scholarly journals Natural-Based Hydrogels for Tissue Engineering Applications

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5858
Author(s):  
Manuel Gomez-Florit ◽  
Alberto Pardo ◽  
Rui M. A. Domingues ◽  
Ana L. Graça ◽  
Pedro S. Babo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
First Generation ◽  
Cell Attachment ◽  
Natural Origin ◽  
Technological Advances ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
Specific Tissue ◽  
New Generation

In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues’ extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.

scholarly journals MEs in Nano-Medicine

2012 ◽  
Vol 134 (06) ◽  
pp. 36-41
Author(s):  
Guy M. Genin ◽  
Ram V. Devireddy
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Osteogenesis Imperfecta ◽  
High Efficiency ◽  
Medical Diagnostics ◽  
Imperial College ◽  
Current Generation ◽  
The Core ◽  
Nano Medicine ◽  
New Generation

This article reviews the use of mechanical engineering techniques in the field of nano-engineered medicines. Nano-engineered solutions now exist for a range of medical diagnostics, therapeutics, and imaging, and are at the core of many of the current generation of regenerative medicine and tissue engineering strategies. Nanoparticles can be developed to absorb energy with high efficiency from photons of certain frequency ranges. The ability to understand specific diseases such as osteogenesis imperfecta based upon such fundamental analyses has been demonstrated by ASME member Sandra Shefelbine of Imperial College London in collaboration with the Buehler group. The tools of nanotechnology have enabled mechanical engineers to engineer the beginnings of an entirely new generation of cures and therapies, and this article has discussed just a sample. In order to serve as a forum for discussion of these advances ASME is recommissioning the Journal of Nanotechnology in Engineering and Medicine.

scholarly journals Marine Algae Polysaccharides as Basis for Wound Dressings, Drug Delivery, and Tissue Engineering: A Review

2020 ◽  
Vol 8 (7) ◽  
pp. 481 ◽  
Author(s):  
Tatyana A. Kuznetsova ◽  
Boris G. Andryukov ◽  
Natalia N. Besednova ◽  
Tatyana S. Zaporozhets ◽  
Andrey V. Kalinin
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Wound Dressing ◽  
Biological Properties ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Treatment Of Wounds ◽  
New Generation ◽  
Dressing Materials

The present review considers the physicochemical and biological properties of polysaccharides (PS) from brown, red, and green algae (alginates, fucoidans, carrageenans, and ulvans) used in the latest technologies of regenerative medicine (tissue engineering, modulation of the drug delivery system, and the design of wound dressing materials). Information on various types of modern biodegradable and biocompatible PS-based wound dressings (membranes, foams, hydrogels, nanofibers, and sponges) is provided; the results of experimental and clinical trials of some dressing materials in the treatment of wounds of various origins are analyzed. Special attention is paid to the ability of PS to form hydrogels, as hydrogel dressings meet the basic requirements set out for a perfect wound dressing. The current trends in the development of new-generation PS-based materials for designing drug delivery systems and various tissue-engineering scaffolds, which makes it possible to create human-specific tissues and develop target-oriented and personalized regenerative medicine products, are also discussed.

scholarly journals Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

2019 ◽  
Vol 9 (17) ◽  
pp. 3540 ◽  
Author(s):  
Ferdows Afghah ◽  
Caner Dikyol ◽  
Mine Altunbek ◽  
Bahattin Koc
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Future Perspective ◽  
Melt Electrospinning ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Potential Applications ◽  
Homogeneous Cell

Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

scholarly journals Tissue Engineering and Regenerative Medicine: A Review

2020 ◽  
Vol 7 (1) ◽  
pp. 10-17
Author(s):  
Aditya Wardhana ◽  
Michelle Valeria
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Specific Growth ◽  
Isolated Cells ◽  
Current Application ◽  
Inducing Factors ◽  
Specific Tissue

Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering. Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh strategi terbaik dalam tissue engineering dan regenerative medicine. Artikel ini berfokus pada konsep, strategi, aplikasi terkini, dan tantangan di masa mendatang pada tissue engineering. Strategi tissue engineering telah banyak berkembangan dan berhasil diterapkan pada kasus-kasus rekonstruksi. Pemahaman mengenai perilaku sel, kecocokan material dengan scaffolds, serta faktor pendukung pertumbuhan untuk masing-masing jaringan atau organ spesifik yang akan diciptakan merupakan kunci keberhasian tissue engineering.

scholarly journals Crosstalk between Substrates and Rho-Associated Kinase Inhibitors in Cryopreservation of Tissue-Engineered Constructs

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Arindam Bit ◽  
Awanish Kumar ◽  
Abhishek Kumar Singh ◽  
Albert A. Rizvanov ◽  
Andrey P. Kiassov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Kinase Inhibitors ◽  
Cell Attachment ◽  
Human Mesenchymal Stem Cells ◽  
Cellular Viability ◽  
Technical Limitation ◽  
Engineered Tissues

It is documented that human mesenchymal stem cells (hMSCs) can be differentiated into various types of cells to present a tool for tissue engineering and regenerative medicine. Thus, the preservation of stem cells is a crucial factor for their effective long-term storage that further facilitates their continuous supply and transportation for application in regenerative medicine. Cryopreservation is the most important, practicable, and the only established mechanism for long-term preservation of cells, tissues, and organs, and engineered tissues; thus, it is the key step for the improvement of tissue engineering. A significant portion of MSCs loses cellular viability while freeze-thawing, which represents an important technical limitation to achieving sufficient viable cell numbers for maximum efficacy. Several natural and synthetic materials are extensively used as substrates for tissue engineering constructs and cryopreservation because they promote cell attachment and proliferation. Rho-associated kinase (ROCK) inhibitors can improve the physiological function and postthaw viability of cryopreserved MSCs. This review proposes a crosstalk between substrate topology and interaction of cells with ROCK inhibitors. It is shown that incorporation of ionic nanoparticles in the presence of an external electrical field improves the generation of ROCK inhibitors to safeguard cellular viability for the enhanced cryopreservation of engineered tissues.

A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration

2008 ◽  
Vol 377 ◽  
pp. 151-166 ◽  
Author(s):  
Larry L. Hench ◽  
Julia M. Polak
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Genetic Basis ◽  
First Generation ◽  
Scar Tissue ◽  
Biologically Active ◽  
Bioactive Glasses ◽  
Osteoprogenitor Cells ◽  
New Generation

Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.

Native honeybee silk membrane: a potential matrix for tissue engineering and regenerative medicine

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54394-54403 ◽  
Author(s):  
Manishekhar Kumar ◽  
Deepak Jain ◽  
Nandana Bhardwaj ◽  
Prerak Gupta ◽  
Samit K. Nandi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Natural Origin ◽  
Potential Matrix

Biomimetic natural origin biomaterials are noteworthy targets for further innovation in biomedical and tissue engineering.

scholarly journals Big Data and Human Geography

2021 ◽  
Author(s):  
Francisco Rowe
Keyword(s):  
Big Data ◽  
Human Geography ◽  
Digital Data ◽  
Ethical Challenges ◽  
Human Interactions ◽  
Technological Advances ◽  
Extensive Coverage ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
And Storage

Technological advances have enabled the emerge of ‘Big Data’ through the production, processing, analysis and storage of large volumes of digital data. Data that could not previously be stored or used to be captured using analog devices can now be digitally recorded. This chapter identifies and discusses the existing and future challenges and opportunities of Big Data for human geography. Big Data offer high geographic and temporal granularity, extensive coverage and instant information to transform our understanding of human interactions and our social world. At the same time, Big Data present major epistemological, methodological and ethical challenges which need to be addressed to realise these opportunities. I identify the key challenges and actions for the future of human geography emerging from the use of Big Data.

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