scholarly journals Nasal muco-ciliary transport time alteration: efficacy of 18B glycyrrhetinic acid

2017 ◽  
Vol 12 ◽  
Author(s):  
Desiderio Passali ◽  
Chiara Cappello ◽  
Giulio Cesare Passali ◽  
Cemal Cingi ◽  
Codrut Sarafoleanu
Keyword(s):  
Nasal Spray ◽  
Nasal Mucosa ◽  
Paranasal Sinuses ◽  
Mucociliary Clearance ◽  
Mucociliary Transport ◽  
Clearance Time ◽  
Vasomotor Rhinitis ◽  
Transport Time ◽  
Clearing System ◽  
Objective Reduction

Background: Mucociliary clearance is the main self-clearing system of the nasal cavity and paranasal sinuses. This is a very important means of non specific defence against continuous organic and inorganic contamination conveyed by air. It works by trapping particles and microorganisms in the mucus and then by transporting the mucous film to the pharynx where it is eliminated with a cough or swallowed. Its congenital or acquired abnormalities are involved in the occurrence of widespread infectious and often severe nose and paranasal sinuses diseases; generally concerning the rhinopharyngealtubal district. Restoring mucociliary clearance of the nasal epithelium when altered thus represents a key therapeutic tool against rhinosinus chronic diseases. This study evaluates the clinical efficacy of the inhalation of a natural compound (Narivent® nasal spray) in chronic vasomotor rhinitis. Methods: The study involved 79 patients suffering from chronic vasomotor rhinitis presenting an increased mucociliary clearance time. Patients were randomized into 2 groups: a first group of 49 subjects and a second group of 30 subjects. The first group was treated with a nasal spray (Narivent® nasal spray) (2 sprays per nostril twice a day) for 30 days. The second group was treated with a nasal spray containing isotonic solution in the same way and for the same period of the first group. Nasal Mucociliary transport time was measured in the patients of both groups before treatment, after 15 days of treatment, and at the end of the 30 days treatment. Results: The study shows how one of the treatments carried out determines a major objective reduction of the mucociliary clearance time in the patients under examination, using the method which involves the use of an insoluble coloured tracer (vegetable carbon), bringing the values back within normal range. At the end of the study we objectivated an increase in the rate of mucociliary transport in 97.9% percentage of patients we enrolled. Conclusions: This study shows the effectiveness of treatment with natural extracts with nasal mucosa restoring function in the treatment of chronic vasomotor rhinitis, a nasal inflammatory disease characterized by morphological and functional alteration of the normal nasal mucosa.

The prognostic value of mucociliary clearance in predicting success in tympanoplasty

1993 ◽  
Vol 107 (10) ◽  
pp. 895-897 ◽  
Author(s):  
F. Giménez ◽  
J. Marco-Algarra
Keyword(s):  
Saccharin Solution ◽  
Prognostic Value ◽  
Mucociliary Clearance ◽  
Mucociliary Transport ◽  
Transport Time ◽  
Failure Group ◽  
Predicting Success ◽  
Cent Sodium ◽  
Success Group ◽  
Normal Transport

AbstractMucociliary and equipressive eustachian tube functions have been studied, using saccharin solution (five per cent sodium saccharinate) and tubal manometry respectively, in 58 ears with chronic disease undergoing tympanoplasty. The position of the perforation site determines the results as the poorest results are obtained from the posterior ones, positive cases (47 per cent) and mean transport time (37.7 minutes), compared to the greater percentage of positive cases (86 per cent) and mean transport time (22.2 minutes) for anterior perforations.When both parameters are analysed together there is a direct relationship between normal equipressive function and normal mucociliary transport time and between negative transport time and tubal blocking. Significant differences in transport times have been found for the anterior and posterior perforations being shorter for the anterior ones.When surgical outcome is correlated with mucociliary transport, the normal transport time percentage is seen to be considerably higher in the success group (50 per cent) than in the failure group (22 per cent).

Influence of topical phenypropanolamine on tachyphylaxis and mucociliary clearance in the human nose

1988 ◽  
Vol 102 (5) ◽  
pp. 408-410 ◽  
Author(s):  
K. Holmberg ◽  
M. Bende
Keyword(s):  
Dose Response ◽  
Mucociliary Clearance ◽  
Mucociliary Transport ◽  
Cent Solution ◽  
Transport Time ◽  
Reduced Dose ◽  
Healthy Humans ◽  
Mucociliary System ◽  
Dose Response Effect ◽  
Human Nose

AbstractTopical nasal phenylpropanolamine in a 2.5 per cent solution (PPA) was used in an evaluation of the possible development of tachyphylaxis and of possible effects on the mucociliary system after one week of treatment in healthy humans. The tendency of PPA to produce tachyphylaxis was evaluated by rhi-nomanometrie measurements of nasal airway resistance after repeated dose-response provocations. The mucociliary transport time was tested with the saccharine-dye test. No reduced dose-response effect or change in mucociliary transport time was found with PPA, thus indicating that one week of treatment does not contribute to such adverse effects.

