scholarly journals Heterogeneity between Ducts of the Same Nuclear Grade Involved by Duct Carcinoma In Situ (DCIS) of the Breast

2010 ◽  
Vol 9 ◽  
pp. CIN.S5505 ◽  
Author(s):  
Naomi A. Miller ◽  
Judith-Anne W. Chapman ◽  
Jin Qian ◽  
William A. Christens-Barry ◽  
Yuejiao Fu ◽  
...  
Keyword(s):  
Digital Image ◽  
Breast Biopsy ◽  
Image Cytometry ◽  
Image Features ◽  
Nuclear Grade ◽  
Management Decision ◽  
Duct Carcinoma ◽  
Quantitative Image ◽  
Management Decision Making ◽  
Nuclear Features

Purpose Nuclear grade of breast DCIS is considered during patient management decision-making although it may have only a modest prognostic association with therapeutic outcome. We hypothesized that visual inspection may miss substantive differences in nuclei classified as having the same nuclear grade. To test this hypothesis, we measured subvisual nuclear features by quantitative image cytometry for nuclei with the same grade, and tested for statistical differences in these features. Experimental design and statistical analysis Thirty-nine nuclear digital image features of about 100 nuclei were measured in digital images of H<E stained slides of 81 breast biopsy specimens. One field with at least 5 ducts was evaluated for each patient. We compared features of nuclei with the same grade in multiple ducts of the same patient with ANOVA (or Welch test), and compared features of nuclei with the same grade in two ducts of different patients using 2-sided t-tests ( P ≤ 0.05). Also, we compared image features for nuclei in patients with single grade to those with the same grade in patients with multiple grades using t-tests. Results Statistically significant differences were detected in nuclear features between ducts with the same nuclear grade, both in different ducts of the same patient, and between ducts in different patients with DCIS of more than one grade. Conclusion Nuclei in ducts visually described as having the same nuclear grade had significantly different subvisual digital image features. These subvisual differences may be considered additional manifestations of heterogeneity over and above differences that can be observed microscopically. This heterogeneity may explain the inconsistency of nuclear grading as a prognostic factor.

scholarly journals Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast

2008 ◽  
Vol 6 ◽  
pp. CIN.S401 ◽  
Author(s):  
David E. Axelrod ◽  
Naomi A. Miller ◽  
H. Lavina Lickley ◽  
Jin Qian ◽  
William A. Christens-Barry ◽  
...  
Keyword(s):  
Image Analysis ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Image Features ◽  
Nuclear Grade ◽  
Image Feature ◽  
Group A ◽  
Group B ◽  
Nuclear Features

Background Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with outcome. Fifty percent of patients had heterogeneous DCIS with more than one nuclear grade. The aim of the current study was to investigate the effect of quantitative nuclear features assessed with digital image analysis on ipsilateral DCIS recurrence. Methods Hematoxylin and eosin stained slides for a cohort of 80 patients with primary breast DCIS were reviewed and two fields with representative grade (or grades) were identified by a Pathologist and simultaneously used for acquisition of digital images for each field. Van Nuys worst nuclear grade was assigned, as was predominant grade, and heterogeneous grading when present. Patients were grouped by heterogeneity of their nuclear grade: Group A: nuclear grade 1 only, nuclear grades 1 and 2, or nuclear grade 2 only (32 patients), Group B: nuclear grades 1, 2 and 3, or nuclear grades 2 and 3 (31 patients), Group 3: nuclear grade 3 only (17 patients). Nuclear fine structure was assessed by software which captured thirty-nine nuclear feature values describing nuclear morphometry, densitometry, and texture. Step-wise forward Cox regressions were performed with previous clinical and pathologic factors, and the new image analysis features. Results Duplicate measurements were similar for 89.7% to 97.4% of assessed image features. The rate of correct classification of nuclear grading with digital image analysis features was similar in the two fields, and pooled assessment across both fields. In the pooled assessment, a discriminant function with one nuclear morphometric and one texture feature was significantly (p = 0.001) associated with nuclear grading, and provided correct jackknifed classification of a patient's nuclear grade for Group A (78.1%), Group B (48.4%), and Group C (70.6%). The factors significantly associated with DCIS recurrence were those previously found, type of initial presentation (p = 0.03) and amount of parenchymal involvement (p = 0.05), along with the morphometry image feature of ellipticity (p = 0.04). Conclusion Analysis of nuclear features measured by image cytometry may contribute to the classification and prognosis of breast DCIS patients with more than one nuclear grade.

