scholarly journals Overactive bladder: Shortage of good medicine and potential role of traditional Chinese medicine

2018 ◽  
Vol 29 (5) ◽  
pp. 215
Author(s):  
StephenShei-Dei Yang
Author(s):  
Qiao Zhang ◽  
Shijun Yue ◽  
Wenxiao Wang ◽  
Yanyan Chen ◽  
Chongbo Zhao ◽  
...  

The coronavirus disease 2019 (COVID-19) spreads and rages around the world and threatens human life. It is disappointing that there are no specific drugs until now. The combination of traditional Chinese medicine (TCM) and western medication seems to be the current more effective treatment strategy for COVID-19 patients in China. In this review, we mainly discussed the relationship between COVID-19 and gut microbiota (GM), as well as the possible impact of TCM combined with western medication on GM in the treatment of COVID-19 patients, aiming to provide references for the possible role of GM in TCM against COVID-19. The available data suggest that GM dysbiosis did occur in COVID-19 patients, and the intervention of GM could ameliorate the clinical condition of COVID-19 patients. In addition, TCMs (e.g., Jinhua Qinggan granule, Lianhua Qingwen capsule, Qingfei Paidu decoction, Shufeng Jiedu capsule, Qingjin Jianghuo decoction, Toujie Quwen granules, and MaxingShigan) have been proven to be safe and effective for the treatment of COVID-19 in Chinese clinic. Among them, Ephedra sinica, Glycyrrhiza uralensis, Bupleurum chinense, Lonicera japonica,Scutellaria baicalensi, and Astragalus membranaceus are common herbs and have a certain regulation on GM, immunity, and angiotensin converting enzyme 2 (ACE2). Notably, Qingfei Paidu decoction and MaxingShigan have been demonstrated to modulate GM. Finally, the hypothesis of GM-mediated TCM treatment of COVID-19 is proposed, and more clinical trials and basic experiments need to be initiated to confirm this hypothesis.


2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.


2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Renjie Zhou ◽  
Hongxing Zhang

Cough is a common clinical symptom, throughout history the medical experts have different discussions on the diagnosis and treatment of cough and put forward different theories on the treatment of cough. Chief physician Zhang Hongxing is a famous old doctor of traditional Chinese medicine in Dezhou city with rich experience in clinical practice and unique academic thoughts. In the treatment of exogenous cough, Director Zhang stressed that the differentiation of syndromes should be focused on ‘wind’ and pay attention to the role of liver ‘wind’ in cough. The prescription of medicines should emphasize on dispelling the ‘wind’ first, to dispel the external ‘wind’, but also to calm the internal ‘wind’, and making good use of Uncaria in medicine. Valuable experience for clinical diagnosis and treatment of exogenous cough was provided.  


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