A Method to Fabricate Liver Tissue Engineering Scaffold

2011 ◽  
Vol 11 ◽  
pp. 73-80 ◽  
Author(s):  
S. Singare ◽  
Shou Yan Zhong ◽  
Zhen Zhong Sun
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Rapid Prototyping ◽  
Tissue Engineering Scaffold ◽  
Biodegradable Material ◽  
Scaffold Fabrication ◽  
Liver Tissue Engineering ◽  
Future Direction ◽  
Silicone Mould ◽  
Printing Machine

In this paper, the authors describe a rapid prototyping method to produce vascularized tissue such as liver scaffold for tissue engineering applications. A scaffold with an interconnected channel was designed using a CAD environment. The data were transferred to a Polyjet 3D Printing machine (Eden 250, Object, Israel) to generate the models. Based on the 3D Printing model, a PDMS (polydimethyl-silicone) mould was created which can be used to cast the biodegradable material. The advantages and limitations of Rapid Prototyping (RP) techniques as well as the future direction of RP development in tissue engineering scaffold fabrication were reviewed.

The Use of Rapid Prototyping to Fabricate Liver Tissue Engineering Scaffold

2011 ◽  
Vol 328-330 ◽  
pp. 658-661
Author(s):  
Singare Sekou ◽  
Shou Yan Zhong ◽  
Zhen Zhong Sun
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Rapid Prototyping ◽  
Glycolic Acid ◽  
Tissue Engineering Scaffold ◽  
Liver Tissue Engineering ◽  
Biodegradable Poly ◽  
Future Direction ◽  
Silicone Mould ◽  
Printing Machine

In this papers, the authors described a rapid prototyping method to produce vascularized tissue such liver scaffold for tissue engineering applications. A scaffold with interconnected channel was designed using CAD environment. The data were transferred to a Polyjet 3D Printing machine (Eden 250, Object, Israel) to generate the models. Based on the 3D Printing model, a PDMS (polydimethyl-silicone) mould was created which can be used to cast the biodegradable poly (L-lactic-co-glycolic acid) (PLGA )material. The advantages and limitations of Rapid Prototyping (RP) techniques as well as the future direction of RP development in tissue engineering scaffold fabrication were reviewed.

scholarly journals Advances in 3D Printing for Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Complex Structure ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Scaffold Fabrication ◽  
Manufacturing Techniques ◽  
Printing Techniques ◽  
State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

Utilizing cellulose from sugarcane bagasse mixed with poly(vinyl alcohol) for tissue engineering scaffold fabrication

2017 ◽  
Vol 100 ◽  
pp. 183-197 ◽  
Author(s):  
Nga Tien Lam ◽  
Rungsima Chollakup ◽  
Wirasak Smitthipong ◽  
Thidarat Nimchua ◽  
Prakit Sukyai
Keyword(s):  
Tissue Engineering ◽  
Sugarcane Bagasse ◽  
Vinyl Alcohol ◽  
Tissue Engineering Scaffold ◽  
Poly Vinyl Alcohol ◽  
Scaffold Fabrication

Miscibility of Poly(Ethylene-co-Vinylalcohol)/Poly(δ-Valerolactone) Blend and Tissue Engineering Scaffold Fabrication Using Naphthalene as Porogen

2018 ◽  
Vol 58 (2) ◽  
pp. 1-23 ◽  
Author(s):  
Waseem Sharaf Saeed ◽  
Abdel-Basit Al-Odayni ◽  
Abdulaziz Ali Alghamdi ◽  
Ahmad Abdulaziz Al-Owais ◽  
Abdelhabib Semlali ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Engineering Scaffold ◽  
Scaffold Fabrication ◽  
Poly Ethylene

scholarly journals Fabrication of nanofiber mats with microstructure gradient by cone electrospinning

2017 ◽  
Vol 7 ◽  
pp. 184798041774847 ◽  
Author(s):  
Yingge Zhou ◽  
George Z Tan
Keyword(s):  
Tissue Engineering ◽  
Process Parameters ◽  
Tissue Engineering Scaffold ◽  
Proof Of Concept ◽  
Scaffold Fabrication ◽  
Manufacturing Technique ◽  
Nanofiber Morphology ◽  
Nanofiber Mats

