scholarly journals Haematological Changes in Peripheral Blood of HIV – Infected Persons with Correlation to CD4 Cell Count

2015 ◽  
Vol 32 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Md Mizanur Rahman ◽  
Susane Giti ◽  
Md Saiful Islam ◽  
Md Mostafizur Rahman
Keyword(s):  
Cell Count ◽  
Peripheral Blood ◽  
Flow Cytometric Analysis ◽  
Armed Forces ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Flow Cytometric ◽  
Erythrocyte Sedimentation ◽  
Haematological Changes ◽  
Cd4 Cell

Objective: Aims at recognizing the haematological abnormalities in peripheral blood associated with HIV infection and to correlate the haematological abnormalities with CD4 cell count to highlight these manifestations with disease progression.Methodology: Observational cross sectional study.Setting: Department of Haematology, Armed Forces Institute of Pathology (AFIP), Dhaka cantonment.Patients: Two hundred four (204) HIV – infected patients receiving antiretroviral therapy aged from three years to 65 years. There were 132 male and 72 female patients.Results: Anaemia was found in 103 (50.5%) cases. Leucopenia and thrombocytopenia were observed in ten (4.9%) and seven (3.4%) cases respectively. Lymphopenia was found in 12 (5.9%) cases. In 50 (24.5%) cases Erythrocyte Sedimentation Rate (ESR) was > 20 mm at the end of 1st hour. Flow cytometric analysis for CD4 cell count showed < 200 cells/cmm in 65 (31.8%) cases, in between 200 cells/cmm and 499 cells/cmm in 117 (57.4%) cases and > 500 cells/cmm in 22 (10.8%) cases.Conclusion: Haematological abnormalities are common in HIV – infected patients and responsible for significant morbidity and mortality in these patients. These abnormalities are more frequent with disease progression. The present study revealed a significant increase in the number of anaemia, leucopenia, lymphopenia and thrombocytopenia with decreasing CD4 cell count.J Bangladesh Coll Phys Surg 2014; 32: 130-136

scholarly journals CD4 count and oral health related quality of life of HIV-infected individuals at a tertiary healthcare center in Dharan – A cross-sectional study

2017 ◽  
Vol 13 (4) ◽  
pp. 392-396
Author(s):  
Ashish Shrestha ◽  
Jyotsna Rimal ◽  
Nimesh Poudyal
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Cell Count ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Related Quality ◽  
Tertiary Healthcare ◽  
Cd4 Cell

Background & Objective:  Patients with severe immuno-suppression are at risk of having poor oral hygiene and severe periodontal diseases, thus limiting their quality of life. The objective of this study was to assess the impact of oral health-related quality of life (OHRQoL) in patients with HIV/AIDS and its association with the CD4 cell count.Materials & Methods:  A cross-sectional study was conducted using Oral Health Impact Profile-14 (OHIP-14) among 122 HIV/AIDS patients visiting the CD4 laboratory at a tertiary healthcare center at Dharan, from January-December 2009. Oral examination and recording of dental indices were done. CD4 cell count was correlated with OHIP-14 and dental indices using Spearman’s rho; p < 0.01 was considered as statistically significant.Results:  Sixty four males and 58 females with median age of 34 years had a mean CD4 cell count of 360.46 cells/mm3 (range=111-1076 cells/mm3). OHRQoL was affected in 25.4% of the individuals with mean OHIP-14 score of 2.5. Most of the individuals (85.7%) were on ART, never used tobacco (68%) or alcohol (74.5%). Mean OHI-S and DMFT were 1.65 and 1.57, respectively and periodontal pocket observed in only 3.3% individuals. The CD4 cell count had no significant positive correlation with OHIP-14 ((rs=0.071; p=0.61), OHI-S (rs=0.21; p=0.127) and DMFT (rs=0.015; p=0.912). There was no significant difference in parameters with regards to gender.Conclusion: Although CD4 cells are an important indicator for clinical aggravation of HIV infection, OHRQoL and oral health as measured by OHI-S, DMFT and CPI are not directly associated to the CD4 cell count.

