Autologous matrix-induced chondrogenesis for the treatment of osteochondral lesions of the talus: A systematic review

This study was performed to determine whether Autologous Matrix-Induced Chondrogenesis (AMIC) is an effective and safe treatment option for patients with symptomatic Osteochondral defects of the Talus (OCTs) and to identify factors that influence the clinical outcome. A systematic review of the literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Three reviewers independently conducted the literature search using the MEDLINE/PubMed database and the Cochrane Database of Systematic Reviews. The databases were queried using the terms “autologous” AND “matrix” AND “induced” AND “chondrogenesis.” Thirteen studies were eligible for review. All studies that compared the preoperative and postoperative mean values of different clinical/functional scores showed significant clinical improvement. The final postoperative mean Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score ranged from 50.9 to 74.5. The included studies indicated that age and body mass index may have a detrimental impact on the postoperative outcome. A higher re-intervention rate is expected with the open technique, mainly because of hardware removal after malleolar osteotomy. This data analysis demonstrated that both arthroscopic and open AMIC procedures are effective and safe for the treatment of OCTs. Level IV, systematic review of therapeutic studies.

Download Full-text

The clinical outcome of the Metha short hip stem: a systematic scoping review

Hip International ◽

10.1177/1120700020903719 ◽

2020 ◽

pp. 112070002090371 ◽

Cited By ~ 1

Author(s):

Michael-Alexander Malahias ◽

Purnachandra Tejaswi ◽

Dimitrios Chytas ◽

Vikram Kadu ◽

Dimitrios Karanikas ◽

...

Keyword(s):

Clinical Outcome ◽

Systematic Reviews ◽

Scoping Review ◽

Hip Resurfacing ◽

Long Term Results ◽

Middle Aged ◽

Cochrane Database ◽

Pubmed Database ◽

Meta Analyses ◽

Age Range

Introduction: Short femoral stems were designed to bridge the gap between conventional straight design stems and hip resurfacing prostheses in total hip arthroplasty (THA). A number of clinical trials have been recently conducted to assess the clinical and safety profile of the cementless, colarless, tapered Metha short hip stem in young or active middle-aged individuals. Methods: A systematic scoping review was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. 4 reviewers independently conducted the search using the MEDLINE/PubMed database and the Cochrane Database of Systematic Reviews. These databases were queried with the terms “short” AND “hip” AND “stem”. Results: From the initial 773 studies we finally chose 12 studies after applying our inclusion-exclusion criteria. The number of operated hips that were included in these studies was 5048 (mean BMI range: 22.7–35.2, mean age range: 44.4–60.4 years, mean follow-up range: 2–9 years). The mean modified Coleman methodology score was 52.3/100, while it ranged from 31/100 to 63/100. All mean clinical outcome scores that were used in the studies illustrated significant postoperative improvement when compared with the respective initial values. The revision rate of the Metha stem for component-related reasons was 2.5%, while the rate of major complications not requiring revision of the Metha stem was 2.8%. Conclusions: The Metha stem performs well in young or active middle-aged THA patients. Further studies are required for the assessment of the long-term results.

Download Full-text

Systematic Reviews and Meta-Analysis in Spine Surgery—How Good Are They in Methodological Quality? A Systematic Review

Global Spine Journal ◽

10.1177/2192568220906810 ◽

2020 ◽

pp. 219256822090681 ◽

Cited By ~ 2

Author(s):

Muthu Sathish ◽

Ramakrishnan Eswar

Keyword(s):

