Tocilizumab and Regression of Rheumatoid Nodules in Patients with Rheumatoid Arthritis: 2 Case Reports

2013 ◽  
Vol s4 (01) ◽  
Author(s):  
Haider M Al Attia
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Reports ◽  
Rheumatoid Nodules

scholarly journals Simultaneous occurrence of accelerated nodulosis in lungs, liver, and kidneys, and acute exacerbation of interstitial pneumonia in a patient with rheumatoid arthritis: an autopsy case report

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Akitake Suzuki ◽  
Shigeki Morita ◽  
Miho Ohshima ◽  
Nobuyoshi Minemura ◽  
Takeshi Suzuki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Exacerbation ◽  
Case Reports ◽  
Pulmonary Nodules ◽  
Rapid Onset ◽  
Simultaneous Occurrence ◽  
Intravenous Cyclophosphamide ◽  
Internal Organs ◽  
Case Presentation ◽  
Rheumatoid Nodules

Abstract Background Accelerated nodulosis (ARN) is a rare variant of rheumatoid nodules (RNs) that is characterized by a rapid onset or the worsening of RNs. It generally develops at the fingers in patients with rheumatoid arthritis (RA) receiving methotrexate (MTX). Few case reports have described ARN at an extracutaneous location. Case presentation An elderly patient with long-standing RA was admitted to our hospital with acute respiratory failure. Computed tomography upon admission showed diffuse ground-glass opacities superimposed with subpleural reticular shadowing and honeycombing and multiple nodules in the lungs and liver. Despite the discontinuation of MTX and introduction of an immunosuppressive regimen with pulse methylprednisolone followed by a tapering dose of prednisolone and intravenous cyclophosphamide, the patient died due to the acute exacerbation (AE) of RA-related interstitial lung disease (ILD) following the parallel waxing and waning of a diffuse interstitial shadow and pulmonary and liver nodules. At autopsy, RNs were scattered throughout both lung fields in addition to extensive interstitial changes. RNs were also detected in the liver and kidneys. The foci of cryptococcosis were mainly identified in alveolar spaces. Based on the clinical and pathological findings, these nodules were most consistent with ARN because of acute increases in the size and number of previously detected pulmonary nodules. Conclusion The present case is noteworthy because ARN was concurrently detected in multiple internal organs and may be associated with the AE of RA-related ILD.

"Pseudorheumatoid" Nodules in Children: Report of 10 Cases

PEDIATRICS ◽  
1970 ◽  
Vol 45 (3) ◽  
pp. 473-478 ◽  
Author(s):  
John D. Burrington
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Inflammatory Cells ◽  
Granuloma Annulare ◽  
Subcutaneous Nodules ◽  
Rheumatoid Nodules ◽  
Clinical Variant ◽  
Ulnar Aspect ◽  
Palm Of The Hand

Subcutaneous nodules, composed of necrotic collagen surrounded by chronic inflammatory cells, occur in about 20% of individuals with rheumatoid arthritis, 10% of those with acute rheumatic fever, and 25% of children with granuloma annulare. Similar subcutaneous lesions indistinguishable from rheumatoid nodules may appear in children who do not develop other stigmata of disease. Mesara and ous lesions of granuloma annulare. Therefore, they felt that, in children, these nodules probably represented a clinical variant of granuloma annulare. Beatty3 described nine children aged 11 days to 9 years with nodules on the scalp, ulnar aspect of the arm, dorsum of the foot, and palm of the hand which appeared histologically to be rheumatoid nodules.

scholarly journals Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases: Current Perspectives and Future Directions

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Atsushi Ogata ◽  
Toshio Tanaka
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Diseases ◽  
Host Defense ◽  
Lupus Erythematosus ◽  
Therapeutic Strategy ◽  
Case Reports ◽  
Systemic Autoimmune Diseases ◽  
Future Directions ◽  
Pilot Studies ◽  
Beneficial Effects

Interleukin (IL)-6 is a cytokine featuring redundancy and pleiotropic activity. While IL-6, when transiently produced, contributes to host defense against acute environmental stress, continuous dysregulated IL-6 production plays a significant pathological role in several systemic autoimmune diseases. In response to the expectation that IL-6 blockade would constitute a novel therapeutic strategy for the treatment of these diseases, tocilizumab, a humanized anti-IL-6 receptor antibody, was developed. Clinical trials have verified the efficacy and the safety of tocilizumab for patients with rheumatoid arthritis, resulting in approval of this innovative biologic for the treatment of rheumatoid arthritis in more than 90 countries worldwide. Pathological analyses of the effect of IL-6 on the development of autoimmune diseases and a considerable number of case reports and pilot studies have also indicated the beneficial effects of this antibody on other systemic autoimmune diseases, including systemic lupus erythematosus, systemic sclerosis, polymyositis, and large-vessel vasculitis.

