Synthesis of Zinc-Containing Amorphous Calcium Phosphate

2012 ◽  
Vol 529-530 ◽  
pp. 119-122 ◽  
Author(s):  
Tomohiro Uchino ◽  
Keitaro Toda
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Therapeutic Agents ◽  
Zn Content ◽  
Acetic Acid Buffer ◽  
Wet Synthesis ◽  
Low Crystalline ◽  
Phosphate Buffered Saline ◽  
Controlled Released

Zinc is an essential trace element in body and has an important role of bone formation. Osteoporosis occurs by imbalance of osteoclasts and osteoblasts activity. The osteoclasts activity lowers the pH of peripheral body environment. Therapeutic agents release material in response to the osteoclasts activity is expected to be a controlled released material. In this study, Zn-containing amorphous calcium phosphate (ACP) powder was synthesized by wet synthesis. Zn content of obtained powders was higher than that of beginning content. ACP powders could be easy to take Zn at wet synthesis. After soaking in phosphate buffered saline for 24 hours, all of synthetic powders were transformed into low crystalline apatite. On the other hand, after soaking in acetic acid buffer for 24 hours, all these powders dissolved. Zn-containing ACP powders are expected to be a Zn controlled released material.

Effect of Synthesis Temperature and Ca/P Ratios on Specific Surface Area of Amorphous Calcium Phosphate

2016 ◽  
Vol 721 ◽  
pp. 172-176 ◽  
Author(s):  
Jana Vecstaudza ◽  
Janis Locs
Keyword(s):  
Calcium Phosphate ◽  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphates ◽  
Synthesis Temperature ◽  
Molar Ratios ◽  
Different Temperatures ◽  
Low Crystalline

Amorphous and low crystalline calcium phosphates are prospective candidates for bone implant manufacturing. Amorphous calcium phosphate (ACP) preparation technologies could be improved in terms of specific surface area (SSA) of obtained products. Current study is dedicated to the effect of synthesis temperature and Ca and P molar ratios (Ca/P) on SSA of ACP. Higher SSA can improve bioactivity of biomaterials. ACP was characterized by XRD, FT-IR, SEM and BET N2 adsorption techniques. Spherical nanoparticles (<45 nm in size) were obtained independently of initial Ca/P ratio and synthesis temperature. For the first time comparison of SSA was shown for ACP obtained at different temperatures (0 °C and 20 °C) and Ca/P molar ratios (1.5, 1.67 and 2.2).

Role of citrate in the formation of enamel-like calcium phosphate oriented nanorod arrays

CrystEngComm ◽  
2019 ◽  
Vol 21 (32) ◽  
pp. 4684-4689 ◽  
Author(s):  
Francesca Carella ◽  
Lorenzo Degli Esposti ◽  
Davide Barreca ◽  
Gian Andrea Rizzi ◽  
Gianmario Martra ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Nanorod Arrays

The effect of citrate on the formation of oriented fluoride doped hydroxyapatite nanorods grown on an amorphous calcium phosphate substrate was investigated.

scholarly journals Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite

Materials ◽  
2021 ◽  
Vol 14 (19) ◽  
pp. 5860
Author(s):  
Syama Santhakumar ◽  
Ayako Oyane ◽  
Maki Nakamura ◽  
Yuto Yoshino ◽  
Mohammed Katib Alruwaili ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Amorphous Calcium Phosphate ◽  
Bone Tissue Regeneration ◽  
Apatite Coating ◽  
Low Crystalline ◽  
Mineralized Collagen

Surface-mineralized collagen sponges have attracted much attention as scaffolds for bone tissue engineering. Recently, we developed amorphous calcium phosphate (ACP) and low-crystalline apatite coating processes on collagen sponges. In the present study, we applied these coating processes to granular collagen sponges (referred to as Col) to compare the bone tissue regeneration capabilities of ACP-coated and apatite-coated Col (referred to as Col-ACP and Col-Ap, respectively) using a rat cranial bone defect model. According to micro-CT and histological analyses, Col-Ap enhanced bone tissue regeneration compared to Col, whereas Col-ACP did not. These results not only demonstrated the superior bone tissue regeneration capability of Col-Ap, but also indicated limitations of the in vitro simulated body fluid (SBF) test used in our previous study. Despite the apatite-forming ability of Col-ACP in SBF, it was ineffective in improving bone tissue regeneration in vivo, unlike Col-Ap, most likely due to the quick resorption of the ACP coating in the defect site. The present results clarified the importance of the coating stability in vivo and revealed that the low-crystalline apatite coating was more beneficial than the ACP coating in the fabrication of surface-mineralized collagen sponges for use as bone tissue engineering scaffolds.

