Serum Zinc Levels and Immune Status of Children with Persistent Diarrhea Following Oral Zinc Supplementation

Background Suboptimal zinc intake may depress thymus function,lymphoproliferation, and T cell-dependent B-cell proliferation,which can impair antibody production. Zinc supplementation canimprove immune function and reduce morbidity.Objective To assess the effect of zinc supplementation on infants'anti-HBs titer after hepatitis B vaccination.Methods A double-blind randomized control trial of 66 healthyinfants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjectswere followed from birth to three months of age and were placedinto two treatment groups using block randomization. One groupreceived zinc supplements with a standard hepatitis B vaccination(zinc group, n=33) and the other group received placebosupplements with standard hepatitis B vaccination (placebo group,n=33). The serum zinc levels were measured at baseline and atthree months. The difference in levels of anti-HBs titer between thezinc and placebo groups was the primary endpoint of this study.Results The serum zinc levels were significantly higher in the zincgroup compared to the placebo group (P = 0.017), with a meandifference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardlessof baseline serum zinc levels, the mean anti-HBs titers weresignificantly higher in the zinc group compared to the placebogroup (P <0.0001; mean difference = 495.8 miU/mL; 95%CI 362.32 to 629.44). Multivariate analysis showed that zincsupplementation was the only variable that influenced anti-HBstiter levels (P < 0.0001).Conclusion Regardless of their initial zinc serum level, infantsreceiving zinc supplements along with standard hepatitis Bvaccination have significantly higher levels of anti-HBs titersthan infants receiving hepatitis B vaccination without zincsupplements.

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Pengaruh suplementasi zink terhadap parameter hematologi atlet sepatu roda setelah latihan endurance

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.27347 ◽

2018 ◽

Vol 15 (1) ◽

Author(s):

Mirza Hapsari Sakti Titis Penggalih ◽

Mustika Cahya Nirmala Dewinta ◽

Choiri Khumaidah Fikriyah ◽

Noni Kustia ◽

Assyifatu Rahmah Zada ◽

...

Keyword(s):

Endurance Training ◽

Endurance Exercise ◽

Zinc Supplementation ◽

Cell Damage ◽

Serum Zinc ◽

Hemoglobin Concentration ◽

Significant Difference ◽

Leukocyte Counts ◽

Zinc Levels ◽

Serum Zinc Levels

Background: In sports such as roller skates, endurance can lead to increased inflammation and muscle cell damage, free radical formation, and zinc excretion from sweat and urine that affect the increased redistribution of zinc from blood to tissue. This mechanism causes a decrease in blood zinc levels, erythrocyte numbers and hemoglobin concentrations, increased leukocyte counts and the body’s oxidative stress parameters that have an impact on the athlete’s performance decline. Zinc supplementation may be given to maintain the athlete’s hematologic parameters during endurance exercise.Objectives: To examine the effect of zinc supplementation on serum zinc level, hemoglobin concentration, erythrocyte and leukocyte counts, and blood MDA level of skate athletes after endurance exercise.Method: This study was an experimental clinical trial using pre and post-test designs on 8 athletes incorporated in the Pre-PON DIY Wheels Team. The study was conducted in two periods, one week of endurance exercise without zinc supplementation and one week of endurance exercise with 30 mg/d of zinc supplementation. Blood sampling was performed on the seventh day of each period, before and after endurance training.Results: There was a decrease in erythrocytes and hemoglobin concentration, and a significant increase in leukocyte count after endurance training in both periods (p<0.05), but no significant difference in serum zinc levels and MDA levels after endurance training in both periods (p>0.05). Although there were no significant differences in all athlete hematologic parameters between two treatments (p>0.05), there was an improvement in serum zinc levels, hemoglobin concentrations, erythrocyte, and leukocyte counts.Conclusion: Zinc supplementation 30 mg/day for one week did not have a significant effect on the athlete’s hematology parameters after endurance exercise.

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Does zinc supplementation improve dietary intake, symptoms of eating problems, and serum zinc levels in hemodialysis patients?

