scholarly journals Normative Data for Median Nerve Conduction in Healthy Young Adults from Punjab, India

2017 ◽  
Vol 08 (S 01) ◽  
pp. S083-S088
Author(s):  
Manjinder Singh ◽  
Sharat Gupta ◽  
Kamal Dev Singh ◽  
Avnish Kumar
Keyword(s):  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Normative Data ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Standardized Protocol ◽  
Conduction Velocities

ABSTRACT Background: Nerve conduction studies (NCSs) are essential for diagnosing various kinds of focal and diffuse neuropathies. Due to the paucity of local NCS data, electrodiagnostic laboratories in Punjab rely on values from Western and other Indian studies. Aim: This study was conducted to provide normative data for median nerve conduction parameters (motor and sensory) in Punjabi populace. Materials and Methods: A cross-sectional study was done on 290 participants (150 males and 140 females), aged 17–21 years, as per standardized protocol. The data were analyzed separately for both genders using SPSS version 20. It consisted of distal latencies and conduction velocities of motor and sensory divisions of median nerve. Student's unpaired t-test was used for statistical analysis. Results: There was no effect of gender on any of the median nerve conduction parameters. Height and weight had nonsignificant negative and positive correlation, respectively (P > 0.05), with conduction velocity in both motor and sensory median nerves. For median motor nerve, the values of distal latency and conduction velocity in males were 2.9 ± 0.16 ms and 60.25 ± 2.99 m/s, respectively, whereas, in females, they were 2.6 ± 0.43 ms and 59.83 ± 2.82 m/s. Similarly, for median sensory nerve, the latency and velocity values in males were 2.8 ± 0.56 ms and 54.81 ± 3.70 m/s, whereas, in females, they were 2.4 ± 0.33 ms and 54.56 ± 3.65 m/s, respectively. Conclusion: The data in this study compared favorably with already existing data. It would help the local electrodiagnostic laboratories in assessing the median nerve abnormalities with greater accuracy in this population subset.

scholarly journals Normal neurophysiologic parameters of the median nerve among adult healthy Sudanese population

2020 ◽  
Vol 10 (4) ◽  
pp. 136-141
Author(s):  
Mohammed Salah Elmagzoub ◽  
Ahmed Hassan Ahmed ◽  
Hussam M A Hameed
Keyword(s):  
Action Potential ◽  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Peak Latency ◽  
Muscle Action Potential ◽  
Sensory Nerve Action

Background: Nerve conduction studies (NCSs) help in delineating the extent distribution of neural lesion, and the diagnosis of peripheral nerve disorders. Because normative nerve conduction parameters were not yet established in Sudan EMG laboratories, this study aims towards having our own reference values, as we are using the American and British parameters. This will allow avoiding the discrepancies that might be induced by many factors. Methods: NCSs were performed in 200 Median nerves of 100 adult healthy Sudanese subjects using standardized techniques. Results: The median SNAP (sensory nerve action potential) values were as follows: distal latency, 2.6±3 ms with a range of (2.3-2.9); peak latency, 3.5±0.5 ms (3.0-4.0); amplitude, 47.7±18.0μV (29.7-65.7); conduction velocity, 53.0±7.8 m/s (45.2-60.8). The following values were obtained for the Median nerve CMAP (compound muscle action potential) at wrist stimulation: distal latency, 3.5±0.5 ms with a range of (3.0-4.0); peak latency, 9.4± 1.0 ms (8.4-10.4); duration, 5.9±0.9 ms (5.0-6.8); amplitude, 12.3±2.5 mV (9.8-14.8); area, 43.0±10.4 mVms (32.6-53.4); conduction velocity, 63.6±6.2 m/s (57.4-69.8). The F wave was 28.4±1.8 ms (26.6-30.2). Conclusion: The overall mean sensory and motor nerve conduction parameters for the tested nerve compared favorably with the existing literature with some discrepancies that were justified.

scholarly journals Reference Values of Sensory and Motor Nerve Conduction for Patients of a Fourth Level Hospital in Bogotá, Colombia

