scholarly journals Effect of Hospital Conditions on Short-Term Colorectal Cancer Outcomes: Experience of One Surgeon in Two Centers

2021 ◽  
Vol 31 (3) ◽  
pp. 210-216
Author(s):  
Ümit Alakuş ◽  
Süleyman Utku Çelik ◽  
Yaşar Subutay Peker ◽  
Barış Türker
Keyword(s):  
Colorectal Cancer ◽  
Cancer Outcomes ◽  
Short Term

Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

2019 ◽  
Vol 26 (7) ◽  
pp. 512-522
Author(s):  
Xian Li ◽  
Long Xia ◽  
Xiaohui Ouyang ◽  
Qimuge Suyila ◽  
Liya Su ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Nude Mice ◽  
Low Dose ◽  
Bioactive Peptides ◽  
Human Colorectal Cancer ◽  
Short Term ◽  
Hct 116

<P>Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. </P><P> Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. </P><P> Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. </P><P> Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. </P><P> Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.</P>

Short term outcome for colorectal cancer patients undergoing surgery in Tertiary care center in Eastern India

2021 ◽  
Vol 47 (2) ◽  
pp. e50-e51
Author(s):  
Abhitesh Singh ◽  
Anshul Jain ◽  
Dillip Muduly ◽  
Mahesh Sultania ◽  
Jyoti Ranjan Swain ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Eastern India ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Colorectal Cancer Patients

scholarly journals Short‐term outcomes of a COVID‐adapted triage pathway for colorectal cancer detection

2021 ◽  
Author(s):  
Janice Miller ◽  
Yasuko Maeda ◽  
Stephanie Au ◽  
Frances Gunn ◽  
Lorna Porteous ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Detection ◽  
Short Term

scholarly journals Associations between initiating antihypertensive regimens on stage I–III colorectal cancer outcomes: A Medicare SEER cohort analysis

2021 ◽  
Author(s):  
Rajesh Balkrishnan ◽  
Raj P. Desai ◽  
Aditya Narayan ◽  
Fabian T. Camacho ◽  
Lucas E. Flausino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Analysis ◽  
Stage I ◽  
Cancer Outcomes

Comparison of colorectal cancer outcomes in young adults and octogenarians

2021 ◽  
Author(s):  
Swetha Prabhakaran ◽  
Joseph Cherng Huei Kong ◽  
Evan Williams ◽  
Stephen Bell ◽  
Satish Warrier ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Cancer Outcomes

Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer

2009 ◽  
Vol 96 (12) ◽  
pp. 1458-1467 ◽  
Author(s):  
J. Neudecker ◽  
F. Klein ◽  
R. Bittner ◽  
T. Carus ◽  
A. Stroux ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Randomized Trial ◽  
Open Surgery ◽  
Prospective Randomized Trial ◽  
Short Term

scholarly journals Diagnosis Setting and Colorectal Cancer Outcomes: The Impact of Cancer Diagnosis in the Emergency Department

2020 ◽  
Vol 255 ◽  
pp. 164-171
Author(s):  
David Weithorn ◽  
Vanessa Arientyl ◽  
Ian Solsky ◽  
Goyal Umadat ◽  
Rebecca Levine ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Emergency Department ◽  
Cancer Diagnosis ◽  
Cancer Outcomes ◽  
The Impact
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