A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration

2008 ◽  
Vol 377 ◽  
pp. 151-166 ◽  
Author(s):  
Larry L. Hench ◽  
Julia M. Polak
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Genetic Basis ◽  
First Generation ◽  
Scar Tissue ◽  
Biologically Active ◽  
Bioactive Glasses ◽  
Osteoprogenitor Cells ◽  
New Generation

Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.

scholarly journals Opening paper 2015- Some comments on Bioglass: Four Eras of Discovery and Development

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Larry L. Hench
Keyword(s):  
Clinical Application ◽  
Tissue Regeneration ◽  
First Generation ◽  
Scar Tissue ◽  
Interfacial Bonding ◽  
Bioactive Glasses ◽  
Commercial Use ◽  
First Time ◽  
Host Tissues

AbstractHistorically the function of biomaterials was to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasseswere discovered in 1969 and provided for the first time an alternative; strong, stable interfacial bonding of an implant with host tissues. In the 1980’s it was discovered that bioactive glasses could be used in particulae form to stimulate osteogenesiswhich thereby led to the concept of regeneration of tissues. This article summarizes the four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglassr. The four eras are; A) Era of Discovery, B) Era of Clinical Application, C) Era of Tissue Regeneration, and D) Era of Innovation. Key scientific and technological questions answered for the first three eras are presented. Questions still to be answered for the fourth era are included to stimulate innovation in the field.

scholarly journals Biomaterials for In Situ Tissue Regeneration: A Review

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 750 ◽  
Author(s):  
Saba Abdulghani ◽  
Geoffrey Mitchell
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Cell Function ◽  
Predictive Modelling ◽  
Ex Situ ◽  
Design And Optimization ◽  
Injured Region ◽  
In Situ Tissue Engineering ◽  
Selection Of

This review focuses on a somewhat unexplored strand of regenerative medicine, that is in situ tissue engineering. In this approach manufactured scaffolds are implanted in the injured region for regeneration within the patient. The scaffold is designed to attract cells to the required volume of regeneration to subsequently proliferate, differentiate, and as a consequence develop tissue within the scaffold which in time will degrade leaving just the regenerated tissue. This review highlights the wealth of information available from studies of ex-situ tissue engineering about the selection of materials for scaffolds. It is clear that there are great opportunities for the use of additive manufacturing to prepare complex personalized scaffolds and we speculate that by building on this knowledge and technology, the development of in situ tissue engineering could rapidly increase. Ex-situ tissue engineering is handicapped by the need to develop the tissue in a bioreactor where the conditions, however optimized, may not be optimum for accelerated growth and maintenance of the cell function. We identify that in both methodologies the prospect of tissue regeneration has created much promise but delivered little outside the scope of laboratory-based experiments. We propose that the design of the scaffolds and the materials selected remain at the heart of developments in this field and there is a clear need for predictive modelling which can be used in the design and optimization of materials and scaffolds.

scholarly journals Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Isabel Izquierdo-Barba ◽  
María Vallet-Regí
Keyword(s):  
Bone Tissue ◽  
Nanostructured Materials ◽  
Tissue Regeneration ◽  
Sol Gel ◽  
Added Value ◽  
Bone Tissue Regeneration ◽  
Chemical Compositions ◽  
Bioactive Glasses ◽  
Gel Glasses ◽  
New Generation

AbstractIn the last decade, the development of third generation bioceramics for Bone Tissue Regeneration has experienced significant progress with the emergence of a new generation of nanostructured materials named mesoporous bioactive glasses (MBG). This new generation of materials, also known as “templated glasses”, presents chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. This article shows an indepth comparative study of the ordered porous structures of MBGs compared to conventional glasses (melt and solgel) andhowthese properties influence the bioactivity process. Moreover, the possibility to tailor the textural and structural properties of these nanostructured materials by an exhaustive control of the different synthesis parameters is also discussed. A brief overview regarding the possibility of using these materials as controlled drug delivery systems and as starting materials for the fabrication of 3D scaffolds for bone tissue regeneration is also given.