Rheumatoid Nodules and Postoperative Complications

2003 ◽  
Vol 24 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Christopher Bibbo ◽  
Robert B. Anderson ◽  
W. Hodges Davis ◽  
Jim Norton
Keyword(s):  
Rheumatoid Arthritis ◽  
Postoperative Outcome ◽  
Infectious Complications ◽  
Chemotherapeutic Agents ◽  
Operative Procedures ◽  
Rheumatoid Nodule ◽  
Foot And Ankle ◽  
Statistical Association ◽  
Rheumatoid Nodules ◽  
Ankle Surgery

The records of 104 patients who underwent reconstructive foot and ankle surgery for deformities secondary to rheumatoid arthritis were reviewed. The use of rheumatoid chemotherapeutic agents, age, sex, rheumatoid nodule status, and the number of concurrent surgical procedures performed was analyzed to determine any association with the postoperative outcome for wound healing and infectious complications. The 104 patients, ranging in age from 23 to 83 years, underwent 725 operative procedures. An overall 32% complication rate was recorded. Analysis of five specific rheumatoid chemotherapeutic agents (NSAIDs, steroids, methotrexate, hydroxychloroquine, gold), age, sex, number of operative procedures performed, and presence of rheumatoid nodules, either alone or in combination, failed to prove a statistical association with either a healing or infectious postoperative complication.

scholarly journals Effects of tofacitinib on the clinical features of periodontitis in patients with rheumatoid arthritis: two case reports

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Tetsuo Kobayashi ◽  
Satoshi Ito ◽  
Akira Murasawa ◽  
Hajime Ishikawa ◽  
Hiromasa Yoshie
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Features ◽  
Case Reports

scholarly journals Meningeal rheumatoid nodules in a 55-year-old man presenting with chronic headaches and oculomotor nerve palsy: an uncommon extra-articular manifestation of rheumatoid arthritis

2019 ◽  
Vol 12 (12) ◽  
pp. e231474 ◽  
Author(s):  
Hafez Mohammad Ammar Abdullah ◽  
Muhammad Omar ◽  
Aiham Jbeli ◽  
Joseph Fanciullo
Keyword(s):  
Rheumatoid Arthritis ◽  
Nerve Palsy ◽  
Neurological Deficits ◽  
Oculomotor Nerve Palsy ◽  
High Dose ◽  
Cns Involvement ◽  
Third Nerve Palsy ◽  
Rheumatoid Nodules ◽  
Organ Systems ◽  
Chronic Headaches

Rheumatoid arthritis (RA) is a multisystem inflammatory disease which can involve many organ systems including the central nervous system (CNS). Though not very common, the results can be severely debilitating. The spectrum of the CNS involvement includes meningitis, encephalitis and occasionally rheumatoid nodules. Its presentation is variable, though very rarely it can present as focal neurological deficits. Imaging can be suggestive, but diagnosis usually requires tissue biopsy. Treatment consists of high-dose steroids and immunosuppressants. We describe the case of a 55-year-old male patient with a history of RA presenting with a third nerve palsy and headache who was found to have rheumatoid nodules on biopsy. CNS involvement in RA should be considered in anyone with rheumatoid arthritis who presents with focal neurological deficits, though infections and space-occupying lesions should also be ruled out.

Rheumatoid arthritic foot. Two manifestations with case studies

1993 ◽  
Vol 83 (5) ◽  
pp. 270-275
Author(s):  
JP Patton ◽  
DP Murdoch ◽  
J Lindsey ◽  
G Young
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Studies ◽  
Diagnostic Features ◽  
Rheumatoid Nodules ◽  
Rheumatoid Arthritic

The authors review rheumatoid arthritis with focus on two pedal manifestations, rheumatoid nodules and digital deformities. The prevalence, presentation, and diagnostic features concerning these entities are discussed, and three case studies are presented.

Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: Three case reports

2014 ◽  
Vol 25 (1) ◽  
pp. 166-168 ◽  
Author(s):  
Sho Mokuda ◽  
Tatsuhiko Miyazaki ◽  
Yukari Saeki ◽  
Junya Masumoto ◽  
Masamoto Kanno ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Epstein Barr Virus ◽  
Case Reports ◽  
Barr Virus ◽  
Epstein Barr
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