Systematic Review ◽

Spine Surgery ◽

Systematic Reviews ◽

Methodological Quality ◽

Meta Analysis ◽

Eligibility Criteria ◽

Cochrane Database ◽

Critical Flaw ◽

Meta Analyses

Study Design: Systematic review. Objectives: To assess the methodological quality of systematic reviews and meta-analyses in spine surgery over the past 2 decades. Materials and Methods: We conducted independent and in duplicate systematic review of the published systematic reviews and meta-analyses between 2000 and 2019 from PubMed Central and Cochrane Database pertaining to spine surgery involving surgical intervention. We searched bibliographies to identify additional relevant studies. Methodological quality was evaluated with AMSTAR score and graded with AMSTAR 2 criteria. Results: A total of 96 reviews met the eligibility criteria, with mean AMSTAR score of 7.51 (SD = 1.98). Based on AMSTAR 2 criteria, 13.5% (n = 13) and 18.7% (n = 18) of the studies had high and moderate level of confidence of results, respectively, without any critical flaws. A total of 29.1% (n = 28) of the studies had at least 1 critical flaw and 38.5% (n = 37) of the studies had more than 1 critical flaw, so that their results have low and critically low confidence, respectively. Failure to analyze the conflict of interest of authors of primary studies included in review and lack of list of excluded studies with justification were the most common critical flaw. Regression analysis demonstrated that studies with funding and studies published in recent years were significantly associated with higher methodological quality. Conclusion: Despite improvement in methodological quality of systematic reviews and meta-analyses in spine surgery in current decade, a substantial proportion continue to show critical flaws. With increasing number of review articles in spine surgery, stringent measures must be taken to adhere to methodological quality by following PRISMA and AMSTAR guidelines to attain higher standards of evidence in published literature.

Download Full-text

The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

Life ◽

10.3390/life10060094 ◽

2020 ◽

Vol 10 (6) ◽

pp. 94

Author(s):

Ewa Trams ◽

Krzysztof Kulinski ◽

Katarzyna Kozar-Kaminska ◽

Stanislaw Pomianowski ◽

Rafal Kaminski

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Platelet Rich Plasma ◽

Meta Analysis ◽

Knee Surgery ◽

Positive Effects ◽

Cochrane Database ◽

Prisma Statement ◽

Meta Analyses ◽

Knee Disorders

In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of knee disorders and during knee surgery has exponentially increased over the last decade. A systematic review with meta-analyses was performed by assessing selected studies of local PRP injections to the knee joint. The study was completed in accordance with 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A multistep search of PubMed, Embase, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov was performed to identify studies on knee surgery and knee lesion treatment with PRP. Of the 4004 articles initially identified, 357 articles focusing on knee lesions were selected and, consequently, only 83 clinical trials were analyzed using the revised Cochrane risk-of-bias tool to evaluate risk. In total, seven areas of meta-analysis reported a positive effect of PRP. Among them, 10 sub-analyses demonstrated significant differences in favor of PRP when compared to the control groups (p < 0.05). This study showed the positive effects of PRP, both on the recovery of knee disorders and during knee surgery; however further prospective and randomized studies with a higher number of subjects and with lower biases are needed.

Download Full-text

Systematic review of pertussis immunisation among Asians

International Journal of Human Rights in Healthcare ◽

10.1108/ijhrh-02-2016-0002 ◽

2016 ◽

Vol 9 (2) ◽

pp. 135-146

Author(s):

Moneeta Pal ◽

Felicity Goodyear-Smith ◽

Daniel Exeter

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

English Language ◽

Whooping Cough ◽

Asian Population ◽

Future Research ◽

Content Type ◽

Cochrane Database ◽

Meta Analyses ◽

Effectiveness Studies

Purpose – The purpose of this paper is to provide a review of the literature on pertussis immunisations among the Asian population. Design/methodology/approach – A systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The review performed searches using the keywords: immun*, vaccine* AND whooping cough or Bordetella pertussis OR B pertussis AND Asia*. The search was conducted on four electronic databases, namely, Medline, CINAHL, Embase and Cochrane Database of Systematic Reviews. Findings – In total, 13 studies of relevance were included in the review after screening 206 articles. The studies were categorised into three literature sections which were: epidemiology of pertussis, vaccine effectiveness studies in Asia and strategies aimed to increase uptake of immunisations against pertussis. Research limitations/implications – Due to financial constraints, the authors only had access to articles published in the English language and full text articles which may limit the generalisability of the review. Originality/value – The review is useful in providing insight into the general trends of pertussis immunisations among Asians and in aiding future research in this area.