The effect of vidian neurectomy on nasal mucociliary clearance

1988 ◽  
Vol 102 (10) ◽  
pp. 894-895 ◽  
Author(s):  
M. A. Greenstone ◽  
P. J. Stanley ◽  
I. S. Mackay ◽  
P. J. Cole
Keyword(s):  
Neural Control ◽  
Mucociliary Clearance ◽  
Control Group ◽  
Mucociliary Transport ◽  
Vasomotor Rhinitis ◽  
Physiological Factors ◽  
Tear Secretion ◽  
Vidian Neurectomy ◽  
Significant Difference ◽  
Nasal Mucociliary Clearance

AbstractThe physiological factors controlling mucociliary transport are largely unknown. Nasal mucociliary clearance was measuredusing the saccharin test in seven patients who had previously undergone vidian neurectomy for vasomotor rhinitis. Persistent denervation was suggested by impaired tear secretion. The control group consisted of thirty-four patients with vasomotor rhinitis who had not had surgery. There was no significant difference in clearance times between the two groups, suggesting that mucociliary transport is well preservedin the absence of neural control.

Nasal changes associated with exercise in athletes: systematic review

2018 ◽  
Vol 132 (3) ◽  
pp. 191-197 ◽  
Author(s):  
P Surda ◽  
A Walker ◽  
J Limpens ◽  
W Fokkens ◽  
M Putala
Keyword(s):  
Systematic Review ◽  
Nasal Mucosa ◽  
Strenuous Exercise ◽  
Nasal Airway ◽  
Mucociliary Transport ◽  
Short Term ◽  
Transport Time ◽  
Type Method ◽  
The Impact ◽  
Nasal Changes

AbstractBackground:The prevalence of rhinitis in athletes has frequently been studied in combination with asthma, but the impact of exercise on the paracrine and secretory functions of nasal mucosa is less well established. This systematic review aimed to examine the effect of exercise on nasal mucosa in elite athletes.Method:A systematic search of Medline, Embase and the non-Medline subset of PubMed, from inception to 8th March 2016, was performed to identify studies on rhinitis in athletes.Results:Of the 373 identified unique articles, a total of 8 studies satisfied the criteria for this review.Conclusion:There is no evidence in the existing literature that indicates a reduction in nasal airway induced by exercise. Olfaction and mucociliary transport time are affected in swimmers, which can likely be attributed to chlorine irritation and which resolves with training cessation. Short-term strenuous exercise may trigger changes in cytology and prolonged mucociliary transport time, which also resolve quickly with rest.

scholarly journals Does laryngopharyngeal reflux disease impair nasal mucociliary transport? A case control prospective study

2020 ◽  
Vol 6 (4) ◽  
pp. 633
Author(s):  
Pooja K. Vasu ◽  
Nayana V. Gopalankutty ◽  
Gangadhara Somayaji
Keyword(s):  
Reflux Disease ◽  
Mucociliary Clearance ◽  
Reference Group ◽  
Laryngopharyngeal Reflux ◽  
Case Control ◽  
Study Group ◽  
Test Duration ◽  
Mucociliary Transport ◽  
Clearance Time ◽  
Laryngopharyngeal Reflux Disease

<p class="abstract"><strong>Background:</strong> Laryngopharyngeal reflux disease (LPRD) is the retrograde reflux of gastro duodenal contents above the level of upper oesophageal sphincter into larynx and pharynx. LPRD can lead to upper respiratory pathology by direct contact of nasal and nasopharyngeal mucosa with the regurgitated gastric acid. Refluxate can damage the cilia, thereby prolonging the mucociliary clearance time (MCT) and consequently affecting the innate defence mechanism of upper airway. Our objective was to analyse the relationship between MCT and LPRD in patients without any nasal pathology.</p><p class="abstract"><strong>Methods:</strong> This study was a prospective case control study, with 45 patients each in the study and reference group. Study group included patients with symptoms of LPRD who fulfilled the reflux symptom index (RSI) score of more than 13 points. The reference group included subjects without LPRD, with RSI less than 13. In both groups, conditions causing impaired MCT like allergic rhinitis, sinusitis, rhinitis and history of smoking were excluded. Chronic sinusitis cases were excluded in both groups using sino-nasal outcome test -22 scoring system. Nasal MCT was measured in all these participants using the Saccharin test. Duration more than 20 minutes was taken as prolonged mucociliary clearance time.  </p><p class="abstract"><strong>Results:</strong> MCT was prolonged in 62% of subjects (28 out of 45) in the study group whereas, in the reference population MCT was normal.</p><p class="abstract"><strong>Conclusions:</strong> LPRD is a contributing factor for impaired nasal mucociliary transport.</p>

scholarly journals Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

2020 ◽  
pp. 014556132092042
Author(s):  
Akif İşlek ◽  
Muhammed Gazi Yıldız
Keyword(s):  
Nasal Obstruction ◽  
Nasal Mucosa ◽  
Severity Score ◽  
Mucociliary Clearance ◽  
Acne Vulgaris ◽  
Clearance Time ◽  
Analog Scale ◽  
Symptom Evaluation ◽  
Acne Treatment ◽  
Nasal Mucociliary Clearance

