scholarly journals Literature–Based Discovery of Salivary Biomarkers for Type 2 Diabetes Mellitus

2015 ◽  
Vol 10 ◽  
pp. BMI.S22177 ◽  
Author(s):  
Mythily Srinivasan ◽  
Corinne Blackburn ◽  
Mohamed Mohamed ◽  
A.V. Sivagami ◽  
Janice Blum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Proteins ◽  
Serum Markers ◽  
Salivary Biomarkers ◽  
Mesh Terms ◽  
Pubmed Database ◽  
Literature Based Discovery

The alarming increase in type 2 diabetes mellitus (T2DM) underscores the need for efficient screening and preventive strategies. Select protein biomarker profiles emerge over time during T2DM development. Periodic evaluation of these markers will increase the predictive ability of diabetes risk scores. Noninvasive methods for frequent measurements of biomarkers are increasingly being investigated. Application of salivary diagnostics has gained importance with the establishment of significant similarities between the salivary and serum proteomes. The objective of this study is to identify T2DM–specific salivary biomarkers by literature–based discovery. A serial interrogation of the PubMed database was performed using MeSH terms of specific T2DM pathological processes in primary and secondary iterations to compile cohorts of T2DM–specific serum markers. Subsequent search consisted of mining for the identified serum markers in human saliva. More than 60% of T2DM–associated serum proteins have been measured in saliva. Nearly half of these proteins have been reported in diabetic saliva. Measurements of salivary lipids and oxidative stress markers that can exhibit correlated saliva plasma ratio could constitute reliable factors for T2DM risk assessment. We conclude that a high percentage of T2DM–associated serum proteins can be measured in saliva, which offers an attractive and economical strategy for T2DM screening.

scholarly journals Serum markers of bone fragility in type-2 diabetes mellitus

2019 ◽  
pp. 78-85
Author(s):  
Rucsandra Miulescu ◽  
Loreta Guja ◽  
Lavinia Ochiana ◽  
Anca Ungurianu ◽  
Oana Șeremet ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Fragility ◽  
Serum Markers

Differential proteome analysis of serum proteins associated with the development of type 2 diabetes mellitus in the KK-Ay mouse model using the iTRAQ technique

2013 ◽  
Vol 84 ◽  
pp. 40-51 ◽  
Author(s):  
Eri Takahashi ◽  
Akinori Okumura ◽  
Hiroyuki Unoki-Kubota ◽  
Hisashi Hirano ◽  
Masato Kasuga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Serum Proteins ◽  
Proteome Analysis

scholarly journals KETOSIS MANAGEMENT IN A TYPE 2 DIABETES MELLITUS PATIENT: A NUTRITIONAL APPROACH

2021 ◽  
Vol 10 (6) ◽  
pp. 3840-3842
Author(s):  
Rupali Das
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Level ◽  
Serum Proteins ◽  
Diabetes Mellitus Patient ◽  
High Fiber ◽  
Molecular Events ◽  
Amount Of Knowledge

Ketosis-inclined type 2 diabetes, an insulin deficiency tends to occur in response to constant hyperglycemia auxiliary to insulin resistance. Hyperglycemia will additionally restrict the secretion of insulin, and a few examinations have even shown a decrease of insulin production at the genetic level by restraining transcription of insulin-producing proteins. Here in this study, we detailed a patient having ketosis in Type 2 Diabetes mellitus and observed all require parameter in dietary management. The patient was found ketone positive in initial days. Due to high level of blood sugar and constipation, he was suggested a diabetic fluid diet and high fiber content meal. Initially Glucose level was 187mg/dl and Hb level- 12.5, after the observation with maintain diet the Hb level- 14.5 and Glucose level was >150mg/dl. Serum proteins and albumin were also found in normal range and the patients found ketone negative in later stage. To date, clinical trials have provided evidence of benefits of Keto diets in terms of clinical outcomes. However, the molecular events responsible for these improvements still remain unclear in spite of the high amount of knowledge on the primary mechanisms of both the diabetes and the metabolic state of ketosis.

scholarly journals Type 2 diabetes mellitus with early phase acute inflammatory protein on serum protein electrophoresis

1970 ◽  
Vol 2 (3) ◽  
pp. 211-214 ◽  
Author(s):  
ET Tuladhar ◽  
VK Sharma ◽  
M Sigdel ◽  
L Shrestha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cellulose Acetate ◽  
Serum Proteins ◽  
Protein Electrophoresis ◽  
Glycemic Status ◽  
Cellulose Acetate Electrophoresis ◽  
Inflammatory Status

Background: The onset of Type 2 diabetes has been associated with low grade systemic inflammation. The inflammatory status has been studied by measuring acute phase reactant proteins like hsCRP, α1- antitrypsin, α1-acid glycoprotein, ceruloplasmin, fibrinogen. Most of these acute phase reactants form α1 and α2 bands on electropherogram of serum proteins. The aim of this study was to evaluate inflammatory status in controlled and uncontrolled type 2 diabetes using cellulose acetate electrophoresis and to find the impact of glycemic status as indicated by HbA1c on inflammation process. Materials and Methods: Serum protein electrophoresis was done on serum samples of 60 cases of Diabetes [controlled and uncontrolled] using cellulose acetate paper technique. The electropherogram obtained was stained with Ponseu S and then quantitated using densitometer. Glycemic status was studied by HbA1c analysis. The density of α1and α2 bands in electropherogram were correlated with HbA1c level. Result: A significant increase in the percentage of α1 and α2 band proteins (0.765 and 0.716, p<0.001) were found with the increasing level of HbA1c. With cutoff of HbA1c 7% (American Diabetic Association recommended), the α1 and α2 serum proteins concentration are significantly higher (p<0.001) in uncontrolled diabetes mellitus compared to controlled diabetes mellitus Conclusion: Cellulose acetate electrophoresis of serum proteins show early phase acute inflammatory status in uncontrolled type 2 diabetes mellitus. The process of systemic inflammation worsens with uncontrolled glycemia as indicated by HbA1c. Inflammatory status should be studied adjunct to glycemic status. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6024 JPN 2012; 2(3): 211-214

