scholarly journals IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population

2021 ◽  
Author(s):  
Maral Ranjbar ◽  
Mojdeh Matloubi ◽  
Shaghayegh Sadegh ◽  
Morteza Fallahpour ◽  
Leila Janani ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Genetic Factors ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Positive Association ◽  
Iranian Population ◽  
Total Serum ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Prick Test

Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.

scholarly journals Association between Two Single Nucleotide Polymorphisms of Thymic Stromal Lymphopoietin (TSLP) Gene and Asthma in Iranian Population

2020 ◽  
Author(s):  
Maral Ranjbar ◽  
Mojdeh Matloubi ◽  
Mohammad-Ali Assarehzadegan ◽  
Morteza Fallahpour ◽  
Fatemeh Sadeghi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Late Onset ◽  
Airway Epithelial Cells ◽  
Thymic Stromal Lymphopoietin ◽  
Iranian Population ◽  
Total Serum ◽  
Inverse Association ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Asthmatic Patients

Thymic stromal lymphopoietin (TSLP) is a cytokine similar to IL-7, which is released by airway epithelial cells in response to injury and inflammation. Current literature is contradictory about the association between different single nucleotide polymorphisms (SNPs) of the TSLP gene and asthma development in different countries. We aimed to evaluate the association between two common TSLP SNPs (rs2289276 and rs2289278) and the risk of asthma in the Iranian population. Genotyping of the TSLP gene was performed in 126 adult asthmatic patients and 300 controls; using the TaqMan genotyping assay. Moreover, total serum IgE level and eosinophil count were assessed. The results indicated that the TT genotype of rs2289276 was inversely associated with the risk of asthma (p=0.002). A similar inverse association was detected in subgroups of atopic (p=0.001) and non-atopic (p=0.005) asthma. Moreover, the TT genotype of this SNP was more prevalent in severe and late-onset categories of asthma. In subgroup analysis, a significant sex-specific association between rs2290276 and asthma was observed in women (p=0.004). The prevalence of rs2289276 was extremely low, which made it infeasible to perform any further analysis. Overall, our findings indicated that rs2290276 SNP of the TSLP gene has a protective phenotype against asthma development in the Iranian population.

Single nucleotide polymorphisms (SNPs) in human lactoferrin geneThis paper is one of a selection of papers published in this Special Issue, entitled 7th International Conference on Lactoferrin: Structure, Function and Applications, and has undergone the Journal's usual peer review process.

2006 ◽  
Vol 84 (3) ◽  
pp. 381-384 ◽  
Author(s):  
Christina T. Teng ◽  
Wesley Gladwell
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Inflammatory Responses ◽  
Peer Review Process ◽  
Genome Project ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Environmental Health Sciences ◽  
Normal Healthy Individual ◽  
Lactoferrin Gene ◽  
And Function

The lactoferrin protein possesses antimicrobial and antiviral activities. It is also involved in the modulation of the immune response. In a normal healthy individual, lactoferrin plays a role in the front-line host defense against infection and in immune and inflammatory responses. Whether genomic variations, such as single nucleotide polymorphisms (SNPs), have an effect on the structure and function of lactoferrin protein and whether these variations contribute to the different susceptibility of individuals in response to environmental insults are interesting health-related issues. In this study, the lactoferrin gene was resequenced as part of the Environmental Genome Project of the National Institute of Environmental Health Sciences, which operates within the National Institutes of Health. Ninety-one healthy donors of different ethnicities were used to establish common SNPs in the exons of the lactoferrin gene in the general population. The data will serve as a basis from which study the association of lactoferrin polymorphism and disease.

scholarly journals Positive Association of Obesity with Single Nucleotide Polymorphisms of Syndecan 3 in the Korean Population

2006 ◽  
Vol 91 (12) ◽  
pp. 5095-5099 ◽  
Author(s):  
Eunyoung Ha ◽  
Mi-Ja Kim ◽  
Bong-Keun Choi ◽  
Jung-Jae Rho ◽  
Dong-Jae Oh ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Positive Association ◽  
Korean Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Susceptibility of the Iranian population to severe acute respiratory syndrome coronavirus 2 infection based on variants of angiotensin I converting enzyme 2

2020 ◽  
Vol 15 (8) ◽  
pp. 507-514
Author(s):  
Alireza Mohebbi ◽  
Fatemeh Sana Askari ◽  
Mohsen Ebrahimi ◽  
Mana Zakeri ◽  
Mohammad Yasaghi ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Single Nucleotide Polymorphisms ◽  
Resistance Mutation ◽  
Iranian Population ◽  
Natural Resistance ◽  
Missense Mutations ◽  
Nucleotide Polymorphisms ◽  
Converting Enzyme ◽  
Viral Glycoprotein ◽  
Single Nucleotide

Background: Variations in the viral receptor human angiotensin-converting enzyme 2 (ACE2) may specify the susceptibility of a certain population to severe acute respiratory syndrome coronavirus 2. Objective: Evaluation of the affinity of severe acute respiratory syndrome coronavirus 2 spike glycoprotein to the Iranian genetic variants of ACE2. Materials & methods: Single nucleotide polymorphisms of ACE2 among the Iranian population were collected from the Iranome database. Missense mutations in the N-terminal peptidase domain were selected for in silico analysis. Results: 17 missense single nucleotide polymorphisms were found at ACE2. Viral glycoprotein had the lowest affinity to ACE2 mutant V485L. Discussion: The V485L variant of ACE2 could be a natural resistance mutation among the Iranian population. In addition, variant S331F can increase slightly the susceptibility to infection with the virus.

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