Dialysis & Transplantation ◽

10.1002/dat.20493 ◽

2010 ◽

Vol 39 (12) ◽

pp. 530-533 ◽

Cited By ~ 1

Author(s):

Jamal Ghaemmaghami ◽

Reza Mahdavi ◽

Elnaz Faramarzi ◽

Noshin Mohammadpour ◽

Hassan Argani

Keyword(s):

Dietary Intake ◽

Zinc Supplementation ◽

Serum Zinc ◽

Hemodialysis Patients ◽

Eating Problems ◽

Zinc Levels ◽

Serum Zinc Levels

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Zinc Supplementation as Adjunctive Therapy in Adults with Tuberculosis in Calabar, Nigeria: A Randomized Controlled Trial

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2019/v29i430079 ◽

2019 ◽

pp. 1-13

Author(s):

Regina I. Ejemot-Nwadiaro ◽

Edisua H. Itam ◽

Emmanuel N. Ezedinachi

Keyword(s):

Zinc Supplementation ◽

Intervention Group ◽

Serum Zinc ◽

Drug Regimen ◽

Haematological Parameters ◽

Control Group ◽

Tb Treatment ◽

Zinc Levels ◽

The Impact ◽

Serum Zinc Levels

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began. Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.

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Efficacy of zinc supplementation on growth and IGF-1 in prepubertal children with idiopathic short statures and low serum zinc levels

Clinical Pediatric Endocrinology ◽

10.1297/cpe.29.63 ◽

2020 ◽

Vol 29 (2) ◽

pp. 63-68

Author(s):

Kei Yoshida ◽

Tatsuhiko Urakami ◽

Yusuke Mine ◽

Junichi Suzuki

Keyword(s):

Zinc Supplementation ◽

Serum Zinc ◽

Prepubertal Children ◽

Zinc Levels ◽

Serum Zinc Levels ◽

Low Serum

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Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults

BMC Geriatrics ◽

10.1186/s12877-021-02224-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yumika Seki ◽

Kota Ishizawa ◽

Tetsuya Akaishi ◽

Michiaki Abe ◽

Koji Okamoto ◽

...

Keyword(s):

Older Adults ◽

Serum Albumin ◽

Zinc Deficiency ◽

Zinc Supplementation ◽

Serum Zinc ◽

Zinc Level ◽

Serum Zinc Level ◽

Swallowing Function ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. Methods A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. Results At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = − 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. Conclusions Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

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Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

BioMed Research International ◽

10.1155/2017/1024769 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 12

Author(s):

Ling-Jun Wang ◽

Ming-Qing Wang ◽

Rong Hu ◽

Yi Yang ◽

Yu-Sheng Huang ◽

...

Keyword(s):

Systematic Review ◽

Nutritional Status ◽

Subgroup Analysis ◽

Zinc Supplementation ◽

Meta Analysis ◽

Serum Zinc ◽

Maintenance Hemodialysis ◽

Randomized Controlled ◽

Zinc Levels ◽

Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

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Improved Swallowing Function after Zinc Supplementation in the Elderly

10.21203/rs.3.rs-115572/v1 ◽

2020 ◽

Author(s):

Yumika Seki ◽

Kota Ishizawa ◽

Tetsuya Akaishi ◽

Michiaki Abe ◽

Okamoto Koji ◽

...

Keyword(s):

Elderly Patients ◽

Serum Albumin ◽

Zinc Deficiency ◽

Zinc Supplementation ◽

Serum Zinc ◽

The Elderly ◽

Zinc Level ◽

Swallowing Function ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In elderly patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before.Methods: A total of 52 elderly subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured.Results: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = -0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the elderly who had comorbid dysphagia and zinc deficiency.Conclusions: Zinc deficiency is associated with compromised swallowing function in elderly patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in elderly patients with zinc deficiency.

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Supplementation of Zinc Sulphate Decrease for Cytokine Levels TNF-Α, IL-1β and IL-6 in Multibacillary Leprosy Patients

Health Notions ◽

10.33846/hn30407 ◽

2020 ◽

Vol 3 (4) ◽

pp. 191-197

Author(s):

Joko Kurnianto ◽

Hertanto W S ◽

Prasetyowati Prasetyowati ◽

Suharyo H. S.

