The Effects of a Recovery Education Program on Rehabilitation Motivation, Symptoms, and Function for Schizophrenic Patients

2006 ◽  
Vol 36 (3) ◽  
pp. 542 ◽  
Author(s):  
Yi Young Kim ◽  
Hyun Sook Park ◽  
Kyung Min Park
Author(s):  
Н.Н. Вейко ◽  
Е.С. Ершова ◽  
М.С. Конькова ◽  
Е.М. Малиновская ◽  
С.В. Костюк

Пространственная организация хроматина важна для нормального функционирования клетки. На архитектуру ядра влияют размеры отдельных фрагментов генома, которые коррелируют с числом копий этих фрагментов. Перемещение локусов 1q12 от поверхности ядра в центральные области является ключевой стадией адаптивного ответа клетки на стресс. Мы предположили, что размер локусов 1q12, который коррелирует с содержанием повтора f-SatIII, может влиять на перемещение этих участков хроматина в ядре. Методом FISH на выделенных лимфоцитах показали, что в контроле локусы 1q12 расположены вблизи поверхности ядра, в ядрах лимфоцитов больных шизофренией (БШ) и облученных контрольных клеток локусы 1q12 расположены в центральных районах ядра. Длительное культивирование облученных лимфоцитов сопровождалось гибелью клеток, и снижением содержания f-SatIII в ДНК. Очевидно, что погибали клетки с большим размером 1q12 (много f-SatIII), обогащая популяцию клетками с низким содержанием f-SatIII. В клетках БШ и в облученных клетках мы обнаружили повышение уровня РНК SATIII. Размеры гетерохроматина 1q12 в клетках человека могут влиять на процессы пролиферации и ответа клетки на стресс. Количественный полиморфизм тандемных повторов генома - один из эпигенетических механизмов регуляции ответа клеток на окислительный стресс. The spatial organization of chromatin is important for the normal functioning of the cell. Genome repeat cluster sizes can affect the chromatin spatial configuration and function. The 1q12 heterochromatin loci movement from the periphery to the center of the nucleus is the cells’ universal response to various types of stress. We hypothesized that a large 1q12 domain could affect chromatin movement, thereby inhibiting adaptive response (AR). Using the FISH method, we shown that in the control, 1q12 loci are located near the surface of the nucleus; in the lymphocyte nuclei of schizophrenic patients and irradiated control cells, 1q12 loci are located in the central regions of the nucleus. During prolonged cultivation, the irradiated cells with a large Large f-SatIII amount die and the population is enriched with the cells with low f-SatIII content. In intact SZ patients’ lymphocytes and in irradiated cells we found an increase in SATIII RNA levels. The size of heterochromatin 1q12 loci in human cells can affect to the proliferation and cells’ adaptive response to stress. Quantitative polymorphism of tandem genome repeats is one of the epigenetic mechanisms of genome expression’s regulation.


Author(s):  
Etika Ariyani Nugroho

The purposes of this study were to evaluate (1) background of character education program implementation on regulations, goal and function; (2) character education program input relate to school culture and teacher competencies; (3) education character program process relate to implementation,monitoring and evaluation, and responsibility; and (4) product, the result of program implementation.This program has been implemented since 2010 in Mataram city- West Nusa Tenggara Province. The results disclosed that the implementation of character education program was need improvement which is indicated by (1) regulations,goal and objective are fulfilled; (2) input component relate to school culture and teacher competencies are partially fulfilled; (3) process component relate to implementation, monitoring and evaluation, and responsibility are partially fulfilled; and (4) product, the result of program implementation relate to students achievement and the internalization of 18 character values are partially fulfilled. It is suggested to improve teacher competencies, family control and manage monitoring-evaluation process.


2009 ◽  
Vol 25 (3-4) ◽  
pp. 312-324 ◽  
Author(s):  
Margaret Swarbrick ◽  
David Roe ◽  
Jay Yudof ◽  
Yaara Zisman

