Self-retained Amniotic Membrane Transplantation for Recurrent Corneal Erosion

2013 ◽  
Vol 04 (02) ◽  
Author(s):  
Yukan Huang Hosam Sheha
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion

scholarly journals Long-term results of corneal collagen crosslinking for recurrent corneal erosion

2021 ◽  
Vol 14 (1) ◽  
pp. 15-24
Author(s):  
Sergey A. Novikov ◽  
Natalya V. Tkachenko ◽  
Oleg A. Frolov ◽  
Akhmed S. Seyfeddin
Keyword(s):  
Corneal Stroma ◽  
Long Term Results ◽  
Amniotic Membrane Transplantation ◽  
Cross Linking ◽  
Professional Activities ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion ◽  
Weak Points ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

BACKGROUND: Recurrent corneal erosion (RCE) is characterized by excacerbation and remission episodes, reduced patients quality of life affecting their daily and professional activities. In case of conservative therapy inefficacy surgical procedures are used (Bowmans membrane polishing with diamond drill, excimer laser phototherapeutic keratectomy, anterior stromal puncture, and amniotic membrane transplantation). All methods have their advantages and weak points, as well as a certain percent of recurrence. In this regard the use of corneal collagen cross-linking is of the interest as an alternative method of the RCE surgical treatment. MATERIALS AND METHODS: 18 patients (20 eyes) with RCE without central corneal stroma scars, aged from 30 to 66 (average 49,5 10,6, all women), after conservative treatment failure (more than 6 months) underwent cross-linking according to the Dresden protocol with the UVX device, version 1000, by IROC INNOCROSS (Switzerland). RESULTS: All patients were asymptomatic and had no recurrence during the observation period (from 1 to 6 years, in average 2,6 1,6). There was a slight but statistically significant BCVA improvement (from 0,93 0,09 at baseline to 0,97 0,07 after intervention). CONCLUSIONS: Crosslinking may be an additional and effective treatment in a number of RCE cases when there is no central corneal stromal scars present. To reduce stromal keratocytes alteration during the procedure modified protocols may be used.

scholarly journals Amniotic membrane transplantation in a patient with impending perforated corneal ulcer caused by Streptococcus mitis: a case report

2019 ◽  
Author(s):  
Fang-Chi Hsiao ◽  
Yaa-Jyuhn James Meir ◽  
Lung-Kun Yeh ◽  
Hsin-Yuan Tan ◽  
Ching-Hsi Hsiao ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Penetrating Keratoplasty ◽  
Unusual Case ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation ◽  
Streptococcus Mitis ◽  
Continuous Administration ◽  
Case Presentation ◽  
Corneal Erosion ◽  
Corneal Scraping

Abstract Background: Streptococcus mitis (S. mitis) belongs to the viridan streptococci group which is rarely isolated as a causative pathogen of corneal ulcer. When it causes keratitis, penetrating keratoplasty (PK) might be necessary. Herein, we demonstrated amniotic membrane transplantation (AMT) can be an easier surgery with acceptable outcomes and less complication. Case presentation: A 63-year-old female Taiwanese presented with right persistent corneal ulcer for nine months. Culture from corneal scraping yielded S. mitis. A right eye descemetocele decreased from 3 mm in diameter to 0.8 mm after continuous administration of topical Vancomycin and Ceftriaxone for two weeks. Due to retarded healing, AMT was performed. Her corneal erosion healed and became clear gradually. Her visual acuity recovered from counting fingers initially to 20/200 finally 17 months after AMT. Conclusion: This unusual case illustrated that antibiotics plus AMT instead of PK may be an effective alternative treatment to promote epithelialization and reduce inflammation in corneas complicated by S. mitis keratitis.

scholarly journals Amniotic membrane transplantation in a patient with an impending perforated corneal ulcer caused by Streptococcus mitis: a case report

2019 ◽  
Author(s):  
Fang-Chi Hsiao ◽  
Yaa-Jyuhn James Meir ◽  
Lung-Kun Yeh ◽  
Hsin-Yuan Tan ◽  
Ching-Hsi Hsiao ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation ◽  
Streptococcus Mitis ◽  
Continuous Administration ◽  
Corneal Ulcers ◽  
Corneal Erosion ◽  
Corneal Scraping ◽  
The Right ◽  
Viridans Group Streptococci

Abstract Background: Streptococcus mitis (S. mitis) belongs to the viridans group streptococci, which is rarely isolated as a causative pathogen of corneal ulcers. When S. mitis causes keratitis, penetrating keratoplasty (PK) might be necessary. Herein, we demonstrated that amniotic membrane transplantation (AMT) may be an easier procedure with acceptable outcomes and with fewer complications. Case presentation: A 63-year-old female presented with a right persistent corneal ulcer that she had suffered from for the past nine months. The culture of a corneal scraping yielded S. mitis. The right eye descemetocele decreased from 3 mm in diameter to 0.8 mm in diameter after the continuous administration of topical vancomycin and ceftriaxone for two weeks. Due to the slow healing, AMT was performed. Her corneal erosion healed and gradually became clear. Her visual acuity recovered from initially counting fingers to 20/200 17 months after AMT. Conclusion: This unusual case illustrated that antibiotics plus AMT may be an effective alternative treatment instead of PK to promote epithelialization and to reduce inflammation in corneas complicated by S. mitis keratitis.

scholarly journals Amniotic membrane transplantation in a patient with an impending perforated corneal ulcer caused by Streptococcus mitis: a case report

