Effect of Octacalcium Phosphate-Based Bone Substitute Materials on Oriented Bone Regeneration

2017 ◽  
Vol 758 ◽  
pp. 223-227
Author(s):  
Osamu Suzuki ◽  
Takahisa Anada
Keyword(s):  
Bone Matrix ◽  
Octacalcium Phosphate ◽  
Tissue Response ◽  
Gelatin Sponge ◽  
Natural Polymers ◽  
Preparation Conditions ◽  
Biological Responses ◽  
Bone Substitute Materials ◽  
Collagen Molecules ◽  
Substitute Materials

The characteristics and the biological responses of octacalcium phosphate (OCP) crystals, obtained in the presence of natural polymers, were summarized based on our studies reported. OCP obtained with collagen molecules in the solution had a plate-like morphology while OCP obtained with gelatin molecules in the solution exhibited elongated morphology toward long axis of the crystals. Oriented bone matrix formation was observed by the OCP inclusion in gelatin sponge in a critical-sized rat calvaria defect within the implantation periods around 8 weeks. It seems likely that specific crystal property of OCP obtained in distinct preparation conditions may affect bone tissue response probably through the modulation of OCP crystal characteristics.

scholarly journals Bone Tissue Response to Different Grown Crystal Batches of Octacalcium Phosphate in Rat Long Bone Intramedullary Canal Area

2021 ◽  
Vol 22 (18) ◽  
pp. 9770
Author(s):  
Yukari Shiwaku ◽  
Ryo Hamai ◽  
Shinichi Sato ◽  
Susumu Sakai ◽  
Kaori Tsuchiya ◽  
...  
Keyword(s):  
Octacalcium Phosphate ◽  
Tissue Response ◽  
Ion Concentration ◽  
Long Bone ◽  
Dissolution Behavior ◽  
Control Group ◽  
Tubular Bone ◽  
Biological Responses ◽  
Intramedullary Canal ◽  
Rat Tibia

The microstructure of biomaterials influences the cellular and biological responses in the bone. Octacalcium phosphate (OCP) exhibits higher biodegradability and osteoconductivity than hydroxyapatite (HA) during the conversion process from OCP to HA. However, the effect of the microstructure of OCP crystals on long tubular bones has not been clarified. In this study, two types of OCPs with different microstructures, fine-OCP (F-OCP) and coarse-OCP (C-OCP), were implanted in rat tibia for 4 weeks. F-OCP promoted cortical bone regeneration compared with C-OCP. The osteoclasts appearance was significantly higher in the C-OCP group than in the control group (defect only) at 1-week post-implantation. To investigate whether the solubility equilibrium depends on the different particle sizes of OCPs, Nano-OCP, which consisted of nanometer-sized OCPs, was prepared. The degree of supersaturation (DS) tended to decrease modestly in the order of C-OCP, F-OCP, and Nano-OCP with respect to HA and OCP in Tris-HCl buffer. F-OCP showed a higher phosphate ion concentration and lower calcium ion concentration after immersion in the buffer than C-OCP. The crystal structures of both OCPs tended to be converted to HA by rat abdominal implantation. These results suggest that differences in the microstructure of OCPs may affect osteoclastogenesis and result in osteoconductivity of this material in long tubular bone by altering dissolution behavior.

Tissue Response to Bone Substitute Materials

1997 ◽  
Vol 3 (S2) ◽  
pp. 263-264
Author(s):  
K. E. Krizan ◽  
D. Lew ◽  
B. B. Farrell ◽  
J. E. Laffoon ◽  
J. C. Keller
Keyword(s):  
Bone Substitute ◽  
Xylenol Orange ◽  
Biological Response ◽  
Tissue Response ◽  
Cranial Bone ◽  
En Bloc ◽  
Transmission Electron ◽  
Bone Substitute Materials ◽  
Plastic Resin ◽  
Substitute Materials

The purpose of this study was to compare the biological response to two bone substitute materials, hydroxyapatite cement (HAC) and demineralized bone (DMB), when placed in canine cranial bone. The implants were surgically positioned in 15 mm diameter defects created in the parietal plate, harvested en bloc at 3 months (m) and 6m postop, and fixed in 70% ethyl alcohol to preserve the xylenol orange bone label. Half of each implant site was processed into paraffin and the other half into Spurr plastic resin. In order to evaluate the osseoinductive properties of DMB, implants were also surgically placed in the rectus femorous muscle, harvested en bloc at 3m post op, fixed in 0.1 M Na phosphate buffer, pH 7.2, decalcified in 5% EDTA, pH 7.2, and embedded in plastic. All implants were evaluated with light microscopy (LM), radiography, energy-dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). Tissue for LM was routinely decalcified with SFFA, embedded in paraffin, sectioned, stained with hematoxylin/eosin, and viewed with a Zeiss transmitted-light photomicroscope [Figs. 1, 2, 5].

Tissue Response to Bone Substitute Materials Supporting Dental Implants

1998 ◽  
Vol 4 (S2) ◽  
pp. 1092-1093
Author(s):  
K. E. Krizan ◽  
D. Lew ◽  
T. Rubey ◽  
J. C. Keller
Keyword(s):  
Dental Implants ◽  
Bone Substitute ◽  
Biological Response ◽  
Tissue Response ◽  
Tissue Adhesive ◽  
Wall Defect ◽  
Extraction Site ◽  
Bone Substitute Materials ◽  
Synthetic Hydroxyapatite ◽  
Substitute Materials

The purpose of this study was to evaluate the biological response of a bone substitute material placed around Ti dental implants surgically positioned in tooth extraction sites of canine mandible. Under general anesthesia six adult mongrel canine had bilateral extractions of the fourth premolarbicuspid. Each extraction site was modeled into a 4 wall defect with box-like dimensions (1.0 mm vertically x 1.2 mm horizontally x 0.75 mm laterally). Utilizing the Branemark technique, screwtype implants with healing screws (10 mm x 4 mm), were placed in the prepared sites. A synthetic hydroxyapatite bone cement (HAC) [BoneSource®, Howmedica Laboratories, Inc.] was prepared and filled in around each implant. As controls, three canine had HAC placed in prepared sites without implants. Prior to periodontal flap suture closure a n-butyl-2-cyanoacrylate biodegradable tissue adhesive [Histoacryl®], was placed over implants and HAC. One canine each was euthanized at one month (m), two m, and three m postop.

