Antibiotic Susceptibility Pattern of Bacterial Isolates from Patients of Respiratory Tract Infection at 43 Centers in Punjab, Pakistan

Background: Respiratory tract infections are one of the commonest types of infections affecting the Indian population and are a significant cause of morbidity and mortality. To deal with multidrug resistance one should be armed with region specific data about the susceptibility patterns of antimicrobials. This study was planned to identify the common pathogens responsible for the respiratory tract infection and their antibiotic susceptibility patterns.Methods: Smears were prepared from the specimens and gram stains of all clinical samples were done. The organisms were grown on various media and identified according to the standard procedures. The susceptibility patterns of the bacterial pathogens were determined following the panel of antimicrobial agents. Descriptive statistics were used for data analysis.Results: Out of 513 samples 471 samples were further processed. Klebsiella (30.42%) was found to be commonest pathogen followed by Pseudomonas (28.36%). Ampicillin and piperacillin /tazobactam combination were found to be highly efficient against Pseudomonas (83% and 58.8% respectively), E. coli (68% and 50.7% respectively), and Klebsiella (43% and 30.3% respectively). Conclusions: In our study, we found penicillins as the most efficacious antimicrobials to treat respiratory pathogens. The study reveals that the antibiotic susceptibility pattern varies across regions. The prescription of a right antibiotic, for a right patient will help to minimize the menace of emergence of antimicrobial resistance.

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Antibiotic susceptibility pattern of bacteria isolated from patients of respiratory tract infection in a tertiary care hospital of Eastern India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20191112 ◽

2019 ◽

Vol 8 (4) ◽

pp. 757

Author(s):

Ashok Prasad ◽

Shatavisa Mukherjee ◽

Nikhil Era ◽

Mala Mukherjee

Keyword(s):

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Antibiotic Susceptibility ◽

Tertiary Care ◽

Care Hospital ◽

Susceptibility Pattern ◽

Eastern India ◽

Antibiotic Susceptibility Pattern ◽

Tract Infections

Background: Respiratory tract infections have been one of the commonest types of infections affecting the Indian population. With antibiotic resistance being a global threat and challenge to healthcare, concerns over skilful and judicious use of existing antibiotics have been on rise. Update on region specific bacterial susceptibility pattern is thus a need. The present study was planned to identify the common pathogens responsible for the respiratory tract infection and their antibiotic susceptibility patterns.Methods: A prospective study was carried out, where subjects with lower respiratory tract (LRT) infection admitted in the Intensive Care Unit in the tertiary care centre in Eastern India during the one-year period were enrolled in the study. Samples such as sputum, suction tip, endotracheal aspirate, bronchial aspirate and pleural fluid were obtained under aseptic precautions and were processed. The bacterial isolates were subjected to susceptibility testing by standard Kirby Bauer disc diffusion methods. The susceptibility patterns of the bacterial pathogens were determined.Results: Out of 234 processed samples, klebsiella (33.44%) was found to be commonest pathogen isolated from all the sites followed by Pseudomonas, staphylococcus and others. Amongst the penicillin group of antibiotics, ampicillin showed highest activity against pseudomonas and E. coli respectively. Antibiotics like penicillin G, ampicillin/sulbactam and amoxicillin/clavulanic acid combination showed lower susceptibility towards most pathogens. Amongst broad spectrum antibiotics, amikacin showed high susceptibility towards pseudomonas species followed by chloramphenicol and tetracycline.Conclusions: With changing trends in microbiological patterns of responsible organisms, knowledge regarding antibiotic susceptibility pattern needs to be regularly revised, thus ensuring prompt initiation of adequate and appropriate antibiotic treatment with better patient outcomes.

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Isolation, Identification and Antibiotic Susceptibility Pattern of Urinary Tract Infection Bacterial Isolates

Letters in Applied NanoBioScience ◽

10.33263/lianbs104.28202830 ◽

2021 ◽

Vol 10 (4) ◽

pp. 2820-2830

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Antibiotic Susceptibility ◽

Gram Negative Bacteria ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Antibiotic Susceptibility Pattern ◽

Gram Negative ◽

Gram Positive Bacteria

Recently, the world's problem has become in the spread of microbes and the extent of their impact on public health, especially the problem of urinary tract infections (UTIs). Therefore, the purpose of the study was to clarify the extent of infection of the urinary tract and the extent of development of these microbes in resistance to antibiotics (antibiotic susceptibility pattern). The pathogens are isolated from hospitals and private medical centers. In this study, two hundred twenty-five urine samples were collected from various sources, where 126 patients were infected with bacteria while 99 patients had no infection. In Gram-negative bacteria, the most common bacteria were E. coli (55.5%) followed by Klebsiella spp (23.0%), Proteus spp (7.14%), Pseudomonas spp (6.34%), and Acinetobacter spp (3.96%). In the Gram-positive bacteria Staphylococcus spp (2.38%) and Enterococcus spp (1.58%) were found. Antibiotic susceptibilities for Gram-negative and positive bacteria were investigated according to clinical laboratory standard institute(CLSI 2019). In Gram-negative bacteria, Amikcin, Impinem, and levofloxacin were sensitive. However, in Gram-positive bacteria, levofloxacin, ofloxacin, and linezolid were sensitive. At the same time, most of the remaining antibiotics are 100% resistant to pathogenic-bacterial isolates. This study showed bacteria that are isolated from urine which causing urinary tract infection and showed resistance to almost all antibiotics, so UTI is difficult to treat by common antibiotics.

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Incidence of Nosocomial Urinary Tract Infections and Antibiotic Susceptibility Pattern of Uropathogenic Bacterial Isolates of Patients from Selected Hospitals in Nsukka, Nigeria

International Journal of Pathogen Research ◽

10.9734/ijpr/2021/v7i330183 ◽

2021 ◽

pp. 7-16

Author(s):

C. O. Aleke ◽

K. O. Ugwu ◽

O. N. Akoma ◽

I. M. Ezeonu

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Urinary Tract Infections ◽

Antibiotic Susceptibility ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Antibiotic Susceptibility Pattern ◽

Tract Infections ◽

Urine Specimens

Urinary Tract Infection (UTI) is one of the significant healthcare and hygienic-based diseases ravaging millions of people, especially in third world countries with poor hospital settings. This cross-sectional and laboratory investigation was done to determine the incidence of nosocomial urinary tract infections (NUTIs) and antibiotic susceptibility pattern of the uropathogenic bacterial isolates from hospital patients in Nsukka, Southeastern Nigeria. Urine specimens of fifty patients were collected and analyzed between May and June 2018. Kirby-Bauer disk diffusion method was used for detection of antibiotic susceptibility pattern for all isolates. Bacteriuria was observed in urine specimens of 31 (62%) out of the 50 participants, with the specimens of 13 yielding significant growth at 42% rate of nosocomial urinary tract infections (NUTIs). The most predominant bacterial isolate of urinary tract infection was Staphylococcus spp. (31%); followed by Escherichia, Klebsiella and Proteus with (23%) each. Isolates were mostly susceptible to Ciprofloxacin (87.1%), while other isolates were mainly resistant to Zinnacef (937%). Pertinent recommendations were made with respect to treatment, multidrug resistance mitigation and aseptic and optimal health services delivery practices.

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