scholarly journals Effect of Non-Surgical Periodontal Therapy on the Severity of Rheumatoid Arthritis—A Clinical and Hematological Study

2020 ◽  
Vol 10 (01) ◽  
pp. 1-9
Author(s):  
Rujuta Krishnakant Pandya ◽  
Monali Amit Shah ◽  
Yesha Hareshkumar Raval
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Therapy

Are neutrophil extracellular traps the link for the cross-talk between periodontitis and rheumatoid arthritis physiopathology?

Rheumatology ◽  
2021 ◽  
Author(s):  
Sicília Rezende Oliveira ◽  
José Alcides A de Arruda ◽  
Ayda Henriques Schneider ◽  
Valessa Florindo Carvalho ◽  
Caio Machado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cross Talk ◽  
Neutrophil Extracellular Traps ◽  
Periodontal Therapy ◽  
Clinical Parameters ◽  
Extracellular Traps ◽  
Early Ra ◽  
The Cross ◽  
High Concentrations ◽  
The Impact

Abstract Objectives Neutrophil extracellular traps (NETs) play a role in the pathogenesis of periodontitis and rheumatoid arthritis (RA). However, it remains poorly understood whether NETs participate in the cross-talk between periodontitis and RA. Herein, we investigated the production of NETs in individuals with periodontitis and RA and its association with clinical parameters. The impact of periodontal therapy on RA and NET release was also assessed. Methods The concentration of NETs and cytokines was determined in the saliva and plasma of individuals with early RA (n = 24), established RA (n = 64), and individuals without RA (n = 76). The influence of periodontitis on the production of NETs and cytokines was also evaluated. Results Individuals with early RA had a higher concentration of NETs in saliva and plasma than individuals with established RA or without RA. Periodontitis resulted in an increase in the concentration of NETs of groups of individuals without RA and with early RA. The proportion of individuals with high concentrations of IL-6, IL-10 and GM-CSF was higher among individuals with periodontitis than among individuals without periodontitis. The concentrations of TNF-α, IL-6, IL-17/IL-25, and IL-28A were particularly high in individuals with early RA. Worse periodontal clinical parameters, RA onset and RA activity were significantly associated with circulating NETs. Periodontal therapy was associated with a reduction in the concentration of NETs and inflammatory cytokines and amelioration in periodontitis and RA. Conclusion This study reveals that NETs are a possible link between periodontitis and RA, with periodontal therapy resulting in a dramatic switch in circulating NET levels.

scholarly journals Nonsurgical Periodontal Therapy decreases the Severity of Rheumatoid Arthritis: A Case–control Study

2016 ◽  
Vol 17 (6) ◽  
pp. 484-488 ◽  
Author(s):  
Neha Khare ◽  
Bhavuk Vanza ◽  
Deepak Sagar ◽  
Kumar Saurav ◽  
Rohit Chauhan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oral Hygiene ◽  
Case Control Study ◽  
Case Control ◽  
Periodontal Therapy ◽  
Clinical Observations ◽  
Nonsurgical Periodontal Therapy ◽  
Group A ◽  
Group B ◽  
Control Study

ABSTRACT Introduction Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions. Several studies suggested a relationship between RA and periodontitis. Recent studies have shown a beneficial effect of periodontal treatment on the severity of active RA. So the aim of this study was to examine the effect of nonsurgical periodontal therapy on the clinical parameters of RA. Materials and methods A total of 60 subjects with moderateto- severe chronic generalized periodontitis and active RA in the age range 18 to 65 were selected for the study. They were divided into two groups. Group A (control group) consisted of 30 subjects with chronic generalized periodontitis and RA, and group B of 30 subjects with chronic generalized periodontitis and RA and they received nonsurgical periodontal therapy (scaling, root planning, and oral hygiene instructions). Evaluation of clinical observations of Simplified Oral Hygiene Index (OHI-S), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), number of swollen joints (SJ), number of tender joints (TJ), values of erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) for patient's global assessment, 3 months disease activity score (DAS) index, and C-reactive protein (CRP) was done at baseline and 3 months. Statistical evaluation of clinical observations was carried out. Results Group B subjects who received nonsurgical periodontal therapy showed statistically significant improvement in all periodontal and RA parameters at 3 months, compared with group A who did not receive periodontal therapy. Conclusion It can be concluded from the result that nonsurgical periodontal therapy may contribute to reduction in severity and symptoms of RA. Clinical significance Rheumatoid arthritis patients should be evaluated for periodontitis and treated for the same in order to reduce its severity level. How to cite this article Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S. Nonsurgical Periodontal Therapy decreases the Severity of Rheumatoid Arthritis: A Case–control Study. J Contemp Dent Pract 2016;17(6):484-488.

