scholarly journals Hyperbaric oxygen treatment of superficial soft tissue lesions in children with oncologic disease

2011 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Eleonora Cesca ◽  
Giacomo Garetto ◽  
Emanuela Frascella ◽  
Simone Cesaro ◽  
Patrizia Dall'Igna ◽  
...  

This study aimed to assess the feasibility and results of hyperbaric oxygen therapy (HOT) as supportive treatment of lesions of superficial soft tissues in children with oncological diseases. This was a retrospective analysis and review of all records of children observed at the Pediatric Hematology-Oncology Department of the University of Padova and treated adjuvantly with HOT. Between 1996 and 2010, 12 patients (5 males and 7 females, median age 7 years, range 0.5-16) underwent HOT. The effectiveness of HOT varied according to the lesion treated. Ten out of 12 patients were cured. Efficacy was most questionable in 2 patients with skin graft and flaps at risk. Compliance to therapy was close to 100%. In just one case, HOT was interrupted for the appearance of local skin metastases close to the site of primary tumor. HOT showed itself to be safe and effective in most patients even those immunocompromised or critically ill.

Cephalalgia ◽  
2014 ◽  
Vol 34 (13) ◽  
pp. 1079-1087 ◽  
Author(s):  
Anja S Petersen ◽  
Mads CJ Barloese ◽  
Rigmor H Jensen

Purpose Our aim was to review the existing literature to document oxygen’s therapeutic effect on cluster headache. Method A PubMed search resulted in 28 hits, and from these and their references we found in total 11 relevant studies. We included six studies that investigated the efficacy of oxygen treatment. One study is observational and the remaining five are RCTs. Another five studies were on hyperbaric oxygen treatment hereof two case studies. Conclusion Oxygen therapy can be administered at different flow rates. Three studies investigate the effect of low-flow oxygen, 6–7 l/min, and found a positive response in 56%, 75% and 82%, respectively, of the patients. One study investigates high-flow oxygen, 12 l/min, and found efficacy in 78% of attacks. The effect of hyperbaric oxygen therapy has been investigated in a few small studies and there is evidence only for an acute, but not a prophylactic effect. Despite the fact that only a few high-quality RCT studies are available, oxygen treatment is close to an ideal treatment because it is effective and safe. However, sufferers of cluster headache do not always have access to oxygen because of logistic and financial concerns.


Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1134
Author(s):  
Sudhanshu Baitule ◽  
Aaran Patel ◽  
Narasimha Murthy ◽  
Sailesh Sankar ◽  
Ioannis Kyrou ◽  
...  

Background and Objectives: Hyperbaric oxygen is a recognised treatment for a range of medical conditions, including treatment of diabetic foot disease. A number of studies have reported an impact of hyperbaric oxygen treatment on glycaemic control in patients undergoing treatment for diabetic foot disease. There has been no systematic review considering the impact of hyperbaric oxygen on glycaemia in people with diabetes. Materials and Methods: A prospectively PROSPERO-registered (PROSPERO registration: CRD42021255528) systematic review of eligible studies published in English in the PUBMED, MEDLINE, and EMBASE databases, based on the following search terms: hyperbaric oxygen therapy, HBO2, hyperbaric oxygenation, glycaemic control, diabetes, diabetes Mellitus, diabetic, HbA1c. Data extraction to pre-determined piloted data collection form, with individual assessment of bias. Results: In total, 10 eligible publications were identified after screening. Of these, six articles reported a statistically significant reduction in blood glucose from hyperbaric oxygen treatment, while two articles reported a statistically significant increase in peripheral insulin sensitivity. Two articles also identified a statistically significant reduction in HbA1c following hyperbaric oxygen treatment. Conclusions: There is emerging evidence suggesting a reduction in glycaemia following hyperbaric oxygen treatment in patients with diabetes mellitus, but the existing studies are in relatively small cohorts and potentially underpowered. Additional large prospective clinical trials are required to understand the precise impact of hyperbaric oxygen treatment on glycaemia for people with diabetes mellitus.


