scholarly journals Improving Resilience in Caregiver of Schizophrenic Patients: A Literature Review

2021 ◽  
Vol 1 ◽  
pp. 159-173
Author(s):  
Warih Mahardini ◽  
Eka Budiarto
Keyword(s):  
Literature Review ◽  
Scientific Evidence ◽  
Assessment Instrument ◽  
Psychiatric Disease ◽  
Adaptive Coping ◽  
The Family ◽  
Schizophrenic Patients ◽  
Online Library ◽  
Positive Outlook ◽  
And Function

AbstractSchizophrenia is a long-term psychiatric disease. It also affects the patient’s companion or caregiver. The caregivers are vulnerable to excessive burdens and stress that can interfere with their role as companions and their functioning in the family. Adequate resilience is needed so that caregivers can deal with stress and function optimally in treating schizophrenic patients. This study aimed to describe efforts to increase resilience in caregivers of schizophrenic patients based on available scientific evidence. The study used a descriptive study method with a literature review approach. The databases used were ProQuest, PubMed, Science Direct, Wiley Online Library, and GARUDA. Articles were selected based on suitability of keywords, topics and the specified inclusion and exclusion criteria. There were six articles found. They were published in the 2015-2021 period. The critical assessment instrument used was the Hawker instrument. There were 12 efforts to increase caregiver resilience of schizophrenia patients, namely identifying and evaluating the experience of caring for and fuctioning of the family, regulating emotions, recognizing characteristics and sources of resilience, increasing and maintaining source of adaptive coping, planning for strengthening adaptive coping, positive outlook on life, having hope, openness to criticism, teachings of faith to be sincere, love and compassion, strengthening social support, doing meditation and yoga mindfulness-cognitive based intervention. The twelve efforts to increase caregiver resilience for schizophrenia patients are obtained from valid scientific evidence. Therefore, they can be used as scientific references to be applied as nursing care intervention.Keywords: Caregiver; resilience; schizophrenia; efforts to increase resilience AbstrakSkizofrenia merupakan penyakit kejiwaan berdampak jangka panjang. Dampak tersebut dialami juga oleh pendamping pasien atau caregiver. Caregiver rentan mengalami beban dan stress berlebih yang dapat mengganggu perannya sebagai pendamping dan keberfungsiannya dalam keluarga. Resiliensi yang adekuat diperlukan agar caregiver dapat menghadapi tekanan serta berfungsi optimal dalam merawat pasien skizofrenia. Penelitian bertujuan untuk menguraikan upaya peningkatan resiliensi pada caregiver pasien skizofrenia berdasarkan bukti ilmiah yang tersedia. Penelitian menggunakan metode studi deskriptif dengan pendekatan literature review. Database yang digunakan ProQuest, PubMed, Science Direct, Wiley Online Library dan GARUDA. Artikel diseleksi berdasarkan kesesuaian kata kunci, topik serta kriteria inklusi dan eksklusi yang ditentukan. Artikel yang digunakan dalam penelitian berjumlah enam artikel yang terbit pada rentang waktu 2015-2021. Instrumen telaah kritis yang digunakan adalah instrumen Hawker. Terdapat 12 upaya peningkatan resiliensi caregiver pasien skizofrenia yaitu mengidentifikasi dan mengevaluasi pengalaman merawat serta keberfungsian keluarga, meregulasi emosi, mengenali karakteristik dan sumber resiliensi, meningkatkan dan mempertahankan sumber koping adaptif, merencanakan penguatan koping adaptif, pandangan hidup positif, adanya harapan, keterbukaan terhadap kritik, ajaran iman untuk tulus ikhlas, rasa cinta dan kasih sayang, penguatan dukungan sosial, melakukan meditasi dan yoga mindfulness-cognitive based intervention. Keduabelas upaya peningkatan resiliensi caregiver pasien skizofrenia didapatkan dari bukti ilmiah yang valid sehingga dapat dijadikan referensi ilmiah untuk diaplikasikan sebagai intervensi asuhan keperawatan.Kata kunci: Caregiver; resiliensi;skizofrenia; upaya peningkatan resiliensi.

scholarly journals Peran Keluarga Dalam Menurunkan Tanda Gejala Halusinasi Pasien Skizofrenia: Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1777-1783
Author(s):  
Nevita Candra Pangestika ◽  
Eka Budiarto
Keyword(s):  
Literature Review ◽  
Family Roles ◽  
Parental Closeness ◽  
The Family ◽  
Schizophrenic Patients ◽  
Long Term Impact ◽  
And Behavior ◽  
Attitudes And Behavior