scholarly journals Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Hala Haq ◽  
Nasir Uddin ◽  
Saleem Ahmed Khan ◽  
Sunia Ghaffar
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Prognostic Markers ◽  
Lymphocytic Leukaemia ◽  
Flow Cytometric Analysis ◽  
Sampling Technique ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Cross Sectional ◽  
Flow Cytometric

Objective: To find out the frequency of ZAP-70, CD38 and CD49d in patients diagnosed with CLL in our population. Methods: This is a cross sectional study conducted in Army Medical College in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi from 1st January 2018 to 30th November 2018. Permission from Institutional Ethical Committee was obtained. Blood samples were collected by non-probability consecutive sampling technique and analyzed for blood counts and flow cytometry was done for ZAP-70, CD38 and CD49d. Manufacturer’s instructions for the kits were strictly followed. Results: Fifty-one newly diagnosed patients with CLL were studied for the prognostic markers in CLL. CD 38 was expressed in 25(49%) and CD49d in 21(41.2%). ZAP-70 expression was not detected in our series of patients. Conclusion: We conclude that CD38 and CD49d expression was detected in almost half of the patients of CLL in our series. CD49d showed statistically positive correlation with CD38, showing that it is a more pragmatic choice for reliable prognostication of CLL along with CD38. doi: https://doi.org/10.12669/pjms.36.3.541 How to cite this:Haq H, Uddin N, Khan SA, Sunia Ghaffar4. Prognostic markers in Chronic Lymphocytic Leukaemia - A flow cytometric analysis. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.541 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Detection of human herpesvirus 7 DNA in peripheral blood reflects mainly CD4+ cell count in patients infected with HIV

2005 ◽  
Vol 76 (2) ◽  
pp. 223-228 ◽  
Author(s):  
David Boutolleau ◽  
Olivia Bonduelle ◽  
Am�lie Sabard ◽  
Laure Devers ◽  
Henri Agut ◽  
...  
Keyword(s):  
Cell Count ◽  
Peripheral Blood ◽  
Human Herpesvirus ◽  
Cd4 Cell Count ◽  
Cd4 Cell

scholarly journals Clinical, Immunological and Virological Responses of Zidovudine-Lamivudine-Nevirapine versus Zidovudine-Lamivudine-Efavirenz Antiretroviral Treatment (ART) Among HIV-1 Infected Children: Asella Teaching and Referral Hospital, South-East Ethiopia

2018 ◽  
Vol 12 (1) ◽  
pp. 11-18
Author(s):  
Abebe Sorsa
Keyword(s):  
Cell Count ◽  
Medical Records ◽  
Viral Suppression ◽  
Age Groups ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Virological Outcomes ◽  
The Mean ◽  
Cd4 Cell ◽  
Hiv 1

Background:Antiretroviral Therapy(ART) remarkably reduced HIV-1 infection-related mortality in children. The efficacy and safety of different ART regimen in pediatric age groups remained issues of debates and available evidence were scarce especially among children taking the of one the two prototypes (NVP or EFV) Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI) as backbone of ART regimen.Therefore, the objective of this study was to compare clinical, immunological and virological responses of zidovudine-lamivudine-nevirapine (AZT+3TC+ NVP)versuszidovudine-lamivudine-efavirenz (AZT+3TC+EFV) ART regimen among HIV-1 infected children.Methods:A retrospective cross-sectional study was done by reviewing medical records of the patients to evaluate clinical, immunological and virological outcomes of NVP+AZT+3TCversusEFV+AZT+3TC ART regimen among HIV-1 infected children. Data were entered into Epi-info version 7.2.2 for clean up and exported to SPSS version 17 for analysis. Paired and Independent t-tests were used to compare the CD4 cell count, weight and virologic level at six months with corresponding baseline value; and the mean weight, CD4 gain and viral suppression across the two ART regimens at six months of ART respectively.Results:Medical records of 122 patients from NVP-based regimen and 61 patients from EFV group were reviewed. After six months of NVP+AZT+3TC treatment, the mean CD4 cell count difference from baseline was 215(95% CI, 175.414-245.613, p<0.001). From EFV+AZT+3TC group, the mean CD4 cell count difference from baseline was 205(95% CI 155.404-235.623, p< 0.001). The mean CD4 count difference between the two regimens was comparable (p 0.145). Similarly, optimal viral suppression was achieved in 82% (100/122) of NVP+AZT+3TC regimen and 83% (44/61) of EFV+AZT+3TC regimen which was still comparable across the two groups.Conclusion:There was no difference in clinical, immunological and virological outcomes among patients taking NVP+AZT+3TC or EFV+AZT+3TC ART regimen.