2021 ◽  
Vol 5 (4) ◽  
pp. 238-241
Author(s):  
Xinli Feng ◽  
Meng Sun

Objective: To investigate the efficacy and mechanism of ultra-early hyperbaric oxygen intervention in the treatment of diffuse axonal injury (DAI). Methods: Eighty-six patients with diffuse axonal injury were selected and then divided into an ultra-early hyperbaric oxygen treatment group and a conventional treatment group with 43 patients in each group. The Glasgow Coma Scale (GCS) on the 10th day (10d), 20th day (20d), and 30th day (30d) after treatment and the Glasgow Outcome Score (GOS) 6 months later were observed and compared between both the groups. Results: The average score of the GCS at 10d, 20d, and 30d as well as the GOS 6 months later in the ultra-early hyperbaric oxygen treatment group were higher than those in the conventional treatment group (P < 0.05). Conclusion: Hyperbaric oxygen therapy is one of the unique and effective methods in clinical treatment especially for the treatment of DAI patients and it is worthy of promotion.


2011 ◽  
Vol 140 ◽  
pp. 238-243
Author(s):  
Qi Quan Zhou ◽  
Xue Feng Zhang ◽  
Ren Zeng Ciwang ◽  
Qiang Zhou ◽  
Yong Fan

Objective: To observe the treatment effects of hyperbaric oxygen on severe acute mountain sickness (ASHS) integrated with multiple organ dysfunction syndromes (MODS). Methods: 2006-2010 admitted to two hospitals in the Tibetan Plateau, 66 cases of patients who got the severe acute mountain sickness complicated by MODS were divided into two groups, 28 cases in the conventional therapy group, 38 cases in hyperbaric oxygen treatment therapy group, oxygen therapy, the conventional therapy concluded oxygen therapy, the treatment of primary disease and enhance the support for treatment of metabolic; hyperbaric oxygen group (was) on the basis of conventional therapy and hyperbaric oxygen therapy was used, the clinical effect of those two groups were compared with; with measured the before and after treatment blood levels of cytokines, to investigate the therapeutic mechanism of hyperbaric oxygen therapy. Results: The efficacy of hyperbaric oxygen treatment group and the treatment time are better than the conventional treatment group, hyperbaric oxygen treatment significantly reduced TNF, IL-6, IL-8 levels, and there is a significant difference between before and after treatment. Conclusion: the method of Hyperbaric oxygen for acute high altitude mountain disease complicated with MODS is reliable and had notable curative effect.


2020 ◽  
Vol 50 (3) ◽  
pp. 230-237
Author(s):  
Younès Benzidi ◽  
◽  
Thibault Duburcq ◽  
Daniel Mathieu ◽  
Erika Parmentier-Decrucq ◽  
...  

Introduction: Inflating endotracheal tube cuffs using water instead of air before hyperbaric oxygen treatment (HBOT) is common. The objective of this study was to assess cuff pressure (Pcuff), when the cuff was inflated using water, in normobaric conditions and during HBOT. Methods: This was a prospective, observational study taking place in hyperbaric centre and intensive care unit of the University Hospital of Lille. Every patient who required tracheal intubation and HBOT at 253.3 kPa (2.5 atmospheres absolute [atm abs]) was included. Pcuff was measured using a pressure transductor connected to the cuff inflating port. Measurements were performed at 'normobaria' (1 atm abs) and during HBOT at 2.5 atm abs. Results: Thirty patients were included between February and April 2016. Recordings were analysable in 27 patients. Mean Pcuff at normobaria was 60.8 (SD 42) cmH2O. Nineteen (70%) of patients had an excessive Pcuff (higher than 30 cmH2O). Coefficient of variation was 69%. Mean Pcuff at 2.5 atm abs was 51.6 (40.7) cmH2O, significantly lower than at normobaria (P < 0.0001). Coefficient of variation was 79%. In only five (18%) patients was Pcuff < 20 cmH2O at 2.5 atm abs. Conclusions: In normobaric conditions, when the cuff was inflated using water and not specifically controlled Pcuff was not predictable. The cuff was typically over-inflated exceeding safe pressure. During HBOT Pcuff decreased slightly.