Digital image acquisition, processing, and analysis in a polymer microscopy laboratory

1994 ◽  
Vol 52 ◽  
pp. 454-455
Author(s):  
Vinod K. Berry ◽  
Xiao Zhang
Keyword(s):  
United States ◽  
Image Analysis ◽  
Digital Image ◽  
Image Acquisition ◽  
Image Transmission ◽  
The United States ◽  
Quantitative Image Analysis ◽  
Quantitative Image

In recent years it became apparent that we needed to improve productivity and efficiency in the Microscopy Laboratories in GE Plastics. It was realized that digital image acquisition, archiving, processing, analysis, and transmission over a network would be the best way to achieve this goal. Also, the capabilities of quantitative image analysis, image transmission etc. available with this approach would help us to increase our efficiency. Although the advantages of digital image acquisition, processing, archiving, etc. have been described and are being practiced in many SEM, laboratories, they have not been generally applied in microscopy laboratories (TEM, Optical, SEM and others) and impact on increased productivity has not been yet exploited as well.In order to attain our objective we have acquired a SEMICAPS imaging workstation for each of the GE Plastic sites in the United States. We have integrated the workstation with the microscopes and their peripherals as shown in Figure 1.

Centralization and Effectiveness of Reward Management in Multinational Enterprises

2018 ◽  
Vol 17 (2) ◽  
pp. 55-65 ◽  
Author(s):  
Michael Tekieli ◽  
Marion Festing ◽  
Xavier Baeten
Keyword(s):  
Decision Making ◽  
Social Identity Theory ◽  
Multinational Enterprises ◽  
Role Identity ◽  
Management Decision ◽  
Role Identities ◽  
Management Decision Making ◽  
New Perspective ◽  
Subsidiary Managers ◽  
The Relationship

Abstract. Based on responses from 158 reward managers located at the headquarters or subsidiaries of multinational enterprises, the present study examines the relationship between the centralization of reward management decision making and its perceived effectiveness in multinational enterprises. Our results show that headquarters managers perceive a centralized approach as being more effective, while for subsidiary managers this relationship is moderated by the manager’s role identity. Referring to social identity theory, the present study enriches the standardization versus localization debate through a new perspective focusing on psychological processes, thereby indicating the importance of in-group favoritism in headquarters and the influence of subsidiary managers’ role identities on reward management decision making.

Emergency management decision-making during severe weather

2006 ◽  
Author(s):  
Leigh A. Baumgart ◽  
Ellen J. Bass ◽  
Brenda Philips ◽  
Kevin Kloesel
Keyword(s):  
Decision Making ◽  
Emergency Management ◽  
Severe Weather ◽  
Management Decision ◽  
Management Decision Making

Providing additional education services for children: Challenges and solutions

2020 ◽  
Vol 18 (4) ◽  
pp. 675-687
Author(s):  
Yu.I. Brodovskaya ◽  
T.A. Smirnova
Keyword(s):  
Consumer Preferences ◽  
Methodological Approach ◽  
Management Decision ◽  
Public Authorities ◽  
Education Services ◽  
Supplementary Education ◽  
Management Decision Making ◽  
Additional Education ◽  
Sociological Studies ◽  
Municipal Level

Subject. This article considers the issues of provision of supplementary education services for children and methodological tools for the formation of educational environment. Objectives. The article aims to assess the level of development of the system of supplementary education of children in Krasnoyarsk and offer a methodological approach to improving the management decision-making procedure in the formation of a portfolio of supplementary education services at the municipal level. Methods. For the study, we used the methods of theoretical, empirical, and logistic analyses, and sociological studies. Results. The article offers concrete solutions to the lack of a methodological approach to providing supplementary education services, considering one of the micro-districts of Krasnoyarsk as a case in point. It also offers tools that can be used by public authorities to organize educational space at the municipal level. Conclusions. A unified methodological approach should be used to provide a system of supplementary education, taking into account financial means, as well as differentiation in the distribution of educational facilities throughout the area. The relevance of the set of supplementary education services and consumer preferences should be taken into account, as well.

Evaluation of an Integrated Traffic Flow Management Decision Making Approach

2010 ◽  
Vol 18 (4) ◽  
pp. 331-358 ◽  
Author(s):  
Shon Grabbe ◽  
Banavar Sridhar ◽  
Avijit Mukherjee
Keyword(s):  
Decision Making ◽  
Traffic Flow ◽  
Management Decision ◽  
Flow Management ◽  
Traffic Flow Management ◽  
Management Decision Making

scholarly journals Quantitative image analysis of microbial communities with BiofilmQ

2021 ◽  
Author(s):  
Raimo Hartmann ◽  
Hannah Jeckel ◽  
Eric Jelli ◽  
Praveen K. Singh ◽  
Sanika Vaidya ◽  
...  
Keyword(s):  
Image Analysis ◽  
Microbial Communities ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Software Tool ◽  
Image Cytometry ◽  
Quantitative Image Analysis ◽  
Space And Time ◽  
Quantitative Image ◽  
Three Dimensional Space

AbstractBiofilms are microbial communities that represent a highly abundant form of microbial life on Earth. Inside biofilms, phenotypic and genotypic variations occur in three-dimensional space and time; microscopy and quantitative image analysis are therefore crucial for elucidating their functions. Here, we present BiofilmQ—a comprehensive image cytometry software tool for the automated and high-throughput quantification, analysis and visualization of numerous biofilm-internal and whole-biofilm properties in three-dimensional space and time.

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