Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults

Abstract Background Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. Methods A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. Results At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = − 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. Conclusions Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

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Improved Swallowing Function after Zinc Supplementation in the Elderly

10.21203/rs.3.rs-115572/v1 ◽

2020 ◽

Author(s):

Yumika Seki ◽

Kota Ishizawa ◽

Tetsuya Akaishi ◽

Michiaki Abe ◽

Okamoto Koji ◽

...

Keyword(s):

Elderly Patients ◽

Serum Albumin ◽

Zinc Deficiency ◽

Zinc Supplementation ◽

Serum Zinc ◽

The Elderly ◽

Zinc Level ◽

Swallowing Function ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In elderly patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before.Methods: A total of 52 elderly subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured.Results: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson’s R = 0.58, p < 0.0001) and time in the S-SPT (Spearman’s rho = -0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the elderly who had comorbid dysphagia and zinc deficiency.Conclusions: Zinc deficiency is associated with compromised swallowing function in elderly patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in elderly patients with zinc deficiency.

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Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽

10.3390/nu13062077 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2077

Author(s):

Jiun-Chi Huang ◽

Ya-Chin Huang ◽

Pei-Yu Wu ◽

Wen-Hsien Lee ◽

Yi-Chun Tsai ◽

...

Keyword(s):

Diastolic Dysfunction ◽

Left Atrial Volume ◽

Serum Zinc ◽

Zinc Level ◽

Volume Index ◽

Serum Zinc Level ◽

Lower Serum ◽

Echocardiographic Parameters ◽

Zinc Levels ◽

Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

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A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200487 ◽

2020 ◽

Vol 7 (3) ◽

pp. 588

Author(s):

Madhubalan T. ◽

Chidambaranathan S. ◽

Ramamoorthy R.

Keyword(s):

Statistical Significance ◽

Serum Zinc ◽

Zinc Level ◽

Serum Zinc Level ◽

Normal Children ◽

Febrile Convulsions ◽

Significant Difference ◽

Zinc Levels ◽

The Brain ◽

Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

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Dysgeusia Due to Zinc Deficiency After Pancreaticoduodenectomy Requiring Continuous Intravenous Zinc Supplementation: a Case Report and Literature Review

10.21203/rs.3.rs-957498/v1 ◽

2021 ◽

Author(s):

Hironobu Hata ◽

Yojiro Ota ◽

Katsuhiko Uesaka ◽

Yutaka Yamazaki ◽

Tsubasa Murata ◽

...

Keyword(s):

Zinc Deficiency ◽

Oral Surgery ◽

Oral Care ◽

Serum Zinc ◽

Zinc Level ◽

Normal Serum ◽

Acrodermatitis Enteropathica ◽

Proximal Jejunum ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies regarding the development of zinc deficiency after PD and presented the case of a patient with zinc deficiency after PD, who required home intravenous zinc replacement.Case presentation: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously under readmission. Her serum zinc levels recovered, and the lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home.Conclusion: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of dysgeusia associated with zinc deficiency after cancer surgery, as well as that induced by chemotherapy or head and neck radiation therapy.

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Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

10.21203/rs.3.rs-705022/v1 ◽

2021 ◽

Author(s):

Jee Wook Kim ◽

Min Soo Byun ◽

Dahyun Yi ◽

Jun Ho Lee ◽

Min Jung Kim ◽

...

Keyword(s):

Serum Zinc ◽

Beta Amyloid ◽

Zinc Level ◽

Amyloid Deposition ◽

Serum Zinc Level ◽

Positron Emission ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

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Zinc deficiency in Japanese children with idiopathic short stature

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0129 ◽

2019 ◽

Vol 32 (10) ◽

pp. 1083-1087 ◽

Cited By ~ 2

Author(s):

Kei Yoshida ◽

Tatsuhiko Urakami ◽

Remi Kuwabara ◽

Ichiro Morioka

Keyword(s):