2020 ◽  
Vol 61 (4) ◽  
Author(s):  
Carolina García Alfonso ◽  
Nancy Molina ◽  
Sonia Patricia Millán Pérez
Keyword(s):  
Median Nerve ◽  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Peroneal Nerve ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Motor Nerve Conduction ◽  
Significant Difference

Objective: To establish normal values of motor and sensory nerve conductions and late responses for the electrodiagnostic laboratory of the hospital universitario San Ignacio. Materials and Methods: Sensory and motor nerve conduction studies were performed on 77 healthy volunteers between 18 and 65 years old, for a total of 154 analyzes, using a standardized technique for measurement. Results: Motor nerve conduction. For the median nerve the latency ≤4.2ms, amplitude ≥3.1mV and conduction velocity ≥50.8m/s. In the ulnar nerve the latency ≤3.6ms, amplitude ≥4.6mV and conduction velocity ≥49m/s. Tibial nerve latency ≤4.4ms, amplitude ≥5mV and conduction velocity ≥41m/s. Peroneal nerve latency ≤4.8ms, amplitude ≥1.6mV and conduction velocity ≥42m/s. Sensory nerve conduction. For the median nerve the latency ≤2.8ms and conduction velocity ≥45m/s. In the ulnar nerve the latency ≤2.7ms and conduction velocity ≥46m/s. Sural nerve latency ≤2.2ms and conduction velocity ≥41m/s. A Shapiro Wilk test was performed, finding that the amplitude parameters for sensory nerve conductions did not follow a normal distribution, so percentile analysis was performed. Only sex showed a statistically significant difference for the parameters of tibial nerve amplitude (p = 0.0099) being greater in women, and latency of the peroneal nerve (p = 0.0091) being greater in men. Conclusion: Normal parameters were established for motor and sensory nerve conductions and late responses for the electrodiagnostic laboratory of the hospital universitario San Ignacio, which mostly correlate with the current reference data, with certain differences that could be related with height and sex, however, additional studies are required to establish this difference.

P0267CLINICAL MANIFESTATIONS, PREVALENCE AND PREDICTORS OF PERIPHERAL NEUROPATHY IN NON DIABETIC CHRONIC KIDNEY DISEASE PATIENTS. A CROSS SECTIONAL STUDY FROM TERTIARY CARE CENTRE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
D PRABHAKAR ◽  
Satya kumar Kothakota ◽  
Umashankar Mishra
Keyword(s):  
Peripheral Neuropathy ◽  
Nerve Conduction ◽  
Motor Nerve ◽  
Serum Magnesium ◽  
Sensory Nerve ◽  
Cross Sectional Study ◽  
Serum Phosphorus ◽  
Motor Neuropathy ◽  
Cross Sectional ◽  
Duration Of Disease

