3D printing technique in the development of self-nanoemulsifying drug delivery system: scope and future prospects

2021 ◽  
Author(s):  
Mohammed S Algahtani ◽  
Javed Ahmad
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Future Prospects ◽  
Printing Technique ◽  
3D Printing Technique

Saponin Stabilized Emulsion as Sustainable Drug Delivery System: Current Status and Future Prospects

2021 ◽  
pp. 217-235
Author(s):  
Priyanka Yatham ◽  
Yogita Dahat ◽  
Arshad Khan ◽  
Rinku Baishya ◽  
Amit K. Srivastava ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Current Status ◽  
Future Prospects

Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy

2020 ◽  
Vol 46 (4) ◽  
pp. 531-538 ◽  
Author(s):  
Ting-Ting Yan ◽  
Zhu-Fen Lv ◽  
Pan Tian ◽  
Min-Mei Lin ◽  
Wei Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Scale ◽  
Individual Drug ◽  
Semi Solid

scholarly journals Tailormade Drug Delivery System: A Novel Trio Concept of 3DP+ Hydrogel+ SLA

2019 ◽  
Vol 9 (4-s) ◽  
pp. 861-866 ◽  
Author(s):  
Lalita Devi ◽  
Punam Gaba ◽  
Hitesh Chopra
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
System A ◽  
Hydrogel Formation ◽  
Organic Fluids ◽  
Dimensional Printing

Hydrogels possess three-dimensional polymeric network structure and equipped for retaining extensive measure of water or organic fluids. This quality makes them as exceptional candidate for the simulation of extra cellular matrixes. For this the three dimensional printing (3DP) has evolved as the technique for the formation of the digital models. The 3DP is capable for processing the prescriptions and the therapeutic gadgets. One of the technique known as stereolithographic (SLA) printing has shown promising results in formulating the hydrogel based system for fabrication. The SLA acts by cross connecting the saps to shape the polymer matrices. Due to water captured in the gels it is conceivable to create the pre- wetted, medicate hydrogels and gadgets. The 3DP helps in formation of tailor made drug delivery system as per needs of patients. Many of Bioinks has been tried up for the hydrogel formation such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose etc. Keywords: 3D Printing, Hydrogel, Steriolithography

Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System

2019 ◽  
Vol 24 (42) ◽  
pp. 5029-5038 ◽  
Author(s):  
Md. Shoaib Alam ◽  
Ayesha Akhtar ◽  
Iftikhar Ahsan ◽  
Sheikh Shafiq-un-Nabi
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Personalized Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Novel Drug Delivery System ◽  
Novel Drug

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology. Methods: This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system. Results: It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role. Conclusion: 3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

3D Printing in Personalized Drug Delivery

2019 ◽  
Vol 24 (42) ◽  
pp. 5062-5071 ◽  
Author(s):  
Afsana ◽  
Vineet Jain ◽  
Nafis Haider ◽  
Keerti Jain
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Personalized Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Personalized Medicines

Background: Personalized medicines are becoming more popular as they enable the use of patient’s genomics and hence help in better drug design with fewer side effects. In fact, several doses can be combined into one dosage form which suits the patient’s demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient. Methods: 3D printing technology uses digitally controlled devices for formulating API and excipients in a layer by layer pattern for developing a suitable personalized drug delivery system as per the need of patient. It includes various techniques like inkjet printing, fused deposition modelling which can further be classified into continuous inkjet system and drop on demand. In order to formulate such dosage forms, scientists have used various polymers to enhance their acceptance as well as therapeutic efficacy. Polymers like polyvinyl alcohol, poly (lactic acid) (PLA), poly (caprolactone) (PCL) etc can be used during manufacturing. Results: Varying number of dosage forms can be produced using 3D printing technology including immediate release tablets, pulsatile release tablets, and transdermal dosage forms etc. The 3D printing technology can be explored successfully to develop personalized medicines which could play a vital role in the treatment of lifethreatening diseases. Particularly, for patients taking multiple medicines, 3D printing method could be explored to design a single dosage in which various drugs can be incorporated. Further 3D printing based personalized drug delivery system could also be investigated in chemotherapy of cancer patients with the added advantage of the reduction in adverse effects. Conclusion: In this article, we have reviewed 3D printing technology and its uses in personalized medicine. Further, we also discussed the different techniques and materials used in drug delivery based on 3D printing along with various applications of the technology.

3D Printing Technology in Customized Drug Delivery System: Current State of the Art, Prospective and the Challenges

2019 ◽  
Vol 24 (42) ◽  
pp. 5049-5061 ◽  
Author(s):  
Farooq A. Khan ◽  
Kaushik Narasimhan ◽  
C.S.V. Swathi ◽  
Sayyad Mustak ◽  
Gulam Mustafa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmaceutical Products ◽  
Drug Formulation ◽  
Formulation Development ◽  
Fused Deposition ◽  
Current State ◽  
3D Printed

Background: 3D printing/Additive Manufacturing seems a pragmatic approach to realize the quest for a truly customized and personalized drug delivery. 3DP technology, with innovations in pharmaceutical development and an interdisciplinary approach to finding newer Drug Delivery Systems can usher a new era of treatments to various diseases. The true potential of this is yet to be realized, and the US-FDA is focusing on the regulatory science of 3D printed medical devices to help patients access this technology safely and effectively. The approval of the first 3D printed prescription medicine by FDA is a promising step in the translation of more research in this area. Methods: A web-search on PubMed, ScienceDirect, and Nature was performed with the keywords Customized 3D printing and Drug delivery, publications dealing with the aspects of drug delivery using 3D printing for personalized or customized delivery were further considered and analyzed and discussed. Results: We present the advantages offered by 3DP over conventional methods of formulation development and discuss the current state of 3DP in pharmaceutics and how it can be used to develop a truly customized drug delivery system, various 3DP technologies including Stereolithography (SLA), Selective Laser Sintering (SLS), Fused Deposition Modelling (FDM), Pressure Assisted Microsyringe (PAM) that have been used to develop pharmaceutical products have been discussed along with their limitations and also the regulatory considerations to help formulation scientists envisaging research in this area with the necessary information. Conclusion: 3D printing has the potential to fabricate a customized drug delivery system. Presence of many drug formulation and the devices are already in the regulatory approval process indicating its success.

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