AbstractSchizophrenia is a mental illness that has a long-term impact. One of the symptoms of schizophrenia is hallucinations. Hallucinations are perceptual disturbances in which the client perceives something that does not exist. One of the things that families do is help family members by playing a role in assisting the clients in controlling hallucinations. The study aimed to determine the role of the family in reducing the hallucination symptoms of schizophrenic patients based on the available evidence. The literature review used Scopus, Science Direct, and GARUDA databases. Articles are selected based on the suitability of keywords, topics, as well as inclusion and exclusion criteria. The appraisal instrument by Hawker was used to select high-quality evidence. The findings of this study highlighted three levels of family roles in reducing symptoms of hallucinations in schizophrenic patients. The first level, the family must be able to see the patient's needs and maintain parental closeness. The second level, the family must be able to provide financial support for patient care, the family should be involved in groups that provide support as well. The third levels, all families must develop a good relationship to help patients with hallucinations to change their attitudes and behavior. Family roles are essential in reducing symptoms of hallucination in schizophrenic patients. This evidence can be used as scientific references to be applied as nursing care interventions.Keywords: Family Roles, Hallucinations, Schizophrenia AbstrakSkizofrenia merupakan penyakit kejiwaan yang memiliki dampak jangka panjang. Salah satu tanda gejala skizofrenia adalah halusinasi. Halusinasi ialah gangguan persepsi di mana klien mempersepsikan sesuatu yang sebenarnya tidak terjadi. Salah satu yang di lakukan keluarga ialah membantu anggota keluarganya dengan cara ikut berperan membantu klien untuk bisa mengontrol halusinasi. Penelitian ini bertujuan untuk mengetahui peran keluarga dalam menurunkan tanda gejala halusinasi pasien skizofrenia berdasarkan literatur evidence yang tersedia. Penelitian menggunakan metode literature review. Database yang digunakan untuk pencarian artikel adalah Scopus, Science Direct, dan GARUDA. Artikel diseleksi berdasarkan kesesuaian dengan kata kunci, topik serta kriteria inklusi dan eksklusi yang telah ditentukan. Hasil penelusuran didapatkan sebanyak 5 artikel, 2 artikel berbahasa Inggris dan 3 artikel berbahasa Indonesia. Instrumen telaah kritis yang digunakan untuk menelaah kualitas artikel adalah instrumen oleh Hawker et al 2002. Terdapat temuan berupa 3 tingkatan peran keluarga dalam menurunkan tanda gejala halusinasi pasien skizofrenia : tingkatan pertama keluarga harus mampu melihat kebutuhan pasien dan mempertahankan kedekatan orangtua, Tingkatan kedua keluarga harus mampu memberikan dukungan financial untuk perawatan pasien dan terlibatan dalam kelompok yang member dukungan dan Tingkatan ketiga keluarga harus mengembangkan hubungan dengan benar untuk membantu pasien halusinasi untuk merubah sikap dan perilaku. Upaya peningkatan peran keluarga dalam menurunkan tanda gejala halusinasi pasien skizofrenia ini didapatkan dari bukti ilmiah yang valid sehingga dapat dijadikan referensi ilmiah untuk diaplikasikan sebagai intervensi asuhan keperawatan.Kata Kunci : Halusinasi, Peran Keluarga, Skizofrenia.

Dukungan Sosial Untuk Meningkatkan Kesejahteraan Psikologis Caregiver Pada Pasien Skizofrenia : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1323-1331
Author(s):  
Azkiyah Fitriana ◽  
Eka Budiarto
Keyword(s):  
Social Support ◽  
Literature Review ◽  
Family Caregiver ◽  
Well Being ◽  
Psychotic Symptoms ◽  
Exclusion Criteria ◽  
Psychological Well Being ◽  
Instrumental Social Support ◽  
The Family ◽  
Schizophrenic Patients