Abstract Background and Aims There is a progressive increase in the prevalence of chronic kidney disease (CKD). The impairment of functions of kidney secondary to CKD leads to uraemia. Peripheral neuropathy is one of the common manifestations of uraemia. The present study focuses on the prevalence, clinical manifestations and predictors of peripheral neuropathy in patients with non-diabetic CKD. Method This was a cross sectional study conducted in the Department of General Medicine, Maharaja Krishna Chandra Gajapathi Medical College and Hospital, Berhampur, Odisha, India from October 2015 to October 2017. Patients with serum creatinine >2 mg/dl, estimated glomerular filtration rate <60 ml/min (calculated by using Modification of Diet in Renal Disease equation), kidney size < 8.5cm on ultrasound abdomen were included in the study and patients with age less than 18 years, patients with diabetes mellitus and other recognizable risk factors for peripheral neuropathy (Alcoholism, Drugs, Connective tissue disorders, Sarcoidosis, Vasculitis, Thyroid dysfunction, HIV, Hansen’s disease, Paraneoplastic disease etc.) and patients on dialysis were excluded. Peripheral neuropathy was assessed by both clinical methods and nerve conduction studies (NCS). Reduced motor nerve conduction velocity, delayed distal latency, fall in the amplitude of compound muscle action potential on Motor Nerve Conduction Study (MNCS) and delay in the peak latencies, reduced sensory nerve action potential on Sensory Nerve Conduction study (SNCS) were considered as evidence for peripheral neuropathy. From upper limb, median nerve and ulnar nerve were selected for MNCS and SNCS. From lower limb, common peroneal and posterior tibial nerves were selected for MNCS and sural nerve was selected for SNCS. Results Total 109 patients were included in the study and 75(68.8%) were proved to have peripheral neuropathy. Majority of the affected patients were in 40 to 50 years age group (n=24;32%). Forty four of 75 (58.6%) were males and 31(41.33%) were females. Patients with both sensory and motor neuropathy were 35(32.1%), 26(23.9%) were affected with only sensory neuropathy, while 14(12.8%) were affected with only motor neuropathy. Patients with clinical neuropathy (patients who have clinical symptoms and signs of neuropathy and also evidence on NCS) were 35(46.6%) and with subclinical neuropathy (only evident on NCS) were 40(53.3%).On univariate analysis, age (p-0.015), hypertension (p-0.031), duration of disease (p<0.0001), serum creatinine (p<0.0001), eGFR (p<0.0001), serum uric acid (p<0.0001), serum parathyroid (p<0.0001), serum phosphorus (p<0.0001), serum calcium (p-0.0003), serum magnesium (p-0.0002) and serum potassium (p-0.0028) were significantly correlated with peripheral neuropathy however on logistic regression analysis, sex [OR-0.058;95%CI(0.004-0.831)], serum parathyroid hormone [OR-1.032;95%CI(2.708-6043.5)], serum phosphorus[OR3.881;95%CI(1.114-13.524)], serum magnesium [OR-127.28;95%CI(0.901-1.113)] and duration of CKD[OR1.109;95%CI(1.005-1.224)] were shown to be independent predictors. Conclusion Peripheral neuropathy is one of the frequent complications of uremia. Subclinical presentation is most common. Serum parathyroid, serum phosphorus, serum magnesium and duration of disease are independent predictors of uremia induced peripheral neuropathy

scholarly journals Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study

2021 ◽  
Vol 9 (1) ◽  
pp. e001698
Author(s):  
Haifa Maalmi ◽  
Kristiaan Wouters ◽  
Hans H C M Savelberg ◽  
Jeroen H P M van der Velde ◽  
Jos P H Reulen ◽  
...  
Keyword(s):  
T Cells ◽  
Adaptive Immunity ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Essential Feature ◽  
Sensory Nerve ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Innate And Adaptive Immunity

IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.

Maximum Motor Nerve Conduction Velocity in XYY Males

1973 ◽  
Vol 45 (3) ◽  
pp. 337-345
Author(s):  
M. O. Wright
Keyword(s):  
General Population ◽  
Median Nerve ◽  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Motor Nerve ◽  
Control Groups ◽  
Motor Nerve Conduction ◽  
Significant Prolongation ◽  
Hospital Group

1. Maximum motor nerve conduction velocities were determined under standard conditions for the median and ulnar nerves in the right forearm in males: (a) from the general population, (b) from a subnormality hospital, and (c) in males with the XYY sex chromosome abnormality. Distal latencies for these nerves were also measured. 2. No significant differences in maximum peripheral motor nerve conduction were found between the two control populations from the general population and from the subnormality hospital. 3. The maximum motor conduction velocity in the median nerve in the XYY group was significantly slowed when compared with both control groups. In the case of the ulnar nerve, maximum motor conduction was significantly slowed when compared with the general population, but not when compared with the subnormality hospital group. 4. There were no significant differences in the mean distal latencies of either the median or ulnar nerves between the two control groups. 5. In the XYY group, the distal latency in the ulnar nerve was significantly prolonged when compared with both control groups. In the case of the median nerve, the distal latency was prolonged significantly when compared with the general population; when the comparison was made with the subnormality hospital group significant prolongation was also observed but was less marked.

scholarly journals Nerve Conduction Velocity in Smokers and Gutka Chewers: A Case-control Study

2021 ◽  
Author(s):  
Bipin Kumar ◽  
Meenakshi Gupta
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Case Control Study ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Case Control ◽  
P Value ◽  
Age Group ◽  
Control Study

