scholarly journals Estimation of Hazard Functions in the Log-Linear Age-Period-Cohort Model: Application to Lung Cancer Risk Associated with Geographical Area

2010 ◽  
Vol 9 ◽  
pp. CIN.S4522 ◽  
Author(s):  
Tengiz Mdzinarishvili ◽  
Michael X. Gleason ◽  
Simon Sherman
Keyword(s):  
Lung Cancer ◽  
San Francisco ◽  
White Women ◽  
Geographical Area ◽  
White Men ◽  
Incidence Rates ◽  
Relative Hazard ◽  
Hazard Functions ◽  
Computing Procedure ◽  
Log Linear

An efficient computing procedure for estimating the age-specific hazard functions by the log-linear age-period-cohort (LLAPC) model is proposed. This procedure accounts for the influence of time period and birth cohort effects on the distribution of age-specific cancer incidence rates and estimates the hazard function for populations with different exposures to a given categorical risk factor. For these populations, the ratio of the corresponding age-specific hazard functions is proposed for use as a measure of relative hazard. This procedure was used for estimating the risks of lung cancer (LC) for populations living in different geographical areas. For this purpose, the LC incidence rates in white men and women, in three geographical areas (namely: San Francisco-Oakland, Connecticut and Detroit), collected from the SEER 9 database during 1975–2004, were utilized. It was found that in white men the averaged relative hazard (an average of the relative hazards over all ages) of LC in Connecticut vs. San Francisco-Oakland is 1.31 ± 0.02, while in Detroit vs. San Francisco-Oakland this averaged relative hazard is 1.53 ± 0.02. In white women, analogous hazards in Connecticut vs. San Francisco-Oakland and Detroit vs. San Francisco-Oakland are 1.22 ± 0.02 and 1.32 ± 0.02, correspondingly. The proposed computing procedure can be used for assessing hazard functions for other categorical risk factors, such as gender, race, lifestyle, diet, obesity, etc.

scholarly journals Weibull-like Model of Cancer Development in Aging

2010 ◽  
Vol 9 ◽  
pp. CIN.S5460 ◽  
Author(s):  
Tengiz Mdzinarishvili ◽  
Simon Sherman
Keyword(s):  
Mathematical Modeling ◽  
Hazard Function ◽  
White Men ◽  
Cancer Registries ◽  
Incidence Rates ◽  
Linear Functions ◽  
Cancer Development ◽  
Additional Parameter ◽  
Men And Women ◽  
Hazard Functions

Mathematical modeling of cancer development is aimed at assessing the risk factors leading to cancer. Aging is a common risk factor for all adult cancers. The risk of getting cancer in aging is presented by a hazard function that can be estimated from the observed incidence rates collected in cancer registries. Recent analyses of the SEER database show that the cancer hazard function initially increases with the age, and then it turns over and falls at the end of the lifetime. Such behavior of the hazard function is poorly modeled by the exponential or compound exponential-linear functions mainly utilized for the modeling. In this work, for mathematical modeling of cancer hazards, we proposed to use the Weibull-like function, derived from the Armitage-Doll multistage concept of carcinogenesis and an assumption that number of clones at age t developed from mutated cells follows the Poisson distribution. This function is characterized by three parameters, two of which ( r and λ) are the conventional parameters of the Weibull probability distribution function, and an additional parameter ( C0) that adjusts the model to the observational data. Biological meanings of these parameters are: r—the number of stages in carcinogenesis, λ—an average number of clones developed from the mutated cells during the first year of carcinogenesis, and C0—a data adjustment parameter that characterizes a fraction of the age-specific population that will get this cancer in their lifetime. To test the validity of the proposed model, the nonlinear regression analysis was performed for the lung cancer (LC) data, collected in the SEER 9 database for white men and women during 1975–2004. Obtained results suggest that: (i) modeling can be improved by the use of another parameter A- the age at the beginning of carcinogenesis; and (ii) in white men and women, the processes of LC carcinogenesis vary by A and C0, while the corresponding values of r and λ are nearly the same. Overall, the proposed Weibull-like model provides an excellent fit of the estimates of the LC hazard function in aging. It is expected that the Weibull-like model can be applicable to fit estimates of hazard functions of other adult cancers as well.

