scholarly journals Thyroid dysfunction in patients of metabolic syndrome: A study from a tertiary care center in India

2021 ◽  
Vol 12 (10) ◽  
pp. 47-50
Author(s):  
Ritu Gupta ◽  
Akhil K Vijayan ◽  
Sushma Choudhary
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Dysfunction ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Cross Sectional

Background: Metabolic syndrome is characterized by hypertension, dyslipidemia, central obesity, glucose intolerance, insulin resistance. Thyroid hormone acts as general pacemaker, accelerating metabolic process and may be associated with metabolic syndrome. There is no information available in literature regarding the prevalence and association of thyroid dysfunction in metabolic syndrome in this central region of the country. Aims and Objective: To estimate the prevalence of thyroid dysfunction in patients of metabolic syndrome. Materials and Methods: It is a duration based prospective cross sectional study including 200 patients of metabolic syndrome. A detailed history, clinical examination and relevant investigations including serum Free T4 (FT4), Free T3 (FT3), Thyroid Stimulating Hormone (TSH) were done. Range, frequencies, percentage, mean, standard deviation and P value were calculated. P value of < 0.05 was taken as significant. Results: Prevalence of thyroid dysfunction in metabolic syndrome patients was 28.5%. Prevalence of subclinical and overt hypothyroidism was 18.5% and 8.5% respectively. In patients with both metabolic syndrome and thyroid dysfunction, most common components associated are diabetes mellitus and hypertriglyceridemia. Conclusion: Thyroid dysfunction is significantly common in metabolic syndrome patients. It should be aggressively detected and treated in these patients for better outcome.

FEMALES HAVE EARLIER DISEASE ONSET THAN MALES AMONG HLA-CW6 POSITIVE PSORIASIS PATIENTS

2021 ◽  
pp. 1-2
Author(s):  
Akhilesh Behra
Keyword(s):  
Age Of Onset ◽  
Care Center ◽  
Tertiary Care ◽  
Disease Onset ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Male And Female ◽  
Female Patients ◽  
Males And Females

Background- Psoriasis is a chronic inammatory relapsing skin disorder. Environmental and genetic factors play an important role in the development of disease. HLA-Cw6 most strongly associated with disease. There is also a difference in HLA-Cw6 positivity in respect to gender, which affect occurrence of disease in males and females. Aims & Objectives- This study was aimed to determine the association of HLA-Cw6 positive and negative psoriasis individuals had any signicant differences in respect to disease onset among male and female Materials & Methods- An Institute based Cross sectional study was done in a tertiary care center in eastern India. All patients attending skin OPD were included in the study. Detailed history and blood samples were collected from patients. HLA-Cw6 typing has done by sequence-specic PCR method. Results- HLA-Cw6 positive female patients had a signicantly early age of onset than male patients (p value-0.009334) (20.88 vs. 27.91yr), while HLA-Cw6 negative patients did not show any signicant difference of age of onset between male and female ( p value- 0.406905) Conclusion- Although men are more commonly affected than female, HLA-Cw6 positive psoriasis female patients show earlier disease onset. This results show that genetic variations in terms of HLA-Cw6 are reected in the age of onset among males and females.

scholarly journals Subclinical Hypothyroidism Prevalence in Pregnant Ladies in AL-Hilla city in Iraq

2018 ◽  
Vol 26 (8) ◽  
pp. 157-163
Author(s):  
Ban Amer Mousa ◽  
Sijal Fadhil Farhood Al Joborae
Keyword(s):  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Adverse Outcomes ◽  
Screening Tests ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Cross Sectional ◽  
Normal Value

Recent guidelines adapted unique pregnancy thyroid function screening tests because pregnancy subclinical hypothyroidism is associated with different adverse outcomes.  There are no data from Iraq about the prevalence of thyroid hypofunction in the 1st trimester of pregnancy. This study aims to find the prevalence of thyroid dysfunction in the 1st trimester.                                              Patients and Methods: In this descriptive cross-sectional study, thyroid stimulating hormone (TSH) was measured in 100 pregnant women from  May 2017-December 2017 in Babylon teaching hospital for maternity and pediatric and in private clinic. If TSH was more than 2.5 mIU/L in the first trimester, free T4 was measured to diagnose then differentiate between subclinical & overt hypothyroidism. If free T4 was in the normal value (0.7-1.8 ng/dl) the diagnosis was subclinical hypothyroidism and if below the normal value, overt hypothyroidism was diagnosed.

scholarly journals Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

2016 ◽  
Vol 2 (2) ◽  
pp. 30
Author(s):  
Manjaree Morgaonkar ◽  
Ramesh Kushwaha ◽  
Savera Gupta ◽  
Suresh Kumar Jain ◽  
Dattatray V. Kulkarni ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Psoriasis Vulgaris ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Systemic Inflammatory Disease ◽  
Significant Difference