Download Full-text

The Association of Periodontitis and Peripheral Arterial Occlusive Disease—A Systematic Review

International Journal of Molecular Sciences ◽

10.3390/ijms20122936 ◽

2019 ◽

Vol 20 (12) ◽

pp. 2936 ◽

Cited By ~ 2

Author(s):

Mark Kaschwich ◽

Christian-Alexander Behrendt ◽

Guido Heydecke ◽

Andreas Bayer ◽

Eike Sebastian Debus ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Peripheral Arterial Occlusive Disease ◽

Case Series ◽

Arterial Occlusive Disease ◽

Occlusive Disease ◽

Pubmed Database ◽

Peripheral Arterial ◽

Meta Analyses ◽

Degrees Of Severity

Background: Observational studies support an association between periodontitis (PD) and atherosclerotic vascular disease, but little is known specifically about peripheral arterial occlusive disease (PAOD). Objectives: To systematically review the evidence for an association between PD and PAOD. Data Sources: Medline via PubMed. Review Methods: We searched the Pubmed database for original studies, case reports, case series, meta-analyses and systematic reviews that assessed whether there is an association between PD (all degrees of severity) and PAOD (all degrees of severity). The reporting of this systematic review was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement following the Population, Intervention, Control, and Outcome (PICO) format. Results: 17 out of 755 detected studies were included in the qualitative synthesis. Nine studies demonstrated associations between PD and PAOD, and two studies reported associations between tooth loss and PAOD. Six studies addressed the pathomechanism regarding PD as a possible trigger for PAOD. No study that dismissed an association could be detected. Odds ratios or hazard ratios ranged from 1.3 to 3.9 in four large cohort studies after adjusting for established cardiovascular risk factors. Conclusions: The presented evidence supports a link between PD and PAOD. Further studies which address the temporality of PD and PAOD and randomized controlled intervention trials examining the causal impact of PD on PAOD are needed. Although our results cannot confirm a causal role of PD in the development of PAOD, it is likely that PD is associated with PAOD and plays a contributing role.

Download Full-text

A Systematic Review of Systematic Reviews on the Epidemiology, Evaluation, and Treatment of Plantar Fasciitis

Life ◽

10.3390/life11121287 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1287

Author(s):

Hye Chang Rhim ◽

Jangwon Kwon ◽

Jewel Park ◽

Joanne Borg-Stein ◽

Adam S. Tenforde

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Plantar Fasciitis ◽

Treatment Options ◽

Research Direction ◽

Future Research ◽

Shockwave Therapy ◽

Cochrane Database ◽

High Level ◽

Meta Analyses

The number of systematic review and meta-analyses on plantar fasciitis is expanding. The purpose of this review was to provide a comprehensive summary of reviews on the topic pertaining to plantar fasciitis, identify any conflicting and inconsistent results, and propose future research direction. A qualitative review of all systematic reviews and meta-analyses related to plantar fasciitis up to February 2021 was performed using PubMed, Embase, Web of Science, and the Cochrane Database. A total of 1052 articles were initially identified and 96 met the inclusion criteria. Included articles were summarized and divided into the following topics: epidemiology, diagnosis, and treatment. While the majority of reviews had high level of heterogeneity and included a small number of studies, there was general consensus on certain topics, such as BMI as a risk factor for plantar fasciitis and extracorporeal shockwave therapy as an effective mode of therapy. A qualitative summary of systematic reviews and meta-analyses published on plantar fasciitis provides a single source of updated information for clinicians. Evidence on topics such as the epidemiology, exercise therapy, or cost-effectiveness of treatment options for plantar fasciitis are lacking and warrant future research.

