scholarly journals Suitability of Capillary Blood for Quantitative Assessment of G6PD Activity and Performances of G6PD Point-of-Care Tests

2015 ◽  
Vol 92 (4) ◽  
pp. 818-824 ◽  
Author(s):  
Germana Bancone ◽  
Cindy S. Chu ◽  
Nongnud Chowwiwat ◽  
Raweewan Somsakchaicharoen ◽  
Pornpimon Wilaisrisak ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Point Of Care ◽  
Capillary Blood ◽  
G6pd Activity ◽  
Point Of Care Tests

scholarly journals P084: Substituting capillary blood for urine in point-of-care pregnancy tests

CJEM ◽  
2018 ◽  
Vol 20 (S1) ◽  
pp. S86-S86
Author(s):  
M. Lafleche ◽  
A. Parent ◽  
E. Katherine Conrad ◽  
A. Bignucolo
Keyword(s):  
Emergency Department ◽  
Abdominal Pain ◽  
Vaginal Bleeding ◽  
Point Of Care ◽  
Capillary Blood ◽  
Predictive Values ◽  
Capillary Blood Sample ◽  
Patient Will ◽  
Sensitivity Specificity ◽  
Point Of Care Tests

Introduction: When a female presents with abdominal pain and vaginal bleeding, a positive b-hcg level helps in the diagnosis of an ectopic pregnancy. A timely diagnosis as well as management is required for these cases. In many emergency departments, there can be delays in laboratory processing of quantitative b-hcg levels as well as qualitative urine pregnancy tests. In others, especially in rural hospitals in Canada, the laboratory closes at night and these tests cannot be processed until the morning. This may also help decrease length of stay for some patients in the emergency department. There are currently new point-of-care b-hcg tests on the market using capillary blood, but these are expensive and not readily available. The purpose of the study is to validate the most inexpensive point of care urine pregnancy tests readily available on the market for use with capillary blood samples. These point-of-care tests have only been studied with urine and whole blood. If validated with capillary blood, it would allow for a very practical, rapid, and inexpensive test which could help doctors and nurses to triage patients in a timely and more efficient fashion. Methods: In our emergency department, 385 patients between the ages of 18-50 with possible pregnancy, abdominal pain or vaginal bleeding will be included in the study. A capillary blood sample will be taken and applied to a cassette point-of-care pregnancy test with four drops of saline. Two independent investigators will assess the test. The results will be compared to a quantitative serum hCG assay and urine. If these tests are not done as part of the patients medical care, the patient will be contacted one month after to enquire if the patient is pregnant or not. The sensitivity, specificity, positive and negative predictive values will be calculated. Results: Data colleciton will begin in January 2018. Conclusion: No conclusions can yet be drawn.

Re-challenging antibiotic resistance with Daniel Berman

2020 ◽  
Author(s):  
Daniel Berman
Keyword(s):  
Bacterial Infections ◽  
Point Of Care ◽  
Healthcare Setting ◽  
Rapid Diagnostic Tests ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Global Threat ◽  
The Right ◽  
Point Of Care Tests

How can we prevent the rise of resistance to antibiotics? In this video, Daniel Berman,  Nesta Challenges, discusses the global threat of AMR and how prizes like the Longitude Prize can foster the development of rapid diagnostic tests for bacterial infections, helping to contribute towards reducing the global threat of drug resistant bacteria. Daniel outlines how accelerating the development of rapid point-of-care tests will ensure that bacterial infections are treated with the most appropriate antibiotic, at the right time and in the right healthcare setting.

scholarly journals Comparison of Four Commercially Available Point-of-Care Tests to Detect Antibodies against Canine Parvovirus in Dogs

Viruses ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 18
Author(s):  
Michèle Bergmann ◽  
Mike Holzheu ◽  
Yury Zablotski ◽  
Stephanie Speck ◽  
Uwe Truyen ◽  
...  
Keyword(s):  
Test Performance ◽  
Point Of Care ◽  
Reference Method ◽  
Canine Parvovirus ◽  
P Value ◽  
Important Indicator ◽  
Specificity And Sensitivity ◽  
Specific Pathogen ◽  
The One ◽  
Point Of Care Tests

Measuring antibodies to evaluate dogs´ immunity against canine parvovirus (CPV) is useful to avoid unnecessary re-vaccinations. The study aimed to evaluate the quality and practicability of four point-of-care (POC) tests for detection of anti-CPV antibodies. The sera of 198 client-owned and 43 specific pathogen-free (SPF) dogs were included; virus neutralization was the reference method. Specificity, sensitivity, positive and negative predictive value (PPV and NPV), and overall accuracy (OA) were calculated. Specificity was considered to be the most important indicator for POC test performance. Differences between specificity and sensitivity of POC tests in the sera of all dogs were determined by McNemar, agreement by Cohen´s kappa. Prevalence of anti-CPV antibodies in all dogs was 80% (192/241); in the subgroup of client-owned dogs, it was 97% (192/198); and in the subgroup of SPF dogs, it was 0% (0/43). FASTest® and CanTiCheck® were easiest to perform. Specificity was highest in the CanTiCheck® (overall dogs, 98%; client-owned dogs, 83%; SPF dogs, 100%) and the TiterCHEK® (overall dogs, 96%; client-owned dogs, 67%; SPF dogs, 100%); no significant differences in specificity were observed between the ImmunoComb®, the TiterCHEK®, and the CanTiCheck®. Sensitivity was highest in the FASTest® (overall dogs, 95%; client-owned dogs, 95%) and the CanTiCheck® (overall dogs, 80%; client-owned dogs, 80%); sensitivity of the FASTest® was significantly higher compared to the one of the other three tests (McNemars p-value in each comparison: <0.001). CanTiCheck® would be the POC test of choice when considering specificity and practicability. However, differences in the number of false positive results between CanTiCheck®, TiterCHEK®, and ImmunoComb® were minimal.

