Background:
The chronotherapy concept attains considerable focus towards itself due to its pulsatile fashion
rather than continuous delivery. The delivery of the right amount of drug to the target organ at the most appropriate time is
fulfilled by using the chronotherapeutic dosage form.
Aim:
The present study aims to develop and evaluate a chronotherapeutic drug delivery system by using natural polymer
for time specific drug delivery at the target site.
Material and Method:
Tamarind seed polysaccharide was extracted and used in the preparation of core tablets. Nine
formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on 6 mm punch. The core tablets were
prepared by using the compression coating method. The three batches F1, F2 and F3 were prepared by using tamarind
gum in different concentration i.e. 45%, 22.5% and 67.5% respectively and compressed at 8 tonnes of pressure on 12 mm
of punch. The finally compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl
alcohol used as a solvent. In a controlled medium, a stability study was performed to evaluate the physical appearance,
drug content and release of the prepared core tablet.
Result:
All the nine formulations of tablets were prepared successfully and the evaluation studies (thickness, weight
variation, hardness, friability etc.) revealed that all the formulations were within the official range. The release study of
the drug revealed that the formulation F7 containing 67.5% of tamarind polymer, coated with 2%, 4% and 5% of ethyl
cellulose solution released 59.68±1.03% (Q50%) drug within 5 h whereas, 87.09±2.08% (Q80%) within 6 h and within 12 h
97.74±2.19% of the drug was released. The formulation F7 was found to be more effective as it released the maximum
amount of drug in a short period as compared with other formulations.
Conclusion:
The coating of core tablets allowed to prepare pharmaceutical dosage form for time specific drug delivery.
These chronotherapeutic core tablets can be used for the treatment of angina pectoris and hypertension etc.
Preparation and Evaluation of Mucoadhesive Beads/Discs of Alginate and Algino-Pectinate of Piroxicam for Colon-Specific Drug Delivery Via Oral Route