Short Stature ◽

Zinc Deficiency ◽

Serum Insulin ◽

Serum Zinc ◽

Zinc Level ◽

Idiopathic Short Stature ◽

Japanese Children ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background and methods We investigated the frequency of zinc deficiency in Japanese children with idiopathic short stature, and evaluated whether serum zinc levels correlated with background factors, including age and standard deviation scores (SDSs) for height and serum insulin-like growth factor (IGF)-1 levels. The study subjects consisted of 89 Japanese children. Results The mean serum zinc level was 79 ± 12 (49–108) μg/dL. Of all the children, 48.3% had a low zinc level, in the 60–80 μg/dL range, and 6.7% had zinc deficiency with a zinc level below 60 μg/dL. The majority with a low zinc level and zinc deficiency were asymptomatic other than for short stature. We found no significant correlations of serum zinc with age, or the SDSs for height and serum IGF-1 levels, in either the entire subject population or those with a zinc level below 80 μg/dL. Conclusions We found a low zinc level to be common in Japanese children with idiopathic short stature, whereas actual zinc deficiency was rare. However, other as yet unknown mechanisms not associated with the growth hormone (GH)-IGF-1 axis could be involved in growth retardation in idiopathic short stature.

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Estimation of serum zinc levels in children with febrile convulsions

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182556 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1518 ◽

Cited By ~ 1

Author(s):

Ubaidur Rehman H. ◽

Shamshad Ahmed Khan ◽

Prakash R. Saldanha

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Diﬀerent studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no signiﬁcant diﬀerence in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a signiﬁcant diﬀerence between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

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Association between serum zinc level and simple febrile seizures in children: a hospital-based study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20183655 ◽

2018 ◽

Vol 6 (9) ◽

pp. 3116

Author(s):

Najmus Saqib ◽

Mahvish Qazi

Keyword(s):

Hospital Admissions ◽

Serum Zinc ◽

Febrile Seizures ◽

Zinc Level ◽

Serum Zinc Level ◽

Chi Square ◽

Febrile Convulsions ◽

Female Ratio ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

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Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

BANTAO Journal ◽

10.2478/bj-2014-0009 ◽

2015 ◽

Vol 12 (1) ◽

pp. 40-44

Author(s):

Itir Yegenaga ◽

Zeki Aydin

Keyword(s):

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

Inadequate Response ◽

Recombinant Erythropoietin ◽

Serum Zinc Level ◽

Human Recombinant Erythropoietin ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

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Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis

Nutrients ◽

10.3390/nu12030764 ◽

2020 ◽

Vol 12 (3) ◽

pp. 764 ◽

Cited By ~ 1

Author(s):

Satoshi Shimizu ◽

Ritsukou Tei ◽

Masahiro Okamura ◽

Nobuteru Takao ◽

Yoshihiro Nakamura ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Zinc Deficiency ◽

Serum Albumin Level ◽

Serum Zinc ◽

Japanese Patients ◽

Zinc Level ◽

Albumin Level ◽

Zinc Levels ◽

Inadequate Dietary Intake ◽

Serum Zinc Levels

Background: It is known that patients on hemodialysis (HD) are prone to developing zinc deficiency due to removal of zinc by HD, inadequate dietary intake, and reduced gastrointestinal zinc absorption. However, the prevalence of zinc deficiency in patients on peritoneal dialysis (PD) has not been well established. Methods: Serum zinc levels were compared between 47 patients on PD and 47 patients on HD matched for age, sex, and duration of dialysis. A serum zinc level < 60 μg/dL was defined as clinical zinc deficiency and a level of 60–80 μg/dL as subclinical zinc deficiency. The prevalence of zinc deficiency and associated clinical factors were determined in both groups. Results: Clinical zinc deficiency was found in 59.6% of the PD group and 70.2% of the HD group (p = 0.391). Subclinical zinc deficiency was found in 40.4% of the PD group and 29.8% of the HD group. Age, body mass index, and serum albumin level were identified as independent predictors of zinc deficiency in the PD group by multivariate analysis. Conclusions: A higher prevalence of clinical and subclinical zinc deficiency was found in patients on PD. The rates were comparable between patients on PD and those on HD after adjustment for confounding factors.

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