2019 ◽  
Author(s):  
Fang-Chi Hsiao ◽  
Yaa-Jyuhn James Meir ◽  
Lung-Kun Yeh ◽  
Hsin-Yuan Tan ◽  
Ching-Hsi Hsiao ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation ◽  
Streptococcus Mitis ◽  
Continuous Administration ◽  
Corneal Ulcers ◽  
Corneal Erosion ◽  
Corneal Scraping ◽  
The Right ◽  
Viridans Group Streptococci

Abstract Background: Streptococcus mitis (S. mitis) belongs to the viridans group streptococci, which is rarely isolated as a causative pathogen of corneal ulcers. When S. mitis causes keratitis, penetrating keratoplasty (PK) might be necessary. Herein, we demonstrated that amniotic membrane transplantation (AMT) may be an easier procedure with acceptable outcomes and with fewer complications. Case presentation: A 63-year-old female presented with a right persistent corneal ulcer that she had suffered from for the past nine months. The culture of a corneal scraping yielded S. mitis. The right eye descemetocele decreased from 3 mm in diameter to 0.8 mm in diameter after the continuous administration of topical vancomycin and ceftriaxone for two weeks. Due to the slow healing, AMT was performed. Her corneal erosion healed and gradually became clear. Her visual acuity recovered from initially counting fingers to 20/200 17 months after AMT. Conclusion: This unusual case illustrated that antibiotics plus AMT may be an effective alternative treatment instead of PK to promote epithelialization and to reduce inflammation in corneas complicated by S. mitis keratitis.

scholarly journals Two case reports of continued progression of chronic ocular graft-versus-host disease without concurrent systemic comorbidities treated by amniotic membrane transplantation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hideto Ikarashi ◽  
Naohiko Aketa ◽  
Eisuke Shimizu ◽  
Yoji Takano ◽  
Tetsuya Kawakita ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Amniotic Membrane ◽  
Case Reports ◽  
Signs And Symptoms ◽  
Amniotic Membrane Transplantation ◽  
Team Approach ◽  
Host Disease ◽  
Graft Versus Host ◽  
Target Organs ◽  
Conjunctival Inflammation

Abstract Background Chronic ocular graft-versus-host disease (oGVHD) is an ocular comorbidity of graft-versus-host disease (GVHD) that usually occurs concurrently with systemic manifestations. Failure to detect and treat oGVHD in its early stages may lead to progression of ocular signs and symptoms leading to oGVHD that is refractory to conventional treatment. Case presentation We report the clinical course of a 19-year-old male and a 59-year-old female with severe and progressive chronic oGVHD without concurrent systemic signs of chronic graft-versus-host disease (cGVHD). Although their systemic conditions had been stable, both suffered from severe oGVHD and were referred to our clinic. Both cases exhibited marked improvement in conjunctival inflammation and fibrotic changes after amniotic membrane transplantation (AMT). Both cases underwent keratoplasty eventually to stabilize ocular surface conditions and to improve visual function. Conclusions We reported the clinical outcomes of 2 cases of chronic oGVHD without concurrent systemic comorbidities that were treated with AMT. The clinician should be aware that cGVHD may persist in target organs even in the absence of concurrent systemic comorbidities following seemingly successful systemic treatment. A multidisciplinary team approach is essential in the early detection and therapeutic intervention for chronic oGVHD.

scholarly journals Comparison of amniotic membrane transplantation with and without cultured limbal epithelium for persistent corneal ulcers

2021 ◽  
Vol 35 (1) ◽  
pp. 739-745
Author(s):  
Rozaliya Hristova ◽  
Yani Zdravkov ◽  
Georgi Markov ◽  
Davide Borroni ◽  
Alexander Oscar ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers ◽  
Limbal Epithelium

scholarly journals Nano-Scale Modifications of Amniotic Membrane Induced by UV and Antibiotic Treatment: Histological, AFM and FTIR Spectroscopy Evidence

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 863
Author(s):  
Simona Cavalu ◽  
George Roiu ◽  
Ovidiu Pop ◽  
Denisa A. Petricas Heredea ◽  
Traian Octavian Costea ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Antibiotic Treatment ◽  
Amniotic Membrane ◽  
Ocular Surface ◽  
Enzymatic Digestion ◽  
Uv Exposure ◽  
Amniotic Membrane Transplantation ◽  
Corneal Tissue ◽  
Nano Scale ◽  
Gentamicin Treatment

The efficiency of amniotic membrane (AM) transplantation in different types of ocular surface disorders is due to its outstanding properties such as antifibrotic, antibacterial, anti-inflammatory and antiangiogenic, working as a versatile scaffold to promote corneal tissue epithelialization. A proper preparation, preservation and clinical application are crucial for the best outcomes in the treatment of different severe ocular disorders, taking into account its fragility. In this context, by combining high-sensitivity tools such as atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy with histological and immunohistochemical examination, we aimed to investigate the ultrastructural modifications of the amniotic membrane (AM) upon UV exposure and/or antibiotic treatment, with relevance for clinical applications in ocular surface surgery. From the morphological point of view, we noticed a loss of cuboidal cells in the basal membrane, accompanied by the splitting of collagen fibers upon UV and/or gentamicin treatment, while structural alteration of proteins was evidenced by the FTIR quantitative analysis of the secondary structure. A decrease in α-helix and β-sheet content, accompanied by increased content in less ordered structures (turns, random and side chains), was noticed after all the treatments. At the nano-scale, AFM details showed modifications of collagen fibrils in terms of their thickness and network compaction upon gentamicin and/or UV treatment. The enzymatic digestion assay demonstrated that UV exposure significantly reduces the degradation rate of the AM, while gentamicin treatment promotes an accelerated enzymatic digestion upon UV exposure. In order to highlight the clinical impact of the research, a clinical case is presented showing the relevance of amniotic membrane transplantation in pterygium surgery.

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