scholarly journals In vitro dissolution characteristics of patent, generic and similar brands of naproxen in various dissolution media

2021 ◽  
Vol 18 (6) ◽  
pp. 1155-1160
Author(s):  
María F. Rocha-Alcaraz ◽  
Erandis D. Torres-Sánchez ◽  
Juan H. Torres-Jasso ◽  
Alán Y. Yáñez-González ◽  
Mireya Z. Reyna-Villela ◽  
...  
Keyword(s):  
Phosphate Buffer ◽  
Grapefruit Juice ◽  
In Vitro Dissolution ◽  
Reference Solution ◽  
Biological Availability ◽  
Dissolution Properties ◽  
Dissolution Tests ◽  
Q Values

Purpose: To investigate the dissolution properties of various brands of naproxen in four dissolution media in order to forecast their biological availability. Methods: Dissolution tests were carried out in a dissolution tester with 48 tablets of different naproxen brands in 900 mL of 0.1 M phosphate buffer, pH 7.4. Subsequently, the medium was modified with 600 mL of buffer plus 300 mL of cola drink, grapefruit or milk. Each sample was taken and brought to a concentration approximating that of a reference solution. Absorbance at 332 nm was determined and the dissolution, Q, was calculated (Q values ≥ 80.0 ± 5 % were acceptable). Results: Dissolution in buffer was > 85 %. In cola drink, it was < 80 %, while in grapefruit juice, it was in the range of 7 - 68 %. Using 2-way ANOVA, these media and the three naproxen brands showed significant differences (F = 68.90, p = 0.0000; F = 23.18, p = 0.0000). With Fisher's LSD test, two of these media contributed consistently to dissolution, and the three drug brands showed statistically different dissolution profiles (p ≤ 0.05). Conclusion: Caution must be exercised cola drink, grapefruit juice and milk are used to administered naproxen as the biological availability of the drug may be altered.

Use of a Round-Bottom Resin Kettle for in vitro Dissolution Testing

1976 ◽  
Vol 59 (2) ◽  
pp. 367-367
Author(s):  
Ross D Kirchhoefer
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Testing ◽  
Drug Bioavailability ◽  
Dissolution Properties ◽  
Dissolution Tests

Abstract Dissolution tests are used to assist in the evaluation of drug bioavailability. A piece of glassware has been designed which allows one to take advantage of the dissolution properties of a 3-neck round-bottom flask and is compatible with and easier to use than existing stirring and bath equipment.

Formulation and Evaluation of Microbially- triggered tablets of Valdecoxib

2010 ◽  
Vol 2 (1) ◽  
Author(s):  
Surender Verma ◽  
S. Singh ◽  
D. Mishra ◽  
Atul Gupta ◽  
Rakesh Sharma
Keyword(s):  
Phosphate Buffer ◽  
Guar Gum ◽  
Oral Route ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Dissolution Study ◽  
Caecal Content ◽  
Model Drug

The objective of present study was to develop colon targeted drug delivery using bacterially triggered approach through oral route. Valdecoxib (COX-2 inhibitor) was chosen as a model drug in order to target it to colon which may prove useful in inflammatory bowel disease and related disorders. Matrix tablets of Valdecoxib were prepared by wet granulation technique utilizing different ratio of Guar gum and Sodium starch glycholate. The prepared matrix tablets were evaluated for uniformity of weight, uniformity of content, hardness and in vitro dissolution study in simulated gastric and intestinal fluid (Phosphate Buffer pH-1.2, pH-6.8 and pH-7.4), followed by Dissolution study in bio-relevant dissolution media Phosphate Buffer (pH-6.8) containing rat caecal content. The results revealed that the formulated batch had released lesser quantity of drug at pH 1.2 and pH 7.4 in 2 hors whereas in biorelevent dissolution media containing rat caecal content it released significantly higher amount of drug which was also significantly higher than the dissolution media of same pH without caecal content (microflora) and it was concluded that guar gum can be used as a potential carrier for targeting drugs to colon.

scholarly journals Automation of dissolution tests

2003 ◽  
Vol 25 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Rolf Rolli
Keyword(s):  
Quality Control ◽  
In Vitro Dissolution ◽  
Pharmaceutical Companies ◽  
Dissolution Testing ◽  
Simultaneous Operation ◽  
Task Forces ◽  
The Core ◽  
Dissolution Tests ◽  
The 1960S

Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality-control laboratories. Recent research works lead to the development of in-vitro dissolution tests as replacements for human and animal bioequivalence studies. For many years, a lot of time and effort has been invested in automation of dissolution tests. There have been a number of in-house solutions from pharmaceutical companies and many have created task forces or even departments to develop automation. Robotic solutions with sequential operation were introduced as well as the simultaneous operation concept developed by SOTAX. Today, pharmaceutical companies focus their resources mainly on the core business and in-house engineering solutions that are very difficult to justify. Therefore, it is important to know the basic considerations in order to plan an automation concept and implement it together with a vendor.

scholarly journals Development and Validation of an Eco-friendly HPLC-UV-DAD Method for the Determination of Allopurinol in Pharmaceuticals with Application to In vitro Dissolution Studies

2021 ◽  
Vol 11 (5) ◽  
pp. 13089-13101
Keyword(s):  
Factorial Design ◽  
Matrix Effects ◽  
Dissolution Kinetics ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Dissolution Studies ◽  
Dissolution Tests ◽  
Development And Validation

In this study, a sustainable HPLC-UV-DAD method was developed and validated for the determination of allopurinol in tablets and optimization of the dissolution test using factorial design. The separation of the analyte from the sample matrix was achieved in 3.01 minutes in a C8 column (4.6 mm X 150 mm X 5 μm), using mobile phase 0.1 mol L-1 HCl (25%) + ethanol (50%) + ultrapure water (25%) by UV detection at 249 nm. The method presented satisfactory analytical parameters of validation (specificity, selectivity, linearity, stability, precision, accuracy, and robustness), showing no matrix effects. The dissolution test was optimized by complete factorial design 23 and, the optimal conditions were: HCl 0.001 mol L-1, apparatus II (paddle) and 75 rpm. The analytical procedures and dissolution tests were applied to allopurinol tablets marketed in Bahia, Brazil, to evaluate the dissolution studies. The pharmaceuticals had similar dissolution profiles and first-order dissolution kinetics. This new and sustainable HPLC-UV-DAD method is friendly to the environment and can be used for the routine pharmaceutical analysis of allopurinol in fixed dosage forms.

Decomposition of Microcystin-LR, Microcystin-RR, and Microcystin-YR in Water Samples Submitted to in Vitro Dissolution Tests

2004 ◽  
Vol 52 (19) ◽  
pp. 5933-5938 ◽  
Author(s):  
Isabel M. Moreno ◽  
Judith Maraver ◽  
Esther C. Aguete ◽  
Manel Leao ◽  
Ana Gago-Martínez ◽  
...  
Keyword(s):  
Water Samples ◽  
In Vitro Dissolution ◽  
Dissolution Tests

scholarly journals Formulation Development and Evaluation of Fast Dissolving Oral Film of Midodrine Hydrochloride

2020 ◽  
Vol 10 (3-s) ◽  
pp. 107-110
Author(s):  
Aashish Marskole ◽  
Sailesh Kumar Ghatuary ◽  
Abhishek Parwari ◽  
Geeta Parkhe
Keyword(s):  
Systemic Circulation ◽  
In Vitro Dissolution ◽  
Systemic Availability ◽  
Solvent Casting ◽  
Formulation Development ◽  
Casting Method ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Dissolution Tests

Oral fast dissolving midodrine hydrochloride films prepared by solvent casting method, PEG 400 was the selected plasticizers, incorporating superdisintegrants such as croscarmellose sodium (CCS) and sodium starch glycolate (SSG) to achieve the goal. Drug content, weight variability, film thickness, disintegration time, endurance, percentage of moisture content, and in vitro dissolution tests were analyzed for the prepared films. In all formulations, the tensile strength value was found from 0.965±0.045 and 1.256±0.032 and the folding capacity was over 100. The assay values ranged from 97.98±0.25 to 99.89±0.36 percent for all formulations. The disintegration time was ranging between 55±9 to 120±6 sec, the minimum time for disintegration was found in formulation F5 (55±9). The prepared F5 formulation shows greater release of the drug (99.25±0.41 percent) within 15 min relative to other formulations. As the drug having low solubility, fast disintegration may leads to more drug availability for dissolution, resulting in faster absorption in systemic circulation increased systemic availability of drug leads to quick onset of action which is prerequisite for hypertension. Keywords: Midodrine hydrochloride, Fast dissolving films, Solvent casting method, Superdisintegrants.

scholarly journals Formulation of Ramipril Tablets Containing Solid Dispersion Employing Selective Polymers to Enhance Dissolution Rate

2020 ◽  
Vol 10 (3-s) ◽  
pp. 142-149
Author(s):  
Inder Kumar ◽  
Sandeep Verma ◽  
Amit Chaudhary
Keyword(s):  
Drug Release ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Phosphate Buffer ◽  
Flow Property ◽  
In Vitro Dissolution ◽  
Standard Data ◽  
Evaporation Technique ◽  
Good Flow