Anticariogenicity of Casein Phosphopeptide-amorphous Calcium Phosphate: A Review of the Literature

2009 ◽  
Vol 10 (3) ◽  
pp. 1-9 ◽  
Author(s):  
Carmen Llena ◽  
Leopoldo Forner ◽  
Pilar Baca
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Soluble Form ◽  
Review Of The Literature ◽  
Dental Biofilm ◽  
Essential Components ◽  
Casein Phosphopeptide ◽  
Bioavailable Calcium ◽  
Caries Lesions

Abstract Aim This review of the literature examines the role of the natural components of saliva in maintaining tooth mineralization and the role of different casein phosphopeptide amorphous calcium phosphate-based (CPP-ACP) compounds in controlling demineralization/ remineralization and their clinical applications. Background A group of peptides, known as CPP, have been shown to stabilize calcium and phosphate preserving them in an amorphous or soluble form known as amorphous calcium phosphate (ACP). Calcium and phosphate are essential components of enamel and dentine and form highly insoluble complexes, but in the presence of CPP they remain soluble and biologically available. This CPP-ACP complex applied to teeth by means of chewing-gum, toothpaste, lozenges, mouth rinses, or sprays is able to adhere to the dental biofilm and enamel hydroxyapatite providing bioavailable calcium and phosphate ions. Review Results Significantly high levels of calcium and phosphate have been found in both biofilm and subsurface incipient caries lesions and in lower level demineralization of enamel or dentine surfaces previously treated with CPP-ACP based compounds. When placed on the surface of a tooth with early carious lesions, pastes with CPP-ACP complexes can prevent tooth demineralization and improve enamel remineralization and enhance fluoride activity. Conclusion Remineralization of white spot lesions has been achieved clinically by applying pastes based on these compounds, and a similar effect to self-applied fluorides has been observed in reducing the appearance of new caries lesions in patients with xerostomia. Clinical Significance Use of CPP-ACP based compounds offers a potential for use in the prevention of dental caries. Citation Llena C, Forner L, Baca P. Anticariogenicity of Casein Phosphopeptide-amorphous Calcium Phosphate: A Review of the Literature. J Contemp Dent Pract 2009 May; (10)3:001-009.

scholarly journals THE EFFECT OF CARBOXYMETHYL CHITOSAN/AMORPHOUS CALCIUM PHOSPHATE TO GUIDE TISSUE REMINERALIZATION OF DENTIN COLLAGEN

2019 ◽  
pp. 181-183
Author(s):  
ROSDIANA NURUL ANNISA ◽  
NILAKESUMA DJAUHARIE ◽  
ENDANG SUPRASTIWI ◽  
NORMA AVANTI
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Matrix Protein ◽  
Carboxymethyl Chitosan ◽  
Control Group ◽  
Group 14 ◽  
Tem Analysis ◽  
Transmission Electron ◽  
Dentin Collagen

Objective: Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) can replace the role of dentine matrix protein 1. Guided tissueremineralization (GTR) is a method of extrafibrillar and intrafibrillar collagen remineralization. This study analyzed the ability of CMC/ACP to achieveintrafibrillar and extrafibrillar remineralization on demineralized dentin.Methods: We divided 12 demineralized occlusal cavities into four groups: 7 days control group, 14 days control group, 7 days CMC/ACP group, and14 days CMC/ACP group. In the control group, the cavities were directly filled with temporary restoration material, while the cavities of the CMC/ACPgroups first underwent application of CMC/ACP and were then filled with temporary restoration material. All samples were stored in a 37°C shakingincubator. 12 samples were analyzed by energy-dispersive X-ray (EDX) spectroscopy and four were analyzed by transmission electron microscope(TEM).Results: From day 7 to day 14, there was a significant increase in calcium and phosphate levels within the CMC/APC groups. The phosphate levelswere much lower than the calcium or minerals formed on the 7th day, in the form of hydroxyapatite. TEM analysis shows that the CMC/ACP groupexhibited more intrafibrillar and extrafibrillar remineralization.Conclusion: CMC/ACP can improve the GTR process.

The synergic role of collagen and citrate in stabilizing amorphous calcium phosphate precursors with platy morphology

2017 ◽  
Vol 49 ◽  
pp. 555-562 ◽  
Author(s):  
José Manuel Delgado-López ◽  
Federica Bertolotti ◽  
Jeppe Lyngsø ◽  
Jan Skov Pedersen ◽  
Antonio Cervellino ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate
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