scholarly journals Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old

2012 ◽  
Vol 113 (12) ◽  
pp. 702-706 ◽  
Author(s):  
M. Arslan ◽  
B. Isik ◽  
M. Kavutcu ◽  
O. Kurtipek
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Rat Liver ◽  
Liver Tissue ◽  
Female Rat ◽  
Sevoflurane Anaesthesia

scholarly journals Pengaruh Paparan Hipoksia terhadap Aktivitas Antioksidan Katalase dan Kadar Malondialdehid (MDA) pada Jaringan Hati Tikus

Jurnal BIOMA ◽  
2014 ◽  
Vol 10 (2) ◽  
pp. 27
Author(s):  
Rini Puspitaningrum ◽  
Amanda Putri Lestari ◽  
Tri Murtiati
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Cell Membrane ◽  
Rat Liver ◽  
Catalase Activity ◽  
Liver Tissue ◽  
Hypoxia Exposure ◽  
Randomized Design ◽  
Mda Content ◽  
Key Words Catalase

Abstract content in the tissue. Hypoxia can make the formation of free radicals or reactive oxygen species (ROS) which reactive to cell membrane. Body will avoid free radicals by producing antioxidant, such as catalase enzyme. The reaction between ROS and cell membrane will form malondialdehyde (MDA). Liver is the main location of catalase. This research was aimed to know the influence of hypoxia exposure toward catalase antioxidant activity and MDA content in the rat liver tissue. This research used experiment method with fully randomized design. Based on one way Anova test (p≤0.01), it was shown that there had no average difference on catalase activity and MDA content toward length hypoxia exposure. The conclusion of this research was no influence of hypoxia exposure toward catalase activity and MDA content in rat liver tissue.   Key words: catalase antioxidant activity, hypoxia, malondialdehyde (MDA) content,rat liver tissue

scholarly journals Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

2020 ◽  
Vol 1 (2) ◽  
pp. 43
Author(s):  
Andri Muhrim Siddiq ◽  
Muhammad In'am Ilmiawan ◽  
Mitra Handini
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Rat Liver ◽  
Liver Tissue ◽  
Seed Oil ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Black Seed ◽  
Black Seed Oil

Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI<1), additive (CI=1) and antagonism effect (CI>1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p > 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.

scholarly journals N-Acetylcysteine Attenuates Monocrotophos-induced Toxicity by Mitigating Oxidative Stress and Structural Changes in Rat Liver

2021 ◽  
Author(s):  
Jagjeet Singh ◽  
Annu Phogat ◽  
Chandra Prakash ◽  
Vijay Kumar ◽  
Vinay Malik
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rat Liver ◽  
Protein Oxidation ◽  
Liver Tissue ◽  
Structural Changes ◽  
Microscopic Analysis ◽  
Stress Generation ◽  
Electron Microscopic ◽  
Pre Treatment

Abstract The present study evaluated the effect of N-acetylcysteine (NAC) against sub chronic monocrotophos (MCP) exposure induced oxidative stress in rat liver. Albino wistar rats were divided into control, NAC treated, MCP and MCP treated groups. An oral dose of MCP (0.9 mg/kg b.wt) and NAC (200 mg/kg b.wt) was administered for 28 days. We observed high oxidative stress generation on MCP exposure in liver tissue as evident by significant increase in lipid peroxidation, protein oxidation and decreased glutathione content followed by altered activities of superoxide dismutase, catalase and acetylcholinesterase. Sub chronic MCP exposure caused an array of cellular and structural alternations in lipids and proteins of liver tissue as depicted by the FTIR, histopathological and electron microscopic analysis. N-acetylcysteine attenuated the loss of glutathione and prevented lipid peroxidation and protein oxidation. Pre-treatment of NAC also restored histological and ultra space structural alternations. So NAC protects oxidative stress and tissue damage induced by sub chronic MCP exposure in rat liver; suggesting the therapeutic and antioxidant potential of NAC.

Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue

2018 ◽  
Vol 448 (1-2) ◽  
pp. 43-50 ◽  
Author(s):  
M. Stojanović ◽  
D. Todorović ◽  
Lj Šćepanović ◽  
D. Mitrović ◽  
S. Borozan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Tissue ◽  
Histological Changes ◽  
Methionine Load

scholarly journals Effects of Lycium Barbarum Aqueous and Ethanol Extracts on High-Fat-Diet Induced Oxidative Stress in Rat Liver Tissue

Molecules ◽  
2011 ◽  
Vol 16 (11) ◽  
pp. 9116-9128 ◽  
Author(s):  
BoKang Cui ◽  
Su Liu ◽  
XiaoJun Lin ◽  
Jun Wang ◽  
ShuHong Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
High Fat Diet ◽  
Liver Tissue ◽  
High Fat ◽  
Lycium Barbarum ◽  
Ethanol Extracts

scholarly journals Dynamics of glutathione reductase activity in rat liver tissues during cryodestruction of the right atrium

2021 ◽  
Vol 273 ◽  
pp. 02014
Author(s):  
Olga Pavlova ◽  
Olga Gulenko ◽  
Konstantin Krupin ◽  
Pavel Boriskin ◽  
Victor Leonov
Keyword(s):  
Oxidative Stress ◽  
Glutathione Reductase ◽  
Rat Liver ◽  
Right Atrium ◽  
Liver Tissue ◽  
Reductase Activity ◽  
The Body ◽  
Glutathione Reductase Activity ◽  
The Right ◽  
Liver Tissues

The metabolic processes of the human body are based on multiple redox reactions and oxidative stress occurs when homeostasis is imbalanced. Antioxidant system of the body is represented by such enzymes as catalase, glutathione reductase, superoxidismutase and glutathione peroxidase. Objective: to study the dynamics of glutathione reductase activity in rat liver tissues after cryodestruction of right atrial myocardium to initiate oxidative stress. Materials and methods: 420 male rats were used. The rats were divided into two groups - intact and experimental, 210 animals in each. To initiate oxidative stress, the experimental group rats underwent cryodestruction of the right atrium. The activity of glutathione reductase in the liver tissue was determined by accumulation of oxidized glutathione before the experiment, as well as on 1, 3, 5, 7 and 14 days of the experiment. Conclusions: oxidative stress arising after cryodestruction of the right atrium up to the 7th day of the experiment provokes a decrease in the glutathione reductase activity in the rat liver tissue, but the start of reparative processes helps to restore the disturbed redox equilibrium in the body and normalize the enzyme level.

scholarly journals Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Andri Muhrim Siddiq ◽  
Muhammad In'am Ilmiawan ◽  
Mitra Handini
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Rat Liver ◽  
Liver Tissue ◽  
Seed Oil ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Black Seed ◽  
Black Seed Oil

Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI<1), additive (CI=1) and antagonism effect (CI>1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p > 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.

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