scholarly journals Race by Sex Differences in Depression Symptoms and Psychosocial Service Use Among Non-Hispanic Black and White Patients With Lung Cancer

2014 ◽  
Vol 32 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Lara Traeger ◽  
Sheila Cannon ◽  
Nancy L. Keating ◽  
William F. Pirl ◽  
Christopher Lathan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Sex Differences ◽  
Black Women ◽  
Service Use ◽  
White Women ◽  
White Men ◽  
Depression Symptoms ◽  
Black And White ◽  
Psychosocial Service ◽  
Black Patients

Purpose This study examined race by sex differences in depression symptoms and psychosocial service use (pastors, social workers, mental health workers, support groups) among patients with lung cancer. Patients and Methods The multiregional Cancer Care Outcomes Research and Surveillance study surveyed black and white adults with stages I to III lung cancer (n = 1,043) about depression symptoms, interest in help for mood, and psychosocial service use. Multivariable logistic regression was used to evaluate race/sex differences in depression symptoms (modified Center for Epidemiologic Studies Depression Scale ≥ 6) and psychosocial service use, independent of demographic, clinical, psychosocial, and behavioral covariates. Results A total of 18.2% screened positive for depression symptoms. This proportion was highest among black men (24.7%), followed by white women (20.6%), black women (15.8%), and white men (15.0%). In adjusted analyses, white women showed greater risk for depression symptoms relative to black women (P = .01) and white men (P = .002), with no other differences among groups. Black patients were less likely than white patients to receive desired help for mood from their doctors (P = .02), regardless of sex. Among all patients, black women were most likely to have contact with pastoral care and social work. Conclusion Race and sex interacted to predict risk of depression symptoms. Covariates accounted for elevated risk among black men. White women showed greater risk than black women and white men, independent of covariates. Black patients may experience greater barriers to receiving help for mood from their doctors. Race by sex differences in contact with psychosocial services highlight potential differences in the extent to which services are available, acceptable, and/or sought by patients.

Factors Influencing Electrophysiologic Responsivity in Normal Adults

1965 ◽  
Vol 8 (4) ◽  
pp. 323-347
Author(s):  
Robert Goldstein ◽  
Benjamin RosenblÜt
Keyword(s):  
Conditioned Stimulus ◽  
White Light ◽  
Pure Tone ◽  
Alpha Rhythm ◽  
White Women ◽  
White Men ◽  
Inverse Relation ◽  
Factors Influencing ◽  
Electrodermal Responses ◽  
Normal Adults

Electrodermal and electroencephalic responsivity to sound and to light was studied in 96 normal-hearing adults in three separate sessions. The subjects were subdivided into equal groups of white men, white women, colored men, and colored women. A 1 000 cps pure tone was the conditioned stimulus in two sessions and white light was used in a third session. Heat was the unconditioned stimulus in all sessions. Previously, an inverse relation had been found in white men between the prominence of alpha rhythm in the EEG and the ease with which electrodermal responses could be elicited. This relation did not hold true for white women. The main purpose of the present study was to answer the following questions: (1) are the previous findings on white subjects applicable to colored subjects? (2) are subjects who are most (or least) responsive electrophysiologically on one day equally responsive (or unresponsive) on another day? and (3) are subjects who are most (or least) responsive to sound equally responsive (or unresponsive) to light? In general, each question was answered affirmatively. Other factors influencing responsivity were also studied.