scholarly journals Profile of antiretroviral and its outcome on patients with HIV-AIDS in Wamena Public Hospital

2019 ◽  
Author(s):  
Erwin Astha Triyono ◽  
Stefania Rany Seran ◽  
Didik Hasmono
Keyword(s):  
Cell Count ◽  
Clinical Condition ◽  
Public Hospital ◽  
Adverse Drug Events ◽  
Healthcare Services ◽  
Antiretroviral Drugs ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

In Papua, HIV/AIDS is characterized as a widespread epidemic, with a prevalence of 2.3% and a case rate of 416.91 per 100.000. The low accessibility of healthcare services is a major challenge for health services in Papua. The purpose of this study was to determine the profile of ARV use and therapy outcomes of HIV/AIDS patients at Wamena Public Hospital in Papua. This research is an observational cross-sectional retrospective study. Data was collected from the medical records of 236 patients who met the inclusion criteria. Study showed that FDC (TDF + 3TC + EFV) is the most frequently used ARV. ARV therapy improved the clinical condition of 14 patients, and 9 patients had a worsening of their clinical condition. There was an increase in CD4 cell count after 6, 12, and 24 months of ARV therapy in 76%; 55%; and 72% of patients. There were 55 adverse drug events that required a change of regimen. Based on this study, the use of antiretroviral drugs improved clinical condition, decreasing the number of IO, and increasing the patient's CD4 cell count.

scholarly journals Prevalence and CD4 Cell Count Pattern of TB Co-infection Among HIV Infected Individuals In Nepal

2013 ◽  
Vol 10 (1) ◽  
pp. 27-36
Author(s):  
Surya Raj Niraula ◽  
SP Barnawal ◽  
AK Agrahari ◽  
N Bista ◽  
DK Yadav ◽  
...  
Keyword(s):  
Cell Count ◽  
Hiv Infections ◽  
Cross Sectional Study ◽  
Cd4 Count ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Ciency Virus ◽  
Human Immunodefi Ciency Virus ◽  
One Year ◽  
Cd4 Cell

Background: Mycobacterium tuberculosis (TB) and Human Immunodefi ciency Virus (HIV) infections are two major public health problems in many parts of the world, particularly in developing counties like Nepal. The objective of the study is to find out prevalence and clinical presentation of the TB co-infection among HIV infected individuals and pattern of CD4 cell count in relation to types of TB and response of ART. Methodology: This is a cross-sectional study carried out in three VCT clinics from Dharan and Kathmandu from April 2010 to March 2011. The appropriate samples, 313 HIV individuals were taken as study sample. Results: The study revealed that more than 36% of individuals were co-infected with TB. Among them, nearly 65% had pulmonary TB, more than one-forth had gland TB. There is signifi cant association of TB co-infection among male compared to females (P=0.021). Fever, weight loss and cough were found to have signifi cant symptoms associated with TB-HIV co-infection. The average CD4 count among TB co-infected population was signifi cantly less compared to uninfected ones just before starting ART (P=0.022) and even after six months (P=0.001). After one year of ART continuation, there was no signifi cant association on average CD4 count among the two groups. But then, the mean CD4 count became more in TB co-infected individuals compared to those who had no TB co-infection. Conclusion: TB-HIV co-infection is an emerging medical issue in Nepal. More than one third of HIV patients are co-infected with TB. Consideration of TB need to be made while caring patients with HIV infection and vice versa. ART plays very important role in increasing CD4 cell count among TB-HIV coinfected patients. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS; 2013; X(1); 27-36 DOI: http://dx.doi.org/10.3126/saarctb.v10i1.8674

scholarly journals Hubungan Jumlah Cluster of Differentiation 4 (CD4) dengan Infeksi Oportunistik Pada Pasien HIV/AIDS di Rumah Sakit Umum Daerah (RSUD) DOK II Jayapura