AbstractSchizophrenia is a condition of inability to think logically. There is a disturbance in motor activity. Caregivers are vulnerable to burdens and stress that can interfere with their role as companions and fuctions in the family. Therefore, social support are needed so that caregivers cab face the stress and burden of caring for schizophrenic patient. The study aimed to determined social supports to Improve The Psychological Well-Being of caregivers of schizophrenia patients based on available evidence. The study used a literature review method. The databased used to search article were PubMed,Science Direct, and GARUDA.there were five article selected based on the suitability of the specified keywords, topic, and inclusion dan exclusion criteria. The articles were published in the 2012-2021 period. The instrument used was the Hawker instrument. There were 5 types of social support found in the articles. Those were social support as a coping streategy, instrumental social support in increasing patient interaction with other, maladaptive coping strategies used by family caregivers, instrumental social support which was positively related to social interaction andshowed lower levels of psychotic symptoms, social support perceived by family caregiver which played and important role as it improved their psychological-well being. These five social support to improve caregiver psychological well-being in schizophrenic patients are obtained from valid scientific avidence. Therefore, they can be used as scientific references to be applied as nursing care intervention.Keywords :Caregiver;schizophrenia;social support;psychological well-being AbstrakSkizofrenia merupakan keadaan dimanapemikiran tidak saling berhubungan secara logis dan adanya gangguan aktivitas motorik. Caregiver rentan mengalami beban dan stress yang dapat menganggu perannya sebagai pendamping dan fungsi dalam keluarga. Sehingga diperlukan dukungan sosial agar caregiver dapat menghadapi stress dan beban dalam merawat pasien skizofrenia.Penelitian bertujuan untuk mengetahui dukungan sosial untuk meningkatkan kesejahteraan psikologis caregiver pasien skizofrenia berdasarkan evidence yang tersedia. Penelitian menggunakan metode literature review. Database yang digunakan untuk pencarian artikel adalah PubMed, Science Direct, GARUDA. Artikel diseleksi berdasarkan kesesuaian dengan kata kunci, topik serta kriteria inklusi dan eksklusi yang ditentukan. Artikel digunakan dalam penelitian berjumlah 5 artikel yang terbit pada rentang waktu 2012-2021. Instrumen yang digunakan adalah instrumen Hawker. Terdapat temuan berupa 5 macam dukungan sosial untuk meningkatkan kesejahteraan psikologis caregiver pada pasien skizofrenia; dukungan sosial sebagai strategi koping, dukungan sosial instrumental meningkatkan interaksi pasien dengan orang lain, pengasuh keluarga menggunakan strategi koping maladaptif, dukungan sosial instrumental berhubungan positif dengan interaksi sosial dan menunjukan tingkat gejala psikotik lebih rendah, dukungan sosial yang dipersepsikan oleh family caregiver berperan penting karena dapat meningkatkan kesejahteraan psikologisnya. Kelimadukungan sosial untuk meningkatkan psikologis caregiver pada pasien skizofrenia ini didapatkan dari bukti ilmiah yang valid sehingga dapat dijadikan referensi ilmiah untuk diaplikasikan sebagai intervensi asuhan keperawatan.Kata kunci: caregiver;dukungan sosial;kesejahteraan psikologis;skizofrenia

scholarly journals FAMILY SUPPORT-BASED PSYCHOEDUCATION IN CARING SCHIZOPHRENIC PATIENTS: A LITERATURE REVIEW

2022 ◽  
Author(s):  
Dwi Indah Iswanti ◽  
Moses Glorino Rumambo Pandin
Keyword(s):  
Mental Health ◽  
Literature Review ◽  
Family Support ◽  
Financial Burden ◽  
Social Needs ◽  
Care Providers ◽  
Family Psychoeducation ◽  
Outcome Framework ◽  
The Family ◽  
Schizophrenic Patients

Background: The burden of family in caring a schizophrenia impacts on psychological shock and emotional burden; lack of disease knowledge and care skills; poor patient medication adherence; the difficulty of getting along with patients; conflict in the family or at work; financial burden; and need adequate social support. Aim: This study discussed how family support takes care of people with schizophrenia with a psychoeducational approach in mental health service settings. Method: A non-systematic literature review was carried out using the PICO (Population, Intervention, Comparison, Outcome) framework utilizing Scopus, CINAHL, and ProQuest databases in the last 5 years, searching with keywords: Family Support AND Schizophrenia OR Family Psychoeducation. Results: Families with schizophrenia experience the most potent stressors on the burden of care borne, in addition to stigma and the frequency of relapse of sufferers. Community care providers can involve the family in various ways, such as providing psychoeducation, supporting the family's physical, emotional and social needs, and behavioral family assessment or family therapy. Conclusion: Mental health services must develop and imply family psychoeducation training.

scholarly journals Terapi Keperawatan terhadap Koping Keluarga Pasien Skizofrenia

2019 ◽  
Vol 7 (3) ◽  
pp. 253
Author(s):  
Irene Febriany Mamo Kitu ◽  
Meidiana Dwidiyanti ◽  
Diyan Yuli Wijayanti
Keyword(s):  
Mental Disorders ◽  
Literature Review ◽  
Family Members ◽  
Google Scholar ◽  
Family Coping ◽  
The Family ◽  
Schizophrenic Patients ◽  
Patient Families

