A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

Uniform Microbubbles (MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel–loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope (SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.

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In vitro evaluation of ultrasound-assisted thrombolysis using targeted ultrasound contrast agents

2008 IEEE Ultrasonics Symposium ◽

10.1109/ultsym.2008.0405 ◽

2008 ◽

Author(s):

Jia-Ling Ruan ◽

Po-Wen Cheng ◽

Suz-Chia Chen ◽

Yueh-Hsun Chuang ◽

Pai-Chi Li

Keyword(s):

Contrast Agents ◽

Ultrasound Contrast Agents ◽

In Vitro Evaluation ◽

Ultrasound Contrast ◽

Targeted Ultrasound ◽

Ultrasound Assisted

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Primary Macrophage-Based Microrobots: An Effective Tumor Therapy In Vivo by Dual-Targeting Function and Near-Infrared-Triggered Drug Release

ACS Nano ◽

10.1021/acsnano.1c00114 ◽

2021 ◽

Author(s):

Van Du Nguyen ◽

Hyun-Ki Min ◽

Ho Yong Kim ◽

Jiwon Han ◽

You Hee Choi ◽

...

Keyword(s):

Drug Release ◽

Near Infrared ◽

Tumor Therapy ◽

Primary Macrophage ◽

Dual Targeting ◽

Triggered Drug Release

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Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films

E3S Web of Conferences ◽

10.1051/e3sconf/202132104011 ◽

2021 ◽

Vol 321 ◽

pp. 04011

Author(s):

Navideh Abbasnezhad ◽

Farid Bakir ◽

Stéphane Champmartin ◽

Mohammadali Shirinbayan

Keyword(s):

Mathematical Model ◽

Drug Release ◽

Flow Rate ◽

Drug Carrier ◽

Diclofenac Sodium ◽

Drug Eluting Stents ◽

In Vitro Drug Release ◽

Drug Eluting ◽

Release Profiles

Drug-eluting stents implanted in blood vessels are subject to various dynamics of blood flow. In this study, we present the evaluation of a mathematical model considering the effect of flow rate, to simulate the kinetic profiles of drug release (Diclofenac Sodium (DS)) from in-vitro from PLGA films. This model solves a set of non-linear equation for modeling simultaneously the burst, diffusion, swelling and erosion involved in the mechanisms of liberation. The release parameters depending on the flow rate are determined using the corresponding mathematical equations. For the evaluation of the proposed model, test data obtained in our laboratory are used. To quantify DS release from drug-carrier PLGA films, we used the flow-through cell apparatus in a closed-loop. Four flow rate values are applied. For each value, the model-substance liberation kinetics showed an increase in drug released with the flow rate. The simulated release profiles show good agreement with the experimental results. Therefore, the use of this model could provide a practical tool to assess in-vitro drug release profiles from polymer matrices under continuous flow rate constraint, and could help improve the design of drug eluting stents.

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Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

Biomaterials Science ◽

10.1039/c6bm00662k ◽

2017 ◽

Vol 5 (1) ◽

pp. 98-110 ◽

Cited By ~ 18

Author(s):

Liu-Jie Zhang ◽

Bo Wu ◽

Wei Zhou ◽

Cai-Xia Wang ◽

Qian Wang ◽

...

Keyword(s):

Drug Release ◽

Hybrid Nanoparticles ◽

Polymer Hybrid ◽

Two Component ◽

Triggered Drug Release

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles composed of DLPE-S-S-MPEG and PCL were developed for intracellular reduction triggered delivery of DOX.

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DEVELOPMENT OF RITONAVIR LOADED NANOPARTICLES: IN VITRO AND IN VIVO CHARACTERIZATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.23145 ◽

2018 ◽

Vol 11 (3) ◽

pp. 284

Author(s):

Pravin S Patil ◽

Shashikant C Dhawale

Keyword(s):

Particle Size ◽

Drug Release ◽

Dissolution Rate ◽

Drug Carrier ◽

Entrapment Efficiency ◽

Significant Rise ◽

Scanning Calorimetry ◽

In Vitro Drug Release

Objective: The purpose of the present investigation was to develop a nanosuspension to improve dissolution rate and oral bioavailability of ritonavir.Methods: Extended-release ritonavir loaded nanoparticles were prepared using the polymeric system by nanoprecipitation technique. Further, the effect of Eudragit RL100 (polymeric matrix) and polyvinyl alcohol (surfactant) was investigated on particle size and distribution, drug content, entrapment efficiency, and in vitro drug release from nanosuspension where a strong influence of polymeric contents was observed. Drug-excipient compatibility and amorphous nature of drug in prepared nanoparticles were confirmed by Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction studies, respectively.Results: Hydrophobic portions of Eudragit RL100 could result in enhanced encapsulation efficiency. However, increase in polymer and surfactant contents lead to enlarged particle size proportionately as confirmed by transmission electron microscopy. Nanosuspension showed a significant rise in dissolution rate with complete in vitro drug release as well as higher bioavailability in rats compared to the pure drug.Conclusion: The nanoprecipitation technique used in present research could be further explored for the development of different antiretroviral drug carrier therapeutics.

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An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment

Biomaterials Science ◽

10.1039/c9bm01794a ◽

2020 ◽

Vol 8 (8) ◽

pp. 2202-2211 ◽

Cited By ~ 1

Author(s):

Li Zhang ◽

Shiyu Zhang ◽

Huajian Chen ◽

Yu Liang ◽

Bingxia Zhao ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Hybrid System ◽

Tumor Treatment ◽

Triggered Drug Release ◽

Ultrasound Assisted ◽

Doxorubicin Delivery

Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.

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Polycaprolactone-Based Mimetic Antimicrobial Peptide Copolymers Vesicles as an Effective Drug-Carrier for Cancer Therapy

Polymers ◽

10.3390/polym11111783 ◽

2019 ◽

Vol 11 (11) ◽

pp. 1783 ◽

Cited By ~ 2

Author(s):

Yusheng Qian ◽

Xinyu Zhou ◽

Jing He ◽

Chuncai Zhou

Keyword(s):

Cancer Therapy ◽

Drug Release ◽

Antimicrobial Peptide ◽

Drug Carrier ◽

Uniform Size ◽

Vesicular Structure ◽

Transmission Electron ◽

Low Concentrations ◽

Carrier Systems

A novel series of amphiphilic mimicking antimicrobial peptide copolymers PCL16-b-Kn can assemble in water to form uniform vesicles. Transmission electron microscopy was used to observe the vesicular structure of the nanoparticles, and dynamic light scattering revealed their uniform size and narrow dispersion. Critical vesiculation concentrations were also tested, revealing that these vesicles can exist at low concentrations. Furthermore, in vitro and intracellular drug release of doxorubicin(DOX)-vesicles were conducted. These vesicles could encapsulate DOX and achieve efficient intracellular drug release. Overall, these copolymer vesicles exhibit potential application value as multifunctional drug-carrier systems with antibacterial capability in cancer therapy.

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