Download Full-text

Functional Outcomes of Bilateral Reverse Total Shoulder Arthroplasty: A Systematic Review

Joints ◽

10.1055/s-0041-1730974 ◽

2021 ◽

Author(s):

Michael-Alexander Malahias ◽

Emmanouil Brilakis ◽

Dimitrios Chytas ◽

Dimitrios Gerogiannis ◽

Grigorios Avramidis ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Shoulder Arthroplasty ◽

Functional Outcomes ◽

Total Shoulder Arthroplasty ◽

Reverse Total Shoulder Arthroplasty ◽

Pubmed Database ◽

Functional Scores ◽

Reverse Total Shoulder

Abstract Purpose To answer the question whether bilateral reverse total shoulder arthroplasty (RTSA) is a safe and effective treatment which results in satisfactory clinical and functional outcomes with low complications rates. A second question to be answered was: what is the quality of the evidence of the already published studies which investigate the use of bilateral RTSA? Methods Two reviewers independently conducted a systematic search according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses using the MEDLINE/PubMed database and the Cochrane Database of Systematic Reviews. These databases were queried with the terms “reverse” AND “total” AND “shoulder” AND “arthroplasty” AND “clinical.” Descriptive statistics were used to summarize the data. Results From the 394 initial studies we finally selected and assessed 6 clinical studies which were eligible to our inclusion–exclusion criteria. The aforementioned studies included in total 203 patients (69% females; mean age range: 67.1–75 years; mean follow-up range: 12–61 months). From those, 168 patients underwent staged bilateral RTSA (mean duration between first and second operation range: 8–21.6 months) and the rest of them a unilateral RTSA as controlled treatment. Almost all mean clinical and functional scores, which were used to assess the therapeutic value of bilateral RTSA, depicted significant postoperative improvement in comparison with the mean preoperative values. The modified Coleman methodology score, which was used to assess the quality of the studies, ranged from a minimum of 36/100 to a maximum of 55/100. Conclusion Despite the lack of high-quality evidence, staged bilateral RTSA seems to be a safe and effective procedure for patients with cuff tear arthropathy, which results in significantly improved clinical and functional outcomes and low reoperations' rates. Level of Evidence Systematic review of level III-IV therapeutic studies.

Download Full-text

How Effective Is Auditory–Verbal Therapy (AVT) for Building Language Development of Children with Cochlear Implants? A Systematic Review

Life ◽

10.3390/life11030239 ◽

2021 ◽

Vol 11 (3) ◽

pp. 239

Author(s):

Paris Binos ◽

Elina Nirgianaki ◽

George Psillas

Keyword(s):

Systematic Review ◽

Young Children ◽

Cochlear Implants ◽

Research Question ◽

Voice Quality ◽

Receptive Vocabulary ◽

Pubmed Database ◽

Mainstream Society ◽

Meta Analyses ◽

Auditory Verbal Therapy

This systematic review sheds light on the effectiveness of auditory–verbal therapy (AVT) outcomes in children with cochlear implants (CIs). The presented outcome is based on research findings from the last 10 years. The systematic review was designed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Critical Appraisal of Treatment Evidence (CATE) checklist. Specific keywords were chosen based on the research question and searched on the PubMed database. All searched papers were analysed based on specific exclusion criteria and classified into four evidence levels. The results revealed that children who participated in AV therapy can achieve linguistic skills at the same level as their hearing peers. Voice quality seemed positively affected, placing young children with CIs in the normal range for receptive vocabulary development. In contrast, reading skills seemed less benefited. AV therapy seems to contribute to integration into mainstream society. Despite the recorded speech and language improvements of young children with CIs, the aim of AV therapy is still not fulfilled. AV therapy can be seen as the best clinical practice for young children with CIs till now, but the lack of well-controlled studies is undermining.

Download Full-text