Unique Dicarboxylate Ion Incorporation in Octacalcium Phosphate

2018 ◽  
Vol 782 ◽  
pp. 3-8
Author(s):  
Taishi Yokoi
Keyword(s):  
Interplanar Spacing ◽  
Octacalcium Phosphate ◽  
Unique Property ◽  
Side Chain ◽  
Guest Molecules ◽  
Precise Control ◽  
Fundamental Properties ◽  
Bone Substitute Materials ◽  
Ion Incorporation ◽  
Substitute Materials

Various dicarboxylate ions can be incorporated into the crystal structure of octacalcium phosphate (OCP). This unique property can be applied to develop functional bone substitute materials. However, there are many unclear points regarding the chemistry of OCP with incorporated dicarboxylate ions. In this review, we discuss the following three topics regarding the fundamental properties of OCP with incorporated dicarboxylate ions: the incorporation of two types of dicarboxylate ions into the OCP interlayer, the precise control of the interplanar spacing for OCP with dicarboxylate ions having a side chain, and the chirality recognition of guest molecules during OCP incorporation phenomena.

Calcium Phosphate Bone Cement (CPBC): Development, Commercialization and Future Challenges

2011 ◽  
Vol 493-494 ◽  
pp. 349-354 ◽  
Author(s):  
Aliassghar Tofighi
Keyword(s):  
Chemical Composition ◽  
Bone Substitute ◽  
Mechanical Performance ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
User Friendliness ◽  
Carbonated Apatite ◽  
Calcium Phosphate Bone Cement ◽  
Bone Substitute Materials ◽  
Substitute Materials

The first generation of synthetic bone substitute materials, hydroxyapatite (or HA), was initially investigated as a “non self-hardening” biomaterial for remodeling of bone defects. CPBCs concepts were used as a platform to initiate a second generation of injectable, self-hardening cement. The variety of CPBC’s chemical composition leads to a better understanding of their mechanism of reaction and their proposed classification: acid-base, mono-component and hydrolysable. After hydration, mixing, and full chemical reaction, these cements have the ability to precipitate different end products (e.g. HA, calcium deficient apatite, carbonated apatite, brushite, etc.). In fact, the initial idea of having higher mechanical performance (>50 MPa in compression) for a bone void filler application was abandoned and has led to a greater focus on cement fast-hardening (<15 min), higher total porosity (>60%), extended performance of injectability (8 to 22 G), fast resorbability (< 2 years) and user-friendliness for the clinicians. A new CPBC combination (cement plus additives) has particularly improved rheological and biointegrity performance. A hybrid of CPBC-DBM (Demineralized Bone Matrix) has also added an osteoinductivity performance to the initial osteoconductive CPBC.This paper will propose a comparison of the chemical composition, reaction, and performance characteristics of major commercially available CPBC products. Furthermore, it will describe today’s surgeon’s CPBC needs as bone substitute materials for different clinical applications. Finally, we will discuss what we learned so far, how we can resolve several clinical impacts & product recall, and how we believe CPBC designers can meet development challenges, and users’ specific requirements.

scholarly journals Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties

2021 ◽  
Vol 11 (11) ◽  
pp. 4930
Author(s):  
Elena Landi ◽  
Stefano Guizzardi ◽  
Elettra Papa ◽  
Carlo Galli
Keyword(s):  
Bone Structure ◽  
Exchange Process ◽  
Bone Matrix ◽  
Molar Ratio ◽  
Thermal Treatments ◽  
Native Bone ◽  
Ion Exchange Process ◽  
Wide Range ◽  
Bone Substitute Materials ◽  
Substitute Materials

Bone substitute materials require specific properties to make them suitable for implantation, such as biocompatibility and resistance to mechanical loads. Mg,Sr-cosubstituted hydroxyapatite (MgSr-HA) is a promising bone scaffold candidate because its structure is similar to the native bone matrix. However, MgSr-HA materials do not typically withstand thermal treatments over 800 °C, because Mg promotes HA degradation to less stable tricalcium phosphate, a compound that, albeit biocompatible, is not found in bone. We, therefore, designed an ion-exchange process to enrich sintered Sr-HA with Mg and obtain MgSr-HA porous constructs. These materials contained a 0.04–0.08 Mg/Ca molar ratio and a 0.12–0.13 Sr/Ca molar ratio, and had up to 20 MPa of compressive strength, suitable for use as bone fillers or scaffolds. Unlike previous synthetic Mg,Sr-substituted apatite powders, the proposed process did not degrade HA and thus preserved its similarity to bone structure. The obtained material thus combines the presence of bioactive Mg and Sr ions in the HA lattice with a 3D morphological/structural organization that can be customized in pore size and distribution, as well as in mechanical strength, thus potentially covering a wide range of clinical applications.

Bone Substitute Materials in Modern Dentistry

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Andrius Geguzis ◽  
Inesa Astramskaite ◽  
Dovile Gabseviciute
Keyword(s):  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials
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