As a versatile nanofiber manufacturing technique, electrospinning has been widely used for tissue engineering scaffold fabrication. However, it remains challenging to create scaffolds with anisotropic microstructure close to native tissues. This article presented a novel electrospinning configuration to generate fibrous mat with microstructure gradient. A series of proof-of-concept tests were performed to investigate the effects of process parameters on the gradient of nanofiber morphology and mat attributes. The technique developed in this study showed great potentials as a fabrication platform for heterogenous nanofiber products.

Bio-Rapid-Prototyping of Tissue Engineering Scaffolds and the Process-Induced Cell Damage

2013 ◽  
Vol 17 ◽  
pp. 1-23 ◽  
Author(s):  
Xiao Yu Tian ◽  
Ming Gan Li ◽  
Xiong Biao Chen
Keyword(s):  
Tissue Engineering ◽  
Rapid Prototyping ◽  
Cell Damage ◽  
Cell Encapsulation ◽  
Tissue Scaffolds ◽  
Fabrication Process ◽  
Laser Exposure ◽  
Ongoing Research ◽  
Research Attention ◽  
Scaffold Fabrication

Tissue scaffolds play a vital role in tissue engineering by providing a native tissue-mimicking environment for cell proliferation and differentiation as well as tissue regeneration. Fabrication of tissue scaffolds has been drawing increasing research attention and a number of fabrication techniques have been developed. To better mimic the microenvironment of native tissues, novel techniques have emerged in recent years to encapsulate cells into the engineered scaffolds during the scaffold fabrication process. Among them, bio-Rapid-Prototyping (bioRP) techniques, by which scaffolds with encapsulated cells can be fabricated with controlled internal microstructure and external shape, shows significant promise. It is noted in the bioRP processes, cells may be continuously subjected to environmental stresses such as mechanical, electrical forces and laser exposure. If the stress is greater than a certain level, the cell membrane may be ruptured, leading to the so-called process-induced cell damage. This paper reviews various cell encapsulation techniques for tissue scaffold fabrication, with emphasis on the bioRP technologies and their technical features. To understand the process-induced cell damage in the bioRP processes, this paper also surveys the cell damage mechanisms under different stresses. The process-induced cell damage models are also examined to provide a cue to the cell viability preservation in the fabrication process. Discussions on further improvements of bioRP technologies are given and ongoing research into mechanical cell damage mechanism are also suggested in this review.

scholarly journals Fabrication 3d Tissue Engineering Scaffold Poly(Ethylene) Diacrylate Filled with Aramid Nanofiber: Mechanical Evaluation and Toxicity

2019 ◽  
Vol 8 (12) ◽  
pp. 1997-2006
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
3D Structure ◽  
Tissue Engineering Scaffold ◽  
Digital Light Processing ◽  
Technical Requirements ◽  
Preliminary Study ◽  
Poly Ethylene ◽  
3D Printing Technique ◽  
Selection Of

The selection of the optimum scaffold fabrication method becomes challenging due to a variety of manufacturing methods, existing biomaterials and technical requirements. Although, Digital light processing (DLP) 3D printing process is one of the SLA techniques which commonly used to fabricate tissue engineering scaffold, however, there is no report published on the fabrication of tissue engineering scaffold-based PEGDA filled with Aramid Nanofiber (ANFs). Hence, the feasible parameter setting for fabricating this material using DLP technique is currently unknown. This work aims to establish the feasible setting parameter via DLP 3D printing to fabricate PEGDA/ANFs 3D tissue engineering scaffold. Preliminary study has been done to identify the accurate composition and curing time setting in producing scaffold. In this work, the researcher has proved the potential and capability of these novel composition biomaterial PEGDA/ANFs to be print via DLP-3D printing technique to form a 3D structure which is not yet been established and has not reported elsewhere.

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