Potential Role of Gut Microbiota in Traditional Chinese Medicine against COVID-19

2021 ◽  
pp. 1-19
Author(s):  
Qiao Zhang ◽  
Shijun Yue ◽  
Wenxiao Wang ◽  
Yanyan Chen ◽  
Chongbo Zhao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Potential Role ◽  
Human Life ◽  
Angiotensin Converting Enzyme 2 ◽  
Ephedra Sinica ◽  
The Relationship ◽  
Basic Experiments

The coronavirus disease 2019 (COVID-19) spreads and rages around the world and threatens human life. It is disappointing that there are no specific drugs until now. The combination of traditional Chinese medicine (TCM) and western medication seems to be the current more effective treatment strategy for COVID-19 patients in China. In this review, we mainly discussed the relationship between COVID-19 and gut microbiota (GM), as well as the possible impact of TCM combined with western medication on GM in the treatment of COVID-19 patients, aiming to provide references for the possible role of GM in TCM against COVID-19. The available data suggest that GM dysbiosis did occur in COVID-19 patients, and the intervention of GM could ameliorate the clinical condition of COVID-19 patients. In addition, TCMs (e.g., Jinhua Qinggan granule, Lianhua Qingwen capsule, Qingfei Paidu decoction, Shufeng Jiedu capsule, Qingjin Jianghuo decoction, Toujie Quwen granules, and MaxingShigan) have been proven to be safe and effective for the treatment of COVID-19 in Chinese clinic. Among them, Ephedra sinica, Glycyrrhiza uralensis, Bupleurum chinense, Lonicera japonica,Scutellaria baicalensi, and Astragalus membranaceus are common herbs and have a certain regulation on GM, immunity, and angiotensin converting enzyme 2 (ACE2). Notably, Qingfei Paidu decoction and MaxingShigan have been demonstrated to modulate GM. Finally, the hypothesis of GM-mediated TCM treatment of COVID-19 is proposed, and more clinical trials and basic experiments need to be initiated to confirm this hypothesis.

The impact of Traditional Chinese Medicine on mitophagy in disease models

2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanisms ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Disease Models ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.

Ethnobotany

2022 ◽  
pp. 270-291
Author(s):  
Akash ◽  
Navneet ◽  
Bhupendra Singh Bhandari ◽  
Surendra Singh Bisht ◽  
Dalip Kumar Mansotra
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Traditional Medicine ◽  
Recent Time ◽  
Ethnomedicinal Plants ◽  
Traditional Medicines ◽  
Relationship Of ◽  
The Relationship

Traditional medicines and natural products from ethnomedicinal plants have great significance in recent time. Various forms of medicines like Ayurveda, traditional Chinese medicine, kampo, Unani, have been plasticising in recent days due to their effectiveness against various human ailments and also have blossomed into the regulated systems of traditional medicine. This chapter reviews the relationship of plants and humans, along with their cultural relationship and role of the traditional medicines, by exploring the methodologies and various concepts for the discovery of various drugs. Further, this will also illustrate traditional medicines that have their incomparable advantages over the modern allopathic medicines.

Ethnobotany

2020 ◽  
pp. 38-57
Author(s):  
Akash ◽  
Navneet ◽  
Bhupendra Singh Bhandari ◽  
Surendra Singh Bisht ◽  
Dalip Kumar Mansotra
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Traditional Medicine ◽  
Recent Time ◽  
Ethnomedicinal Plants ◽  
Traditional Medicines ◽  
Relationship Of ◽  
The Relationship

Traditional medicines and natural products from ethnomedicinal plants have great significance in recent time. Various forms of medicines like Ayurveda, traditional Chinese medicine, kampo, Unani, have been plasticising in recent days due to their effectiveness against various human ailments and also have blossomed into the regulated systems of traditional medicine. This chapter reviews the relationship of plants and humans, along with their cultural relationship and role of the traditional medicines, by exploring the methodologies and various concepts for the discovery of various drugs. Further, this will also illustrate traditional medicines that have their incomparable advantages over the modern allopathic medicines.

scholarly journals A Correlation among the COVID-19 Spread, Particulate Matters, and Angiotensin-Converting Enzyme 2: A Review

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Zafran Khan ◽  
Daniya Ualiyeva ◽  
Asaf Khan ◽  
Nasib Zaman ◽  
Sanjeep Sapkota ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Potential Role ◽  
Lung Cells ◽  
Particulate Matters ◽  
Converting Enzyme ◽  
Long Distance ◽  
Angiotensin Converting Enzyme 2 ◽  
The Cost ◽  
The Relationship

Air pollution (AP) is one of the leading causes of health risks because it causes widespread morbidity and mortality every year. Its impact on the environment includes acid rain and decreased visibility, but more importantly, it also has an impact on human health. The rise of COVID-19 demonstrates the cost of failing to manage AP. COVID-19 can be spread through the air, and atmospheric particulate matters (PMs) can create a good atmosphere for the long-distance spread of the virus. Moreover, these PMs can cause lung cell inflammation, thereby increasing sensitivity and the severity of symptoms in COVID-19 patients. In this study, we emphasized the potential role of PMs in the spread of COVID-19. The relationship among COVID-19, PMs, and angiotensin-converting enzyme 2 (ACE2) (receptor involved in virus entry into lung cells and inflammation) was also summarized.

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

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