Introduction: Chemicals that are present in cigarette/bidi smoke and gutka have been known to cause subclinical changes in myelin sheaths of peripheral nerves. Despite the antiquity and popularity of smoking and gutka chewing, its effect has not been investigated systematically in young adults. Aim: To investigate the chronic effects of smoking and gutka chewing on Nerve Conduction Velocity (NCV). Materials and Methods: The case-control study was conducted in the Department of Physiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, from November 2018 to December 2020. A 40 male smokers (age group 20-60 years), 40 gutka chewers (age group 20-60 years) along with 40 age matched healthy male controls. The nerve conduction study was performed by using fully computerised Electromyography (EMG) and NCV machine. Sensory Nerve Conduction Velocity (SNCV) and Motor Nerve Conduction Velocity (MNCV) test of median and ulnar nerves was performed on subjects. Data was analysed by using unpaired t-test. Results: In this study of comparative analysis of total 120 subjects, [40 controls and 80 cases (40 cases of smokers and tobacco chewers each)], statistically significant changes (p-value <0.05) were found in the sensory NCV of both the nerves and motor NCV of median nerve in smokers whereas no such changes were found in motor NCV of both nerves in gutka chewers. Conclusion: It can be concluded that smoking causes more reduction in NCV than gutka chewing.

scholarly journals Effect of Hand Held Vibrating Tools on Nerve Conduction Study in Dental Residents

2020 ◽  
Vol 17 (4) ◽  
pp. 451-455
Author(s):  
Rekha Limbu ◽  
Dilip Thakur ◽  
Nirmala Limbu ◽  
Prakash Parajuli ◽  
Shivalal Sharma ◽  
...  
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Cross Sectional Study ◽  
Medical Residents ◽  
P Value ◽  
Cross Sectional ◽  
Repetitive Exposure ◽  
Significant Difference ◽  
Nerve Dysfunction

Background: Repetitive exposure to vibration has been shown to induce peripheral nerve dysfunction. Dentists are exposed to handheld vibrating tools in their daily clinical practice. Most of the studies are done in dentists who have symptoms such as paresthesia and numbness of the hands. Thus, we conducted the study to explore the effect of vibration on nerve conduction variables in apparently healthy asymptomatic dental residents. Methods: This cross-sectional study enrolled 22 dental residents and age matched 22 medical residents as controls. Nerve conduction study was performed in median and ulnar nerves of both hands. Results: Anthropometric and cardiorespiratory variables were comparable between the groups. There were no statistically significant differences between dental and medical residents in the sensory conduction variables (right median onset latency=2.05±0.27 vs 1.91±0.21, p value=0.07; right median amplitude =27.80±8.11 vs 29.55±7.04, p=0.45; right median conduction velocity = 59.54±7.05 vs 61.06±5.15, p= 0.42) and motor conduction variables (right median distal latency = 2.87±0.38 vs 2.87±0.38, p= 0.94; right median distal amplitude=10.71±2.19 vs 11.10±2.37, p=0.58; right median conduction velocity= 70.57±13.16 vs 68.53±7.73, p= 0.54) of median and ulnar nerves. Further, there was no significant difference between the dominant and non-dominant hands of dental residents. Conclusions: Hand held vibration tools did not alter nerve conduction study parameters of dental residents. Keywords: Dentists; nerve conduction study; vibration.

scholarly journals Comparing the Diagnostic Accuracy of Simple Tests to Screen for Diabetic Peripheral Neuropathy: Protocol for a Cross-Sectional Study (Preprint)

2017 ◽  
Author(s):  
Kate Goddard ◽  
Prashanth Vas ◽  
Alistair Purves ◽  
Viktoria McMillan ◽  
Thomas Langford ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diagnostic Accuracy ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Velocity Measurement ◽  
Sural Nerve ◽  
Nerve Conduction Velocity ◽  
Cross Sectional Study ◽  
Cross Sectional