Bioactive glasses for in situ tissue regeneration

2004 ◽  
Vol 15 (4) ◽  
pp. 543-562 ◽  
Author(s):  
Larry L. Hench ◽  
Ionnis D. Xynos ◽  
Julia M. Polak
Keyword(s):  
Tissue Regeneration ◽  
Bioactive Glasses

scholarly journals Hemodynamic loads distinctively impact the secretory profile of biomaterial-activated macrophages – implications for in situ vascular tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 132-147 ◽  
Author(s):  
Tamar B. Wissing ◽  
Eline E. van Haaften ◽  
Suzanne E. Koch ◽  
Bastiaan D. Ippel ◽  
Nicholas A. Kurniawan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Activated Macrophages ◽  
Scaffold Degradation

Macrophages play a governing role in material-driven tissue regeneration. Here we show that the paracrine signals of macrophages to direct tissue regeneration and scaffold degradation are dependent on hemodynamic loads.

NOVEL TRACHEAL PROSTHESIS AND IN SITU TISSUE ENGINEERING TO ENHANCE TISSUE REGENERATION ON IT

ASAIO Journal ◽  
2001 ◽  
Vol 47 (2) ◽  
pp. 179
Author(s):  
Tatsuo Nakamura ◽  
Eriko Kawanami ◽  
Hiroki Ueda ◽  
Seijun Fukuda ◽  
Shin-ichi Itoi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Tracheal Prosthesis ◽  
In Situ Tissue Engineering

scholarly journals Natural-Based Hydrogels for Tissue Engineering Applications

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5858
Author(s):  
Manuel Gomez-Florit ◽  
Alberto Pardo ◽  
Rui M. A. Domingues ◽  
Ana L. Graça ◽  
Pedro S. Babo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
First Generation ◽  
Cell Attachment ◽  
Natural Origin ◽  
Technological Advances ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
Specific Tissue ◽  
New Generation

In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.

scholarly journals Progress and Current Limitations of Materials for Artificial Bile Duct Engineering

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7468
Author(s):  
Qiqi Sun ◽  
Zefeng Shen ◽  
Xiao Liang ◽  
Yingxu He ◽  
Deling Kong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bile Duct ◽  
Tissue Regeneration ◽  
Bile Ducts ◽  
Gastrointestinal Surgery ◽  
Bile Leakage ◽  
Biologically Active ◽  
Comprehensive Collection ◽  
Unidirectional Flow ◽  
Reflux Cholangitis

Bile duct injury (BDI) and bile tract diseases are regarded as prominent challenges in hepatobiliary surgery due to the risk of severe complications. Hepatobiliary, pancreatic, and gastrointestinal surgery can inadvertently cause iatrogenic BDI. The commonly utilized clinical treatment of BDI is biliary-enteric anastomosis. However, removal of the Oddi sphincter, which serves as a valve control over the unidirectional flow of bile to the intestine, can result in complications such as reflux cholangitis, restenosis of the bile duct, and cholangiocarcinoma. Tissue engineering and biomaterials offer alternative approaches for BDI treatment. Reconstruction of mechanically functional and biomimetic structures to replace bile ducts aims to promote the ingrowth of bile duct cells and realize tissue regeneration of bile ducts. Current research on artificial bile ducts has remained within preclinical animal model experiments. As more research shows artificial bile duct replacements achieving effective mechanical and functional prevention of biliary peritonitis caused by bile leakage or obstructive jaundice after bile duct reconstruction, clinical translation of tissue-engineered bile ducts has become a theoretical possibility. This literature review provides a comprehensive collection of published works in relation to three tissue engineering approaches for biomimetic bile duct construction: mechanical support from scaffold materials, cell seeding methods, and the incorporation of biologically active factors to identify the advancements and current limitations of materials and methods for the development of effective artificial bile ducts that promote tissue regeneration.

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