Non-cultured epithelial cells in platelet-rich plasma for the resurfacing of massive and chronic fullthickness burns: A case series

Background: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are injectable treatments for knee osteoarthritis. The focus of previous studies has compared their efficacy against each other as monotherapy. However, a new trend of combining these 2 injections has emerged in an attempt to have a synergistic effect. Purpose: To systematically review the clinical literature examining the combined use of PRP + HA. Design: Systematic review. Methods: A systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed and Embase. The following search terms were used: knee osteoarthritis AND platelet rich plasma AND hyaluronic acid. The review was performed by 2 independent reviewers who applied the inclusion/exclusion criteria and independently extracted data, including methodologic scoring, PRP preparation technique, HA composition, and patient-reported outcomes (PROs). Results: A total of 431 articles were screened, 12 reviewed in full, and 8 included in the final analysis: 2 case series, 3 comparative, and 3 randomized studies. Average follow-up was 9 months. The modified Coleman Methodology Score was 38.13 ± 13.1 (mean ± SD). Combination therapy resulted in improved PROs in all studies. Of the comparative and randomized studies, 2 demonstrated that combination therapy was superior to HA alone. However, when PRP alone was used as the control arm (4 studies), combination therapy was not superior to PRP alone. Conclusion: Combination therapy with PRP + HA improves PROs and is superior to HA alone but is not superior to PRP alone.

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Foot and Ankle Injections in Athletes

Sports Health A Multidisciplinary Approach ◽

10.1177/19417381211003619 ◽

2021 ◽

pp. 194173812110036

Author(s):

Jonathan K. Ochoa ◽

Christopher E. Gross ◽

Robert B. Anderson ◽

Andrew R. Hsu

Keyword(s):

English Language ◽

Platelet Rich Plasma ◽

Empirical Studies ◽

Autologous Blood ◽

Case Series ◽

Placental Tissue ◽

Ankle Injuries ◽

Extensive Literature ◽

Foot And Ankle ◽

Level Of Evidence

Context: Injections are commonly used by health care practitioners to treat foot and ankle injuries in athletes despite ongoing questions regarding efficacy and safety. Evidence Acquisition: An extensive literature review was performed through MEDLINE, Google Scholar, and EBSCOhost from database inception to 2021. Keywords searched were injections, athletes, sports, foot and ankle, corticosteroids, platelet-rich plasma, and placental tissue. Search results included articles written in the English language and encompassed reviews, case series, empirical studies, and basic science articles. Study Design: Clinical review. Level of Evidence: Level 4. Results: Corticosteroids, platelet-rich plasma/autologous blood, anesthetic, and placental tissue injections are commonly used in the treatment of foot and ankle injuries. Primary indications for injections in athletes include plantar fasciitis, Achilles tendinosis, isolated syndesmotic injury, and ankle impingement with varying clinical results. Conclusions: Despite promising results from limited case series and comparative studies, the data for safety and efficacy of injections for foot and ankle injuries in athletes remain inconclusive.

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REMOVAL OF ARYLAMINE-DNA ADDUCTS IN CULTURED EPITHELIAL-CELLS OF RAT AND HUMAN URINARY-BLADDER AND MAMMARY-GLAND

International Journal of Oncology ◽

10.3892/ijo.5.5.997 ◽

1994 ◽

Author(s):

M DEBIECRYCHTER ◽

K ZUKOWSKI ◽

M TADA ◽

MC POIRIER ◽

CY WANG

Keyword(s):

Mammary Gland ◽

Epithelial Cells ◽

Urinary Bladder ◽

Dna Adducts ◽

Human Urinary Bladder ◽

Cultured Epithelial Cells

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Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

Aesthetic Plastic Surgery ◽

10.1007/s00266-021-02406-0 ◽

2021 ◽

Author(s):

Benjamin Talei ◽

Orr Shauly ◽

Daniel Gould

Keyword(s):

Hair Loss ◽

Platelet Rich Plasma ◽

Case Series

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Progesterone-Modulated Induction of Apoptosis by Interferon-Tau in Cultured Epithelial Cells of Bovine Endometrium1

Biology of Reproduction ◽

10.1095/biolreprod.102.006924 ◽

2003 ◽

Vol 68 (2) ◽

pp. 673-679 ◽

Cited By ~ 23

Author(s):

Bingtuan Wang ◽

Chaowu Xiao ◽

Alan K. Goff

Keyword(s):

Epithelial Cells ◽

Interferon Tau ◽

Cultured Epithelial Cells ◽

Induction Of Apoptosis

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Eviscerated Corneas as Tissue Source for Ex Vivo Expansion of Limbal Epithelial Cells on Platelet-Rich Plasma Gels

Current Eye Research ◽

10.3109/02713683.2016.1141962 ◽

2016 ◽

Vol 41 (12) ◽

pp. 1543-1547 ◽

Cited By ~ 2

Author(s):

Leonard G. Heydenrych ◽

Donald F. du Toit ◽

Colleen M. Aldous

Keyword(s):

Epithelial Cells ◽

Ex Vivo ◽

Platelet Rich Plasma ◽

Ex Vivo Expansion ◽

Tissue Source

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Cultured epithelial cells derived from human foetal pancreas as a model for the study of cystic fibrosis: further analyses on the origins and nature of the cell types

Journal of Cell Science ◽

10.1242/jcs.90.1.73 ◽

1988 ◽

Vol 90 (1) ◽

pp. 73-77

Author(s):

A. Harris ◽

L. Coleman

Keyword(s):

Cystic Fibrosis ◽

Tissue Culture ◽

Epithelial Cells ◽

Culture System ◽

Cultured Cells ◽

Cell Types ◽

Cultured Epithelial Cells ◽

Different Cell Types ◽

Foetal Pancreas

The establishment of a tissue-culture system for epithelial cells derived from human foetal pancreas has recently been reported. Further analyses have now been made on these cells in vitro, together with parallel investigation of the distribution of different cell types within the intact foetal pancreas. Results support the view that the cultured cells are ductal in origin and nature. Pancreatic epithelial cell cultures have also been established from foetuses with cystic fibrosis.

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