Objectives: The study aims to investigate the possible side effects of isotretinoin use on the nasal mucosa with objective methods in the treatment of acne vulgaris. Methods: Before the treatment, nasal mucociliary clearance time (MCT) was measured in all patients. Also all patients were asked to complete the questionnaires about the nasal dryness (visual analog scale [VAS]), nasal obstruction (Nasal Obstruction Symptom Evaluation [NOSE]), and presence of epistaxis (Epistaxis Severity Score [ESS]). Both MCT and questionnaires were reevaluated in patients who completed the treatment. Results: The results of 101 patients were evaluated. Before treatment, mean duration of nasal mucociliary clearance (NMC) was 9.55 ± 1.30 minutes, nasal dryness (VAS) value was 2.7 ± 0.7, NOSE score was 2.1 ± 1.1, and ESS score was 1.2 ± 0.7; after treatment, the duration of NMC was 13.80 ± 2.29 minutes, VAS value was 3.3 ± 1.1, NOSE score was 3.2 ± 1.3, and ESS score was 2.1 ± 1.2 ( P = .018, .150, .027, .011, respectively). Conclusion: The nasal mucosa is adversely affected in patients due to regular use of isotretinoin in the acne treatment, anamnesis should be checked in all nasal surgeries, and routine ear nose throat control should be recommended for these patients.

Mucociliary Clearance in Experimental Chronic Sinusitis

1996 ◽  
Vol 10 (5) ◽  
pp. 271-280 ◽  
Author(s):  
Judith M. Czaja ◽  
Thomas V. McCaffrey
Keyword(s):  
Paranasal Sinuses ◽  
Mucociliary Clearance ◽  
Chronic Sinusitis ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Infected Group ◽  
Mucociliary Transport ◽  
India Ink ◽  
Photometric Technique ◽  
Transport Patterns

Abnormal mucociliary clearance in the paranasal sinuses is a significant factor in the pathogenesis of sinusitis. This study examined effects of chronic sinusitis on ciliary beat frequency (CBF), mucociliary transport (MCT) velocity, mucociliary transport patterns, and histology of sinus mucosa in rabbits. Two groups of rabbits were studied: uninfected (n = 9) and infected (n = 18). Maxillary sinus ostia in all animals were occluded, and sinuses in the infected group were inoculated with 108 cfu of Streptococcus pneumoniae. Chronic sinusitis developed over 6 weeks and was confirmed by histopathology and culture. Evaluation of the MCT mechanism included 1) measurement of CBF using a photometric technique, 2) direct measurement of MCT velocity, and 3) analysis of MCT patterns with inert India ink. In seven of nine (77.8%) uninfected animals, the mean CBF was 11.5 Hz (±.39 Hz) initially and 11.3 Hz (±.32 Hz) 6 weeks after occlusion (P = 0.69). MCT velocity measured 20.6 mm/min (±1.40 mm/min) initially and 16.85 mm/min (±1.96 mm/min) 6 weeks after occlusion (P = 0.16). In the infected group, there were statistically significant decreases in CBF (P < 0.05) and measured MCT velocity (P < 0.05). Examination of MCT in infected animals showed patterns of misdirected flow, pooling, and stagnation. Histopathologic changes included significant losses of ciliated epithelium and mucosal abnormalities consistent with chronic sinusitis. Chronic sinusitis secondary to long-standing bacterial infection leads to alterations in CBF, MCT velocity, and MCT patterns in the paranasal sinuses of rabbits.

Comparison of Nasal and Bronchial Mucociliary Clearance in Young Non-Smokers

1982 ◽  
Vol 62 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Edith Puchelle ◽  
F. Aug ◽  
J. M. Zahm ◽  
A. Bertrand
Keyword(s):  
Nasal Mucosa ◽  
Particle Deposition ◽  
Inverse Relationship ◽  
Mucociliary Clearance ◽  
Central Zone ◽  
Transport Rate ◽  
Mucociliary Transport ◽  
Initial Particle ◽  
Total Deposition ◽  
Initial Deposition