2021 ◽  
Vol 1 ◽  
pp. 159-173
Author(s):  
Warih Mahardini ◽  
Eka Budiarto

AbstractSchizophrenia is a long-term psychiatric disease. It also affects the patient’s companion or caregiver. The caregivers are vulnerable to excessive burdens and stress that can interfere with their role as companions and their functioning in the family. Adequate resilience is needed so that caregivers can deal with stress and function optimally in treating schizophrenic patients. This study aimed to describe efforts to increase resilience in caregivers of schizophrenic patients based on available scientific evidence. The study used a descriptive study method with a literature review approach. The databases used were ProQuest, PubMed, Science Direct, Wiley Online Library, and GARUDA. Articles were selected based on suitability of keywords, topics and the specified inclusion and exclusion criteria. There were six articles found. They were published in the 2015-2021 period. The critical assessment instrument used was the Hawker instrument. There were 12 efforts to increase caregiver resilience of schizophrenia patients, namely identifying and evaluating the experience of caring for and fuctioning of the family, regulating emotions, recognizing characteristics and sources of resilience, increasing and maintaining source of adaptive coping, planning for strengthening adaptive coping, positive outlook on life, having hope, openness to criticism, teachings of faith to be sincere, love and compassion, strengthening social support, doing meditation and yoga mindfulness-cognitive based intervention. The twelve efforts to increase caregiver resilience for schizophrenia patients are obtained from valid scientific evidence. Therefore, they can be used as scientific references to be applied as nursing care intervention.Keywords: Caregiver; resilience; schizophrenia; efforts to increase resilience AbstrakSkizofrenia merupakan penyakit kejiwaan berdampak jangka panjang. Dampak tersebut dialami juga oleh pendamping pasien atau caregiver. Caregiver rentan mengalami beban dan stress berlebih yang dapat mengganggu perannya sebagai pendamping dan keberfungsiannya dalam keluarga. Resiliensi yang adekuat diperlukan agar caregiver dapat menghadapi tekanan serta berfungsi optimal dalam merawat pasien skizofrenia. Penelitian bertujuan untuk menguraikan upaya peningkatan resiliensi pada caregiver pasien skizofrenia berdasarkan bukti ilmiah yang tersedia. Penelitian menggunakan metode studi deskriptif dengan pendekatan literature review. Database yang digunakan ProQuest, PubMed, Science Direct, Wiley Online Library dan GARUDA. Artikel diseleksi berdasarkan kesesuaian kata kunci, topik serta kriteria inklusi dan eksklusi yang ditentukan. Artikel yang digunakan dalam penelitian berjumlah enam artikel yang terbit pada rentang waktu 2015-2021. Instrumen telaah kritis yang digunakan adalah instrumen Hawker. Terdapat 12 upaya peningkatan resiliensi caregiver pasien skizofrenia yaitu mengidentifikasi dan mengevaluasi pengalaman merawat serta keberfungsian keluarga, meregulasi emosi, mengenali karakteristik dan sumber resiliensi, meningkatkan dan mempertahankan sumber koping adaptif, merencanakan penguatan koping adaptif, pandangan hidup positif, adanya harapan, keterbukaan terhadap kritik, ajaran iman untuk tulus ikhlas, rasa cinta dan kasih sayang, penguatan dukungan sosial, melakukan meditasi dan yoga mindfulness-cognitive based intervention. Keduabelas upaya peningkatan resiliensi caregiver pasien skizofrenia didapatkan dari bukti ilmiah yang valid sehingga dapat dijadikan referensi ilmiah untuk diaplikasikan sebagai intervensi asuhan keperawatan.Kata kunci: Caregiver; resiliensi;skizofrenia; upaya peningkatan resiliensi.


1993 ◽  
Vol 87 (9) ◽  
pp. 352-353
Author(s):  
A.S. Williams

This article describes the structure, content, and function of a specialized adaptive diabetes education program in a large, community-based blindness rehabilitation agency.


Author(s):  
Erin C. Dunn ◽  
E. Sally Rogers ◽  
Dori S. Hutchinson ◽  
Asya Lyass ◽  
Kim L. MacDonald Wilson ◽  
...  

2006 ◽  
Vol 8 (3) ◽  
pp. 353-357 ◽  

The disrupted in schizophrenia 1 (DISC1) gene has been identified as a schizophrenia susceptibility gene based on linkage and single nucleotide polymorphism (SNP) association studies and clinical data, suggesting that risk SNPs impact on hippocampal structure and function. We hypothesized that altered expression of DISC1 and/or its molecular partners (nuclear distribution element-like [NUDEL], fasciculation and elongation protein zeta-i [FEZ1], and lissencephaly 1 [LIS1]) may underlie its pathogenic role in schizophrenia and explain its genetic association. We examined the expression of DISC1 and its binding partners in the hippocampus and dorsolateral prefrontal cortex of postmortem human brains of schizophrenic patients and controls. We found no difference in the expression of DISC1 mRNA in schizophrenia, and no association with previously identified risk SNPs. However, the expression of NUDEL, FEZ1, and LIS1 was significantly reduced in tissue from schizophrenic subjects, and the expression of each showed association with high-risk DISC1 polymorphisms. These data suggest involvement of genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia.


2014 ◽  
Vol 37 (4) ◽  
pp. 329-332 ◽  
Author(s):  
Shu-Ping Chen ◽  
Terry Krupa ◽  
Rosemary Lysaght ◽  
Elizabeth McCay ◽  
Myra Piat

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