Permasalahan yang terjadi pada pasien skizofrenia tidak hanya melibatkan pasien itu sendiri tetapi juga melibatkan keluarga sebagai orang terdekat dari pasien tersebut. Keluarga mempunyai beban tersendiri saat merawat anggota keluarga yang mengalami gangguan jiwa. Terapi keperawatan diberikan kepala keluarga agar koping keluarga lebih efektif dalam menghadapi situasi yang ditimbulkan selama perawatan pasien skizofrenia. Literature ini bertujuan untuk mengetahui terapi keperawatan yang dapat digunakan pada keluarga agar koping keluarga lebih efektif. Metode yang digunakan dalam penulisan ini yaitu literature review dengan menggunakan artikel/ jurnal dari tahun 2003 – 2019 dan pencarian artikel melalui Science Direct, Google Scholar dan Pubmed. Tema artikel yang digunakan yaitu terapi keperawatan terkait dengan koping keluarga pasien skizofrenia. Hasil sintesa dari artikel-artikel yang telah ditelusuribahwa terapi keperawatan spesialis mampu mengatasi masalah koping pada keluarga pasien skizofrenia namun perlu adanya penelitian lebih lanjut tentang terapi keperawatan komplementer terhadap masalah koping keluarga pada pasien skizofrenia.  Kata kunci: terapi keperawatan, koping keluarga, skizofrenia  NURSING THERAPY TOWARD THE COPING OF FAMILLIES OF SCHIZOPHRENIC PATIENTS: A LITERATURE REVIEW ABSTRACTThe problems that occur in schizophrenic patients not only involve the patient himself but also involve the family as the closest person to the patient. Families have their own burdens when caring for family members who experience mental disorders. Nursing therapy is given by the head of the family so that family coping is more effective in dealing with situations caused during the treatment of schizophrenic patients. This literature aims to determine nursing therapy that can be used in families so that family coping is more effective. The method used in this writing is the literature review by using articles / journals from 2003 - 2019 and searching articles through Science Direct, Google Scholar and Pubmed. The theme of the article used was nursing therapy related to coping with the family of schizophrenic patients. The results of the synthesis of the articles that have been traced that specialist nursing therapy is able to overcome coping problems in the family of schizophrenic patients but need further research on complementary nursing therapy on family coping problems in schizophrenic patients  Keywords: nursing therapy, family coping, schizophrenic 

PENERAPAN GREEN COMPUTING PADA KUISIONER INSTRUMEN PENILAIAN KINERJA DOSEN DI POLITEKNIK NEGERI SUBANG

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Nunu Nugraha Purnawan
Keyword(s):  
Data Collection ◽  
Literature Review ◽  
Performance Assessment ◽  
Research Method ◽  
Field Research ◽  
Green Computing ◽  
Assessment Instrument ◽  
Computer Hardware ◽  
Model Free ◽  
Collection Methods

The lecturer's performance assessment by students in the form of an online Lecturer Performance Assessment Instrument Questionnaire (KIPKD) is in line with the work concepts of Green Computing by utilizing computer hardware and software better, more efficiently and more useful. KIPKD online POLSUB uses Google Forms, because it has an attractive and responsive look, provides a fairly complete choice of stuffing model, free, the results are neatly arranged and can be analyzed easily. This research method uses literature review in the form of books, journals that discuss about topics related to the use of Google Forms as a medium in the manufacture of questionnaires for surveys and data collection, as well as related to the concept of Green Computing. While data collection methods used in field research by way of observation of the system running in the academic POLSUB. The use of KIPKD online illustrates that POLSUB participates in preserving the environment, with no 12 paper/year rims, equivalent to 12 tree trunks.

