Securing an IoT Medical System Using AI and a Unidirectional Network Device: Application to a Driver

Security in systems and networks has always been a major issue for IT administrators. When it comes to medical applications, this concern is much more important due to the sensitivity of data and the risks that may be caused due to alteration or falsification of such critical information. The proposed paper presents a solution to assure the best security possible in such an environment. Thus, based on an application that monitors a driver’s health while driving his car, a data diode will be implemented in order to assure security of the system by forcing unidirectional flow of network data to the healthcare provider side. Added to that, an AI-based program will be developed to verify the confidentiality, the integrity and the availability of the exchanged data and to check the patient health for abnormalities. Every sub-part of the system has been tested separately and results have shown that falsified data has been filtered out of the received end, e.g. the healthcare provider side.

How 3D Printing Is Reshaping Translational Research

“Translational Research” has traditionally been defined as taking basic scientific findings and developing new diagnostic tools, drugs, devices and treatment options for patients, that are translated into practice, reach the people and populations for whom they are intended and are implemented correctly. The implication is of a unidirectional flow from “the bench to bedside”. The rapidly emergent field of additive manufacturing (3D printing) is contributing to a major shift in translational medical research. This includes the concept of bidirectional or reverse translation, early collaboration between clinicians, bio-engineers and basic scientists, and an increasingly entrepreneurial mindset. This coincides with, and is strongly complemented by, the rise of systems biology. The rapid pace at which this type of translational research can occur brings a variety of potential pitfalls and ethical concerns. Regulation surrounding implantable medical devices is struggling to keep up. 3D printing has opened the way for personalization which can make clinical outcomes hard to assess and risks putting the individual before the community. In some instances, novelty and hype has led to loss of transparency of outcomes with dire consequence. Collaboration with commercial partners has potential for conflict of interest. Nevertheless, 3D printing has dramatically changed the landscape of translational research. With early recognition and management of the potential risks, the benefits of reshaping the approach to translational research are enormous. This impact will extend into many other areas of biomedical research, re-establishing that science is more than a body of research. It is a way of thinking.

Progress and Current Limitations of Materials for Artificial Bile Duct Engineering

Bile duct injury (BDI) and bile tract diseases are regarded as prominent challenges in hepatobiliary surgery due to the risk of severe complications. Hepatobiliary, pancreatic, and gastrointestinal surgery can inadvertently cause iatrogenic BDI. The commonly utilized clinical treatment of BDI is biliary-enteric anastomosis. However, removal of the Oddi sphincter, which serves as a valve control over the unidirectional flow of bile to the intestine, can result in complications such as reflux cholangitis, restenosis of the bile duct, and cholangiocarcinoma. Tissue engineering and biomaterials offer alternative approaches for BDI treatment. Reconstruction of mechanically functional and biomimetic structures to replace bile ducts aims to promote the ingrowth of bile duct cells and realize tissue regeneration of bile ducts. Current research on artificial bile ducts has remained within preclinical animal model experiments. As more research shows artificial bile duct replacements achieving effective mechanical and functional prevention of biliary peritonitis caused by bile leakage or obstructive jaundice after bile duct reconstruction, clinical translation of tissue-engineered bile ducts has become a theoretical possibility. This literature review provides a comprehensive collection of published works in relation to three tissue engineering approaches for biomimetic bile duct construction: mechanical support from scaffold materials, cell seeding methods, and the incorporation of biologically active factors to identify the advancements and current limitations of materials and methods for the development of effective artificial bile ducts that promote tissue regeneration.

TAPHONOMY AND DEPOSITIONAL SETTING OF THE SHRINGASAURUS INDICUS (ARCHOSAUROMORPHA: ALLOKOTOSAURIA) BONEBED FROM THE MIDDLE TRIASSIC DENWA FORMATION, SATPURA GONDWANA BASIN, INDIA

ABSTRACT A bonebed of multiple skeletons of the Triassic horned reptile Shringasaurus indicus was discovered in the upper Denwa Formation, Satpura Gondwana Basin, India. The monotaxic bonebed contains multiple individuals of different ontogenic stages indicating herding behavior by Shringasaurus indicus. The herd was a mixed-sex herd. The adult and sub-adult bones in the bonebed exceed the number of juvenile bones. The distribution of the bones was slightly patchy, bones of different individuals were admixed, and several bones were piled up implying mass mortality. The bonebed occurs in a fine-grained mudrock that is hydraulically incompatible with long-distance transport and concentration by currents. Sedimentary facies analysis indicates that the bonebed accumulated and was buried in a crevasse splay deposit between two ENE-WSW trending channel-fill complexes. The northern channel-fill complex was formed by unidirectional flow with lateral channel migration towards the south and with minor contemporaneous tectonic subsidence. Repeated breaching of the levee by this channel flow led to the incremental development of the crevasse splay deposit. The herd of Shringasaurus indicus, which lived near to the perennial channel, was drowned en masse and the carcasses were trapped within the muddy sediments of the crevasse splay deposit. Apart from a partially articulated skeleton, the rest of the bones were disarticulated but remained associated. The bones show little evidence of post-mortem modifications. With a continuous supply of the sediments through the spillover channels, the bones were buried before complete disarticulation and dispersal had taken place.

Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers

Endothelial and epithelial cellular barriers play a vital role in the selective transport of solutes and other molecules. The properties and function of these barriers are often affected in case of inflammation and disease. Modelling cellular barriers in vitro can greatly facilitate studies of inflammation, disease mechanisms and progression, and in addition, can be exploited for drug screening and discovery. Here, we report on a parallelizable microfluidic platform in a multiwell plate format with ten independent cell culture chambers to support the modelling of cellular barriers co-cultured with 3D tumor spheroids. The microfluidic platform was fabricated by microinjection molding. Electrodes integrated into the chip in combination with a FT-impedance measurement system enabled transepithelial/transendothelial electrical resistance (TEER) measurements to rapidly assess real-time barrier tightness. The fluidic layout supports the tubeless and parallelized operation of up to ten distinct cultures under continuous unidirectional flow/perfusion. The capabilities of the system were demonstrated with a co-culture of 3D tumor spheroids and cellular barriers showing the growth and interaction of HT29 spheroids with a cellular barrier of MDCK cells.

89 Do Corticosteroid and Local Anaesthetic Hip Injections Administered Proximal or Distal to The Zona Orbicularis Have an Effect on Patient Satisfaction?

Aim Pubofemoral and ischiofemoral ligaments blend to make zona orbicularis. Zonaorbicularis has been suggested to force fluid from peripheral compartment to central compartment in unidirectional flow. This study aims to assess whether injection of corticosteroid with local anaesthetic injected either proximal or distal to the zona orbicularis has effect on patient satisfaction. Method This retrospective study investigated consecutive patients undergoing ultrasound guided hip injections at a single centre in the UK between November 2018 and March 2019. Patients were identified using IMPAX© picture archiving and communications system. Radiographs were assessed to see if radiopaque dye and therefore corticosteroid and local anaesthetic had been injected proximal or distal to the zona orbicularis. Clinic letters were accessed on the electronic patient record and we recorded whether patients had pain relief at 24 hours and 2 weeks following hip injection. Results 133 Patients were identified during the study period, of which 40 were included. At 24 hours post-injection 72% of patients were satisfied and 28% were unsatisfied, for which there was 76% and 70% satisfaction for proximal and distal injections respectively (p = 0.63). At 2 weeks post-injection 45% of patients were satisfied and 55% of patients unsatisfied, for which there was 47% and 44% satisfaction for proximal and distal injections respectively (p = 0.9). Conclusions Overall patient satisfaction is high following hip corticosteroid and local anaesthetic injection. No difference was found between injections proximal and distal to the zona orbicularis. Further research is needed to quantify the association between proximal and distal injections.

Data-Driven Simulation of Pedestrian Movement with Artificial Neural Network

To predict pedestrian movement is of vital importance in a wide range of applications. Recently, data-driven models are receiving increasing attention in pedestrian dynamics studies, demonstrating a great potential in enhancing simulation performance. This paper presents a pedestrian movement simulation model based on the artificial neural network, in which two submodels are, respectively, used to predict velocity displacement and velocity direction angle at each time step. Destination information, the pedestrian’s historical movement information, neighboring pedestrians, and environmental obstacles within a semicircular-shaped perception area are used as inputs to learn pedestrian movement behavioral rules. In the velocity direction angle submodel, a novel division method on pedestrian’s perception area is adopted. Specifically, perception radius is divided into several bands, and perception angle range is divided into a number of sectors, establishing a weighted spatial matrix to represent varied influences of neighboring pedestrians and obstacles. Experiments on two typical scenarios, the unidirectional flow and bidirectional flow in a long straight corridor, were conducted to obtain pedestrian movement datasets. Then, a series of simulation cases were conducted to investigate the proper values for critical parameters, including perception radius, perception angle division, weights of the spatial matrix, and historical movement adoption. In comparison of pedestrian trajectory between simulation results and real data, the mean trajectory error (MTE) and mean destination error (MDE) are, respectively, 0.114 m and 0.171 m in the unidirectional flow scenario, which are, respectively, 0.204 m and 0.362 m in the bidirectional flow scenario. In addition, the fundamental diagram representing density-velocity and density-flow relationships in simulation results agree well with that in real data. The results demonstrate great capacity and credibility of the presented model in simulating pedestrian movement in real applications.