Non-Surgical Periodontal Therapy Decreases Periodontal Pocket Depth and Clinical Attachment Loss of Rheumatoid Arthritis Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3376-3377
Author(s):  
Marryam Riaz ◽  
Sohaib Shujaat ◽  
Ayesha Fahim ◽  
Shamail Zafar ◽  
Mariyah Javed ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gingival Recession ◽  
Periodontal Therapy ◽  
Periodontal Pocket ◽  
P Value ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Public And Private ◽  
Attachment Loss ◽  
Before And After

Objective: The objective of the present study was to determine the effect of non-surgical periodontal therapy on the disease severity in rheumatoid arthritis patients. Methods: Five hundred and twenty arthritis patients were included in the study, using consecutive non-probability sampling from the outpatient department of various public and private hospitals of Pakistan. Patients with periodontitis along with systemic Rheumatoid Arthritis (RA) were included in the study. Clinical parameters taken for the severity of periodontitis were the Gingival recession (GV), Periodontal Pocket Depth (PPD) and Clinical Attachment Loss (CAL). Independent sample t-test was used for significance before and after non-surgical periodontal therapy. Data was presented with mean (standard deviation). Results: The PPD and CAL of Rheumatoid Arthritis patients were found to be decreased significantly following non-surgical periodontal treatment (p value < 0.05), unlike the gingival recession, which did not decrease significantly (p value > 0.05). Conclusion: The PPD and CAL values of periodontal patients with rheumatoid arthritis were significantly reduced after giving non-surgical Periotherapy along with oral hygiene instruction. Keywords: arthritis; gingiva; periodontitis; periodontal pocket

scholarly journals Effects of non-surgical periodontal therapy on periodontal clinical data in periodontitis patients with rheumatoid arthritis: a meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu Huang ◽  
Zheng Zhang ◽  
Youli Zheng ◽  
Zhulan Zhao ◽  
Yang Zhong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Publication Bias ◽  
Clinical Efficacy ◽  
Clinical Data ◽  
Random Effect ◽  
Random Effect Model ◽  
Periodontal Therapy ◽  
Sensitivity Analyses ◽  
Controlled Trials ◽  
Cochrane Central Register

Abstract Backgrounds To date, there is still no consensus about the clinical efficacy of non-surgical periodontal therapy in rheumatoid arthritis (RA) patients with periodontitis. Therefore, the aim of this study was to summarize clinical data regarding the efficacy of scaling and root planing (SRP) in patients with RA and periodontitis compared to non-RA periodontitis patients. Methods We selected randomized controlled trials (RCTs) that compared periodontal clinical data in RA as compared to non-RA periodontitis patients by searching Embase, PubMed and Cochrane Central Register of Controlled Trials and by manually retrieving from the earliest records to March 8, 2021. The overall effect size of plaque index (PI), gingival index (GI), attachment loss (AL), probing depth (PD) and bleeding on probing (BOP) were calculated by either a fixed or random-effect model, and subgroup analyses were conducted according to the different time points of follow-up. Two investigators extracted the data and assess the accuracy of the obtained results with 95% of Confidence Intervals (CI). Cochrane Collaboration's tool was responsible for the evaluation of the literature quality and the inter-study heterogeneity was evaluated by Q test and I2 statistic. Sensitivity analyses were applied for results with heterogeneity. Publication bias was determined by Begg's test, Egger's test and the trim-and-fill method. Results Seven RCTs including 212 patients eventually met the inclusion criteria for the study. As the primary results, the change of PD was not statistically significant and in the secondary results changes of PI, GI, AL and BOP were also not statistically significant in RA patients with periodontitis compared to non-RA periodontitis patients. In subgroup analysis, a larger BOP reduction at 3 months, PI and AL reduction at 6 months were observed in patients with RA and periodontitis group. The results of sensitivity analyses had no significant effect. No evidence of potential publication bias was tested. There were some limitations due to the small number of eligible RCTs. Conclusions SRP is equally effective in RA as compared to non-RA periodontitis patients. It suggests RA does not affect the clinical efficacy of non-surgical periodontal therapy. These results could serve evidence-based practice.

