Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants

2018 ◽  
Vol 782 ◽  
pp. 212-217
Author(s):  
Ipek Karacan ◽  
Joshua Chou ◽  
Besim Ben-Nissan ◽  
Innocent J. Macha ◽  
Sophie Cazalbou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Poly Lactic Acid ◽  
Adverse Side Effects ◽  
New Novel ◽  
Metallic Implants ◽  
Ceramic Hydroxyapatite ◽  
Acid Coating ◽  
Dual Drug

The new novel implant designs include the functionality of advanced drug delivery systems in order to improve osteointegration and to inhibit the implant-related post-operative infections. In this research, Ti6Al4V metallic implants were coated with the multifunctional-dual slow drug delivery coating which includes a polymeric matrix system based on a poly-lactic acid thin film and a bioactive ceramic hydroxyapatite. This system consists of two different kinds of pharmaceuticals, which are gentamicin and simvastatin. It is reported in this paper that the simvastatin and gentamicin containing poly-lactic acid coating which was applied uniformly and successfully with and without hydroxyapatite microspheres. Most importantly, the release rate of drugs was controlled with PLA matrix and HAp microspheres which have different dissolution rates in order to prevent the high dosages causing adverse side-effects of drugs.

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen

2013 ◽  
Vol 33 (7) ◽  
pp. 4002-4008 ◽  
Author(s):  
Ana Paula Serafini Immich ◽  
Manuel Lis Arias ◽  
Núria Carreras ◽  
Rafael Luís Boemo ◽  
José Antonio Tornero
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

2013 ◽  
Vol 21 (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Nita Tudorachi ◽  
Rodica Lipsa ◽  
Cornelia Vasile ◽  
Fanica Mustata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Aspartic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

Biodegradable poly(lactide-co-glycolide-co-ε-caprolactone) block copolymers – evaluation as drug carriers for a localized and sustained delivery system

2015 ◽  
Vol 3 (41) ◽  
pp. 8143-8153 ◽  
Author(s):  
Ji Hoon Park ◽  
Hwi Ju Kang ◽  
Doo Yeon Kwon ◽  
Bo Keun Lee ◽  
Bong Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Poly Lactic Acid ◽  
Sustained Delivery ◽  
System P ◽  
Biodegradable Poly

To develop an appropriate drug carrier for drug delivery systems, we prepared random poly(lactide-co-glycolide-co-ε-caprolactone) (PLGC) copolymers in comparison to commercial poly(lactic acid-co-glycolic acid) (PLGA) grades.

Sign in / Sign up

Export Citation Format

Share Document