BACKGROUND Various tests are used to detect diabetic peripheral neuropathy by assessing sense perception in the feet. Tests vary in terms of time and resources required. Simple tests are those that can be conducted quickly and easily in primary care without laboratory equipment. There are some limitations to these simple tests, an example being the variable amplitude of the 128 Hz tuning fork. A new test, VibraTip (McCallan Medical, UK), might be a valuable alternative as it emits a consistent amplitude and may offer improved diagnostic accuracy. OBJECTIVE The aims of this study are to estimate the diagnostic accuracy of the VibraTip device for diabetic peripheral neuropathy against the reference standard of sural nerve conduction velocity measurement, and to assess whether the VibraTip offers superior diagnostic accuracy to other routine tests based on vibration or touch. METHODS The study will prospectively recruit adults with type 2 diabetes who are due to attend a routine follow-up clinic. A cross-sectional study design will be employed to assess the diagnostic accuracy of 5 standard index tests for peripheral neuropathy, including VibraTip. The reference test will be sural nerve conduction velocity measurement. RESULTS Funding is being sought to conduct this research. The outcomes assessed will be the diagnostic accuracy of the 5 index tests against sural nerve conduction velocity measurement, including sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio. Receiver operating characteristic curves will be constructed and compared for each test. CONCLUSIONS This study will be the first within-study comparison of 5 simple tests for screening diabetic peripheral neuropathy and will address uncertainties in the potential benefits of using VibraTip in comparison with the other tests.

scholarly journals Role of Electro-Diagnostic Tests In Early Detection of Diabetic Neuropathy

1970 ◽  
Vol 24 (1) ◽  
pp. 34-44
Author(s):  
Zahed Ali ◽  
Maliha Hakim ◽  
Monirul Islam ◽  
Nirmalendu Bikash Bhowmik ◽  
Shamsun Nahar ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Action Potential ◽  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Sensory Nerve ◽  
Diabetic Patients ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action

Since the peripheral nerve has the ability to regenerate, therapeutic intervention at earlier stages expected to have a better result in the treatment of diabetic neuropathy. So early detection of diabetic neuropathy is one of the major goals in its management. Purpose: The purpose of present study is to evaluate the efficacy of the electrodiagnostic tests to detect diabetic neuropathy at an early stage (before development of the signs of neuropathy). Method: 30 diabetic patients with or without symptoms of diabetic neuropathy were included in the test group. Diabetic patients with signs of neuropathy and with other complications, like stroke, peripheral vascular diseases were excluded. Twenty six control subjects (non-diabetic with no family history of diabetes) were included. Both the groups were matched for age. To see the functional status of peripheral nerves motor nerve conduction velocity (NCV), compound muscle action potentials (CAMP) of median nerve were studied. Sensory nerve conduction velocities (NCV), and sensory nerve action potential (SNAP) of median and sural nerves were also measured. Results: Sensory nerve conduction velocity of sural nerve was significantly slowed (43.84±8.23 vs 48.23±5.03 m/sec, p < .05) in diabetic patients. Sural sensory nerve action potential has lower in amplitude (13.31±7.03 vs 14.24±4.714 mv, p<.3) in diabetic patients. Median sensory nerve conduction velocity did show difference (50.89+8.23 vs 57.17±6.67 m/s, p < .01) and median sensory nerve action potential has significantly lower in amplitude (3.86±1.016 vs 7.39±4.79, p < .001) in diabetic patients. No significant difference was found in median nerve motor conduction velocity between the two groups of subjects. Amplitude of compound muscle action potential of median nerve also shows no significant variations.Considering mean±SD value of conduction parameter as the cut off value, sural nerve sensory conduction velocity was found slowed in 8 diabetic subjects (26%). Sural nerve sensory action potential was of lower amplitude in 12 diabetic subjects (40%). Eleven diabetic subjects (36%) had lower amplitude for median sensory nerve action potential (SNAP). For compound muscle action potential (CAMP) and sensory nerve action potential (SNAP) half the mean value of control was the cut off point. Conclusion: The result suggests that in diabetic patients of Bangladesh with or without symptoms of neuropathy, abnormalities of nerve conduction parameters can be detected early by routine electrodiagnostic monitoring. Sensory nerve conduction parameters are affected more than motor ones. Amplitude abnormalities are slightly more common than conduction velocity or latency abnormalities for sensory studies. Lower extremity nerves were affected more. Sural median nerve has the highest abnormalities in diabetic patients with early neuropathy. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3038 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) :34-44

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