ANFIS Based Modeling of the Hormonal Effects of GLP-2 on the Mean Arterial Pressure and Blood Volume of Rats

Background: The mean arterial pressure serves as an expression of blood pressure in patients on chronic hemodialysis. Serum calcium phosphorus product is considered as a risk factor of vascular calcification that is associated with hypertension in the patients of end stage renal disease. The literature regarding this relationship is inconsistent therefore this study is designed to determine the correlation between calcium phosphorus product and mean arterial pressure among hemodialysis patients with end stage renal disease. Methods: A total of 110 patients of end stage renal disease on hemodialysis for at least one year, 20 to 60 years of age were included. Patients with primary or tertiary hyperparathyroidism, peripheral vascular disease, malignancy, hypertension secondary to any cause other than kidney disease were excluded. Mean arterial pressure was calculated according to the standard protocol in lying position. Blood samples for estimation of serum calcium and phosphorous were taken and was sent immediately to the laboratory for serum analysis. Results: Mean age was 44.17 ± 10.94 years. Mean calcium phosphorous product was 46.71 ± 7.36 mg/dl and mean arterial pressure was 103.61 ± 12.77 mmHg. The values of Pearson correlation co-efficient (r) were 0.863 for age group 20 to 40 years and 0.589 for age group 41 to 60 years. This strong positive correlation means that high calcium phosphorous product goes with high mean arterial pressure (and vice versa) for both the age groups. Conclusion: A strong positive relationship exists between the mean arterial pressure and calcium phosphorous product and is independent of patients’ age.

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Hubungan Mean Arterial Pressure (MAP) Dengan Preeklamsia Pada Ibu Hamil Di Puskesmas Bontobangun Kabupaten Bulukumba

Jurnal Kesehatan Panrita Husada ◽

10.37362/jkph.v5i2.376 ◽

2020 ◽

Vol 5 (2) ◽

pp. 138-145

Author(s):

Ely Kurniati ◽

Rusnawati

Keyword(s):

Mean Arterial Pressure ◽

Arterial Pressure ◽

Pregnant Women ◽

Sampling Method ◽

Blood Pressure Measurement ◽

Test Results ◽

Historical Cohort ◽

Measurement Results ◽

History Of ◽

The Mean

Preeclampsia complicates 4-7% of pregnancies and remains the leading cause of maternal and fetal morbidity and mortality worldwide. Despite improvements in health care over the last decade, preeclampsia remains the second most common cause of maternal mortality in Indonesia. This study aims to determine whether the mean arterial pressure (MAP) is related to the incidence of preeclampsia in pregnant women at the Bontobangun Puskesmas, Bulukumba district for the period 2018 to 2019. This research uses a descriptive-analytic approach with Historical Cohort Studies, namely by looking at the cohort book of the history of blood pressure measurement results for pregnant women at the Bontobangun Public Health Center, Bulukumba Regency for the period 2018 to 2019. Determining the sample using the sampling method taken by purposive sampling. 31 samples of pregnant women who experienced preeclampsia and 31 controls were pregnant women with normal conditions who had certain criteria (matching) with the sample. The results explained that from the paired T-test results, the value of α> 0.037 so that it is said that there is a relationship between mean artery pressure (MAP) and the incidence of preeclampsia in pregnant women at Bontobangun puskesmas for the period 2018-2019.

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The Use of Biochemical and Biophysical Markers in Early Screening for Preeclampsia in Mongolia

Medical Sciences ◽

10.3390/medsci6030057 ◽

2018 ◽

Vol 6 (3) ◽

pp. 57

Author(s):

Urjindelger Tserensambuu ◽

Ariunbold Chuluun-Erdene ◽

Munkhtsetseg Janlav ◽

Erkhembaatar Tudevdorj

Keyword(s):