scholarly journals N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dandan Shan ◽  
Joseph M. Johnson ◽  
Syrena C. Fernandes ◽  
Hannah Suib ◽  
Soyoon Hwang ◽  
...  
Keyword(s):  
Single Molecule ◽  
High Performance ◽  
Point Of Care ◽  
Capillary Blood ◽  
Molecular Testing ◽  
Sample Collection ◽  
Protein Assay ◽  
N Protein ◽  
Protein Levels ◽  
Percent Agreement

AbstractThe COVID-19 pandemic continues to have an unprecedented impact on societies and economies worldwide. There remains an ongoing need for high-performance SARS-CoV-2 tests which may be broadly deployed for infection monitoring. Here we report a highly sensitive single molecule array (Simoa) immunoassay in development for detection of SARS-CoV-2 nucleocapsid protein (N-protein) in venous and capillary blood and saliva. In all matrices in the studies conducted to date we observe >98% negative percent agreement and >90% positive percent agreement with molecular testing for days 1–7 in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals. N-protein load decreases as anti-SARS-CoV-2 spike-IgG increases, and N-protein levels correlate with RT-PCR Ct-values in saliva, and between matched saliva and capillary blood samples. This Simoa SARS-CoV-2 N-protein assay effectively detects SARS-CoV-2 infection via measurement of antigen levels in blood or saliva, using non-invasive, swab-independent collection methods, offering potential for at home and point of care sample collection.

scholarly journals The performance of hepatitis C virus ( HCV ) antibody point‐of‐care tests on oral fluid or whole blood and dried blood spot testing for HCV serology and viral load among individuals at higher risk for HCV in South Africa

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Nishi Prabdial‐Sing ◽  
Lucinda Gaelejwe ◽  
Lillian Makhathini ◽  
Jayendrie Thaver ◽  
Morubula Jack Manamela ◽  
...  
Keyword(s):  
South Africa ◽  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Whole Blood ◽  
Oral Fluid ◽  
Point Of Care ◽  
Hcv Antibody ◽  
Point Of Care Tests ◽  
Blood Spot

scholarly journals O3-S6.05 Perceptions on point-of-care tests for sexually transmitted infections-disconnect between frontline clinicians and professionals in industry

2011 ◽  
Vol 87 (Suppl 1) ◽  
pp. A82-A83 ◽  
Author(s):  
Y.-H. Hsieh ◽  
C. Gaydos ◽  
T. Hogan ◽  
O. Uy ◽  
J. Jackman ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Sexually Transmitted ◽  
Point Of Care Tests

Comparative study of i-SENS glucometers in neonates using capillary blood samples

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ha Nui Kim ◽  
Soo-Young Yoon
Keyword(s):  
Reference Values ◽  
Point Of Care ◽  
Evaluation Process ◽  
Capillary Blood ◽  
Performance Criteria ◽  
Accuracy Evaluation ◽  
Blood Samples ◽  
Average Reference ◽  
Error Grid ◽  
Accuracy Performance

Abstract Objectives The accuracy of point-of-care blood glucometers in the detection and evaluation of neonatal hypoglycemia is a concern. This study compared the performance of three i-SENS glucometers with that of the YSI 2300 STAT Plus Analyzer, which was used as a reference. Methods The leftover neonatal capillary blood samples of 319 patients were used in this study. The evaluation process and accuracy performance criteria were based on the International Organization for Standardization 15197:2013 guidelines. The evaluation involved three i-SENS glucometers (BAROzen H Expert plus, CareSens PRO, and CareSens H Beat) and the ACCU-CHEK® Inform II glucometer. Results The accuracy evaluation yielded acceptable results as follows: a) 100 and 100% for BAROzen H Expert plus; 99.8 and 100% for CareSens PRO; 98.7%, and 97.2% for CareSens H Beat glucometers were within the range of ±0.8 mmol/L (15 mg/dL) and ±15% of the average reference values at glucose concentrations <5.55 mmol/L (100 mg/dL) and ≥5.55 mmol/L (100 mg/dL), respectively, and b) all estimated glucose values (100%) were within the zones A and B of Consensus Error Grid for all three i-SENS glucometers. There was good correlation between the glucose values estimated by the glucometers and the reference values (R>0.990). Conclusions This study demonstrated that i-SENS glucometers exhibit acceptable performance and can be used as effective point-of-care devices in neonates.

Toward quantitative assessment of deformational plagiocephaly and brachycephaly at the point-of-care

2021 ◽  
Vol 8 (02) ◽  
Author(s):  
Reza Seifabadi ◽  
Fereshteh Aalamifar ◽  
Seyed Hossein Hezaveh ◽  
Can Kocabalkanli ◽  
Kelly Wilburn ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Point Of Care ◽  
Deformational Plagiocephaly

COVID-19 point-of-care tests and their application in the great Indian healthcare delivery pyramid

2021 ◽  
Vol 8 (1) ◽  
pp. 57-67
Author(s):  
Tanisha Bharara ◽  
Anita Chakravarti ◽  
L. Sumitra Devi ◽  
Shalini Upadhyay
Keyword(s):  
Point Of Care ◽  
Healthcare Delivery ◽  
Point Of Care Tests
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