Race Difference in Auditory Sensitivity

1964 ◽  
Vol 7 (4) ◽  
pp. 389-393 ◽  
Author(s):  
David C. Shepherd ◽  
Robert Goldstein ◽  
Benjamin Rosenblüt
Keyword(s):  
White Women ◽  
White Men ◽  
Sensitivity Study ◽  
Auditory Sensitivity ◽  
Race Difference ◽  
Men And Women ◽  
Auditory Thresholds ◽  
Békésy Audiometry ◽  
Method Of Adjustment ◽  
Better Than

Two separate studies investigated race and sex differences in normal auditory sensitivity. Study I measured thresholds at 500, 1000, and 2000 cps of 23 white men, 26 white women, 21 negro men, and 24 negro women using the method of limits. In Study II thresholds of 10 white men, 10 white women, 10 negro men, and 10 negro women were measured at 1000 cps using four different stimulus conditions and the method of adjustment by means of Bekesy audiometry. Results indicated that the white men and women in Study I heard significantly better than their negro counterparts at 1000 and 2000 cps. There were no significant differences between the average thresholds measured at 1000 cps of the white and negro men in Study II. White women produced better auditory thresholds with three stimulus conditions and significantly more sensitive thresholds with the slow pulsed stimulus than did the negro women in Study II.

Intersectional discrimination from black women, white women, black men, or white men impacts young adult black women’s affective states and risky health cognitions

2021 ◽  
pp. 1-17
Author(s):  
Abby G. Lieberman ◽  
Michelle L. Stock ◽  
Katarina E. AuBuchon ◽  
Janine B. Beekman ◽  
Sharon F. Lambert
Keyword(s):  
Black Women ◽  
Young Adult ◽  
Black Men ◽  
White Women ◽  
White Men ◽  
Affective States ◽  
Health Cognitions

scholarly journals “Mostly Rich White Men, Nothing in Common”: Latino Views on Political (Under) Representation in the Trump Era

2021 ◽  
pp. 000276422199676
Author(s):  
Cristina Mora ◽  
Julie A. Dowling ◽  
Michael Rodríguez-Muñiz
Keyword(s):  
San Francisco ◽  
Political Representation ◽  
White Men ◽  
People Of Color ◽  
Elected Officials ◽  
State Governments ◽  
Data Set ◽  
Political Theories ◽  
Representative Process ◽  
Depth Interviews

The idea of U.S. democracy rests on the assumption that all citizens will see their issues and needs reflected in elected officials. Yet, historically this has not been the case, as racialized minorities have been excluded and systematically marginalized from the representative process. Today, nonwhite populations remain significantly underrepresented in federal and state governments. Although scholars have examined the effects and mechanics of ethnoracial political representation, less is known about how individuals from minoritized populations perceive and make sense of political (under)representation. Drawing on a novel data set of 71 in-depth interviews with Latinos in the Chicagoland area and the San Francisco Bay, this article examines Latino understandings of representation. Our findings show that respondents view Latinos and other “people of color” as largely underrepresented amid an exceedingly white federal government. Yet Latino sentiments on the issue go beyond race, as respondents contend that class and a record of experience advocating on behalf of immigrant and working-class communities also matters for feeling represented by elected officials. Our findings make a case for bridging the sociological literature on racialization and political theories on representation, and have implications for understanding broader notions of political belonging and government trust.

scholarly journals Trends in Lung Cancer Incidence Rates, Oklahoma 2005–2010

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0119251 ◽  
Author(s):  
Dana S. Mowls ◽  
D. Robert McCaffree ◽  
Laura A. Beebe
Keyword(s):  
Lung Cancer ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Lung Cancer Incidence ◽  
Cancer Incidence Rates

scholarly journals Comorbidities associated with HPV and HSV infections among people living with HIV-1 in the Southeastern US: a retrospective clinical cohort study

2019 ◽  
Author(s):  
Yuanfan Ye ◽  
Greer A. Burkholder ◽  
Howard W. Wiener ◽  
Russell Griffin ◽  
Stella Aslibekyan ◽  
...  
Keyword(s):  
Large Scale ◽  
White Women ◽  
Incidence Rates ◽  
People Living With Hiv ◽  
Anogenital Warts ◽  
Gender And Race ◽  
Clinical Cohort ◽  
Southeastern Us ◽  
Living With Hiv ◽  
Hiv 1