Pengembangan Instrumen Penilaian Kinerja pada Praktikum Struktur dan Fungsi Sel Di SMA Negeri 1 Kota Jambi

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Nugroho Budhiwaluyo ◽  
Rayandra Asyhar ◽  
Bambang Hariyadi
Keyword(s):  
Performance Assessment ◽  
Student Performance ◽  
Cell Structure ◽  
Structure And Function ◽  
Assessment Instrument ◽  
Product Performance ◽  
Development Model ◽  
Test Results ◽  
Validity And Reliability ◽  
And Function

  This research aims to produce a final product in the form of a performance-assessment instrument on Cell Structure and Function experiment. The development model is ADDIE. Based on expert's judgment, the instrument was valid and can be tested in the field. Field-test results shown that the product performs high validity and reliability value on measuring student performance on Cell Structure and Function experiment. Therefore, it is concluded that this performance-assessment instrument theoretically and practically has a good quality for measuring student performance in both process and product performance on Cell Structure and Function experiment. Keywords: Development, Performance-Assessment Instrument, Cell Structure and Function Experiment 

scholarly journals AB0602 IMPACT OF SOCIOECONOMIC FACTORS ON PAIN AND FUNCTION IN KNEE OSTEOARTHRITIS: A SYSTEMATIC LITERATURE REVIEW

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1337.2-1337
Author(s):  
T. W. Swinnen ◽  
M. Willems ◽  
I. Jonkers ◽  
F. P. Luyten ◽  
J. Vanrenterghem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Knee Osteoarthritis ◽  
Socioeconomic Factors ◽  
Systematic Literature Review ◽  
Intervention Effects ◽  
Socioeconomic Outcomes ◽  
And Function ◽  
The Impact

Background:The personal and societal burden of knee osteoarthritis (KOA) urges the research community to identify factors that predict its onset and progression. A mechanistic understanding of disease is currently lacking but needed to develop targeted interventions. Traditionally, risk factors for KOA are termed ‘local’ to the joint or ‘systemic’ referring to whole-body systems. There are however clear indications in the scientific literature that contextual factors such as socioeconomic position merit further scientific scrutiny, in order to justify a more biopsychosocial view on risk factors in KOA.Objectives:The aims of this systematic literature review were to assess the inclusion of socioeconomic factors in KOA research and to identify the impact of socioeconomic factors on pain and function in KOA.Methods:Major bibliographic databases, namely Medline, Embase, CINAHL, Web of Science and Cochrane, were independently screened by two reviewers (plus one to resolve conflicts) to identify research articles dealing with socioeconomic factors in the KOA population without arthroplasty. Included studies had to quantify the relationship between socioeconomic factors and pain or function. Main exclusion criteria were: a qualitative design, subject age below 16 years and articles not written in English or Dutch. Methodological quality was assessed via the Cochrane risk of bias tools for randomized (ROB-II) and non-randomized intervention studies (ROBIN-I) and the Newcastle-Ottawa Scale for assessing the quality of non-randomised studies. Due to heterogeneity of studies with respect to outcomes assessed and analyses performed, no meta-analysis was performed.Results:Following de-duplication, 7639 articles were available for screening (120 conflicts resolved without a third reader). In 4112 articles, the KOA population was confirmed. 1906 (25%) were excluded because of knee arthroplasty and 1621 (21%) because of other issues related to the population definition. Socioeconomic factors could not be identified in 4058 (53%) papers and were adjusted for in 211 (3%) articles. In the remaining papers covering pain (n=110) and/or function (n=81), education (62%) and race (37%) were most frequently assessed as socioeconomic factors. A huge variety of mainly dichotomous or ordinal socioeconomic outcomes was found without further methodological justification nor sensitivity analysis to unravel the impact of selected categories. Although the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was the most popular instrument to assess pain and function, data pooling was not possible as socioeconomic factors estimates were part of multilevel models in most studies. Overall results showed that lower education and African American race were consistent predictors of pain and poor function, but those effects diminished or disappeared when psychological aspects (e.g. discrimination) or poverty estimates were taken into account. When function was assessed using self-reported outcomes, the impact of socioeconomic factors was more clear versus performance-based instruments. Quality of research was low to moderate and the moderating or mediating impact of socioeconomic factors on intervention effects in KOA is understudied.Conclusion:Research on contextual socioeconomic factors in KOA is insufficiently addressed and their assessment is highly variable methodologically. Following this systematic literature review, we can highlight the importance of implementing a standardised and feasible set of socioeconomic outcomes in KOA trials1, as well as the importance of public availability of research databases including these factors. Future research should prioritise the underlying mechanisms in the effect of especially education and race on pain and function and assess its impact on intervention effects to fuel novel (non-)pharmacological approaches in KOA.References:[1]Smith TO et al. The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis J Rheumatol 2019. 46:981–9.Disclosure of Interests:None declared.

scholarly journals Actin-membrane interaction in fibroblasts: what proteins are involved in this association?