scholarly journals An Evaluation of Non-Surgical Periodontal Therapy in Patients with Rheumatoid Arthritis

2015 ◽  
Vol 9 (1) ◽  
pp. 150-153 ◽  
Author(s):  
Caio V.G Roman-Torres ◽  
José S Neto ◽  
Marcio A Souza ◽  
Humberto O Schwartz-Filho ◽  
William C Brandt ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Laboratory Tests ◽  
Laboratory Data ◽  
Periodontal Therapy ◽  
Rheumatoid Arthritis Group ◽  
Reactive Protein ◽  
Probing Depth ◽  
Health Group ◽  
Oral Hygiene Instruction

aim of this study was to evaluate the efficacy of periodontal scaling and oral hygiene instruction for patients with mild chronic periodontitis and rheumatoid arthritis through clinical periodontal parameters and laboratory tests for CRP (C- reactive protein) and ESR (erythrocyte sedimentation rate). Twelve individuals with rheumatoid arthritis and 12 healthy individuals were evaluated, with a mean age of 45.38 and 46.75 respectively, all female and with mild, chronic periodontitis. The participants were evaluated clinically and periapical radiographs were taken (T1), after which periodontal treatment was instituted. After ninety days (T2), new clinical and laboratory data were obtained. Probing depth, bleeding index, and plaque indexes were observed in both groups, and the results demonstrated reductions but no statistical differences. Laboratory tests for CRP and ESR produced higher values for the rheumatoid arthritis group with T1- T2 reductions on the average, but the values were still higher than in the health group. We conclude that periodontal therapy in patients with rheumatoid arthritis and mild chronic periodontitis showed a improvement in the periodontal clinical parameters and laboratory tests that were evaluated.

scholarly journals Effects of Non-surgical Periodontal Therapy on Periodontal Clinical Data in Periodontitis Patients With Rheumatoid Arthritis: a Meta-analysis

2021 ◽  
Author(s):  
Yu Huang ◽  
Zheng Zhang ◽  
Youli Zheng ◽  
Zhulan Zhao ◽  
Yang Zhong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Publication Bias ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Periodontal Therapy ◽  
Sensitivity Analyses ◽  
Cochrane Central Register ◽  
Randomized Controlled Clinical Trials

Abstract Backgrounds: To date, there is still no consensus about the clinical efficacy of non-surgical periodontal therapy in rheumatoid arthritis (RA) patients with periodontitis. Therefore, the overall aim of this study was to summarize available data regarding the clinical efficacy of scaling and root planing (SRP) in patients with RA and periodontitis compared to patients with periodontitis alone.Methods: A meta-analysis of existing randomized controlled clinical trials (RCTs) was conducted. The eligible RCTs were selected through Embase, PubMed and Cochrane Central Register of Controlled Trials and manual retrieval from the earliest records to March 15, 2020 to extract data. The overall effect size of plaque index (PI), gingival index (GI), attachment loss (AL), probing depth (PD) and bleeding on probing (BOP) were calculated by either a fixed or random-effect model, and subgroup analyses were conducted according to the different time points of follow-up. Cochrane Collaboration's tool was responsible for the evaluation of the literature quality and the inter-study heterogeneity was evaluated by Q test and I2 statistic. The authors applied sensitivity analysis for results with heterogeneity. Publication bias was determined by Begg's test, Egger's test and the trim-and-fill method.Results: Eight RCTs eventually met the inclusion criteria for the study. The overall outcomes concerned PI, GI, PD, Al and BOP were 0.42(95% CI 0.02, 0.81), 0.03(95% CI -0.03, 0.10),-0.06mm (95% CI -0.18, 0.06), 0.16mm (95% CI-0.03, 0.36) and 4.15(95% CI -0.26, 8.55), respectively. In subgroup analysis, a larger BOP reduction at 3 months, PI and AL reduction at 6 months were observed in patients with RA and periodontitis group. The results of sensitivity analyses had no significant effect. No evidence of potential publication bias was tested.Conclusions: The authors conclude that SRP is equally effective in patients with periodontitis and RA than in periodontitis ones. This result suggests RA does not affect the clinical efficacy of non-surgical periodontal therapy.

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