Evaluating traumatic brain injury using conventional magnetic resonance imaging and susceptibility-weighted imaging in dogs

(1) Background: Blood brain barrier (BBB) disruption following traumatic brain injury (TBI) results in a secondary injury by facilitating the entry of neurotoxins to the brain parenchyma without filtration. In the current paper, we aimed to review previous dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) studies to evaluate the occurrence of BBB disruption after TBI. (2) Methods: In electronic databases (PubMed, Scopus, Embase, and the Cochrane Library), we searched for the following keywords: dynamic contrast-enhanced OR DCE AND brain injury. We included studies in which BBB disruption was evaluated in patients with TBI using DCE-MRI. (3) Results: Four articles were included in this review. To assess BBB disruption, linear fit, Tofts, extended Tofts, or Patlak models were used. KTrans and ve were increased, and the values of vp were decreased in the cerebral cortex and predilection sites for diffusion axonal injury. These findings are indicative of BBB disruption following TBI. (4) Conclusions: Our analysis supports the possibility of utilizing DCE-MRI for the detection of BBB disruption following TBI.

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Traumatic brain injury in piglets of different ages: techniques for lesion analysis using histology and magnetic resonance imaging

Journal of Neuroscience Methods ◽

10.1016/s0165-0270(02)00361-8 ◽

2003 ◽

Vol 123 (2) ◽

pp. 201-206 ◽

Cited By ~ 31

Author(s):

Loretta L Grate ◽

Jeffrey A Golden ◽

P.Jack Hoopes ◽

Jill V Hunter ◽

Ann-Christine Duhaime

Keyword(s):

Magnetic Resonance Imaging ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Different Ages ◽

Lesion Analysis

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Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing–remitting multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458512442991 ◽

2012 ◽

Vol 18 (11) ◽

pp. 1585-1591 ◽

Cited By ~ 9

Author(s):

Delphine Wybrecht ◽

Françoise Reuter ◽

Wafaa Zaaraoui ◽

Anthony Faivre ◽

Lydie Crespy ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Sclerosis ◽

Magnetic Resonance ◽

Physical Disability ◽

Conventional Magnetic Resonance Imaging ◽

Global Approach ◽

Resonance Imaging ◽

Conventional Magnetic Resonance ◽

Magnetic Resonance Imaging Mri ◽

Mri Changes

Background: The ability of conventional magnetic resonance imaging (MRI) to predict subsequent physical disability and cognitive deterioration after a clinically isolated syndrome (CIS) is weak. Objectives: We aimed to investigate whether conventional MRI changes over 1 year could predict cognitive and physical disability 5 years later in CIS. We performed analyses using a global approach (T2 lesion load, number of T2 lesions), but also a topographic approach. Methods: This study included 38 patients with a CIS. At inclusion, 10 out of 38 patients fulfilled the 2010 revised McDonald’s criteria for the diagnosis of multiple sclerosis. Expanded Disability Status Scale (EDSS) evaluation was performed at baseline, year 1 and year 5, and cognitive evaluation at baseline and year 5. T2-weighted MRI was performed at baseline and year 1. We used voxelwise analysis to analyse the predictive value of lesions location for subsequent disability. Results: Using the global approach, no correlation was found between MRI and clinical data. The occurrence or growth of new lesions in the brainstem was correlated with EDSS changes over the 5 years of follow-up. The occurrence or growth of new lesions in cerebellum, thalami, corpus callosum and frontal lobes over 1 year was correlated with cognitive impairment at 5 years. Conclusion: The assessment of lesion location at the first stage of multiple sclerosis may be of value to predict future clinical disability.

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