surface-Area Carbon for Flexible and High-Energy Supercapacitors

2016 ◽  
Vol 8 (51) ◽  
pp. 35191-35202 ◽  
Author(s):  
M. Karnan ◽  
K. Subramani ◽  
N. Sudhan ◽  
N. Ilayaraja ◽  
M. Sathish
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Aloe Vera ◽  
High Energy

Synthesis of High Surface Area Porous Silica through Aging Techniques

2000 ◽  
Vol 59 (3) ◽  
pp. 64-67
Author(s):  
S. Rajeshkumar ◽  
V. S. Sandhya ◽  
P. Krishna Pillai ◽  
K. G. K. Warrier
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica

scholarly journals Cinnamon-Derived Hierarchically Porous Carbon as an Effective Lithium Polysulfide Reservoir in Lithium–Sulfur Batteries

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1220 ◽  
Author(s):  
Ranjith Thangavel ◽  
Aravindaraj G. Kannan ◽  
Rubha Ponraj ◽  
Karthikeyan Kaliyappan ◽  
Won-Sub Yoon ◽  
...  
Keyword(s):  
Surface Area ◽  
Porous Carbon ◽  
Pore Volume ◽  
High Surface ◽  
Electronic Conductivity ◽  
High Surface Area ◽  
High Energy ◽  
Superior Performance ◽  
Lithium Sulfur Batteries ◽  
Lithium Sulfur

Lithium–sulfur batteries are attractive candidates for next generation high energy applications, but more research works are needed to overcome their current challenges, namely: (a) the poor electronic conductivity of sulfur, and (b) the dissolution and migration of long-chain polysulfides. Inspired by eco-friendly and bio-derived materials, we synthesized highly porous carbon from cinnamon sticks. The bio-carbon had an ultra-high surface area and large pore volume, which serves the dual functions of making sulfur particles highly conductive and acting as a polysulfide reservoir. Sulfur was predominantly impregnated into pores of the carbon, and the inter-connected hierarchical pore structure facilitated a faster ionic transport. The strong carbon framework maintained structural integrity upon volume expansion, and the unoccupied pores served as polysulfide trapping sites, thereby retaining the polysulfide within the cathode and preventing sulfur loss. These mechanisms contributed to the superior performance of the lithium-sulfur cell, which delivered a discharge capacity of 1020 mAh g−1 at a 0.2C rate. Furthermore, the cell exhibited improved kinetics, with an excellent cycling stability for 150 cycles with a very low capacity decay of 0.10% per cycle. This strategy of combining all types of pores (micro, meso and macro) with a high pore volume and ultra-high surface area had a synergistic effect on improving the performance of the sulfur cathode.

Ultra-high surface area nano-porous silica from expanded perlite: Formation and characterization

2017 ◽  
Vol 43 (14) ◽  
pp. 11495-11504 ◽  
Author(s):  
Walt Wheelwright ◽  
Ralph P. Cooney ◽  
Sudip Ray ◽  
Zoran Zujovic ◽  
Karnika de Silva
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Porous Silica ◽  
Expanded Perlite

Boosting pseudocapacitive charge storage in in situ functionalized carbons with a high surface area for high-energy asymmetric supercapacitors

2018 ◽  
Vol 2 (10) ◽  
pp. 2314-2324 ◽  
Author(s):  
Hao Zhang ◽  
Mingjie Lu ◽  
Huanlei Wang ◽  
Yan Lyu ◽  
Dong Li ◽  
...  
Keyword(s):  
Surface Area ◽  
Doping Level ◽  
High Surface ◽  
High Surface Area ◽  
High Energy ◽  
Charge Storage ◽  
Asymmetric Supercapacitors ◽  
Heteroatom Doping

The porosity and heteroatom doping level can be tuned for jellyfish-derived carbons to adjust capacitive and pseudocapacitive contributions.

Construction of High-Energy-Density Supercapacitors from Pine-Cone-Derived High-Surface-Area Carbons

ChemSusChem ◽  
2014 ◽  
Vol 7 (5) ◽  
pp. 1435-1442 ◽  
Author(s):  
Kaliyappan Karthikeyan ◽  
Samuthirapandiyan Amaresh ◽  
Sol Nip Lee ◽  
Xueliang Sun ◽  
Vanchiappan Aravindan ◽  
...  
Keyword(s):  
Energy Density ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
High Energy ◽  
High Energy Density ◽  
Pine Cone
Sign in / Sign up

Export Citation Format

Share Document