scholarly journals Factors associated with mortality from tuberculosis in Iran: an application of a generalized estimating equation-based zero-inflated negative binomial model to national registry data

2019 ◽  
Vol 41 ◽  
pp. e2019032
Author(s):  
Fatemeh Sarvi ◽  
Abbas Moghimbeigi ◽  
Hossein Mahjub ◽  
Mahshid Nasehi ◽  
Mahmoud Khodadost
Keyword(s):  
Risk Factors ◽  
Negative Binomial ◽  
Public Health Problem ◽  
Estimating Equation ◽  
Negative Binomial Model ◽  
Generalized Estimating Equation ◽  
Binomial Model ◽  
Global Public Health ◽  
Related Factors ◽  
Generalized Estimating

OBJECTIVES: Tuberculosis (TB) is a global public health problem that causes morbidity and mortality in millions of people per year. The purpose of this study was to examine the relationship of potential risk factors with TB mortality in Iran.METHODS: This cross-sectional study was performed on 9,151 patients with TB from March 2017 to March 2018 in Iran. Data were gathered from all 429 counties of Iran by the Ministry of Health and Medical Education and Statistical Center of Iran. In this study, a generalized estimating equation-based zero-inflated negative binomial model was used to determine the effect of related factors on TB mortality at the community level. For data analysis, R version 3.4.2 was used with the relevant packages.RESULTS: The risk of mortality from TB was found to increase with the unemployment rate (βˆ=0.02), illiteracy (βˆ=0.04), household density per residential unit (βˆ=1.29), distance between the center of the county and the provincial capital (βˆ=0.03), and urbanization (βˆ=0.81). The following other risk factors for TB mortality were identified: diabetes (βˆ=0.02), human immunodeficiency virus infection (βˆ=0.04), infection with TB in the most recent 2 years (βˆ=0.07), injection drug use (βˆ=0.07), long-term corticosteroid use (βˆ=0.09), malignant diseases (βˆ=0.09), chronic kidney disease (βˆ=0.32), gastrectomy (βˆ=0.50), chronic malnutrition (βˆ=0.38), and a body mass index more than 10% under the ideal weight (βˆ=0.01). However, silicosis had no effect.CONCLUSIONS: The results of this study provide useful information on risk factors for mortality from TB.

Estimating Rates of Recurrent Peritonitis for Patients on CAPO

1985 ◽  
Vol 5 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Edward F. Vonesh
Keyword(s):  
Risk Factors ◽  
Medical Devices ◽  
Negative Binomial ◽  
Survival Curve ◽  
Probability Model ◽  
Major Complication ◽  
Poisson Model ◽  
Negative Binomial Model ◽  
Binomial Model ◽  
The Mean

Recurrent peritonitis is a major complication of Continuous Ambulatory Peritoneal Dialysis (CAPD). As a therapy for patients with end stage renal disease, CAPD entails a continuous interaction between patient and various medical devices. The assumptions one makes regarding this interaction play an essential role when estimating the rate of recurrent peritonitis for a given patient population. Assuming that each patient has a constant rate of peritonitis, two models for evaluating the risk of recurrent peritonitis are considered. One model, the Poisson probability model, applies when the rate of peritonitis is the same from patient to patient. When this occurs, the frequency of peritoneal infections will be randomly distributed among patients (Corey, 1981). A second model, the negative binomial probability model, applies when the rate of peritonitis varies from one patient to another. In this event, the distribution of peritoneal infections will differ from patient to patient. The poisson model would be applicable when, for example, patients behave similarly with respect to their interactions with the medical devices and with potential risk factors. The negative binomial model, on the other hand, makes allowances for patient differences both in terms of their handling of routine exchanges and in their exposure to various risk factors. This paper provides methods for estimating the mean peritonitis rate under each model. In addition, “survival” curve estimates depicting the probability of remaining peritonitis free (i.e. “surviving”) over time are provided. It is shown, using data from a multi-center clinical trial, that the risk of peritonitis is best described in terms of survival curves rather than the mean peritonitis rate. For both models, the mean peritonitis rate was found to be 0.85 episodes per year. However, under the negative binomial model, the one-year survival rate, expressed as the percentage of patients remaining free of peritonitis, is 52% as compared with only 42% under the Poisson model. Moreover, the negative binomial model provided a significantly better fit to the observed frequency of peritonitis. These findings suggest that the negative binomial model provides a more realistic and accurate portrayal of the risk of peritonitis and that this risk is not nearly as high as would otherwise be indicated by a Poisson analysis.

scholarly journals Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing Zhao ◽  
Zhihua Li ◽  
Chengbei Hou ◽  
Fei Sun ◽  
Jing Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gender Differences ◽  
Density Lipoprotein ◽  
Estimating Equation ◽  
High Plasma ◽  
Plasma Homocysteine ◽  
Lipoprotein Cholesterol ◽  
Outcome Variable ◽  
Generalized Estimating Equation ◽  
Generalized Estimating

Abstract Background Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels. Methods In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16–102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Fasting blood samples were collected to measure the biochemical indexes. The outcome variable was Hcy level, and a generalized estimating equation (GEE) analysis was used to identify the associations of interest based on gender. Results Males exhibited increased Hcy levels (16.37 ± 9.66 vs 11.22 ± 4.76 μmol/L) and prevalence of HHcy (37.0% vs 11.3%) compared with females. Hcy levels and HHcy prevalence increased with age in both genders, except for the 16- to 29-year-old group. GEE analysis indicated that irrespective of gender, aspartate aminotransferase, creatinine, uric acid, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were positively correlated with Hcy levels, and alanine aminotransferase, total cholesterol and glucose were negatively correlated with Hcy levels. However, age, BMI and triglycerides (TGs) were positively correlated with Hcy levels exclusively in females. Conclusions Gender differences in risk factors for high plasma Hcy levels were noted. Although common correlational factors existed in both genders, age, BMI and TGs were independent risk factors for Hcy levels specifically in females.