1. Nasal and bronchial mucociliary clearance have been studied in ten non-smokers (aged 19–23 years). Nasal mucociliary transport was evaluated by measuring the transport rate of a single radioactive (99mTc) particle deposited on the nasal mucosa. Bronchial clearance was measured after inhalation of insoluble radioactive anionic particles (diameter 7.4 ± 1.5 μm). The initial deposition of the aerosol and subsequent clearance over 1 h was monitored with a γ-camera 2. The initial particle deposition was concentrated centrally and was similar in all subjects. The percentage of the total deposition located in the central zone was 78.2 ± 5.8. The range for nasal transport rate (0–12.6 mm/min) and bronchial mucociliary clearance (18.1–77.0%) was large 3. An inverse relationship (rs = −0.63, P < 0.05) was observed between nasal transport rate and bronchial clearance, suggesting that, in young non-smokers, the lower the rate of the nasal mucociliary transport the faster the bronchial mucociliary clearance.

Alteration of airflow and mucociliary transport in normal subjects

1993 ◽  
Vol 107 (7) ◽  
pp. 603-604 ◽  
Author(s):  
G. S. Barr ◽  
A. K. Tewary
Keyword(s):  
Healthy Volunteers ◽  
Inverse Relationship ◽  
Mucociliary Clearance ◽  
Normal Subjects ◽  
Mucociliary Transport ◽  
Nasal Airflow ◽  
Clearance Time ◽  
Particle Clearance

The effect that variation of nasal airflow has on the mucociliary clearance was studied in healthy volunteers.The nasal saccharin particle clearance time was found to have an inverse relationship with the nasal airflow.

scholarly journals Perbedaan transpor mukosiliar pada pemberian larutan garam hipertonik dan isotonik penderita rinosinusitis kronis

2016 ◽  
Vol 46 (2) ◽  
pp. 121
Author(s):  
Sarwastuti Hendradewi ◽  
Novi Primadewi ◽  
Nurmala Shofiyati
Keyword(s):  
Chronic Rhinosinusitis ◽  
Hypertonic Saline ◽  
Paranasal Sinuses ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Solution Treatment ◽  
Mucociliary Transport ◽  
Transport Time ◽  
Hypertonic Saline Solution ◽  
Significant Difference

Latar belakang: Rinosinusitis kronis (RSK) merupakan inflamasi mukosa hidung dan sinus paranasal dengan jangka waktu gejala 12 minggu atau lebih. Transpor mukosiliar merupakan suatu mekanisme pertahanan lokal pada hidung dan sinus paranasal. Pada RSK terjadi disfungsi transpor mukosiliar. Tujuan: Mengetahui perbedaan transpor mukosiliar pada pemberian larutan garam hipertonik dan isotonik pada penderita RSK. Metode: Penelitian eksperimental murni dengan desain uji klinis randomisasi. Sampel terdiri dari dua kelompok, yaitu RSK yang mendapat larutan garam isotonik dan RSK yang mendapat larutan garam hipertonik. Tiap kelompok terdiri dari 25 sampel. Waktu transpor mukosiliar dilakukan pra dan pasca terapi memakai uji sakarin. Hasil: Secara keseluruhan, selama dua minggu masa terapi, didapati penurunan waktu transpor mukosiliar pada kelompok pasien yang diberi larutan garam hipertonik (13,00±2,12 menit) lebih besar dibandingkan pada kelompok pasien yang diberi larutan garam isotonik (6,84±2,54 menit) dan secara statistik terdapat perbedaan yang signifikan (p<0,001). Kesimpulan: Pemberian larutan garam hipertonik dapat menurunkan waktu transpor mukosiliar lebih besar dibandingkan larutan garam isotonik pada penderita rinosinusitis kronis.Kata kunci: Transpor mukosiliar, larutan garam isotonik, larutan garam hipertonik, rinosinusitis kronis ABSTRACT Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinuses mucosa with periods of symptoms 12 weeks or more. Mucociliary transport plays a role as local defense mechanism of the nasal and paranasal sinuses. In CRS, there are dysfunctions on the mucociliary transport. Purpose: This study aimed to find out the difference of mucociliary transport after nasal washing with hypertonic and isotonic saline solutions in patients with CRS. Methods: This was a pure experimental study with randomized controlled trial designs. The sample was divided into 2 groups: CRS with isotonic saline solution and CRS with hypertonic saline solution treatment. Each group was consisted of twenty five samples. The mucociliary transport time examination were performed pre and post treatment by using saccharin test. Result: During the 2 weeks of therapy, the overall of mucociliary transport time reduction in the group of patients given hypertonic saline solution (13.00±2.12 minutes) were bigger than in the group of patients who were given isotonic saline solution (6.84±2.54 minutes) and there was a significant difference statistically (p<0.001). Conclusion: Hypertonic saline solution is better than isotonic saline solution in reducing mucociliary transport time.Keywords: Mucociliary transport, isotonic saline solution, hypertonic saline solution, chronic rhinosinusitis

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