Mean Arterial Pressure ◽

Arterial Pressure ◽

Pulsatility Index ◽

Uterine Artery ◽

Maternal Serum ◽

Operating Characteristics ◽

Early Screening ◽

Roc Curve Analysis ◽

Detection Rates ◽

The Mean

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality, particularly in developing countries. In Mongolia, preeclampsia and eclampsia have occurred among pregnancy complications at a rate of 25% in recent years. Recent studies in the literature have screened for preeclampsia by combining maternal factors with biomarkers. This study was conducted using prospective cohort research including 393 singleton pregnancies at 11–13+6 weeks. Maternal plasmas pregnancy-associated plasma protein-A (PAPP-A) and maternal serum placental growth factor (PlGF) were measured using Perkin Elmer time-resolved fluoroimmunoassay (DELFIA) kits, and the measurement of mean arterial pressure (MAP) was performed by automated devices and the uterine artery pulsatility index was measured by Doppler ultrasound. In the study population, there were 16.7% showing complicated preeclampsia. The receiver-operating characteristics (ROC) curve analysis showed a sensitivity of 71.21%, and a specificity of 75.54% when the mean arterial pressure cut-off was 89.5 mm; while a sensitivity of 33.36% and specificity of 77.68% were observed when the uterine artery mean pulsatility index (mPI) cut-off was 2.34; a sensitivity of 79.66% and specificity of 44.04% were observed when the PAPP-A cut-off was 529.1 mU/L; and a sensitivity of 74.58% and specificity of 46.6% were observed when the PlGF cut-off was 39.87 pg/mL. The detection rates following the combination of markers with the maternal history were as follows: 62.7% with mean arterial pressure, 69.5–82.9% with two markers 86.5% with three markers and 91.4% with four markers. In conclusion, the mean arterial pressure was highly sensitive and demonstrated its easy usage and cost-effectiveness as a predictive marker for the early screening of preeclampsia from other biomarkers.

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Maternal responses to long-term hypoxemia in sheep

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1989.256.6.r1340 ◽

1989 ◽

Vol 256 (6) ◽

pp. R1340-R1347 ◽

Cited By ~ 6

Author(s):

T. Kitanaka ◽

R. D. Gilbert ◽

L. D. Longo

Keyword(s):

Heart Rate ◽

Blood Flow ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Blood Volume ◽

Cardiovascular Responses ◽

Uterine Blood Flow ◽

O2 Uptake ◽

Arterial Po2

To determine the maternal cardiovascular responses to long-term hypoxemia, we studied three groups of animals: 1) pregnant ewes (n = 20) at 110-115 days gestation subjected to hypoxia for up to 28 days; 2) pregnant ewes (n = 4) that served as normoxic controls; and 3) nonpregnant ewes (n = 6) subjected to hypoxemia for up to 28 days. We measured mean arterial pressure, heart rate, uterine blood flow, and uterine vascular resistance continuously for 1 h/day while the ewe was exposed to an inspired O2 fraction of 12-13% for at least 17 days. Arterial PO2, O2 saturation, hemoglobin, arteriovenous O2 difference, and uterine O2 uptake were measured daily while blood volume and erythropoietin concentration were measured weekly. In the pregnant hypoxic group arterial PO2 decreased from a control value of 101.5 +/- 5.1 to 59.2 +/- 5.1 Torr within a few minutes, where it remained throughout the study. The hemoglobin concentration increased from 8.9 +/- 0.5 to 10.0 +/- 0.5 g/dl within 24 h where it remained, whereas erythropoietin concentration increased from 16.6 +/- 2.1 to 39.1 +/- 7.8 mU/ml at 24 h but then returned to near-control levels. Arterial glucose concentration, mean arterial pressure, and cardiac output decreased slightly but insignificantly. In contrast, body weight, heart rate, blood volume, uterine blood flow, uterine O2 flow, uteroplacental O2 uptake, and the concentrations of catecholamines and cortisol remained relatively constant. Thus both pregnant and nonpregnant sheep experience relatively minor cardiovascular and hematologic responses in response to long-term hypoxemia of moderate severity.

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Vascular Abnormalities and Pulmonary Hypertension in the Berkeley Sickle Mouse.

Blood ◽

10.1182/blood.v106.11.3185.3185 ◽

2005 ◽

Vol 106 (11) ◽

pp. 3185-3185

Author(s):

David R. Archer ◽

Shawn Elms ◽

Joshua Boutwell ◽

Jennifer Perry ◽

Roy Sutliff

Keyword(s):