1984 ◽  
Vol 99 (1) ◽  
pp. 95s-103s ◽  
Author(s):  
P Mangeat ◽  
K Burridge
Keyword(s):  
Plasma Membrane ◽  
Actin Filaments ◽  
Stress Fiber ◽  
Membrane Interaction ◽  
Microfilament Bundles ◽  
The Family ◽  
Form Part ◽  
Membrane Attachment ◽  
A Chain ◽  
And Function

In this review we discuss some of the proteins for which a role in linking actin to the fibroblast plasma membrane has been suggested. We focus on the family of proteins related to erythrocyte spectrin, proteins that have generally been viewed as having an organization and a function in actin-membrane attachment similar to those of erythrocyte spectrin. Experiments in which we precipitated the nonerythrocyte spectrin within living fibroblasts have led us to question this supposed similarity of organization and function of the nonerythrocyte and erythrocyte spectrins. Intracellular precipitation of fibroblast spectrin does not affect the integrity of the major actin-containing structures, the stress fiber microfilament bundles. Unexpectedly, however, we found that the precipitation of spectrin results in a condensation and altered distribution of the vimentin class of intermediate filaments in most cells examined. Although fibroblast spectrin may have a role in the attachment of some of the cortical, submembranous actin, it is surprising how little the intracellular immunoprecipitation of the spectrin affects the cells. Several proteins have been found concentrated at the ends of stress fibers, where the actin filaments terminate at focal contacts. Two of these proteins, alpha-actinin and fimbrin, have properties that suggest that they are not involved in the attachment of the ends of the bundles to the membrane but are more probably involved in the organization and cross-linking of the filaments within the bundles. On the other hand, vinculin and talin are two proteins that interact with each other and may form part of a chain of attachments between the ends of the microfilament bundles and the focal contact membrane. Their role in this attachment, however, has not been established and further work is needed to examine their interaction with actin and to identify any other components with which they may interact, particularly in the plasma membrane.

A Family of Genes Clustered at the Triplo-lethal Locus of Drosophila melanogaster Has an Unusual Evolutionary History and Significant Synteny With Anopheles gambiae

Genetics ◽  
2003 ◽  
Vol 165 (2) ◽  
pp. 613-621 ◽  
Author(s):  
Douglas R Dorer ◽  
Jamie A Rudnick ◽  
Etsuko N Moriyama ◽  
Alan C Christensen
Keyword(s):  
Phylogenetic Analysis ◽  
Drosophila Melanogaster ◽  
Anopheles Gambiae ◽  
Evolutionary History ◽  
Codon Bias ◽  
Good Target ◽  
The Family ◽  
Genes Encoding ◽  
And Function ◽  
Gambiae Genome

Abstract Within the unique Triplo-lethal region (Tpl) of the Drosophila melanogaster genome we have found a cluster of 20 genes encoding a novel family of proteins. This family is also present in the Anopheles gambiae genome and displays remarkable synteny and sequence conservation with the Drosophila cluster. The family is also present in the sequenced genome of D. pseudoobscura, and homologs have been found in Aedes aegypti mosquitoes and in four other insect orders, but it is not present in the sequenced genome of any noninsect species. Phylogenetic analysis suggests that the cluster evolved prior to the divergence of Drosophila and Anopheles (250 MYA) and has been highly conserved since. The ratio of synonymous to nonsynonymous substitutions and the high codon bias suggest that there has been selection on this family both for expression level and function. We hypothesize that this gene family is Tpl, name it the Osiris family, and consider possible functions. We also predict that this family of proteins, due to the unique dosage sensitivity and the lack of homologs in noninsect species, would be a good target for genetic engineering or novel insecticides.

scholarly journals New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3888
Author(s):  
Boon-Peng Puah ◽  
Juriyati Jalil ◽  
Ali Attiq ◽  
Yusof Kamisah
Keyword(s):  
Immune Cells ◽  
Scientific Evidence ◽  
Special Role ◽  
Real Potential ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
The Relationship ◽  
Cancer Activity ◽  
Reduced Risk

Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. Previous scientific evidence exhibited that the anti-cancer activity of lycopene relies on its ability to suppress oncogene expressions and induce proapoptotic pathways. To further explore the real potential of lycopene in cancer prevention, this review discusses the new insights and perspectives on the anti-cancer activities of lycopene which could help to drive new direction for research. The relationship between inflammation and cancer is being highlighted, whereby lycopene suppresses cancer via resolution of inflammation are also discussed herein. The immune system was found to be a part of the anti-cancer system of lycopene as it modulates immune cells to suppress tumor growth and progression. Lycopene, which is under the family of carotenoids, was found to play special role in suppressing lung cancer.

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