<p class="abstract"><strong>Background:</strong> Psoriasis, a common skin disorder is now considered as systemic inflammatory disease. Its chronic inflammatory state is thought to predispose patients to metabolic syndrome (MetS), which is a significant predictor of cardiovascular events. The objective of the study is to investigate the prevalence of metabolic syndrome in psoriatic patients with only cutaneous involvement and to evaluate the correlation between presence of MetS and psoriasis severity</p><p class="abstract"><strong>Methods:</strong> We performed hospital based, cross-sectional study on 100 adult patients with psoriasis vulgaris and equi-numbered age and sex matched controls. MetS was diagnosed by revised National Cholesterol Education Program’s Adult Panel III criteria.</p><p class="abstract"><strong>Results:</strong> A higher prevalence of metabolic syndrome was found in psoriasis patients as compared to controls [28 (28%) vs 9 (9%), P value=0.0005].Impaired fasting glucose level, hypertension, hypertriglyceridemia and abdominal obesity were more prevalent in psoriasis group. No statistically significant difference was found between prevalence of low levels of HDL and presence of metabolic syndrome. Presence of metabolic syndrome was not associated with severity and duration of psoriasis. Female patients with psoriasis were more frequently having metabolic syndrome.</p><strong>Conclusions:</strong> Prevalence of metabolic syndrome is higher in patients with psoriasis irrespective of its duration and severity. This stresses on the need of regular evaluation for the presence of MetS or any of its components in psoriasis patients so as to allow early detection and management.

scholarly journals Dermoscopic Characteristics of Melasma in Indians: A Cross-sectional Study

2017 ◽  
Vol 1 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Manas Chatterjee ◽  
Shekhar Neema
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Number Of Patients ◽  
Effect Of Therapy ◽  
Pigmentary Pattern

ABSTRACT Introduction The aim of this study was to assess the various dermoscopic features of melasma in Indian population. Materials and methods A total of 100 cases of clinically diagnosed melasma and 50 controls without melasma or any other facial pigmentation were studied dermoscopically at a tertiary care center in Eastern India. The various described relevant patterns of pigmentation on dermoscopy were recorded. Similar patterns were also looked for in the control population and the two compared. Statistical analysis was done with Fisher's exact test and a p-value of <0.05 was considered statistically significant. Results Cases consisted of 75 females and 25 males with an average age of 36 years as against an average age of 35 years for controls. Of the various patterns of pigmentation, reticuloglobular pigmentation was statistically significant in association with melasma (p < 0.0001). The unpatterned patchy brown black pigment was also significantly associated with melasma as compared to controls (p - 0.0346). A granular pigmentary pattern was also shown to be significantly associated with a diagnosis of melasma (p - 0.0123). Telangiectasia was seen more frequently in patients as compared to controls (p - 0.0327). Perifollicular brown black globules were not significantly correlated with a diagnosis of melasma. More than one pattern was present in a number of patients. Conclusion Dermoscopy of melasma can be used for diagnosis, prognosis, and response or adverse effect of therapy. Study limitations Lack of direct correlation with histopathology and inclusion of therapy naïve as well as patients on therapy were major limitations of this study. How to cite this article Neema S, Chatterjee M. Dermoscopic Characteristics of Melasma in Indians: A Cross-sectional Study. Int J Dermoscop 2017;1(1):6-10.

scholarly journals Common menstrual disorders in adolescent girls attending a tertiary care center

2020 ◽  
Vol 9 (3) ◽  
pp. 1164
Author(s):  
Hibina K. P. ◽  
Nishi Roshini K. ◽  
Andrews M. A.
Keyword(s):  
Adolescent Girls ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Tertiary Care Center ◽  
Menstrual Disorders ◽  
Cross Sectional ◽  
Medical College ◽  
Medical Disorders

Background: Menstrual disorders are an important cause of concern among adolescent girls. Most problems are physiological but few have underlying pathology which has adverse effect on the future reproductive health Aim of the study was to know the prevalence and to evaluate the underlying cause of the menstrual problems in adolescent girls seeking medical care.Methods: This is a cross sectional study conducted in in 215 adolescent girls aged 13-19 years who sought medical care over a period of 12 months for menstrual complaints from the department of obstetrics and gynecology, Govt. Medical College, Thrissur, a tertiary care center in middle of Kerala, South India. Data was analyzed by SPSS software and p value <0.05 was taken statistically significant.Results: Dysmenorrhea was the most common problem (57.5%), followed by scanty menstruation (35.35%) and 25.2% of girls suffered from premenstrual symptoms. Hypothyroidism was seen in 2.4% of girls 40% were anemic. Statistically significant association was found between hypothyroidism and features of hyperandrogenemia with cycle irregularity. Ultrasonographic evidence of polycystic ovarian morphology was identified among 61.9% girls with irregular cycles.Conclusions: Even though majority of menstrual issues are self-limiting proper evaluation and follow up for medical disorders like hypothyroidism and anemia are important and appropriate intervention is crucial for future reproductive and general health of adolescents presenting with Menstrual disorders.

scholarly journals A Cross-Sectional Study of Thyroid Dysfunction in Patients Suffering from Liver Cirrhosis in a Tertiary Care Hospital in Bengaluru, India