Pulmonary Hypertension ◽

Cardiac Output ◽

Mean Arterial Pressure ◽

Endothelial Dysfunction ◽

Mouse Model ◽

Arterial Pressure ◽

Right Ventricular ◽

The Mean

Abstract Clinically, pulmonary hypertension is a major risk factor for mortality in adults with sickle cell disease. Contributing factors probably include red cell hemolysis and vaso-occlusive injury with their associated oxidative and inflammatory stimuli. Previously, we have described RBC hemolysis and endothelial oxidative stress in the Berkeley sickle mouse model and extend those studies in this work to investigate cardiovascular and endothelial dysfunction. Eight to ten month old homozygous and hemizygous Berkeley sickle mice and C57BL/6 control mice were used for all aspects of these experiments. In vivo measurements of mean arterial pressure and right ventricular pressures were conducted in fully anesthetized mice using a pressure transducer inserted in the carotid and right ventricle respectively. Following in vivo readings hearts were excised for measurement of ventricular mass. The ascending aorta was removed and cut into 5 mm rings for in vitro studies of agonist- induced contractility and relaxation. The mean arterial pressure of the hemizygous sickle mice (70.6 ± 3.4) was significantly lower than the control mice (86.0 ± 3.1) and the mean arterial pressure of homozygous sickle mice (59.0 ± 2.2 mmHg) was significantly lower than the hemizygous and control mice (p≤0.05 and p≤0.001, respectively). The right ventricular pressure showed a trend that approached significance (p= 0.08) such that pressures in homozygous mice were ≥ than those in hemizygous which were ≥ than those in control mice. Increased basal cardiac output was suggested by significant left ventricular hypertrophy. In vitro examination of potassium chloride activation of voltage gated calcium channels showed no significant difference in sensitivity or maximal contraction. Similarly, there was no difference in sensitivity to the α1 agonist, phenylephrine. However, both hemi- and homozygous mice showed a significant reduction in maximal force of contraction (normalized to cross sectional area when compared to controls. Maximal acetylcholine induced relaxation of aortic rings was significantly reduced (p≤0.05) in homozygous sickle mice compared to controls. The same effect was not seen with sodium nitroprusside induced relaxation indicating that the acetylcholine effect was not due to effects on the smooth muscle but was endothelium-dependent. The Berkeley mouse model shows cardiac hypertrophy consistent with the increased cardiac output associated with chronic anemia and a reduced basal mean arterial blood pressure similar to that seen in humans. 8–10 month old mice have increased right ventricular pressure and RV mass indicative of pulmonary hypertension. Further endothelial dysfunction is characterized by a reduction in the maximal relaxation elicited by acetylcholine. Therefore, the Berkeley mouse is a good model for investigating sickle related endothelial dysfunction.

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Modelling the effect of IV drugs on the mean arterial pressure: efficiency of a GARCH model

European Journal of Anaesthesiology ◽

10.1097/00003643-200606001-00482 ◽

2006 ◽

Vol 23 (Supplement 37) ◽

pp. 134-135

Author(s):

S. Bras ◽

C. S. Nunes ◽

P. Amorim

Keyword(s):

Mean Arterial Pressure ◽

Arterial Pressure ◽

Garch Model ◽

The Mean

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Haemodynamic and Blood Volume Studies in Long-Term Haemodialysis Patients, and in Patients with Successfully Transplanted Kidneys

Clinical Science ◽

10.1042/cs045155s ◽

1973 ◽

Vol 45 (s1) ◽

pp. 155s-157s

Author(s):

J. Tuckman ◽

J.-L. Benninger ◽

F. Reubi

Keyword(s):

Mean Arterial Pressure ◽

Cardiac Index ◽

Arterial Pressure ◽

Blood Volume ◽

Peripheral Resistance ◽

Total Blood Volume ◽

Total Blood ◽

Transplanted Kidneys ◽

Very High

1. Stabilized hypertensive haemodialysis patients, as well as those with normotension, had a greatly elevated cardiac index (CI) that was not due to hypervolemia, but was most likely secondary to their anaemic condition. The hypertension itself was not accompanied by hypervolaemia, but was associated with a relatively very high total peripheral resistance. 2. In eight patients with successfully transplanted kidneys the following results were found. (a) Five were clearly hypertensive and had supine mean arterial pressure between 117 and 143 mmHg. It is noted that they were receiving prednisone at the time of the studies. (b) CI was normal in seven. (c) Total blood volume was normal in all. (d) The presence of wide-open arterio-venous fistulae was not associated with an increase in CI.

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The role of hemodynamic factors on urinary calcium and magnesium excretion

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y69-108 ◽

1969 ◽

Vol 47 (7) ◽

pp. 619-626 ◽

Cited By ~ 10

Author(s):

A. Gonda ◽

N. Wong ◽

J. F. Seely ◽

J. H. Dirks

Keyword(s):

Mean Arterial Pressure ◽

Arterial Pressure ◽

Divalent Cations ◽

Fractional Excretion ◽

Urinary Calcium ◽

Sodium Reabsorption ◽

Left Renal Artery ◽

Renal Handling ◽

The Mean ◽

Calcium And Magnesium

The effects of unilateral vasodilatation and alterations in the mean arterial pressure upon the renal handling of calcium and magnesium were studied by clearance methods in dogs. Unilateral vasodilatation was produced by infusion of acetylcholine or bradykinin into the left renal artery, while arterial pressure was altered by aortic constriction, carotid occlusion and vagotomy, or by systemic infusion of angiotensin. Urinary electrolyte excretion was increased markedly by the infusion of each vasodilator and also varied directly with the mean arterial pressure, despite the absence of any significant changes in the filtered load. The fractional excretion of both calcium and magnesium correlated significantly with that of sodium. These results indicate that acute changes in renal hemodynamics modify the tubular reabsorption of divalent cations as well as alter sodium reabsorption.

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