Thyroid dysfunction in patients with metabolic syndrome in medical ICU of Zagazig university hospitals

Background: Metabolic syndrome is characterized by hypertension, dyslipidemia, central obesity, glucose intolerance, insulin resistance. Thyroid hormone acts as general pacemaker, accelerating metabolic process and may be associated with metabolic syndrome. There is no information available in literature regarding the prevalence and association of thyroid dysfunction in metabolic syndrome in this central region of the country. Aims and Objective: To estimate the prevalence of thyroid dysfunction in patients of metabolic syndrome. Materials and Methods: It is a duration based prospective cross sectional study including 200 patients of metabolic syndrome. A detailed history, clinical examination and relevant investigations including serum Free T4 (FT4), Free T3 (FT3), Thyroid Stimulating Hormone (TSH) were done. Range, frequencies, percentage, mean, standard deviation and P value were calculated. P value of < 0.05 was taken as significant. Results: Prevalence of thyroid dysfunction in metabolic syndrome patients was 28.5%. Prevalence of subclinical and overt hypothyroidism was 18.5% and 8.5% respectively. In patients with both metabolic syndrome and thyroid dysfunction, most common components associated are diabetes mellitus and hypertriglyceridemia. Conclusion: Thyroid dysfunction is significantly common in metabolic syndrome patients. It should be aggressively detected and treated in these patients for better outcome.

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Association of metabolic syndrome and its components with thyroid dysfunction in females

International Journal of Diabetes in Developing Countries ◽

10.4103/0973-3930.34754 ◽

2007 ◽

Vol 27 (1) ◽

pp. 24 ◽

Cited By ~ 4

Author(s):

L Chandra ◽

S Shrestha ◽

BKL Das ◽

N Baral

Keyword(s):

Metabolic Syndrome ◽

Thyroid Dysfunction

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Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome

Diabetes & Metabolism Journal ◽

10.4093/dmj.2015.39.1.66 ◽

2015 ◽

Vol 39 (1) ◽

pp. 66 ◽

Cited By ~ 23

Author(s):

Prabin Gyawali ◽

Jyoti Shrestha Takanche ◽

Raj Kumar Shrestha ◽

Prem Bhattarai ◽

Kishor Khanal ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Dysfunction

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Association of prothrombotic adipokine (plasminogen activator inhibitor-1) with TSH in metabolic syndrome: a case control study

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2017-0046 ◽

2017 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Ashok Kumar Ahirwar ◽

Archana Singh ◽

Anju Jain ◽

Kirti Kaim ◽

Shilpa Bhardwaj ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Dysfunction ◽

Case Control Study ◽

Plasminogen Activator Inhibitor ◽

Case Control ◽

Plasminogen Activator Inhibitor 1 ◽

The Mean ◽

Activator Inhibitor ◽

Pai 1 ◽

Control Study

AbstractBackgroundMetabolic syndrome (MetS) involves a cluster of cardiovascular risk factors, including abnormal lipids, insulin resistance and hypertension. The aim of the present study is to investigate associations between thyroid profile and the pro-thrombotic mediator, plasminogen activator inhibitor-1 (PAI-1), in MetS and identify associated biochemical markers.Materials and methodsThe present study was a case control study and consisted of 50 diagnosed cases of MetS and 50 healthy volunteers as controls. MetS cases were further divided into two groups based on the presence and absence of subclinical hypothyroidism (SCH). Data collected included demographic profile, clinical history and routine lab investigation. Special investigations included the thyroid function test and serum PAI-1 levels.ResultsThe mean serum thyroid-stimulating hormone (TSH) levels were significantly higher in MetS cases as compared to controls (5.7 ± 1.2 mIU/L vs. 2.3 ± 1.6 mIU/L, p < 0.0001), although the mean triiodothyronine (TConclusionThe present study points towards the presence of thyroid dysfunction, in the form of subclinical hypothyroidism (SCH), in cases of MetS. In the presence of thyroid dysfunction, abnormal adipocytes may release adipokines, such as PAI-1, which lead to increased risk of thrombotic episodes in these patients. Hence, SCH should be appropriately managed.

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Assessment of Thyroid Dysfunction in Patients with Metabolic Syndrome and its Correlation with Individual Parameters of Metabolic Syndrome

International Journal of Contemporary Medical Research [IJCMR] ◽

10.21276/ijcmr.2020.7.3.24 ◽

2020 ◽

Vol 7 (3) ◽

Author(s):

Uma MA ◽

Perisetty Tulasi Kumari ◽

Nagarajan N

Keyword(s):

Metabolic Syndrome ◽

Thyroid Dysfunction

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Study of thyroid dysfunction in metabolic syndrome and association with its components

Current Medicine Research and Practice ◽

10.1016/j.cmrp.2017.11.010 ◽

2018 ◽

Vol 8 (1) ◽

pp. 3-7 ◽

Cited By ~ 3

Author(s):

Manoj Saluja ◽

Pavankumar Pyarsabadi ◽

Shivcharan Jelia ◽

Saurabh Chittora ◽

Yogesh Swami ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Dysfunction

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Maternal Thyroid Antibodies Associates With Cardiometabolic Risk Factors in Children at the Age of 16

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2017-01137 ◽

2017 ◽

Vol 102 (11) ◽

pp. 4184-4190 ◽

Cited By ~ 3

Author(s):

Anna-Leena Heikkinen ◽

Fanni Päkkilä ◽

Anna-Liisa Hartikainen ◽

Marja Vääräsmäki ◽

Tuija Männistö ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Thyroid Dysfunction ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Thyroid Peroxidase ◽

Serum Samples ◽

Free T4 ◽

Maternal Thyroid

Abstract Context and Objective The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children. Design, Setting, and Participants This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs). Cardiometabolic risk factors in children at the age of 16 years were evaluated via blood sampling and clinical examination. Data were available for 3229 to 4176 mother–child pairs. Main Outcome Measures Waist circumference, blood pressure, lipids and lipoproteins, and insulin resistance were measured. Odds ratios (ORs) with 95% confidence intervals (CIs) of cardiometabolic risk factors in children with and without mothers with thyroid dysfunction or antibodies were calculated with logistic regression and adjusted for covariates. Results Children of TPO-Ab–positive mothers had higher odds of metabolic syndrome (OR, 2.57; 95%, CI 1.26 to 5.25) and waist circumference indicative of metabolic syndrome (OR, 1.69; 95% CI, 1.14 to 2.50). They were also more likely to be overweight or obese (OR, 1.56; 95% CI, 1.04 to 2.34). Maternal thyroid dysfunction or Tg-Ab positivity did not associate with cardiometabolic risk factors in children. Conclusion Metabolic syndrome, greater waist circumference, and higher body mass index were more prevalent in children of TPO-Ab–positive mothers, indicating an adverse cardiovascular health profile.

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