Keyword(s):

Proinflammatory Cytokines ◽

Zinc Sulfate ◽

Zinc Sulphate ◽

Zinc Supplementation ◽

Serum Zinc ◽

Control Group ◽

Tnf Α ◽

Leprosy Patients ◽

Zinc Levels ◽

Serum Zinc Levels

Background: The role of zinc as an anti-oxidant and anti-inflammatory has been widely proven, this substance is relatively inexpensive and easily available to the public. Serum zinc levels of leprosy patients and patients with leprosy reactions are lower compared to healthy people, and proinflammatory cytokines including TNF-α, IL-1β and IL-6 play a role in the mechanism of leprosy reactions. Research on the effect of zinc supplementation on leprosy sufferers who have not experienced a reaction has not been done. Objective: To analyze the effect of 40 mg / day dose of zinc sulphate supplementation for 12 weeks on the levels of proinflammatory cytokines levels TNF-α, IL-1β and IL-6 in type MB leprosy patients. Method: This is an experimental study using a randomized control group pretest and posttest design. The study participants were MB patients with 121 patients who did not experience a leprosy reaction, the sample was taken randomly as many as 31 patients as a supplementation group (treatment), and 31 patients as Control group. BMI measurements, food intake by re-call method, Hb level using Hematology Analyzer, serum zinc levels using Atomic Absorption Spectrophotometry (AAS) method, TNF-α, IFN-γ, and IL-1β levels used the ELISA method. Data were analysed using chi-square and t-tests. Results: Zinc sulfate supplementation dose of 40 mg / day for 12 weeks in type MB leprosy patients was able to maintain a decrease in zinc levels of 1.22 pg / dL higher than leprosy patients who did not receive zinc supplementation, reduce levels of IL-1β (p=0.032). However, statistically there is insufficient evidence to reduce levels of TNF-α (p=0.063) and IL-6 (p=0.389) and risk factors. Conclusion: The study confirmed that 40 mg / day supplementation of zinc sulfate for 12 weeks in type MB leprosy patients able to maintain a decrease in serum zinc levels, reduce IL-1β levels. Keywords: Supplementation, Cytokines, Type MB leprosy

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Linear growth patterns in small for gestational age and preterm infants after zinc supplementation

Paediatrica Indonesiana ◽

10.14238/pi55.1.2015.23-8 ◽

2015 ◽

Vol 55 (1) ◽

pp. 23

Author(s):

Caecilia Nancy Setiawan ◽

Gatot Irawan Sarosa ◽

Mexitalia Setiawati

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Linear Growth ◽

Zinc Supplementation ◽

Serum Zinc ◽

Growth Patterns ◽

Median Percentage ◽

The Third ◽

Zinc Levels ◽

Serum Zinc Levels

Background Low birth weight (LBW) infants are at risk for growth disturbances due to intrauterine zinc deficiency. Zinc supplementation is expected to improve the linear growth of LBW babies. Objective To assess the effect of zinc supplementation on linear growth in preterm and small for gestational age (SGA) infants. Methods This quasi-experimental study had a pre- and post-test design. Subjects were LBW infants hospitalized in Kariadi Hospital during March-December 2011, consisted of SGA and preterm neonates. All subjects were given 5 mg of zinc syrup daily for 3 months. Subjects’ head circumference, weight, and length were measured monthly. Serum zinc levels were measured before and after supplementation. Data were analyzed with Chi-square test, independent T-test, and general linear model repeated measure. Results A total of 61 subjects were enrolled consisted of 31 preterm and 30 SGA neonates. Mean serum zinc levels in the preterm group were 168.2 (SD 54.5) μg/dL pre-supplementation and 163.6 (SD 50.7) μg/dL post-supplementation (P=0.049), while mean serum zinc levels in the SGA group were 174.8 (SD 46.6) μg/dL pre-supplementation and 167.4 (SD 49.4) μg/dL post-supplementation (P=0.271). Median percentage preterm weight and length increased from 87.3 to 102.4% in the third month (P<0.001) and from 95.8 to 103.9% in the third month (P<0.001), respectively. Median percentage SGA weight and length increased from 73.5 to 98.3% in the third month (P<0.001) and from 94.5 to 102.2% in the third month (P<0.001), respectively. Conclusion Both, the preterm and SGA infants exhibit catch-up growth after three months of zinc supplementation. [

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