scholarly journals Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiayue Yang ◽  
Cheng Yang ◽  
Hong Shen ◽  
Wenjun Wu ◽  
Zhen Tian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lung Adenocarcinoma ◽  
Serum Proteins ◽  
Early Stage ◽  
Serum Biomarker ◽  
Ms Analysis ◽  
Increased Risk

Abstract Background Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM patients for the early diagnosis of LAC. Methods The clinical information of hospitalized T2DM patients diagnosed with various cancers was collected by reviewing medical records in Wuxi People’s Hospital Affiliated to Nanjing Medical University from January 1, 2015, to June 30, 2020. To discover diagnostic biomarkers for early-stage LAC in the T2DM population, 20 samples obtained from 5 healthy controls, 5 T2DM patients, 5 LAC patients and 5 T2DM patients with LAC (T2DM + LAC) were subjected to sequential windowed acquisition of all theoretical fragment ion mass spectrum (SWATH-MS) analysis to identify specific differentially-expressed proteins (DEPs) for LAC in patients with T2DM. Then, these results were validated by parallel reaction monitoring MS (PRM-MS) and ELISA analyses. Results Lung cancer was the most common malignant tumor in patients with T2DM, and LAC accounted for the majority of cases. Using SWATH-MS analysis, we found 13 proteins to be unique in T2DM patients with early LAC. Two serum proteins were further validated by PRM-MS analysis, namely, pregnancy-zone protein (PZP) and insulin-like growth factor binding protein 3 (IGFBP3). Furthermore, the diagnostic values of these proteins were validated by ELISA, and PZP was validated as a novel serum biomarker for screening LAC in T2DM patients. Conclusions Our findings indicated that PZP could be used as a novel serum biomarker for the identification of LAC in T2DM patients, which will enhance auxiliary diagnosis and assist in the selection of surgical treatment at an early stage.

scholarly journals Hypertension, Exercises, Physical Therapy and Type 2 Diabetes Mellitus Elderly

2019 ◽  
pp. 1-4
Author(s):  
Vanderléia Maria de Farias ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Diseases ◽  
Short Review ◽  
Non Invasive ◽  
Pubmed Database ◽  
Cardiovascular Tests

Objective: As the cardiovascular disease produced by the association of the hypertension and type 2 diabetes mellitus in elderly people is a worldwide disturb of the actually, this work was done by a research at the PubMed database. Background: The cardiovascular characteristics expressed the quality of life meliorate, the risk factors that occurs, the use of non-invasive cardiovascular tests, the diabetes prevention programs, and the new physical therapies. Material and methods: The research was done through of the use of the key-words: hypertension and cardiovascular diseases and diabetes and elderly and therapy, and exercise in PubMed database. Results: It was founded 36 publications about this theme and put all together to find characteristics that are bellowed to these cardiovascular diseases. Conclusion: This new short review not pretends to fulfil the theme but it was to show ways of successful treatments.

Pulmonary Pathology Among Patients with Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-analysis

2020 ◽  
Vol 16 (7) ◽  
pp. 759-769 ◽  
Author(s):  
Minaxi Saini ◽  
Sivachidambaram Kulandaivelan ◽  
Virender Kumar Bansal ◽  
Vikram Saini ◽  
Suresh Sharma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Meta Analysis ◽  
Lung Pathology ◽  
Exclusion Criteria ◽  
Pubmed Database ◽  
Restrictive Type

Background: Restrictive lung pathology was reported in the previous meta-analysis among patients with Type 2 Diabetes mellitus (T2DM) which is date back to 2010. Objective: To see the effect of T2DM on pulmonary functions through updated systematic review and meta-analysis. Data source: PubMed. Study eligibility criteria: English language case-control or cross-sectional studies, published between 1 January 2010 to 31 August 2018. Participants and intervention: We selected 22 articles that met our inclusion and exclusion criteria. Results reveal that among patients with T2DM all variables were reduced except %FEV1/FVC which shows statistically nonsignificant results with P=0.46. This confirms that T2DM patients have a restrictive type of lung pathology. Limitation: Only articles from the PubMed database were included. Study appraisal and synthesis methods: Methodological quality of the study was assessed using Newcastle-Ottawa Quality Assessment Scale. Meta-analysis was done using Review Manager 5.3 (RevMan 5.3) and meta-regression was conducted using R statistical software. Results: We selected 22 articles that met our inclusion and exclusion criteria. Results reveal that among patients with T2DM all variables were reduced except %FEV1/FVC which shows statistically nonsignificant results with P=0.46. This confirms that T2DM patients have a restrictive type of lung pathology. Limitation: Only articles from the PubMed database were included. Limitation: Only articles from PubMed database were included. Conclusion and implications of key findings: This review affirms the existing evidence of restrictive pathology among patients with T2DM. The future study could be conducted to see the effect of various rehabilitation protocols on pulmonary function among patients with T2DM.

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