scholarly journals Maintaining euthyroidism: fundamentals of thyroid hormone physiology, iodine metabolism and hypothyroidism

2017 ◽  
Vol 59 (4) ◽  
pp. 11-21
Author(s):  
De Wet Wolmarans
Keyword(s):  
Clinical Practice ◽  
Thyroid Hormone ◽  
Clinical Management ◽  
Current Paper ◽  
Hormone Regulation ◽  
Iodine Metabolism ◽  
Clinical Consequences ◽  
Hormone Homeostasis ◽  
Clinical Overview ◽  
Curative Agent

Thyroid-related pathologies, especially subclinical and clinical hypothyroidism, are commonly described in clinical practice. While illnesses related to aberrant thyroid hormone homeostasis are the most prevalent endocrinological conditions diagnosed, important aspects related to thyroid hormone physiology are often overlooked. Further, the only known physiological purpose of iodine is its requirement for the synthesis of thyroxine (T4) and triiodothyronine (T3). However, although it can be applied as curative agent in the management of thyrotoxicosis, the halogen is often prescribed and used inappropriately with significant, but preventable clinical consequences. In an attempt to kindle a better understanding of aspects related to aberrant thyroid hormone regulation, iodine metabolism, and the clinical management of thyroid related pathology, the current paper provides a physiological and clinical overview of said constructs from a hypothyroid perspective.

scholarly journals Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Marie-Louise Hartoft-Nielsen ◽  
Malene Boas ◽  
Sofie Bliddal ◽  
Åase Krogh Rasmussen ◽  
Katharina Main ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Normal Development ◽  
Endocrine Disrupting Chemicals ◽  
Hormone Regulation ◽  
Foetal Development ◽  
Endocrine Disrupting ◽  
Industrial Use ◽  
Hormone Homeostasis ◽  
Maternal Thyroid ◽  
Hormone Influence

Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals—endocrine disrupting chemicals (EDCs)—has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce.

scholarly journals Thyroid hormone regulation of beta-adrenergic receptor number.

1977 ◽  
Vol 252 (8) ◽  
pp. 2787-2789 ◽  
Author(s):  
L T Williams ◽  
R J Lefkowitz ◽  
A M Watanabe ◽  
D R Hathaway ◽  
H R Besch
Keyword(s):  
Thyroid Hormone ◽  
Adrenergic Receptor ◽  
Hormone Regulation ◽  
Beta Adrenergic Receptor ◽  
Beta Adrenergic ◽  
Receptor Number

scholarly journals Thyroid Hormone and the Neuroglia: Both Source and Target

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Petra Mohácsik ◽  
Anikó Zeöld ◽  
Antonio C. Bianco ◽  
Balázs Gereben
Keyword(s):  
Thyroid Hormone ◽  
Cell Function ◽  
Hormone Regulation ◽  
Mediobasal Hypothalamus ◽  
Iodothyronine Deiodinase ◽  
Neuronal Gene ◽  
Health And Disease ◽  
And Function ◽  
The Brain

Thyroid hormone plays a crucial role in the development and function of the nervous system. In order to bind to its nuclear receptor and regulate gene transcription thyroxine needs to be activated in the brain. This activation occurs via conversion of thyroxine to T3, which is catalyzed by the type 2 iodothyronine deiodinase (D2) in glial cells, in astrocytes, and tanycytes in the mediobasal hypothalamus. We discuss how thyroid hormone affects glial cell function followed by an overview on the fine-tuned regulation of T3 generation by D2 in different glial subtypes. Recent evidence on the direct paracrine impact of glial D2 on neuronal gene expression underlines the importance of glial-neuronal interaction in thyroid hormone regulation as a major regulatory pathway in the brain in health and disease.

THE INFLUENCE OF THE PLASMA INORGANIC IODINE CONCENTRATION ON THYROID FUNCTION IN DEHALOGENASE DEFICIENCY

1967 ◽  
Vol 55 (2) ◽  
pp. 361-368 ◽  
Author(s):  
R. McG. Harden ◽  
W. D. Alexander ◽  
S. Papadopoulos ◽  
M. T. Harrison ◽  
S. Macfarlane
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Iodine Concentration ◽  
Rapid Rise ◽  
Normal Range ◽  
Hormone Synthesis ◽  
Thyroid Hormone Synthesis ◽  
Iodine Metabolism ◽  
Inorganic Iodine ◽  
Circulating Levels

ABSTRACT Iodine metabolism and thyroid function were studied in a patient with hypothyroidism and goitre due to dehalogenase deficiency. Initially the plasma inorganic iodine (PII) level was within the normal range but circulating levels of hormone were low and the thyroid clearance and absolute uptake of iodine (AIU) by the thyroid were high. Administration of iodide supplements resulted in a rapid rise in the plasma thyroxine concentration and restoration of the euthyroid state. Thyroid hormone synthesis appeared to proceed normally when the PII exceeded 1.0 μg/100 ml. This was achieved by increasing the intake of iodide by 612 μg per day. At PII levels around 10 μg/100 ml there was evidence of increased levels of circulating thyroid hormone.

scholarly journals The Defeat Depression Campaign

1997 ◽  
Vol 21 (3) ◽  
pp. 148-150 ◽  
Author(s):  
Ann Macaskill ◽  
Norman Macaskill ◽  
A. Nicol
Keyword(s):  
Clinical Practice ◽  
Royal College ◽  
Questionnaire Survey ◽  
Clinical Management ◽  
The Public ◽  
Health Practitioners ◽  
The Impact

The Royal College of Psychiatrists launched a five year campaign in 1992 to better inform health practitioners and the public about depression. A questionnaire survey of Sheffield general practitoners (GPs) to assess the impact of the Defeat Depression Campaign on their knowledge and clinical management of depression was carried out in May 1994, half way through the campaign. Overall, 75% of GPs who responded indicated that the Defeat Depression Campaign had had little or no impact on their clinical practice. It would appear that at its mid-point the Defeat Depression Campaign failed to achieve its main goals in relation to educating GPs about depression and its management.

scholarly journals Thyroid hormone regulation of apoptotic tissue remodeling during anuran metamorphosis

Cell Research ◽  
2001 ◽  
Vol 11 (4) ◽  
pp. 245-252 ◽  
Author(s):  
Yun-Bo SHI ◽  
Liezhen FU ◽  
Shao Chung Victor HSIA ◽  
Akihiro TOMITA ◽  
Daniel BUCHHOLZ
Keyword(s):  
Thyroid Hormone ◽  
Tissue Remodeling ◽  
Hormone Regulation
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