2021 ◽  
Vol 5 (4) ◽  
pp. 242-245
Author(s):  
Xinli Feng ◽  
Ying Chang

Objective: To observe the clinical effect of hyperbaric oxygen in the treatment of sudden deafness. Methods: Ninety-six patients with sudden deafness diagnosed by the otolaryngology department were divided into 2 groups which comprised of 48 patients in the conventional treatment group and the other 48 patients in the hyperbaric oxygen treatment group. Both groups were treated with methylcobalamin, vitamin B1, and ginkgo biloba extract. The patients in the hyperbaric oxygen treatment group were given hyperbaric oxygen therapy of 2.0 ATA once a day. Each course of treatment lasted 10 days and after two courses of treatment, the clinical efficacies of the two groups were compared. Results: After two courses of treatment, the effect of treatment in the hyperbaric oxygen treatment group was significantly better than that of the conventional treatment group. Conclusion: Hyperbaric oxygen therapy can effectively improve the hearing level of patients with sudden deafness and the overall effective rate of treatment.


2020 ◽  
Vol 17 (4) ◽  
Author(s):  
Yi Liang ◽  
Na Fan ◽  
Xiaoling Zhong ◽  
Wenhui Fan

: Coronavirus disease 2019 (COVID-19) is currently a pandemic affecting the world, and there is no specific therapeutic drug available. Hypoxemia is a common clinical manifestation of severe patients, and oxygen therapy is the main treatment. This article reports for the first time the computed tomography (CT) imaging dynamic changes in a case of 69-year-old male with severe type of COVID-19 treated by hyperbaric oxygen, which provides a more effective regimen for severe COVID-19 patients with hypoxemia. We emphasize that hyperbaric oxygen treatment for COVID-19 is a preliminary attempt, and more clinical studies are required to confirm its efficacy.


2020 ◽  
pp. 261-265
Author(s):  
Jonathan W. Brügger ◽  
Glenn A. Rauscher ◽  
John P. Florian ◽  

Hyperoxic myopia is a phenomenon reported in individuals who have prolonged exposure to an increased partial pressure of oxygen (PO2) and subsequently have a myopic (nearsighted) change in their vision. To date, there are numerous accounts of hyperoxic myopia in dry hyperbaric oxygen treatment patients; however, there have been only three confirmed cases reported in wet divers. This case series adds four confirmed cases of hyperoxic myopia in wet divers using 1.35 atmospheres (ATM) PO2 at the Navy Experimental Diving Unit (NEDU). The four divers involved were the first author’s patients at NEDU. Conditions for two divers were confirmed via record review, whereas the other two divers were diagnosed by the first author. All subjects were interviewed to correlate subjective data with objective findings. Each subject completed five consecutive six-hour hyperoxic (PO2 of 1.35 ATM) dives with 18-hour surface intervals. Each individual was within the U. S. Navy Dive Manual’s standards for general health. Visual acuity was measured prior to diving. Within three to four days after diving, the individuals reported blurry vision with an associated myopic refraction shift. Each diver had spontaneous resolution of his myopia over the next two to three weeks, with no significant residual symptoms. The divers in this case series were exposed to an increased PO2 (1.35 ATM for 30 hours over five days), a lesser exposure than that in other reports of hyperoxic myopia in wet divers diagnosed with hyperoxic myopia (1.3-1.6 ATM for 45-85 hours in 12-18 days). Furthermore, this pulse of exposure was more concentrated than typically seen with traditional hyperbaric oxygen therapy. Hyperoxic myopia continues to be a risk for those conducting intensive diving with a PO2 between 1.3-1.6 ATM. Additional investigation is warranted to better define risk factors and PO2 limits regarding ocular oxygen toxicity.


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