Abstract Background The southeastern US is a domestic epicenter for incident HIV with high prevalence of human papillomavirus (HPV) and herpes simplex virus (HSV) co-infections. However, epidemics of HPV and HSV- associated clinical conditions (CC) among people living with HIV-1 infection (PLWH) are not fully known. Methods Electronic medical records (EMR) of PLWH attending one of the leading HIV clinics in the southeastern US between 2006 and 2018 were reviewed and analyzed. The retrospective study was nested within the University of Alabama at Birmingham HIV clinical cohort, which has electronically collected over 7000 PLWH’s clinical and sociobehavioral data since 1999. Incidence rates of HPV-related CC including anogenital warts, penile, anal, cervical, and vaginal/vulvar low- and high-grade squamous intraepithelial lesions (LSIL and HSIL) and HSV- related CC including anogenital herpetic ulcers were estimated in per 10000 person years. Joinpoint regressions were performed to examine temporal changes in the trends of incident CC. All rates and trends were stratified by gender and race. Results Of the 4,484 PLWH eligible individuals (3,429 men, 1,031 women, and 24 transgender), we observed 1,038 and 425 patients with HPV-and HSV-related CC respectively, and 163 patients with both conditions. The mean log10 viral load (VL) was higher in all of the case groups than the non-cases with neither conditions (5.0) (whereas the median nadir CD4 counts (cells/uL) was higher in the non-cases than in any of the case groups (P<0.05). Anogenital warts, anal LSIL, HSIL, and cancer were more likely to be diagnosed among HIV-infected men than women. White men presented more frequently with anal LSIL and anal and penile cancers than black men (P<0.03). White women were also more likely to be diagnosed with cervical HSIL (P=0.023) and cancer (P=0.037) than black women By contrast, herpetic ulcers were more frequent in women than men. Conclusions There were significant differences between gender and race with incidence of HPV- and HSV-related CC among HIV patients. EMR-based studies provide insights on understudied epidemics; however, large-scale studies in other regions are needed to generalize current findings and draw public health attention to co-infection induced non-AIDS defining comorbidities among PLWH.

scholarly journals LUNG CANCER INCIDENCE IN VARIOUS CITIES OF THE WORLD (REVIEW)

2020 ◽  
Vol 66 (3) ◽  
pp. 239-246
Author(s):  
Liliya Zhuykova ◽  
Yevgeniy Choynzonov ◽  
Olga Ananina ◽  
Nina Lyakhova ◽  
Lidiya Pikalova
Keyword(s):  
Lung Cancer ◽  
New York ◽  
New York City ◽  
Cancer Incidence ◽  
Rural Areas ◽  
Urban Areas ◽  
New York State ◽  
Incidence Rates ◽  
Lung Cancer Incidence ◽  
Cancer Incidence Rates

Apart from smoking, an urban factor is an established risk factor for lung cancer. Lung cancer is associated with environmental factors, occupational exposure, bad habits and lifestyle factors. Approximately 17% of the annual deaths from lung cancer among adults are attributable to exposure to carcinogens located in the surface layer of the urban atmosphere, with industrial pollution and occupational hazards. According to recent data, 97% of cities in low- and middle-income countries with a population of more than 100 thousand people do not meet WHO recommendations for air quality; in high-income countries, this figure has been reduced to 49%. In the United States, the studies demonstrated that the prevalence of combined lung cancer was higher in urban areas (10.2%) than in rural areas (4.8%). There was a difference in the lung cancer incidence rates between the populations of the New York City and the New York State. In males, the lung cancer incidence rates were 1.4 times higher in the New York City than in the New York State (68.9 ± 1.2 0/0000 versus 48.5 ± 0.2 0/0000). In females, the lung cancer incidence rates were 1.2 times higher in the New York City than in the New York State (43.0 ± 0.3 and 34.9 ± 0.1 0/0000, respectively). In China, in urban areas, the lung cancer incidence mortality rates were 36.6 0/0000 and 28.9 0/0000, respectively. In rural areas, the corresponding values were 33.4 and 26.6 0/0000, respectively. Although the lung cancer incidence and mortality rates are higher in urban areas than in rural areas, these differences are gradually decreasing: the incidence rate between urban and rural areas has decreased from 2.1 to 1.1. The issue of the impact of environment on the incidence of lung cancer is challenging. The outdoor environment affects people’s health with varying degrees of intensity both in time and in space.

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