2021 ◽  
Vol 09 (23) ◽  
pp. 1904-1908
Author(s):  
Vishal M. Kalmani ◽  
Madhuvan H.S ◽  
Ravishankar S.N. ◽  
Thimmareddy S.R ◽  
Kavana M
Keyword(s):  
Liver Cirrhosis ◽  
Thyroid Hormone ◽  
Thyroid Dysfunction ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Thyroid Abnormalities

BACKGROUND Thyroid abnormalities are seen in most of the patients suffering from liver cirrhosis. Cirrhosis of the liver is the major cause of morbidity and mortality worldwide. Cirrhosis plays a vital role in the thyroid hormone metabolism and thyroid hormone circulation by producing thyroid binding globulin. Hence, it is seen that the thyroid dysfunction is associated with the severity of liver disease. We wanted to study the changes in the levels of thyroid hormones in patients suffering from alcoholic liver cirrhosis. METHODS In this cross-sectional study, 50 patients who were admitted to the IP department and ICU of General Medicine Department of Akash Hospital, Devanahalli, for symptoms of cirrhosis of liver were evaluated for their thyroid profile along with other relevant investigations. RESULTS Among the 50 patients studied, 43 were male and 7 were female. 17 patients had an increase in their thyroid stimulating hormone (TSH). These patients also had a significant association with various LFT parameters such as indirect bilirubin, AST, ALT, APS, and GGT. These 17 patients who had increase in TSH also had associated hepatic complications such as - jaundice (41 %), hepatic encephalopathy (35.29 %), bleeding varices (29.4 %), and portal hypertension (82.35 %). CONCLUSIONS Thyroid abnormalities are not uncommon in patients with cirrhosis. Hypothyroidism is the most common abnormality that was detected. Rate of complications is also high in patients with elevated levels of TSH. A fair amount of suspicion is required for detecting thyroid abnormalities in patients suffering from cirrhosis. KEYWORDS Cirrhosis, Thyroid Hormone, Hypothyroidism, Hyperthyroidism, Thyroiditis

Association between metabolic syndrome and thyroid stimulating hormone - A cross sectional study

2019 ◽  
Vol 9 (2) ◽  
pp. 87-90
Author(s):  
Karanam Madhuri ◽  
◽  
Rishi Kumar Venkatachalam ◽  
A Nasreen Begum ◽  
Shamsheer Khan P ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stimulating Hormone

Prehospital Intubations Are Associated with Elevated Endotracheal Tube Cuff Pressures: A Cross-Sectional Study Characterizing ETT Cuff Pressures at a Tertiary Care Emergency Department

2021 ◽  
pp. 1-4
Author(s):  
Ruo S. Chen ◽  
Laurel O’Connor ◽  
Matthew R. Rebesco ◽  
Kara L. LaBarge ◽  
Edgar J. Remotti ◽  
...  
Keyword(s):  
Endotracheal Tube ◽  
Cuff Pressure ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Endotracheal Tube Cuff ◽  
Cross Sectional ◽  
Tube Cuff ◽  
Respiratory Therapists ◽  
Significant Difference

Abstract Introduction: Emergency Medical Services (EMS) providers are trained to place endotracheal tubes (ETTs) in the prehospital setting when indicated. Endotracheal tube cuffs are traditionally inflated with 10cc of air to provide adequate seal against the tracheal lumen. There is literature suggesting that many ETTs are inflated well beyond the accepted safe pressures of 20-30cmH2O, leading to potential complications including ischemia, necrosis, scarring, and stenosis of the tracheal wall. Currently, EMS providers do not routinely check ETT cuff pressures. It was hypothesized that the average ETT cuff pressure of patients arriving at the study site who were intubated by EMS exceeds the safe pressure range of 20-30cmH2O. Objectives: While ETT cuff inflation is necessary to close the respiratory system, thus preventing air leaks and aspiration, there is evidence to suggest that over-inflated ETT cuffs can cause long-term complications. The purpose of this study is to characterize the cuff pressures of ETTs placed by EMS providers. Methods: This project was a single center, prospective observational study. Endotracheal tube cuff pressures were measured and recorded for adult patients intubated by EMS providers prior to arrival at a large, urban, tertiary care center over a nine-month period. All data were collected by respiratory therapists utilizing a cuff pressure measurement device which had a detectable range of 0-100cmH2O and was designed as a syringe. Results including basic patient demographics, cuff pressure, tube size, and EMS service were recorded. Results: In total, 45 measurements from six EMS services were included with ETT sizes ranging from 6.5-8.0mm. Mean patient age was 52.2 years (67.7% male). Mean cuff pressure was 81.8cmH2O with a range of 15 to 100 and a median of 100. The mode was 100cmH2O; 40 out of 45 (88.9%) cuff pressures were above 30cmH2O. Linear regression showed no correlation between age and ETT cuff pressure or between ETT size and cuff pressure. Two-tailed T tests did not show a significant difference in the mean cuff pressure between female versus male patients. Conclusion: An overwhelming majority of prehospital intubations are associated with elevated cuff pressures, and cuff pressure monitoring education is indicated to address this phenomenon.

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