Objective: The present work based on formulation of Ramipril tablets containing solid dispersion employing selective polymers. The objective of the preparation is to prepare the solid dispersion of the Ramipril, which has more responsive value in terms of the dissolution rate. Method: Solid dispersion complex was prepared with two different carriers PEG 6000 and PVP K30. Nine formulations were developed and each formulation were subjected to pre compression and post compression parameters. Result and Discussion:  Pre-compression and post compression parameters were studied which had shown good flow property and compiled the standard data. In-vitro dissolution studies shows more than 90 % drug release in phosphate buffer pH 6.8 in 30 min. Out of all formulation F4 showed 92.55±0.67 % drug release with in 30min which was the best result rest of the formulation. Conclusion: Ramipril tablets were successfully prepared and evaluated. F4 formulation shows the greater dissolution rate in phosphate buffer pH 6.8 as compared to other formulations. When compared with marketed formulation it also shows better results. Therefore, Ramipril solid dispersion tablets enhanced the dissolution rate and can be more efficacious for improving oral bioavailability of Ramipril. Keywords: Solid dispersion, Ramipril, Solvent Evaporation Technique.

scholarly journals The Relationships between Process Parameters and Polymeric Nanofibers Fabricated Using a Modified Coaxial Electrospinning

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 843 ◽  
Author(s):  
Honglei Zhou ◽  
Zhaorong Shi ◽  
Xi Wan ◽  
Hualing Fang ◽  
Deng-Guang Yu ◽  
...  
Keyword(s):  
Process Parameters ◽  
Hydroxypropyl Methylcellulose ◽  
Taylor Cone ◽  
Electrostatic Energy ◽  
In Vitro Dissolution ◽  
Process Conditions ◽  
Sheath Fluid ◽  
Dissolution Tests ◽  
Important Challenge

The concrete relationship between the process parameters and nanoproduct properties is an important challenge for applying nanotechnology to produce functional nanomaterials. In this study, the relationships between series of process parameters and the medicated nanofibers’ diameter were investigated. With an electrospinnable solution of hydroxypropyl methylcellulose (HPMC) and ketoprofen as the core fluid, four kinds of nanofibers were prepared with ethanol as a sheath fluid and under the variable applied voltages. Based on these nanofibers, a series of relationships between the process parameters and the nanofibers’ diameters (D) were disclosed, such as with the height of the Taylor cone (H, D = 125 + 363H), with the angle of the Taylor cone (α, D = 1576 − 19α), with the length of the straight fluid jet (L, D = 285 + 209L), and with the spreading angle of the instable region (θ, D = 2342 − 43θ). In vitro dissolution tests verified that the smaller the diameters, the faster ketoprofen (KET) was released from the HPMC nanofibers. These concrete process-property relationships should provide a way to achieve new knowledge about the electrostatic energy-fluid interactions, and to meanwhile improve researchers’ capability to optimize the coaxial process conditions to achieve the desired nanoproducts.

Design and Development of Microparticulate Drug Delivery System of Hydrochlorothiazide

1970 ◽  
Vol 9 (3) ◽  
pp. 3282-3286
Author(s):  
S.S. Sakhare ◽  
A.K. Mali
Keyword(s):  
Drug Delivery ◽  
Solid Particles ◽  
In Vitro Dissolution ◽  
Uniform Size ◽  
Dissolution Properties ◽  
Particle Size Determination ◽  
Evaporation Technique ◽  
Novel Drug

Microparticles open up new vistas of research in the development of novel drug delivery systems. Microparticles are defined as particulate dispersions or solid particles with size range of 1-1000 µm.  Hydrochlorothiazide (HCT), diuretic drug, is practically insoluble in water and has a solubility of 250µg/mL in 0.1 N HCl (25 °C). Presently, the improvement of drug solubility is one of the most challenging fields in pharmaceutical development, therefore, we choose hydrochlorothiazide for the micro-particulate drug delivery. Microparticles of hydrochlorothiazide were prepared by solvent evaporation technique. The prepared microparticles were evaluated for various properties. Particle size determination of microparticles by optical microscopy showed uniform size distribution. The in vitro dissolution studies of hydrochlorothiazide microparticles showed better release effect (99.45%) over a period of 60 min as compared to pure drug. Thus a successful attempt was made to formulate microparticles of this BCS class II drug which resulted in increase in dissolution properties of hydrochlorothiazide microparticles.

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