Persistent environmental reservoirs on farms as risk factors forCampylobacterin commercial poultry

2011 ◽  
Vol 140 (5) ◽  
pp. 916-924 ◽  
Author(s):  
J. ELLIS-IVERSEN ◽  
A. RIDLEY ◽  
V. MORRIS ◽  
A. SOWA ◽  
J. HARRIS ◽  
...  
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Estimating Equation ◽  
Equation Model ◽  
The Other ◽  
Generalized Estimating Equation ◽  
Temporal Aspects ◽  
Commercial Poultry ◽  
Developed World ◽  
Generalized Estimating

SUMMARYCampylobacteris the most common known source of human bacterial enteritis in the developed world and poultry is considered the main source. Broilers often become colonized withCampylobacterduring rearing, and then contaminate the farm environment. The objective of this study was to identifyCampylobacter-positive environmental reservoirs on farms, as these pose a risk to broiler flocks becoming colonized withCampylobacter. We considered the temporal aspects of exposure and colonization. A longitudinal study monitored six conventional rearing farms over 2 years. The broiler flocks, catchers' equipment, vehicles, shed surrounds, shed entrance, other equipment, farm entrance, other animals, puddles, dead birds, mains water and drinkers were systematically sampled 2–4 times per flock. A multivariable generalized estimating equation model was used to assess associations between contaminated environmental sites and colonized broiler flocks. The associations were adjusted for confounders and other known risk factors. To further assess temporality of contamination, the sequence of contamination of the different environmental sites and the flocks was established. Contaminated shed entrances and anterooms, contaminated drinkers and shedding ofCampylobacterby other animals such as cattle, dogs, wildlife and rodents were significantly associated with positive flocks. The reservoir of ‘other animals’ was also the reservoir most commonly positive before the flock became colonized. The other sites usually became contaminated after the flock was colonized.

Robust inference in the multilevel zero-inflated negative binomial model

2019 ◽  
Vol 47 (2) ◽  
pp. 287-305 ◽  
Author(s):  
Eghbal Zandkarimi ◽  
Abbas Moghimbeigi ◽  
Hossein Mahjub ◽  
Reza Majdzadeh
Keyword(s):  
Negative Binomial ◽  
Negative Binomial Model ◽  
Robust Inference ◽  
Binomial Model

scholarly journals Prevalence and Associated Factors of Anemia among Muslim Students, Nakhon Si Thammarat, Thailand: A Cross-Sectional Study

2021 ◽  
Vol 58 ◽  
pp. 004695802110134
Author(s):  
Chutima Rattanawan ◽  
Suraiya Cheloh ◽  
Asma Maimahad ◽  
Malatee Tayeh
Keyword(s):  
Public Health ◽  
Associated Factors ◽  
Public Health Problem ◽  
Economic Factor ◽  
Cross Sectional Study ◽  
School Age ◽  
Global Public Health ◽  
Related Factors ◽  
Cross Sectional ◽  
Prevalence Of Anemia

Anemia is a global public health problem. The prevalence of anemia among different ages, genders or ethnic groups must be clarified in order to solve problems. This study proposed to determine the prevalence and factors related to anemia among the Muslim school-age population in Nakhon Si Thammarat, Thailand. Socio-demographic and anthropometric data were collected by a structured questionnaire. Blood samples were collected from 200 school-age subjects. The thalassemia screening was performed with KKU-OF and KKU-DCIP reagents. The prevalence of anemia in this study was 36.5%, divided into males and females, 33.3% and 39.1%, respectively. The means of Hb, Hct, MCV, MCH, and MCHC in the anemic group were significantly lower. The positive results for KKU-OF or KKU-DCIP or both were 15.0%, 2.5%, and 1.0%, respectively. The result of positive OF test was a significantly independent factor for anemia. The number of family members was 5 to 7 and more than 7 persons are related factors for anemia in this study. In summary, the contribution of thalassemia and socio-economic factor are associated factors to anemia in this population. These findings should be addressed in public health strategies for the control of anemia of school-aged Muslims in the region.

Assessing recurrence of depression using a zero-inflated negative binomial model: A secondary analysis of lifelog data

2021 ◽  
Vol 300 ◽  
pp. 113919
Author(s):  
Narimasa Kumagai ◽  
Aran Tajika ◽  
Akio Hasegawa ◽  
Nao Kawanishi ◽  
Hirokazu Fujita ◽  
...  
Keyword(s):  
Negative Binomial ◽  
Secondary Analysis ◽  
Negative Binomial Model ◽  
Binomial Model
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