2018 ◽  
Vol 7 (1) ◽  
pp. 16-21
Author(s):  
Mirna Widiyanti ◽  
Hotma Hutapea
Keyword(s):  
Cell Count ◽  
Opportunistic Infection ◽  
Opportunistic Infections ◽  
Chi Square ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Chi Square Test ◽  
Cd4 Cell ◽  
The Relationship ◽  
Hiv Aids

Human Immunodeficiency Virus (HIV) is an infection that attacks and weakens the immune system. HIV infection causes a decrease in the number of Cluster Differentiation 4 (CD4) thereby increasing the progression of the disease and lead to high risk of opportunistic infections (OI). The purpose of this study was to examine the relationship between CD4 cell count with opportunistic infections in patients infected with HIV/AIDS. Analytical research methods using cross-sectional design, by taking medical records. The population in this study were 67 patients with HIV/AIDS in the VCT Clinic Dok II Hospital Jayapura 2014. Data were processed with the Chi Square test hypotheses. Based on the results of hypothesis testing of 67 patients, there were 21 people have opportunistic infections. Tuberculosis is an opportunistic infection that is most common (17.9%). Significance of the relationship seen in the low CD4 counts (< 350 cells/mm3) and found value of 0.02 (CI 95%) which indicates that there is a relationship if p<0.05. Conclusion: there is a relationship between CD4 cell count with opportunistic infections.Key words: CD4, opportunistic infection, HIV/AIDS, hospital.

scholarly journals Prevalence and Predictors of Malaria in Human Immunodeficiency Virus Infected Patients in Beira, Mozambique

2018 ◽  
Vol 15 (9) ◽  
pp. 2032 ◽  
Author(s):  
Francesco Di Gennaro ◽  
Claudia Marotta ◽  
Damiano Pizzol ◽  
Kajal Chhaganlal ◽  
Laura Monno ◽  
...  
Keyword(s):  
Cell Count ◽  
Cross Sectional Study ◽  
Malaria Prevalence ◽  
Medical Attention ◽  
Hiv Positive ◽  
Hiv Patients ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Malaria Test

Co-infection between malaria and HIV has major public health implications. The aims of this study were to assess the malaria prevalence and to identify predictors of positivity to malaria Test in HIV positive patients admitted to the health center São Lucas of Beira, Mozambique. A retrospective cross-sectional study was performed from January 2016 to December 2016. Overall, 701 adult HIV patients were enrolled, positivity to malaria test was found in 232 (33.0%). These patients were found to be more frequently unemployed (76.3%), aged under 40 (72.0%), with a HIV positive partner (22.4%) and with a CD4 cell count <200 (59.9%). The following variables were predictors of malaria: age under 40 (O.R. = 1.56; 95%CI: 1.22–2.08), being unemployed (O.R. = 1.74; 95%CI: 1.24–2.21), irregularity of cotrimoxazole prophylaxis’s (O.R. = 1.42; 95%CI: 1.10–1.78), CD4 cell count <200 (O.R. = 2.01; 95%CI: 1.42–2.32) and tuberculosis comorbidity (O.R. = 1.58; 95%CI: 1.17–2.79). In conclusion, high malaria prevalence was found in HIV patients accessing the out-patients centre of São Lucas of Beira. Our findings allowed us to identify the profile of HIV patients needing more medical attention: young adults, unemployed, with a low CD4 cell count and irregularly accessing to ART and cotrimoxazole prophylaxis.

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